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The map label for this gene is apt [H]

Identifier: 33863082

GI number: 33863082

Start: 885624

End: 886142

Strand: Direct

Name: apt [H]

Synonym: PMT0810

Alternate gene names: 33863082

Gene position: 885624-886142 (Clockwise)

Preceding gene: 33863078

Following gene: 33863087

Centisome position: 36.73

GC content: 51.25

Gene sequence:

>519_bases
TTGGATCTTCGCCACCTCATTCAAGACGTACCAGACTTTCCAAAACCTGGAATTCTCTTTCGGGACATCAGTCCCCTGCT
GCGTGATCCCGATGGCTGGGATGAAGTGATGCGACAGCTAGGAGATCTCTGCACAGAACTCAAACCCGATTTAATTGTCG
GAATCGAATCACGTGGATTCATTGTGGGAACAGCTTTAGCAACGAATCGGAAAATCGGCTTTGTTCCGGTTAGGAAGCCT
GGCAAATTGCCTGGTGATGTTCTTGGCATCGACTATTCCCTGGAGTACGGCAGCGATCGGCTCGAGATTCATGCGGATGC
TCTGCAAGGTCATCCCCGTGTCTTATTGGTGGACGACCTTCTGGCGACTGGAGGAACTGCAAGAGCCACAGTCGAGTTAA
TCGAGAAAGCTGGTGGCGATCTGGTGGGATGTGGTTTTGTGATCGAATTAGCCGCTCTCGGCGGGCGGCAGCAACTTCCA
GTTGAGATACCAGTGAAGTCACTGATTATCTACTCCTGA

Upstream 100 bases:

>100_bases
GGGTTTCTGTGGCTGAACAGTTGATGAAGGATCTGAAGTGGTTGTTGCATTAATCATGGCTGCGATGATGCCAGGCCTAA
GGCCCCTGCGTCACCACTCT

Downstream 100 bases:

>100_bases
TCATTTTCCCAATCGAGAACCTGCTGATACTGAGCCAAGCTGAGTAAACCGAAACTCCAAAGCACGACCGGCAGAGGTGC
TTGCTCAAGTTCTGCCTGAC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MDLRHLIQDVPDFPKPGILFRDISPLLRDPDGWDEVMRQLGDLCTELKPDLIVGIESRGFIVGTALATNRKIGFVPVRKP
GKLPGDVLGIDYSLEYGSDRLEIHADALQGHPRVLLVDDLLATGGTARATVELIEKAGGDLVGCGFVIELAALGGRQQLP
VEIPVKSLIIYS

Sequences:

>Translated_172_residues
MDLRHLIQDVPDFPKPGILFRDISPLLRDPDGWDEVMRQLGDLCTELKPDLIVGIESRGFIVGTALATNRKIGFVPVRKP
GKLPGDVLGIDYSLEYGSDRLEIHADALQGHPRVLLVDDLLATGGTARATVELIEKAGGDLVGCGFVIELAALGGRQQLP
VEIPVKSLIIYS
>Mature_172_residues
MDLRHLIQDVPDFPKPGILFRDISPLLRDPDGWDEVMRQLGDLCTELKPDLIVGIESRGFIVGTALATNRKIGFVPVRKP
GKLPGDVLGIDYSLEYGSDRLEIHADALQGHPRVLLVDDLLATGGTARATVELIEKAGGDLVGCGFVIELAALGGRQQLP
VEIPVKSLIIYS

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=45.6140350877193, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI71773201, Length=124, Percent_Identity=50, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1786675, Length=157, Percent_Identity=48.4076433121019, Blast_Score=150, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17509087, Length=168, Percent_Identity=46.4285714285714, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=172, Percent_Identity=43.0232558139535, Blast_Score=121, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=166, Percent_Identity=33.1325301204819, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136334, Length=171, Percent_Identity=43.859649122807, Blast_Score=124, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 18631; Mature: 18631

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRHLIQDVPDFPKPGILFRDISPLLRDPDGWDEVMRQLGDLCTELKPDLIVGIESRGF
CCHHHHHHHCCCCCCCCEEHHCCCHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCE
IVGTALATNRKIGFVPVRKPGKLPGDVLGIDYSLEYGSDRLEIHADALQGHPRVLLVDDL
EEEEEEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEEEEEHHHCCCCCEEEEEHH
LATGGTARATVELIEKAGGDLVGCGFVIELAALGGRQQLPVEIPVKSLIIYS
HHCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCEEECHHEEEEEC
>Mature Secondary Structure
MDLRHLIQDVPDFPKPGILFRDISPLLRDPDGWDEVMRQLGDLCTELKPDLIVGIESRGF
CCHHHHHHHCCCCCCCCEEHHCCCHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCE
IVGTALATNRKIGFVPVRKPGKLPGDVLGIDYSLEYGSDRLEIHADALQGHPRVLLVDDL
EEEEEEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCCEEEEEEHHHCCCCCEEEEEHH
LATGGTARATVELIEKAGGDLVGCGFVIELAALGGRQQLPVEIPVKSLIIYS
HHCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCEEECHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA