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The map label for this gene is lytC [H]

Identifier: 33862667

GI number: 33862667

Start: 442365

End: 443459

Strand: Reverse

Name: lytC [H]

Synonym: PMT0394

Alternate gene names: 33862667

Gene position: 443459-442365 (Counterclockwise)

Preceding gene: 33862668

Following gene: 33862666

Centisome position: 18.39

GC content: 55.98

Gene sequence:

>1095_bases
ATGGCCTCGGCTCCATCCCGCCCTCTCATCCTGCTGGTGGTTGGTGCCTTGCAGATCCCTTTGGTTTTGGCAGCGTTGCC
GGCCAGAGCGGCAAGTGCTTTAGCGGCCTGGGCACTTGGAATCGACGGGGTGTTGCAGTTGCGTACATCAAGAGGGGCTC
GTCTAGAAGCGTTCTTTCAACCAGCGGATGGGGCCCAAGGAGCAAAGGTCTGGATTGATTTTCCTGGAGAATTGAGCCGC
TCCCGCAGCCTGCGGGGTAGCGGGCCGGTGCGTGCAATTCGTTTGGGGATACCAACGCCTGGCTCAACTCGACTGGTGAT
TGAGTTCAAACCATCAATCTCTCTGAATCCAAATCAGCTCAAGCTGATAGGAACCTCTCCGGACCGCTGGAAGCTCAACT
TCGAAGGCTTACCGACCCGCGGGCTTCGCCCTATCGGTGAAGGAGACCTGACAGCATCAACTTTGAGCCGATGGGCTCCT
GGAATCCGGATTACACCCACACGGACGCCTATCAATGCCTCTGGTTTGCCGAATGTTCCCCGCGGGCGCTTTAGAGTTGT
CATTGACCCTGGTCATGGTGGTCCAGACCCTGGTGCTATAGGGATTCGCGGTCTACGTGAGACGGATGTTGTTCTCGATG
TTTCCCTTCAGGTGGCCCAGCTATTAGAAGCTCGAGGGGTGCAGGTCATCATGACCCGCACAGCTGATGTGGATTTGGAT
CTACCGCCAAGAGTGGCGATCGCCAATCGAGTAGGTGCTACTGCATTTGTAAGCATTCATGCCAATGCCATCAGCATGTC
CAGACCACAGGTCAATGGAATCGAAACTTTCTATTTCTCTGATTCCCGTTCAGCCAGGTTGGCGTCTCATATCCAGCAAC
AGGTGCTGAACGTCTCCCCTGGGAGCCCCAACAGAGGGGTCAGACGGGGCCGTTTCTTTGTCATCCGGCGAACCACAATG
CCCTCCGCCCTAGTTGAGACAGGTTTTTTAACAGGACGGCTAGATGCTCCTCGGCTGGCTTCAGCAGCCCATCGCCGCAA
GTTGGCTCTGGCTATTGCTACTGGCATCCTCAACTATTTGCAGGGGGTCCGTTGA

Upstream 100 bases:

>100_bases
CAGGGTGCAGCCATTGCTCCTGTGGATAACTCGCACATTGGTCGCATTCGCGCGCAAATGCCAAGCCTCCAACACCGGCA
GTCAGCACTGTTCTGAGCCA

Downstream 100 bases:

>100_bases
AGCCTCGCTTGGGATTATTTGATAGCGGCGTGGGTGGGTTGACTGTGCTCAGGCGAGTGCTGGAGCGCCATGGGCAGGTG
CCTTGCCTCTATCTCGGTGA

Product: cell wall hydrolase/autolysin

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MASAPSRPLILLVVGALQIPLVLAALPARAASALAAWALGIDGVLQLRTSRGARLEAFFQPADGAQGAKVWIDFPGELSR
SRSLRGSGPVRAIRLGIPTPGSTRLVIEFKPSISLNPNQLKLIGTSPDRWKLNFEGLPTRGLRPIGEGDLTASTLSRWAP
GIRITPTRTPINASGLPNVPRGRFRVVIDPGHGGPDPGAIGIRGLRETDVVLDVSLQVAQLLEARGVQVIMTRTADVDLD
LPPRVAIANRVGATAFVSIHANAISMSRPQVNGIETFYFSDSRSARLASHIQQQVLNVSPGSPNRGVRRGRFFVIRRTTM
PSALVETGFLTGRLDAPRLASAAHRRKLALAIATGILNYLQGVR

Sequences:

>Translated_364_residues
MASAPSRPLILLVVGALQIPLVLAALPARAASALAAWALGIDGVLQLRTSRGARLEAFFQPADGAQGAKVWIDFPGELSR
SRSLRGSGPVRAIRLGIPTPGSTRLVIEFKPSISLNPNQLKLIGTSPDRWKLNFEGLPTRGLRPIGEGDLTASTLSRWAP
GIRITPTRTPINASGLPNVPRGRFRVVIDPGHGGPDPGAIGIRGLRETDVVLDVSLQVAQLLEARGVQVIMTRTADVDLD
LPPRVAIANRVGATAFVSIHANAISMSRPQVNGIETFYFSDSRSARLASHIQQQVLNVSPGSPNRGVRRGRFFVIRRTTM
PSALVETGFLTGRLDAPRLASAAHRRKLALAIATGILNYLQGVR
>Mature_363_residues
ASAPSRPLILLVVGALQIPLVLAALPARAASALAAWALGIDGVLQLRTSRGARLEAFFQPADGAQGAKVWIDFPGELSRS
RSLRGSGPVRAIRLGIPTPGSTRLVIEFKPSISLNPNQLKLIGTSPDRWKLNFEGLPTRGLRPIGEGDLTASTLSRWAPG
IRITPTRTPINASGLPNVPRGRFRVVIDPGHGGPDPGAIGIRGLRETDVVLDVSLQVAQLLEARGVQVIMTRTADVDLDL
PPRVAIANRVGATAFVSIHANAISMSRPQVNGIETFYFSDSRSARLASHIQQQVLNVSPGSPNRGVRRGRFFVIRRTTMP
SALVETGFLTGRLDAPRLASAAHRRKLALAIATGILNYLQGVR

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=266, Percent_Identity=30.4511278195489, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082163, Length=336, Percent_Identity=25.8928571428571, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 38871; Mature: 38739

Theoretical pI: Translated: 12.24; Mature: 12.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASAPSRPLILLVVGALQIPLVLAALPARAASALAAWALGIDGVLQLRTSRGARLEAFFQ
CCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEC
PADGAQGAKVWIDFPGELSRSRSLRGSGPVRAIRLGIPTPGSTRLVIEFKPSISLNPNQL
CCCCCCCCEEEEECCCCHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCEE
KLIGTSPDRWKLNFEGLPTRGLRPIGEGDLTASTLSRWAPGIRITPTRTPINASGLPNVP
EEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCEECCCCCCCCCCCCCCCC
RGRFRVVIDPGHGGPDPGAIGIRGLRETDVVLDVSLQVAQLLEARGVQVIMTRTADVDLD
CCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCEEEEEEECCCCCCC
LPPRVAIANRVGATAFVSIHANAISMSRPQVNGIETFYFSDSRSARLASHIQQQVLNVSP
CCCCEEEHHCCCCEEEEEEEECEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCC
GSPNRGVRRGRFFVIRRTTMPSALVETGFLTGRLDAPRLASAAHRRKLALAIATGILNYL
CCCCCCCCCCEEEEEEECCCCHHHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QGVR
HCCC
>Mature Secondary Structure 
ASAPSRPLILLVVGALQIPLVLAALPARAASALAAWALGIDGVLQLRTSRGARLEAFFQ
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEC
PADGAQGAKVWIDFPGELSRSRSLRGSGPVRAIRLGIPTPGSTRLVIEFKPSISLNPNQL
CCCCCCCCEEEEECCCCHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCEE
KLIGTSPDRWKLNFEGLPTRGLRPIGEGDLTASTLSRWAPGIRITPTRTPINASGLPNVP
EEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCEECCCCCCCCCCCCCCCC
RGRFRVVIDPGHGGPDPGAIGIRGLRETDVVLDVSLQVAQLLEARGVQVIMTRTADVDLD
CCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCEEEEEEECCCCCCC
LPPRVAIANRVGATAFVSIHANAISMSRPQVNGIETFYFSDSRSARLASHIQQQVLNVSP
CCCCEEEHHCCCCEEEEEEEECEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCC
GSPNRGVRRGRFFVIRRTTMPSALVETGFLTGRLDAPRLASAAHRRKLALAIATGILNYL
CCCCCCCCCCEEEEEEECCCCHHHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QGVR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]