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The map label for this gene is ppnK

Identifier: 33862641

GI number: 33862641

Start: 414495

End: 415403

Strand: Direct

Name: ppnK

Synonym: PMT0368

Alternate gene names: 33862641

Gene position: 414495-415403 (Clockwise)

Preceding gene: 33862640

Following gene: 33862642

Centisome position: 17.19

GC content: 56.11

Gene sequence:

>909_bases
GTGCCCTGTGTCGGACTGATCGTTAATGACGGCAAAGAGTTGGCGGTAGAGACCGCATTGACCCTTCAGTCGCGGCTTGA
ACAGGCTGGTATCGAAGTGGTCAGAGCAAGTAGTTCTGGTGGAATGGTTGGCTTTGCCAATCCAGATCAGCATTTGCGCC
TGCTTGGTTACAACGCGTGCGTACCTGAGGGTTTCGATGCCTCGATGGCACTGGCGATTGTTCTGGGTGGTGATGGCACC
GTGCTTTCGGCGGCACGGCAGACAGCTCCTGTGCAGGTGCCAATCCTCACCATCAACACCGGACACCTTGGCTTCCTGGC
GGAGGCCTATTTGGCTGATCTCGATCGGGTGATTGAGCAGGTGCTTAACAAGCAGTGGACGATTGAGGAGCGTTGCACCC
TGGTGGTGAGTGTGTTGCGCGGTGATCAGTGCCGCTGGGAGGCACTCTCTTTGAATGAAATGGCCTTGCATCGTGAACCA
CTCACCAGCATGTGTCATTTCGAAGTCGCGATCGGTCGCCATGCGCCAGTGGATATCTCTGCTGATGGTGTGATCCTCTC
GACGCCTACGGGATCAACGGCTTATGCACTCAGTGCAGGAGGCCCGGTGATTACACCTGAGTGCCCGGTGCTTCAGCTTG
CACCGATTGCCCCTCATTCGCTGGCGTCAAGAGCGCTGGTTTTCAGCGACCAGGAGCCAGTGACTGTGTTTCCAGCGACG
GCGGATCGCTTGATGATGGTGGTTGATGGCAGTGCGGGTTGTTATGTGTGGCCAGAAGACCGAGTACTGATTCGTCGTAG
TGATCATCCTGTGAGATTTGTGCGCTTGGCAGATCACGAGTTCTTCCAGGTGTTGCGCAACAAGTTGGGCTGGGGTTTGC
CGCATGTTGCCAAACCTGATCGACCATGA

Upstream 100 bases:

>100_bases
CGATAGCCGATCGTGTGCTGGATGAAGCATCGCCGTAGTGCATCATCCAAAAACAGCTGAATCCCCATAAAGTGAGCTCG
TTCTTTGCTTCATTCGATCG

Downstream 100 bases:

>100_bases
CCTGTAGGGCCCTCTGCTTGCAGTGGGGGGGGGAGAGATTGCGGTTTCCTTTGCTCTGGGGAGGGCTGGCGGTAGGTCTC
AGCGTTCTTTCAGCTATTGG

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase 1

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MPCVGLIVNDGKELAVETALTLQSRLEQAGIEVVRASSSGGMVGFANPDQHLRLLGYNACVPEGFDASMALAIVLGGDGT
VLSAARQTAPVQVPILTINTGHLGFLAEAYLADLDRVIEQVLNKQWTIEERCTLVVSVLRGDQCRWEALSLNEMALHREP
LTSMCHFEVAIGRHAPVDISADGVILSTPTGSTAYALSAGGPVITPECPVLQLAPIAPHSLASRALVFSDQEPVTVFPAT
ADRLMMVVDGSAGCYVWPEDRVLIRRSDHPVRFVRLADHEFFQVLRNKLGWGLPHVAKPDRP

Sequences:

>Translated_302_residues
MPCVGLIVNDGKELAVETALTLQSRLEQAGIEVVRASSSGGMVGFANPDQHLRLLGYNACVPEGFDASMALAIVLGGDGT
VLSAARQTAPVQVPILTINTGHLGFLAEAYLADLDRVIEQVLNKQWTIEERCTLVVSVLRGDQCRWEALSLNEMALHREP
LTSMCHFEVAIGRHAPVDISADGVILSTPTGSTAYALSAGGPVITPECPVLQLAPIAPHSLASRALVFSDQEPVTVFPAT
ADRLMMVVDGSAGCYVWPEDRVLIRRSDHPVRFVRLADHEFFQVLRNKLGWGLPHVAKPDRP
>Mature_301_residues
PCVGLIVNDGKELAVETALTLQSRLEQAGIEVVRASSSGGMVGFANPDQHLRLLGYNACVPEGFDASMALAIVLGGDGTV
LSAARQTAPVQVPILTINTGHLGFLAEAYLADLDRVIEQVLNKQWTIEERCTLVVSVLRGDQCRWEALSLNEMALHREPL
TSMCHFEVAIGRHAPVDISADGVILSTPTGSTAYALSAGGPVITPECPVLQLAPIAPHSLASRALVFSDQEPVTVFPATA
DRLMMVVDGSAGCYVWPEDRVLIRRSDHPVRFVRLADHEFFQVLRNKLGWGLPHVAKPDRP

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=251, Percent_Identity=27.8884462151394, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788968, Length=222, Percent_Identity=35.5855855855856, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320794, Length=251, Percent_Identity=29.4820717131474, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6325068, Length=160, Percent_Identity=33.75, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322509, Length=250, Percent_Identity=28.8, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573828, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573830, Length=251, Percent_Identity=27.4900398406374, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573832, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161077047, Length=251, Percent_Identity=27.4900398406374, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573826, Length=246, Percent_Identity=27.6422764227642, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK1_PROMM (Q7V8H9)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894201.1
- ProteinModelPortal:   Q7V8H9
- SMR:   Q7V8H9
- STRING:   Q7V8H9
- GeneID:   1729235
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0368
- NMPDR:   fig|74547.1.peg.368
- eggNOG:   COG0061
- HOGENOM:   HBG713904
- OMA:   CVPEGFD
- ProtClustDB:   PRK02649
- BioCyc:   PMAR74547:PMT0368-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 32557; Mature: 32426

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCVGLIVNDGKELAVETALTLQSRLEQAGIEVVRASSSGGMVGFANPDQHLRLLGYNAC
CCEEEEEEECCCCEEHHHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCCEEEEEECCCC
VPEGFDASMALAIVLGGDGTVLSAARQTAPVQVPILTINTGHLGFLAEAYLADLDRVIEQ
CCCCCCCCEEEEEEECCCCCEEHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
VLNKQWTIEERCTLVVSVLRGDQCRWEALSLNEMALHREPLTSMCHFEVAIGRHAPVDIS
HHCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHCCHHHHHEEEEEECCCCCCEEC
ADGVILSTPTGSTAYALSAGGPVITPECPVLQLAPIAPHSLASRALVFSDQEPVTVFPAT
CCCEEEECCCCCEEEEEECCCCEECCCCCCEEECCCCCHHHHCEEEEECCCCCEEEEECC
ADRLMMVVDGSAGCYVWPEDRVLIRRSDHPVRFVRLADHEFFQVLRNKLGWGLPHVAKPD
CCEEEEEEECCCCEEECCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCC
RP
CC
>Mature Secondary Structure 
PCVGLIVNDGKELAVETALTLQSRLEQAGIEVVRASSSGGMVGFANPDQHLRLLGYNAC
CEEEEEEECCCCEEHHHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCCEEEEEECCCC
VPEGFDASMALAIVLGGDGTVLSAARQTAPVQVPILTINTGHLGFLAEAYLADLDRVIEQ
CCCCCCCCEEEEEEECCCCCEEHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
VLNKQWTIEERCTLVVSVLRGDQCRWEALSLNEMALHREPLTSMCHFEVAIGRHAPVDIS
HHCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHCCHHHHHEEEEEECCCCCCEEC
ADGVILSTPTGSTAYALSAGGPVITPECPVLQLAPIAPHSLASRALVFSDQEPVTVFPAT
CCCEEEECCCCCEEEEEECCCCEECCCCCCEEECCCCCHHHHCEEEEECCCCCEEEEECC
ADRLMMVVDGSAGCYVWPEDRVLIRRSDHPVRFVRLADHEFFQVLRNKLGWGLPHVAKPD
CCEEEEEEECCCCEEECCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCC
RP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642