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The map label for this gene is menB [H]

Identifier: 33862678

GI number: 33862678

Start: 455321

End: 456214

Strand: Reverse

Name: menB [H]

Synonym: PMT0405

Alternate gene names: 33862678

Gene position: 456214-455321 (Counterclockwise)

Preceding gene: 33862679

Following gene: 33862677

Centisome position: 18.92

GC content: 54.81

Gene sequence:

>894_bases
ATGGCTATGGATTCCAATCGGTTTGATAGGAGGCCAAGACAGGTTTTGCCTGGCAAGCCCACGATCGAATGGGAACCCTG
GGGTGAATATCAAGACGTCCTGCTTGATCGCAGTTCAGAAGGAATTGCCAGGGTTGCGATTGATCGTCCGACCAAGCGCA
ATGCTTTCCGACCACGCACGGTGATGGAACTCTGTGATGCGTTTACCAGAATTCGAGACGACCAACGTTTAGGCGTGGTT
TTGTTCACCGGTGTTGGACCTGCTGACGATGGCGGCTATGCCTTTTGTGCAGGTGGTGACCAAAGTGTGCGCGGCGACGG
TGGCTACCTCGATGAGGAGGGTTTGCCGCGCCTCAATGTTCTCGACCTACAGCGCATCATTCGCAGCTTGCCAAAGGTTG
TGATTGCACTTGTCGCTGGCTATGCGATCGGCGGCGGCCAAGTGCTGCACTTGTTATGTGATCTCAGTCTGGCGGCAGAG
AATGCCGTGTTTGGGCAAACCGGTCCCAAGGTGGGCAGCTTTGATGGTGGCTTTGGTGCTGGTTACCTAGCCAGAGTCGT
GGGGCAACGCAAGGCTCGTGAAATCTGGTTTCTCTGTCGTCAATACGGAGCTGAAGAAGCGCTGAAAATGGGGTTGATCA
ACGAGATTGTTCCTCTTGATGGTCTTGAAGCAGAGGGAGTGCGTTGGGCAAGAGAGGTGTTGCAGCACAGCCCCACAGCC
ATCCGCTGCCTGAAGGCCGCATTCAATGCTGAAACCGATGGCTTGGCAGGACTTCAGGAGCTAGCCGGCCAGGCCACCCA
TCTGTTCTATCGAACGGATGAAGCCCAGGAGGGGCGAAATGCTTTTCTACAAAAACGACGTCCAGATTTTTCAGGCTCAG
GCTGGCTTCCCTAA

Upstream 100 bases:

>100_bases
ATCGGCGTCAAGATTCATCGATGAGGCAACAGCTTCGCGAGGGATTGATGATGCATCTGCAGTCGATTTCCCAAAATGGC
CACATTGATCTTTGATCCCG

Downstream 100 bases:

>100_bases
CCAGCCGCTCTAGGCAGCGTCATGATTGACGCATCGTTTGCTTTGGGGAAGGAGTTCTTGCTACCGCTTCCACTGCCGCT
GCTGCCCTCCCTGATTCATG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MAMDSNRFDRRPRQVLPGKPTIEWEPWGEYQDVLLDRSSEGIARVAIDRPTKRNAFRPRTVMELCDAFTRIRDDQRLGVV
LFTGVGPADDGGYAFCAGGDQSVRGDGGYLDEEGLPRLNVLDLQRIIRSLPKVVIALVAGYAIGGGQVLHLLCDLSLAAE
NAVFGQTGPKVGSFDGGFGAGYLARVVGQRKAREIWFLCRQYGAEEALKMGLINEIVPLDGLEAEGVRWAREVLQHSPTA
IRCLKAAFNAETDGLAGLQELAGQATHLFYRTDEAQEGRNAFLQKRRPDFSGSGWLP

Sequences:

>Translated_297_residues
MAMDSNRFDRRPRQVLPGKPTIEWEPWGEYQDVLLDRSSEGIARVAIDRPTKRNAFRPRTVMELCDAFTRIRDDQRLGVV
LFTGVGPADDGGYAFCAGGDQSVRGDGGYLDEEGLPRLNVLDLQRIIRSLPKVVIALVAGYAIGGGQVLHLLCDLSLAAE
NAVFGQTGPKVGSFDGGFGAGYLARVVGQRKAREIWFLCRQYGAEEALKMGLINEIVPLDGLEAEGVRWAREVLQHSPTA
IRCLKAAFNAETDGLAGLQELAGQATHLFYRTDEAQEGRNAFLQKRRPDFSGSGWLP
>Mature_296_residues
AMDSNRFDRRPRQVLPGKPTIEWEPWGEYQDVLLDRSSEGIARVAIDRPTKRNAFRPRTVMELCDAFTRIRDDQRLGVVL
FTGVGPADDGGYAFCAGGDQSVRGDGGYLDEEGLPRLNVLDLQRIIRSLPKVVIALVAGYAIGGGQVLHLLCDLSLAAEN
AVFGQTGPKVGSFDGGFGAGYLARVVGQRKAREIWFLCRQYGAEEALKMGLINEIVPLDGLEAEGVRWAREVLQHSPTAI
RCLKAAFNAETDGLAGLQELAGQATHLFYRTDEAQEGRNAFLQKRRPDFSGSGWLP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=275, Percent_Identity=28, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI31542718, Length=256, Percent_Identity=29.6875, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4502327, Length=265, Percent_Identity=29.811320754717, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI70995211, Length=231, Percent_Identity=25.974025974026, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788597, Length=272, Percent_Identity=62.8676470588235, Blast_Score=356, Evalue=1e-99,
Organism=Escherichia coli, GI1787659, Length=253, Percent_Identity=30.4347826086957, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI221142681, Length=258, Percent_Identity=31.0077519379845, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082183, Length=210, Percent_Identity=29.0476190476191, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787660, Length=266, Percent_Identity=29.3233082706767, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788682, Length=202, Percent_Identity=28.7128712871287, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=258, Percent_Identity=30.2325581395349, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17554946, Length=273, Percent_Identity=28.9377289377289, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17540714, Length=234, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17549921, Length=214, Percent_Identity=27.1028037383178, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=196, Percent_Identity=30.1020408163265, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=254, Percent_Identity=25.1968503937008, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129971, Length=284, Percent_Identity=29.2253521126761, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24653477, Length=284, Percent_Identity=29.2253521126761, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24653139, Length=277, Percent_Identity=29.2418772563177, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357171, Length=277, Percent_Identity=27.0758122743682, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24654903, Length=206, Percent_Identity=27.6699029126214, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 32592; Mature: 32461

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMDSNRFDRRPRQVLPGKPTIEWEPWGEYQDVLLDRSSEGIARVAIDRPTKRNAFRPRT
CCCCCCCHHCCCHHCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCHH
VMELCDAFTRIRDDQRLGVVLFTGVGPADDGGYAFCAGGDQSVRGDGGYLDEEGLPRLNV
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCH
LDLQRIIRSLPKVVIALVAGYAIGGGQVLHLLCDLSLAAENAVFGQTGPKVGSFDGGFGA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
GYLARVVGQRKAREIWFLCRQYGAEEALKMGLINEIVPLDGLEAEGVRWAREVLQHSPTA
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHH
IRCLKAAFNAETDGLAGLQELAGQATHLFYRTDEAQEGRNAFLQKRRPDFSGSGWLP
HHHHHHHHCCCCCHHHHHHHHCCHHHEEEEECCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AMDSNRFDRRPRQVLPGKPTIEWEPWGEYQDVLLDRSSEGIARVAIDRPTKRNAFRPRT
CCCCCCHHCCCHHCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCHH
VMELCDAFTRIRDDQRLGVVLFTGVGPADDGGYAFCAGGDQSVRGDGGYLDEEGLPRLNV
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCH
LDLQRIIRSLPKVVIALVAGYAIGGGQVLHLLCDLSLAAENAVFGQTGPKVGSFDGGFGA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
GYLARVVGQRKAREIWFLCRQYGAEEALKMGLINEIVPLDGLEAEGVRWAREVLQHSPTA
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHH
IRCLKAAFNAETDGLAGLQELAGQATHLFYRTDEAQEGRNAFLQKRRPDFSGSGWLP
HHHHHHHHCCCCCHHHHHHHHCCHHHEEEEECCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]