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The map label for this gene is ffh [H]

Identifier: 33862622

GI number: 33862622

Start: 398342

End: 399835

Strand: Direct

Name: ffh [H]

Synonym: PMT0349

Alternate gene names: 33862622

Gene position: 398342-399835 (Clockwise)

Preceding gene: 33862621

Following gene: 33862623

Centisome position: 16.52

GC content: 55.49

Gene sequence:

>1494_bases
ATGTTTGAAGAACTTTCAGCCCGCTTTGAAGATGCAGTTAAGGGGCTGAGAGGCCAGGCAAAGATCAGCGATACCAATGT
TGAGGATGCTCTTAAGCAGGTGCGACGTGCCCTTTTAGGGGCTGATGTGAGTCTTGAGGTCGTGCGCGAGTTTGTCGAGG
AGGTGCGGCAGAAGGCAGTTGGTGCGGAAGTGGTGCGAGGTGTGACTCCTGATCAGAAGTTTGTTCAGGTGGTGCATCAG
CAGCTGGTGGAGGTGATGGGTGGTGATAACGCTCCCATGGCTGAGGCTGAAGATTCACCAACAGTGGTGCTGATGGCTGG
ATTGCAGGGGGCTGGCAAAACCACTGCAACAGCGAAGCTTGGACTTCACCTCAAAGATCAGGGTCAGCGGCCCCTGATGG
TGGCTGCTGATGTCTATCGGCCGGCTGCCATTGATCAGCTCCGCACCCTGGGTGAGCAGATCGGAGTGGATGTGTTCAGC
CTCGGAGACGATGTCAAACCTGAGGAGATCGCGGCAGCAGGACTTGCCAAGGCTCGTGAGGAAGGTTTTGACACCTTGTT
AGTGGATACGGCAGGTCGGCTGCAGATCGATACAGAGATGATGGAGGAAATGGTGCGAATTCGTTCTGCCGTAGAGCCCG
ATGAAGTGCTCTTGGTGGTGGATTCGATGATTGGTCAGGAGGCGGCTGAACTCACTCGGGCCTTCCACGACAAGGTTGGT
ATCACTGGATCTGTTCTCACCAAGCTGGATGGTGATTCCCGCGGTGGGGCTGCGCTTTCGATTCGCAAGGTGAGTGGTCA
GCCGATCAAGTTCATCGGTACTGGAGAAAAGGTTGAGGCTTTGCAACCTTTTCATCCGGAACGGATGGCCAGCCGCATCC
TCGGTATGGGCGATGTGCTCACCCTGGTGGAGAAAGCTCAGAAGGAGGTGGAGCTTGCTGATGTTGAGAAGATGCAGAAG
AAGCTGCAGGAAGCTTCGTTTGATTTCTCCGATTTCCTGCAACAGATGCGACTGATCAAACGGATGGGTTCTCTCGGTGG
TTTGATCAAGATGATGCCGGGCATGAACAAGCTGGATGACGGCATGCTCAAGCAGGGTGAGCAGCAGCTCAAGCGCATCG
AGGCCATGATTGGCTCGATGACTGCTGATGAGCGCAATCAGCCTGAATTGCTTGCTTCACAGCCTTCTCGTCGTCGTCGT
ATCGCTGGTGGGAGTGGCCATAGCCCCGCTGACGTGGACAAAGTTTTGGCTGATTTTCAGAAAATGCGTGGCTTTATGCA
GCAGATGAGTAAGGGCGGTGGCATGCCTGGAATGCCTGGAATGCCTGGAATGCCTGGAATGGGTGGTGGGTTGCCCGGTA
TGGGGGGACCTGGTGGTGGCATGTCTGGCATGGGAGGCGCAGGCATGCCAGAGCCAGCTTCAGGTGGTCGCGGTGGTGGT
TCCCCCAGGCGTCAGCGACCGGTGAAAAAGAAGAAGGGATTTGGAGAGTTGTAA

Upstream 100 bases:

>100_bases
GCGCCTGCATGAATACATCAGCGGCAAATAATCACTGTTCTGCCTAAGGGCTAGCCATTGCTTTTTACGATGAGCTCAAA
GCCCTTGGCACGTAGGCACC

Downstream 100 bases:

>100_bases
TTGGCCGCAGGTTATGGTTGTTGTTTGGCGTGTGTGTAAAACACCGCTGAACCATCCACCTTTTCGAACTTAGGGCCACG
ATGATCAAGCTCCGCCTGAA

Product: signal recognition particle protein (SRP54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MFEELSARFEDAVKGLRGQAKISDTNVEDALKQVRRALLGADVSLEVVREFVEEVRQKAVGAEVVRGVTPDQKFVQVVHQ
QLVEVMGGDNAPMAEAEDSPTVVLMAGLQGAGKTTATAKLGLHLKDQGQRPLMVAADVYRPAAIDQLRTLGEQIGVDVFS
LGDDVKPEEIAAAGLAKAREEGFDTLLVDTAGRLQIDTEMMEEMVRIRSAVEPDEVLLVVDSMIGQEAAELTRAFHDKVG
ITGSVLTKLDGDSRGGAALSIRKVSGQPIKFIGTGEKVEALQPFHPERMASRILGMGDVLTLVEKAQKEVELADVEKMQK
KLQEASFDFSDFLQQMRLIKRMGSLGGLIKMMPGMNKLDDGMLKQGEQQLKRIEAMIGSMTADERNQPELLASQPSRRRR
IAGGSGHSPADVDKVLADFQKMRGFMQQMSKGGGMPGMPGMPGMPGMGGGLPGMGGPGGGMSGMGGAGMPEPASGGRGGG
SPRRQRPVKKKKGFGEL

Sequences:

>Translated_497_residues
MFEELSARFEDAVKGLRGQAKISDTNVEDALKQVRRALLGADVSLEVVREFVEEVRQKAVGAEVVRGVTPDQKFVQVVHQ
QLVEVMGGDNAPMAEAEDSPTVVLMAGLQGAGKTTATAKLGLHLKDQGQRPLMVAADVYRPAAIDQLRTLGEQIGVDVFS
LGDDVKPEEIAAAGLAKAREEGFDTLLVDTAGRLQIDTEMMEEMVRIRSAVEPDEVLLVVDSMIGQEAAELTRAFHDKVG
ITGSVLTKLDGDSRGGAALSIRKVSGQPIKFIGTGEKVEALQPFHPERMASRILGMGDVLTLVEKAQKEVELADVEKMQK
KLQEASFDFSDFLQQMRLIKRMGSLGGLIKMMPGMNKLDDGMLKQGEQQLKRIEAMIGSMTADERNQPELLASQPSRRRR
IAGGSGHSPADVDKVLADFQKMRGFMQQMSKGGGMPGMPGMPGMPGMGGGLPGMGGPGGGMSGMGGAGMPEPASGGRGGG
SPRRQRPVKKKKGFGEL
>Mature_497_residues
MFEELSARFEDAVKGLRGQAKISDTNVEDALKQVRRALLGADVSLEVVREFVEEVRQKAVGAEVVRGVTPDQKFVQVVHQ
QLVEVMGGDNAPMAEAEDSPTVVLMAGLQGAGKTTATAKLGLHLKDQGQRPLMVAADVYRPAAIDQLRTLGEQIGVDVFS
LGDDVKPEEIAAAGLAKAREEGFDTLLVDTAGRLQIDTEMMEEMVRIRSAVEPDEVLLVVDSMIGQEAAELTRAFHDKVG
ITGSVLTKLDGDSRGGAALSIRKVSGQPIKFIGTGEKVEALQPFHPERMASRILGMGDVLTLVEKAQKEVELADVEKMQK
KLQEASFDFSDFLQQMRLIKRMGSLGGLIKMMPGMNKLDDGMLKQGEQQLKRIEAMIGSMTADERNQPELLASQPSRRRR
IAGGSGHSPADVDKVLADFQKMRGFMQQMSKGGGMPGMPGMPGMPGMGGGLPGMGGPGGGMSGMGGAGMPEPASGGRGGG
SPRRQRPVKKKKGFGEL

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=442, Percent_Identity=31.6742081447964, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI226371618, Length=383, Percent_Identity=32.3759791122715, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI89061728, Length=158, Percent_Identity=39.2405063291139, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI295424842, Length=313, Percent_Identity=28.7539936102236, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI23308697, Length=313, Percent_Identity=28.7539936102236, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1788963, Length=456, Percent_Identity=48.9035087719298, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1789874, Length=271, Percent_Identity=32.8413284132841, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=443, Percent_Identity=30.4740406320542, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI193206261, Length=298, Percent_Identity=30.2013422818792, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325345, Length=449, Percent_Identity=30.7349665924276, Blast_Score=243, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6320498, Length=315, Percent_Identity=22.5396825396825, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17647949, Length=442, Percent_Identity=31.9004524886878, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24641198, Length=323, Percent_Identity=24.7678018575851, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 53103; Mature: 53103

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEELSARFEDAVKGLRGQAKISDTNVEDALKQVRRALLGADVSLEVVREFVEEVRQKAV
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GAEVVRGVTPDQKFVQVVHQQLVEVMGGDNAPMAEAEDSPTVVLMAGLQGAGKTTATAKL
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHC
GLHLKDQGQRPLMVAADVYRPAAIDQLRTLGEQIGVDVFSLGDDVKPEEIAAAGLAKARE
CEEECCCCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
EGFDTLLVDTAGRLQIDTEMMEEMVRIRSAVEPDEVLLVVDSMIGQEAAELTRAFHDKVG
CCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHHHCC
ITGSVLTKLDGDSRGGAALSIRKVSGQPIKFIGTGEKVEALQPFHPERMASRILGMGDVL
CCHHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHCCCCCHHHHHHHHHCCHHHH
TLVEKAQKEVELADVEKMQKKLQEASFDFSDFLQQMRLIKRMGSLGGLIKMMPGMNKLDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GMLKQGEQQLKRIEAMIGSMTADERNQPELLASQPSRRRRIAGGSGHSPADVDKVLADFQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHH
KMRGFMQQMSKGGGMPGMPGMPGMPGMGGGLPGMGGPGGGMSGMGGAGMPEPASGGRGGG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SPRRQRPVKKKKGFGEL
CCHHCCCCHHHCCCCCC
>Mature Secondary Structure
MFEELSARFEDAVKGLRGQAKISDTNVEDALKQVRRALLGADVSLEVVREFVEEVRQKAV
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GAEVVRGVTPDQKFVQVVHQQLVEVMGGDNAPMAEAEDSPTVVLMAGLQGAGKTTATAKL
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHC
GLHLKDQGQRPLMVAADVYRPAAIDQLRTLGEQIGVDVFSLGDDVKPEEIAAAGLAKARE
CEEECCCCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
EGFDTLLVDTAGRLQIDTEMMEEMVRIRSAVEPDEVLLVVDSMIGQEAAELTRAFHDKVG
CCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHHHCC
ITGSVLTKLDGDSRGGAALSIRKVSGQPIKFIGTGEKVEALQPFHPERMASRILGMGDVL
CCHHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHCCCCCHHHHHHHHHCCHHHH
TLVEKAQKEVELADVEKMQKKLQEASFDFSDFLQQMRLIKRMGSLGGLIKMMPGMNKLDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GMLKQGEQQLKRIEAMIGSMTADERNQPELLASQPSRRRRIAGGSGHSPADVDKVLADFQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHH
KMRGFMQQMSKGGGMPGMPGMPGMPGMGGGLPGMGGPGGGMSGMGGAGMPEPASGGRGGG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SPRRQRPVKKKKGFGEL
CCHHCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]