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The map label for this gene is thrS [H]

Identifier: 335055517

GI number: 335055517

Start: 1269993

End: 1271984

Strand: Direct

Name: thrS [H]

Synonym: NA

Alternate gene names: 335055517

Gene position: 1269993-1271984 (Clockwise)

Preceding gene: 94310104

Following gene: 94310106

Centisome position: 32.33

GC content: 60.64

Gene sequence:

>1992_bases
ATGGGCCGGCGCCACAAAAGAAGCTATGCTCCGCTCGCCACATCGCCTGAAGGCCGGTGCAGCGGAATCCTCGAGAGGTG
CAAGATGATCGTAATCACGCTGCCAGACGGTTCCCGTCGTGAGTATCCCGGCCCCGTCACGGTGGCCGAAGTGGCGCAGA
GCATTGGCTCCGGACTGGCCAAAGCAGCGCTCGCCGGCAAGGTCGATGGTCGCATGGTCGATACGAGCTTCAGGATCGAC
CAGGATGCGTCGCTGTCCATCGTCACGGACAAGGATGCAGATGGCGTCGACGTGATTCGTCACTCGACGGCTCACTTGCT
GGCCTACGCTGTCAAGGAGCTGTATCCCGACGCGCAGGTCACGATCGGTCCGGTCATTGACAACGGCTTCTACTACGACT
TCTCGTACAAGCGTCCCTTCACGCCGGAAGACCTTGCCGCCATCGAAAAGAAGATGACGGAACTCGCCCGCAAGGACGAG
AAGGTGTCGCGCGAGGTATGGAATCGCGATGAGGCGGTGGCCCTGTTCGAGTCGATGGGCGAGAAGTACAAGGCCGAGAT
CATTGCGTCGATTCCCGCGGATCAGGAGATCGGCCTCTATCGCGAAGGCAGCTTCGTCGACCTGTGCCGTGGCCCGCACG
TACCGTCCACGGGAAAGCTCAAGGTCTTCAAGCTGATGAAGGTGGCCGGTGCCTACTGGCGCGGCGACTCGAACAACGAG
ATGCTCCAGCGTATCTACGGTACGGCCTGGGCGAAGAAGGAAGACCAGGACGCCTACCTGCATATGCTGGAGGAGGCTGA
GAAGCGCGATCACCGCCGCCTGGGCAAGACACTTGACCTGTTCCATCTGCAGGAAGAGGCGCCTGGCATGGTGTTCTGGC
ACCCGAAGGGCTGGCAGGTGTGGCAGGCCGTCGAGCAATACATGCGCGGCCGTCTGGGTCAGGCCGGCTATGAGGAAGTG
CGCACGCCGCAGGTGATGGATCGTTCGCTCTGGGAGCGTTCCGGCCACTGGGACAACTATAAAGAGAACATGTTTGTCAC
GGAGTCGGAGAAGCGCGATTACGCGATCAAGCCGATGAACTGCCCGGGCCATGTGCAGATCTTCAACCACGGCCTGCGCT
CGTACCGCGACCTGCCGCTGCGTCTTGCCGAATTCGGTGCGTGCCATCGCAACGAGCCCTCGGGAGCGTTGCACGGGCTG
ATGCGTGTGCGAGGTTTTGTGCAGGATGATGCGCATATTTTCTGCACGGAAGAGCAGATCGTCGAGGAGGCCAAGGCCTT
CAACGAACTCGCGTTCTCGATCTATGACGACTTTGGCTTCAAGGATGTCGCGGTGAAGCTGTCGCTGCGCCCGGAAAAGC
GCGCGGGTTCGGACGCGGTCTGGGATCACGCCGAGGATGGCCTGCGCCTGGCGCTGCGTGCCTGTGGCGTGGAGTGGGAG
GAGCTGCCGGGCGAGGGTGCTTTCTACGGCCCGAAGGTCGAGTACCACATCAAGGATGCAATCGGCCGCTCGTGGCAGTG
CGGCACGCTGCAGCTCGATCTGGTGCTGCCGGAGCGCCTGGGCGCCGAGTACGTCTCCGAGGATAATTCCCGGAAGCGAC
CGGTCATGCTGCACCGCGCGATCCTTGGTTCGTTCGAGCGCTTCCTGGGTATCTTGCTGGAAAACCACGCGGGTGCGCTG
CCGGCCTGGCTGGCTCCAGAGCAGGTGGTGGTGATGAATATCGCCGAATCCCAGTCGGAATATGCTGAAAACGTTGTGCA
ACTCTTGCAAAAACAAGGGTTTAGGGCCAAGGCGGATTTGCGTAACGAGAAAATTACGTATAAAATTCGCGAGCATTCCC
TCCAGAAGATCCCTTACCTGCTGGTAATTGGCGACAAGGAGCGGGATGCCAATCAAGTGGCCGTGCGTGCCCGTGGCAAC
GTGGATCTGGGTGTCATGCCTGTTTCCGCGTTTGTGGAGCGTCTGCAACAGGACGTTTCCAGCAAAGCCTGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:
NA

Sequences:

>Translated_663_residues
MGRRHKRSYAPLATSPEGRCSGILERCKMIVITLPDGSRREYPGPVTVAEVAQSIGSGLAKAALAGKVDGRMVDTSFRID
QDASLSIVTDKDADGVDVIRHSTAHLLAYAVKELYPDAQVTIGPVIDNGFYYDFSYKRPFTPEDLAAIEKKMTELARKDE
KVSREVWNRDEAVALFESMGEKYKAEIIASIPADQEIGLYREGSFVDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSNNE
MLQRIYGTAWAKKEDQDAYLHMLEEAEKRDHRRLGKTLDLFHLQEEAPGMVFWHPKGWQVWQAVEQYMRGRLGQAGYEEV
RTPQVMDRSLWERSGHWDNYKENMFVTESEKRDYAIKPMNCPGHVQIFNHGLRSYRDLPLRLAEFGACHRNEPSGALHGL
MRVRGFVQDDAHIFCTEEQIVEEAKAFNELAFSIYDDFGFKDVAVKLSLRPEKRAGSDAVWDHAEDGLRLALRACGVEWE
ELPGEGAFYGPKVEYHIKDAIGRSWQCGTLQLDLVLPERLGAEYVSEDNSRKRPVMLHRAILGSFERFLGILLENHAGAL
PAWLAPEQVVVMNIAESQSEYAENVVQLLQKQGFRAKADLRNEKITYKIREHSLQKIPYLLVIGDKERDANQVAVRARGN
VDLGVMPVSAFVERLQQDVSSKA
>Mature_662_residues
GRRHKRSYAPLATSPEGRCSGILERCKMIVITLPDGSRREYPGPVTVAEVAQSIGSGLAKAALAGKVDGRMVDTSFRIDQ
DASLSIVTDKDADGVDVIRHSTAHLLAYAVKELYPDAQVTIGPVIDNGFYYDFSYKRPFTPEDLAAIEKKMTELARKDEK
VSREVWNRDEAVALFESMGEKYKAEIIASIPADQEIGLYREGSFVDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSNNEM
LQRIYGTAWAKKEDQDAYLHMLEEAEKRDHRRLGKTLDLFHLQEEAPGMVFWHPKGWQVWQAVEQYMRGRLGQAGYEEVR
TPQVMDRSLWERSGHWDNYKENMFVTESEKRDYAIKPMNCPGHVQIFNHGLRSYRDLPLRLAEFGACHRNEPSGALHGLM
RVRGFVQDDAHIFCTEEQIVEEAKAFNELAFSIYDDFGFKDVAVKLSLRPEKRAGSDAVWDHAEDGLRLALRACGVEWEE
LPGEGAFYGPKVEYHIKDAIGRSWQCGTLQLDLVLPERLGAEYVSEDNSRKRPVMLHRAILGSFERFLGILLENHAGALP
AWLAPEQVVVMNIAESQSEYAENVVQLLQKQGFRAKADLRNEKITYKIREHSLQKIPYLLVIGDKERDANQVAVRARGNV
DLGVMPVSAFVERLQQDVSSKA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=634, Percent_Identity=40.8517350157729, Blast_Score=484, Evalue=1e-136,
Organism=Homo sapiens, GI38570111, Length=615, Percent_Identity=40.4878048780488, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI20070344, Length=649, Percent_Identity=37.1340523882897, Blast_Score=411, Evalue=1e-114,
Organism=Escherichia coli, GI1788013, Length=636, Percent_Identity=59.1194968553459, Blast_Score=796, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=163, Percent_Identity=30.6748466257669, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71984184, Length=634, Percent_Identity=39.1167192429022, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71984192, Length=634, Percent_Identity=39.1167192429022, Blast_Score=470, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322112, Length=628, Percent_Identity=40.2866242038217, Blast_Score=468, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6322654, Length=394, Percent_Identity=37.5634517766497, Blast_Score=291, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24583842, Length=631, Percent_Identity=39.4611727416799, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI28574141, Length=631, Percent_Identity=39.4611727416799, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24583839, Length=631, Percent_Identity=39.4611727416799, Blast_Score=488, Evalue=1e-138,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 75035; Mature: 74904

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRRHKRSYAPLATSPEGRCSGILERCKMIVITLPDGSRREYPGPVTVAEVAQSIGSGLA
CCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
KAALAGKVDGRMVDTSFRIDQDASLSIVTDKDADGVDVIRHSTAHLLAYAVKELYPDAQV
HHHHHCCCCCEEEECEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCE
TIGPVIDNGFYYDFSYKRPFTPEDLAAIEKKMTELARKDEKVSREVWNRDEAVALFESMG
EEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
EKYKAEIIASIPADQEIGLYREGSFVDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSNNE
HHHHHHHEEECCCCCCCCEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHH
MLQRIYGTAWAKKEDQDAYLHMLEEAEKRDHRRLGKTLDLFHLQEEAPGMVFWHPKGWQV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHEEECCCCCCEEEECCCCCHH
WQAVEQYMRGRLGQAGYEEVRTPQVMDRSLWERSGHWDNYKENMFVTESEKRDYAIKPMN
HHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEECCCC
CPGHVQIFNHGLRSYRDLPLRLAEFGACHRNEPSGALHGLMRVRGFVQDDAHIFCTEEQI
CCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECHHHH
VEEAKAFNELAFSIYDDFGFKDVAVKLSLRPEKRAGSDAVWDHAEDGLRLALRACGVEWE
HHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHCCCHH
ELPGEGAFYGPKVEYHIKDAIGRSWQCGTLQLDLVLPERLGAEYVSEDNSRKRPVMLHRA
HCCCCCCCCCCEEEEEEHHHCCCCCCCCEEEEEEECHHHHCHHHHCCCCCCCCHHHHHHH
ILGSFERFLGILLENHAGALPAWLAPEQVVVMNIAESQSEYAENVVQLLQKQGFRAKADL
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHCC
RNEKITYKIREHSLQKIPYLLVIGDKERDANQVAVRARGNVDLGVMPVSAFVERLQQDVS
CCCEEEEEEHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHH
SKA
CCC
>Mature Secondary Structure 
GRRHKRSYAPLATSPEGRCSGILERCKMIVITLPDGSRREYPGPVTVAEVAQSIGSGLA
CCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
KAALAGKVDGRMVDTSFRIDQDASLSIVTDKDADGVDVIRHSTAHLLAYAVKELYPDAQV
HHHHHCCCCCEEEECEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCE
TIGPVIDNGFYYDFSYKRPFTPEDLAAIEKKMTELARKDEKVSREVWNRDEAVALFESMG
EEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
EKYKAEIIASIPADQEIGLYREGSFVDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSNNE
HHHHHHHEEECCCCCCCCEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHH
MLQRIYGTAWAKKEDQDAYLHMLEEAEKRDHRRLGKTLDLFHLQEEAPGMVFWHPKGWQV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHEEECCCCCCEEEECCCCCHH
WQAVEQYMRGRLGQAGYEEVRTPQVMDRSLWERSGHWDNYKENMFVTESEKRDYAIKPMN
HHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEECCCC
CPGHVQIFNHGLRSYRDLPLRLAEFGACHRNEPSGALHGLMRVRGFVQDDAHIFCTEEQI
CCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECHHHH
VEEAKAFNELAFSIYDDFGFKDVAVKLSLRPEKRAGSDAVWDHAEDGLRLALRACGVEWE
HHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHCCCHH
ELPGEGAFYGPKVEYHIKDAIGRSWQCGTLQLDLVLPERLGAEYVSEDNSRKRPVMLHRA
HCCCCCCCCCCEEEEEEHHHCCCCCCCCEEEEEEECHHHHCHHHHCCCCCCCCHHHHHHH
ILGSFERFLGILLENHAGALPAWLAPEQVVVMNIAESQSEYAENVVQLLQKQGFRAKADL
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHCC
RNEKITYKIREHSLQKIPYLLVIGDKERDANQVAVRARGNVDLGVMPVSAFVERLQQDVS
CCCEEEEEEHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHH
SKA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA