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The map label for this gene is era [H]

Identifier: 33862628

GI number: 33862628

Start: 404536

End: 405486

Strand: Direct

Name: era [H]

Synonym: PMT0355

Alternate gene names: 33862628

Gene position: 404536-405486 (Clockwise)

Preceding gene: 33862626

Following gene: 33862629

Centisome position: 16.78

GC content: 57.31

Gene sequence:

>951_bases
ATGTCACCTGACGCCATGGAGTCTCTCCCTGAGGGATATCGTTCCGGTTTTGTTGCATTAATTGGCAGGCCCAATGTGGG
CAAATCCACCTTGGTGAATCAGTTGGTGGGAGAGAAGGTGGCGATTACTTCTCCTGTGGCGCAGACCACGCGCAATCGGC
TGCGAGCCATCGTCACCACCTCCGAGGCTCAGATGGTGCTAGTGGACACCCCTGGAATTCACAAACCTCACCATTTGCTT
GGTGAACGGCTGGTGCAAAGCGCCCGTGCAGCCATTGGTGAGGTTGACCTGGTGTTGCTTCTGCTTGAGGGCTGTGAATC
GCCCGGTTGTGGCGATGCTTTTATCGTGGAGCTGCTACGCCAGCAGGATCTGCCGGTGTTAGTTGCTCTTAATAAGTGGG
ATCGTGTTGCCGAGCAGCAACAAGACCCGGCGGAGGAGGCTTATCGGCAGCTGTTGGCAGACTCTGCTTGGCCGCTCATA
CGTTGCAGTGCGATTAGTGGTGAGGGATGCAATGGTCTTGTAGAAGCTTTAGTGGGGCACCTGCCACTAGGCCCCCAGCT
CTATCCAGCGGAGATGGTGTGTGATCAGCCGGAGCGGGTGCTGCTGGCTGAACTGATTCGCGAGCAGGTGCTGATGCATA
CCCGTGAGGAGGTGCCCCATAGCGTGGCGGTGAGCATTGATCGGGTTGAAGAGATGCCTGTTGCCAATGGACGGCCTGGT
CGACAGGGGAGGACGGCTGTGTTGGCTACCGTGCTGGTGGAACGCAAGAGCCAGAAGGGGATCCTGATCGGCAAGGGAGG
CTCGATGTTGAAGACCATTGGTCAGGGAGCGCGCTTGCAGATGCAGACCTTGATCGATGGCCCTGTCTACCTAGAACTGT
TTGTGAAGGTGGTGCCTGATTGGCGCTCTAAGCCAGCGCGATTGGCGGAGCTTGGTTATGAGGGCAAGTGA

Upstream 100 bases:

>100_bases
GAGCGGTGATTTCAATCGCTTGTTCAAAGCTTGGCGCTGGGGTGCTCATGGATGTTATGCATGCTTTCAGTCAGGCTATG
GGGCCACATTGAGCCAGGTC

Downstream 100 bases:

>100_bases
TTATTGCCTGTTTCAAATGGGCGACTGAGAGGATTGATGAATGCTTGATCATCCAAACCCCTTTTTTAAGTCTTTTGGGC
TGAAGTTATTTCTTCAGGGA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSPDAMESLPEGYRSGFVALIGRPNVGKSTLVNQLVGEKVAITSPVAQTTRNRLRAIVTTSEAQMVLVDTPGIHKPHHLL
GERLVQSARAAIGEVDLVLLLLEGCESPGCGDAFIVELLRQQDLPVLVALNKWDRVAEQQQDPAEEAYRQLLADSAWPLI
RCSAISGEGCNGLVEALVGHLPLGPQLYPAEMVCDQPERVLLAELIREQVLMHTREEVPHSVAVSIDRVEEMPVANGRPG
RQGRTAVLATVLVERKSQKGILIGKGGSMLKTIGQGARLQMQTLIDGPVYLELFVKVVPDWRSKPARLAELGYEGK

Sequences:

>Translated_316_residues
MSPDAMESLPEGYRSGFVALIGRPNVGKSTLVNQLVGEKVAITSPVAQTTRNRLRAIVTTSEAQMVLVDTPGIHKPHHLL
GERLVQSARAAIGEVDLVLLLLEGCESPGCGDAFIVELLRQQDLPVLVALNKWDRVAEQQQDPAEEAYRQLLADSAWPLI
RCSAISGEGCNGLVEALVGHLPLGPQLYPAEMVCDQPERVLLAELIREQVLMHTREEVPHSVAVSIDRVEEMPVANGRPG
RQGRTAVLATVLVERKSQKGILIGKGGSMLKTIGQGARLQMQTLIDGPVYLELFVKVVPDWRSKPARLAELGYEGK
>Mature_315_residues
SPDAMESLPEGYRSGFVALIGRPNVGKSTLVNQLVGEKVAITSPVAQTTRNRLRAIVTTSEAQMVLVDTPGIHKPHHLLG
ERLVQSARAAIGEVDLVLLLLEGCESPGCGDAFIVELLRQQDLPVLVALNKWDRVAEQQQDPAEEAYRQLLADSAWPLIR
CSAISGEGCNGLVEALVGHLPLGPQLYPAEMVCDQPERVLLAELIREQVLMHTREEVPHSVAVSIDRVEEMPVANGRPGR
QGRTAVLATVLVERKSQKGILIGKGGSMLKTIGQGARLQMQTLIDGPVYLELFVKVVPDWRSKPARLAELGYEGK

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=76, Percent_Identity=47.3684210526316, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1788919, Length=310, Percent_Identity=37.4193548387097, Blast_Score=189, Evalue=1e-49,
Organism=Escherichia coli, GI87082120, Length=165, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI2367268, Length=178, Percent_Identity=30.8988764044944, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24646434, Length=251, Percent_Identity=27.4900398406374, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34358; Mature: 34227

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPDAMESLPEGYRSGFVALIGRPNVGKSTLVNQLVGEKVAITSPVAQTTRNRLRAIVTT
CCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHEEEEE
SEAQMVLVDTPGIHKPHHLLGERLVQSARAAIGEVDLVLLLLEGCESPGCGDAFIVELLR
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
QQDLPVLVALNKWDRVAEQQQDPAEEAYRQLLADSAWPLIRCSAISGEGCNGLVEALVGH
HCCCCEEEEECHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHC
LPLGPQLYPAEMVCDQPERVLLAELIREQVLMHTREEVPHSVAVSIDRVEEMPVANGRPG
CCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
RQGRTAVLATVLVERKSQKGILIGKGGSMLKTIGQGARLQMQTLIDGPVYLELFVKVVPD
CCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHCCC
WRSKPARLAELGYEGK
CCCCCHHHHHCCCCCC
>Mature Secondary Structure 
SPDAMESLPEGYRSGFVALIGRPNVGKSTLVNQLVGEKVAITSPVAQTTRNRLRAIVTT
CCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHEEEEE
SEAQMVLVDTPGIHKPHHLLGERLVQSARAAIGEVDLVLLLLEGCESPGCGDAFIVELLR
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
QQDLPVLVALNKWDRVAEQQQDPAEEAYRQLLADSAWPLIRCSAISGEGCNGLVEALVGH
HCCCCEEEEECHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHC
LPLGPQLYPAEMVCDQPERVLLAELIREQVLMHTREEVPHSVAVSIDRVEEMPVANGRPG
CCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
RQGRTAVLATVLVERKSQKGILIGKGGSMLKTIGQGARLQMQTLIDGPVYLELFVKVVPD
CCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHCCC
WRSKPARLAELGYEGK
CCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA