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The map label for this gene is sds [H]

Identifier: 33862665

GI number: 33862665

Start: 440568

End: 441539

Strand: Reverse

Name: sds [H]

Synonym: PMT0392

Alternate gene names: 33862665

Gene position: 441539-440568 (Counterclockwise)

Preceding gene: 33862666

Following gene: 33862662

Centisome position: 18.31

GC content: 53.7

Gene sequence:

>972_bases
ATGGCCACCGTTACTGAGCTGCTGCAGCCGGTCGAGCTGGATCTTGAGACCCTGCTCACTGATCTGCGCAGCTTGATTGG
TGCCGGTCATCCCATTCTTCAAGCAGCGGCAGAGCACTTATTCAGTGCCGGGGGCAAACGCCTTCGCCCGGGCATTGTGC
TGTTGATCTCAAGAGCTTTATCTGCCGATGGTGATCTCTCGGCCCGTCATCGTCGGCTGGCGGAGATTACCGAGATGATC
CACACGGCTTCTCTTGTTCACGACGACGTCGTCGATGAGGCTGCCACTCGCCGAGGCGTGGCCACTGTTCATAGCCGTTT
CAATCATCGCGTTGCGGTTTTGGCAGGTGATTTTCTATTCGCACAGGCCAGTTGGCATCTGGCTAATCTGGATAACTTAG
CTGTGGTCAAGCTTCTCAGTCGGGTCATCATGGACCTCGCGGATGGGGAGGTGAAGCAGGGCCTCTATCGCTATGACACA
GGCCAATCATTTGCGACATATCTAGAGAAGAGCTATTGCAAGACGGCTTCTCTAATGGCCAACAGTGTGCAGGCTGCCGG
CGTACTCAGTGGTGAGAGTGTTGAGCATCAGAAATTACTGCATCACTTCGGTCGCCAGCTTGGACTCGCCTTTCAGGTTG
TCGATGACATCCTCGACTTCACAGGCAGTGAACAGCAATTAGGCAAACCTGCCGCGAGTGATTTGGCCAGTGGCTATCTA
ACGGCACCGGCTCTCTATGCGCTAGAAGAGCATTTAGCTCTAGCTCGTCTGATTGAGCGAGAGTTCAGCGAAGAGGACGA
TCTTGATCAAGCCCTTGAGCTGGTGCGTAATTCGCAGGCCATTTCACGCAGCCGTCAGTTGGCTGAAGATTTTGCCAGGG
AATCTCGTGAAGCCATCGCTTGGCTACCAGATTCACCTTGCCAGCGTGCATTAATGGAACTACCTGATTTTGTTTTAAGC
CGTCTCTACTGA

Upstream 100 bases:

>100_bases
ACGCGTGCTACGCCATGGTTGGGCGAGCGTCCTCAAGTTGAGTTGGTTTCACTGCAATGTCCTGCCTGCGCCTCGTAAGA
TCACTCCACCGAGGGAATCC

Downstream 100 bases:

>100_bases
GCTTTTCAGAGTGCATCCCAAGCCTGCTGGAGATGGTCAAGAACGGTTTTTAACTGAGCGATTTGACGAGGATTCTCATC
TTTAAACTTGCCATCGCAAT

Product: polyprenyl synthetase; solanesyl diphosphate synthase (sds)

Products: diphosphate; all-trans-nonaprenyl diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MATVTELLQPVELDLETLLTDLRSLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISRALSADGDLSARHRRLAEITEMI
HTASLVHDDVVDEAATRRGVATVHSRFNHRVAVLAGDFLFAQASWHLANLDNLAVVKLLSRVIMDLADGEVKQGLYRYDT
GQSFATYLEKSYCKTASLMANSVQAAGVLSGESVEHQKLLHHFGRQLGLAFQVVDDILDFTGSEQQLGKPAASDLASGYL
TAPALYALEEHLALARLIEREFSEEDDLDQALELVRNSQAISRSRQLAEDFARESREAIAWLPDSPCQRALMELPDFVLS
RLY

Sequences:

>Translated_323_residues
MATVTELLQPVELDLETLLTDLRSLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISRALSADGDLSARHRRLAEITEMI
HTASLVHDDVVDEAATRRGVATVHSRFNHRVAVLAGDFLFAQASWHLANLDNLAVVKLLSRVIMDLADGEVKQGLYRYDT
GQSFATYLEKSYCKTASLMANSVQAAGVLSGESVEHQKLLHHFGRQLGLAFQVVDDILDFTGSEQQLGKPAASDLASGYL
TAPALYALEEHLALARLIEREFSEEDDLDQALELVRNSQAISRSRQLAEDFARESREAIAWLPDSPCQRALMELPDFVLS
RLY
>Mature_322_residues
ATVTELLQPVELDLETLLTDLRSLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISRALSADGDLSARHRRLAEITEMIH
TASLVHDDVVDEAATRRGVATVHSRFNHRVAVLAGDFLFAQASWHLANLDNLAVVKLLSRVIMDLADGEVKQGLYRYDTG
QSFATYLEKSYCKTASLMANSVQAAGVLSGESVEHQKLLHHFGRQLGLAFQVVDDILDFTGSEQQLGKPAASDLASGYLT
APALYALEEHLALARLIEREFSEEDDLDQALELVRNSQAISRSRQLAEDFARESREAIAWLPDSPCQRALMELPDFVLSR
LY

Specific function: Possible role in synthesis of the nonaprenyl side chain of plastoquinone or in synthesis of other prenyl chains such as undekaprenyl pyrophosphate [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=312, Percent_Identity=39.4230769230769, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI169808399, Length=333, Percent_Identity=27.3273273273273, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4758430, Length=222, Percent_Identity=26.5765765765766, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI83700220, Length=222, Percent_Identity=26.5765765765766, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1789578, Length=287, Percent_Identity=35.8885017421603, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1786623, Length=228, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17505681, Length=297, Percent_Identity=35.6902356902357, Blast_Score=187, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6319475, Length=299, Percent_Identity=37.123745819398, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6325188, Length=295, Percent_Identity=24.0677966101695, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651612, Length=316, Percent_Identity=37.9746835443038, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI21356309, Length=370, Percent_Identity=27.027027027027, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281365769, Length=270, Percent_Identity=23.7037037037037, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24660002, Length=270, Percent_Identity=23.7037037037037, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR014120
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: 2.5.1.11

Molecular weight: Translated: 35522; Mature: 35391

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVTELLQPVELDLETLLTDLRSLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISRAL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
SADGDLSARHRRLAEITEMIHTASLVHDDVVDEAATRRGVATVHSRFNHRVAVLAGDFLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHH
AQASWHLANLDNLAVVKLLSRVIMDLADGEVKQGLYRYDTGQSFATYLEKSYCKTASLMA
HHHCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHH
NSVQAAGVLSGESVEHQKLLHHFGRQLGLAFQVVDDILDFTGSEQQLGKPAASDLASGYL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHCCHH
TAPALYALEEHLALARLIEREFSEEDDLDQALELVRNSQAISRSRQLAEDFARESREAIA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
WLPDSPCQRALMELPDFVLSRLY
CCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATVTELLQPVELDLETLLTDLRSLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISRAL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
SADGDLSARHRRLAEITEMIHTASLVHDDVVDEAATRRGVATVHSRFNHRVAVLAGDFLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHH
AQASWHLANLDNLAVVKLLSRVIMDLADGEVKQGLYRYDTGQSFATYLEKSYCKTASLMA
HHHCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHH
NSVQAAGVLSGESVEHQKLLHHFGRQLGLAFQVVDDILDFTGSEQQLGKPAASDLASGYL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHCCHH
TAPALYALEEHLALARLIEREFSEEDDLDQALELVRNSQAISRSRQLAEDFARESREAIA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
WLPDSPCQRALMELPDFVLSRLY
CCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: all-trans-octaprenyl diphosphate; isopentenyl diphosphate

Specific reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-nonaprenyl diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]