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The map label for this gene is proA [H]

Identifier: 33862709

GI number: 33862709

Start: 490299

End: 491615

Strand: Reverse

Name: proA [H]

Synonym: PMT0436

Alternate gene names: 33862709

Gene position: 491615-490299 (Counterclockwise)

Preceding gene: 33862710

Following gene: 33862708

Centisome position: 20.39

GC content: 53.61

Gene sequence:

>1317_bases
ATGACAACTTCCCCTGGAGTTCCTGAGCCTTCCGCCCAGTTGCTGCGACTTGCAGCAGAGGTGCGGCAAGCAGCCATGGC
TCTTGGGCAAAGTGATGACAACCAGCGGCGTAAGGCCCTGATGGCAATGGCCAATGCTTTGCTGTCAAGCTCTGAGCAGA
TCGTGAGGGCTAATCAACTCGATTTAGAGAAGGCTCGAACTGAGGGACTTGCTTCTGCCCTGATGGCGCGGCTCAGGCTT
GATGAAAGCAAACTCAACTCGGCTATCGAGGGGCTCAGGCAGTTGGCTCAATTAACTGATCCCCTTGGTTTGCGTCAGTT
GCATCGTGAACTGGATCAAGACCTTGTGCTGGAGCGCATCACCGTTCCTCTTGGAGTCCTGGGGGTAATCTTTGAGGCGC
GCCCAGATGCCGTAATTCAGATCACTTCACTGGCAATTCGCTCTGGCAATGGCGCACTTCTCAAGGGCGGCAGCGAAGCA
AGCCACACCAATCAGGCCATCATTGAGGCGTTGAAGAATGGTCTGGCTGAAACAGAGATCGATCCCGAGGCAATTGCCTT
ACTCAAGACCCGTCAGGAAAGCCTTGCCCTACTTCGCCTTGATGGCCTAGTGGATTTGATCATCCCTCGCGGCAGCAACG
AACTGGTGCGTTTCATTCAAGACAACACACGAATTCCGGTTCTTGGTCATGCGGACGGAATCTGTCATCTCTATCTCGAT
GCCGCGGCGGATCTGAAGCAGGCCCTACAGATTGCAATCGATAGCAAGACCCAGTACCCCGCAGCATGCAACTCTATTGA
AACTCTGCTTATTCATCAGTCCATTGCACCGTCGTTTTTAGAGCTTGCAATTCCTGCATTTCTTCAGGCCGGGGTTCGTC
TGCTTGGGGATTCAGCTAGCCGGGCTTTAGGAGTAGAAGAGTCAGCAAGTGAAGAGGATTGGGCTACGGAATATCTCGAT
CTGATTCTGTCAGTGAAAGTGGTGCCTGATCTAGAGGGAGCCCTGGATCACATCCGTCGCTATAGCTCCCGTCACACGGA
GGCGATTGTCAGCAATGATCAGGAGACGGCTGAGCGTTTTCTCCAAGCTGTCGATAGTGCCGGTGTTTTTCACAATTGCT
CCACGCGTTTTGCCGATGGATTCCGTTATGGCTTTGGAGCCGAGGTTGGAATCAGTACTCAAACACTGCCTCCAAGGGGG
CCGGTTGGCTTGGAAGGGCTGGTGACCTATCGCTATCGGTTACGTGGACAAGGCCACATTGTGGCGGACTATGCCAATGG
TGAATGCATGTTCACTCACCGGGACCTACCGCTGTGA

Upstream 100 bases:

>100_bases
GCTGGTCGCCTGGGGGCAGCTCGACTTGCCCTTCAACGTCTCTTAAGTGTCGGCAATGCCCCTTGAGGCGTAATGATGAG
CACAGCTGTGCCGCGCTGTG

Downstream 100 bases:

>100_bases
TCAATCGTCTCCCTTTAGGAGCCATTCATGTTAACGATGTGCGCTTGTGGGCCCACGTGGGTGTGCTTGACCATGAAAGA
CGTGAAGGCCAGTGGTTCAG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTTSPGVPEPSAQLLRLAAEVRQAAMALGQSDDNQRRKALMAMANALLSSSEQIVRANQLDLEKARTEGLASALMARLRL
DESKLNSAIEGLRQLAQLTDPLGLRQLHRELDQDLVLERITVPLGVLGVIFEARPDAVIQITSLAIRSGNGALLKGGSEA
SHTNQAIIEALKNGLAETEIDPEAIALLKTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYLD
AAADLKQALQIAIDSKTQYPAACNSIETLLIHQSIAPSFLELAIPAFLQAGVRLLGDSASRALGVEESASEEDWATEYLD
LILSVKVVPDLEGALDHIRRYSSRHTEAIVSNDQETAERFLQAVDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRG
PVGLEGLVTYRYRLRGQGHIVADYANGECMFTHRDLPL

Sequences:

>Translated_438_residues
MTTSPGVPEPSAQLLRLAAEVRQAAMALGQSDDNQRRKALMAMANALLSSSEQIVRANQLDLEKARTEGLASALMARLRL
DESKLNSAIEGLRQLAQLTDPLGLRQLHRELDQDLVLERITVPLGVLGVIFEARPDAVIQITSLAIRSGNGALLKGGSEA
SHTNQAIIEALKNGLAETEIDPEAIALLKTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYLD
AAADLKQALQIAIDSKTQYPAACNSIETLLIHQSIAPSFLELAIPAFLQAGVRLLGDSASRALGVEESASEEDWATEYLD
LILSVKVVPDLEGALDHIRRYSSRHTEAIVSNDQETAERFLQAVDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRG
PVGLEGLVTYRYRLRGQGHIVADYANGECMFTHRDLPL
>Mature_437_residues
TTSPGVPEPSAQLLRLAAEVRQAAMALGQSDDNQRRKALMAMANALLSSSEQIVRANQLDLEKARTEGLASALMARLRLD
ESKLNSAIEGLRQLAQLTDPLGLRQLHRELDQDLVLERITVPLGVLGVIFEARPDAVIQITSLAIRSGNGALLKGGSEAS
HTNQAIIEALKNGLAETEIDPEAIALLKTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYLDA
AADLKQALQIAIDSKTQYPAACNSIETLLIHQSIAPSFLELAIPAFLQAGVRLLGDSASRALGVEESASEEDWATEYLDL
ILSVKVVPDLEGALDHIRRYSSRHTEAIVSNDQETAERFLQAVDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRGP
VGLEGLVTYRYRLRGQGHIVADYANGECMFTHRDLPL

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=423, Percent_Identity=46.3356973995272, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI21361368, Length=423, Percent_Identity=46.3356973995272, Blast_Score=337, Evalue=1e-92,
Organism=Escherichia coli, GI1786438, Length=398, Percent_Identity=37.9396984924623, Blast_Score=289, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17569967, Length=424, Percent_Identity=42.2169811320755, Blast_Score=330, Evalue=9e-91,
Organism=Caenorhabditis elegans, GI17569969, Length=424, Percent_Identity=42.2169811320755, Blast_Score=330, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6324899, Length=447, Percent_Identity=42.7293064876958, Blast_Score=359, Evalue=1e-100,
Organism=Drosophila melanogaster, GI21357643, Length=409, Percent_Identity=45.9657701711491, Blast_Score=331, Evalue=5e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 47529; Mature: 47398

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSPGVPEPSAQLLRLAAEVRQAAMALGQSDDNQRRKALMAMANALLSSSEQIVRANQL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
DLEKARTEGLASALMARLRLDESKLNSAIEGLRQLAQLTDPLGLRQLHRELDQDLVLERI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TVPLGVLGVIFEARPDAVIQITSLAIRSGNGALLKGGSEASHTNQAIIEALKNGLAETEI
HHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCC
DPEAIALLKTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYLD
CHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEHH
AAADLKQALQIAIDSKTQYPAACNSIETLLIHQSIAPSFLELAIPAFLQAGVRLLGDSAS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHH
RALGVEESASEEDWATEYLDLILSVKVVPDLEGALDHIRRYSSRHTEAIVSNDQETAERF
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LQAVDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYRYRLRGQGHI
HHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCEE
VADYANGECMFTHRDLPL
EEEECCCEEEEECCCCCC
>Mature Secondary Structure 
TTSPGVPEPSAQLLRLAAEVRQAAMALGQSDDNQRRKALMAMANALLSSSEQIVRANQL
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
DLEKARTEGLASALMARLRLDESKLNSAIEGLRQLAQLTDPLGLRQLHRELDQDLVLERI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TVPLGVLGVIFEARPDAVIQITSLAIRSGNGALLKGGSEASHTNQAIIEALKNGLAETEI
HHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCC
DPEAIALLKTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYLD
CHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEHH
AAADLKQALQIAIDSKTQYPAACNSIETLLIHQSIAPSFLELAIPAFLQAGVRLLGDSAS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHH
RALGVEESASEEDWATEYLDLILSVKVVPDLEGALDHIRRYSSRHTEAIVSNDQETAERF
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LQAVDSAGVFHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLEGLVTYRYRLRGQGHI
HHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCEE
VADYANGECMFTHRDLPL
EEEECCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA