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The map label for this gene is menB [H]

Identifier: 326424148

GI number: 326424148

Start: 3243909

End: 3244787

Strand: Reverse

Name: menB [H]

Synonym: NA

Alternate gene names: 326424148

Gene position: 3244787-3243909 (Counterclockwise)

Preceding gene: 27366432

Following gene: 27366430

Centisome position: 98.87

GC content: 49.37

Gene sequence:

>879_bases
ATGGGAACCACCATGGCTAAAACAGTAGGCATCACTGAAGCAGAACTTTACGCACCAGTTAATTGGAATGACTGTAGTGC
GCCCTATGAAGATATTCAGTACCACAAGTCGGAAGACGGCATTGCAAAAATCACCATTGCACGCCCTCAAGTGCGTAATG
CATTTCGCCCGCAAACCGTCAAAGAAATGATCCAAGCACTGGCGGATGCTCGCTATGACTCTAACGTGGGCGTGATCATT
TTGACCGGTCTCGGTGAAGACGCGTTCTGCTCTGGCGGCGACCAGAAGATCCGCGGTGATTACGGCGGCTATAAAGATGA
CTCTGGTGTTCATCACCTGAATGTTCTTGATTTCCAACGTGATATTCGTACTTGTCCAAAACCTGTTATTGCGTCAGTCG
CTGGTTGGGCTGTCGGTGGCGGCCACGTTCTTCATATGATGTGTGACTTAACCATCGCGGCTGAAAACGCGCAATTTGGT
CAAACTGGACCAAAAGTGGGCTCGTTTGATGGCGGTTGGGGTGCGTCATACATGGCACGTATTGTCGGACAGAAAAAAGC
ACGTGAGATTTGGTTCCTATGTCGTTTTTATGACGCTCAAGAAGCGTTGGATATGGGGCTAGTGAACACGGTCGTCCCTG
TAGAAGAATTAGAGAAAGAAACCGTACGTTGGTGTCGTGAAGTACTTCAGCACAGCCCGATGGCATTGCGTTGCCTTAAA
GCAGCATTGAACGCCGATTGCGATGGTCAAGCGGGTCTTCAAGAGTTGGCGGGCAACGCCACAATGATGTTCTATATGAC
GGATGAAGGGCAAGAAGGGCGCAATGCGTTCAACGAAAAACGTCGTCCAGACTTCAATAAGTTTCCACGCAACCCTTAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:
NA

Sequences:

>Translated_292_residues
MGTTMAKTVGITEAELYAPVNWNDCSAPYEDIQYHKSEDGIAKITIARPQVRNAFRPQTVKEMIQALADARYDSNVGVII
LTGLGEDAFCSGGDQKIRGDYGGYKDDSGVHHLNVLDFQRDIRTCPKPVIASVAGWAVGGGHVLHMMCDLTIAAENAQFG
QTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVEELEKETVRWCREVLQHSPMALRCLK
AALNADCDGQAGLQELAGNATMMFYMTDEGQEGRNAFNEKRRPDFNKFPRNP
>Mature_291_residues
GTTMAKTVGITEAELYAPVNWNDCSAPYEDIQYHKSEDGIAKITIARPQVRNAFRPQTVKEMIQALADARYDSNVGVIIL
TGLGEDAFCSGGDQKIRGDYGGYKDDSGVHHLNVLDFQRDIRTCPKPVIASVAGWAVGGGHVLHMMCDLTIAAENAQFGQ
TGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVEELEKETVRWCREVLQHSPMALRCLKA
ALNADCDGQAGLQELAGNATMMFYMTDEGQEGRNAFNEKRRPDFNKFPRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=246, Percent_Identity=34.1463414634146, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI31542718, Length=252, Percent_Identity=31.3492063492063, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4502327, Length=254, Percent_Identity=29.9212598425197, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=30.622009569378, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=30.622009569378, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=30.622009569378, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI25453481, Length=250, Percent_Identity=24.8, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI51538573, Length=250, Percent_Identity=24.8, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4757966, Length=250, Percent_Identity=24.8, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI51538581, Length=250, Percent_Identity=24.8, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4757968, Length=250, Percent_Identity=25.2, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI49355787, Length=250, Percent_Identity=25.2, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI157694516, Length=226, Percent_Identity=23.4513274336283, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI70995211, Length=234, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI213417737, Length=226, Percent_Identity=23.4513274336283, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI68989263, Length=214, Percent_Identity=28.9719626168224, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI116235487, Length=235, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788597, Length=280, Percent_Identity=86.0714285714286, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1787659, Length=244, Percent_Identity=29.9180327868852, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082183, Length=237, Percent_Identity=29.535864978903, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI221142681, Length=209, Percent_Identity=31.5789473684211, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1787660, Length=259, Percent_Identity=27.7992277992278, Blast_Score=74, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=284, Percent_Identity=32.0422535211268, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI25145438, Length=258, Percent_Identity=32.9457364341085, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=231, Percent_Identity=27.7056277056277, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17535521, Length=213, Percent_Identity=27.6995305164319, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=278, Percent_Identity=25.1798561151079, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=203, Percent_Identity=29.064039408867, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI20129971, Length=269, Percent_Identity=32.7137546468402, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24653477, Length=269, Percent_Identity=32.7137546468402, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24653139, Length=276, Percent_Identity=28.6231884057971, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21357171, Length=217, Percent_Identity=30.4147465437788, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24654903, Length=205, Percent_Identity=29.7560975609756, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922422, Length=190, Percent_Identity=26.8421052631579, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 32236; Mature: 32105

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTTMAKTVGITEAELYAPVNWNDCSAPYEDIQYHKSEDGIAKITIARPQVRNAFRPQTV
CCCCHHHHCCCCHHHEEECCCCCCCCCCHHHHHHCCCCCCEEEEEEECHHHHHCCCCHHH
KEMIQALADARYDSNVGVIILTGLGEDAFCSGGDQKIRGDYGGYKDDSGVHHLNVLDFQR
HHHHHHHHHCCCCCCCCEEEEECCCCCHHCCCCCCEECCCCCCCCCCCCCEEEEHHHHHH
DIRTCPKPVIASVAGWAVGGGHVLHMMCDLTIAAENAQFGQTGPKVGSFDGGWGASYMAR
HHHHCCHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
IVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVEELEKETVRWCREVLQHSPMALRCLK
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
AALNADCDGQAGLQELAGNATMMFYMTDEGQEGRNAFNEKRRPDFNKFPRNP
HHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
GTTMAKTVGITEAELYAPVNWNDCSAPYEDIQYHKSEDGIAKITIARPQVRNAFRPQTV
CCCHHHHCCCCHHHEEECCCCCCCCCCHHHHHHCCCCCCEEEEEEECHHHHHCCCCHHH
KEMIQALADARYDSNVGVIILTGLGEDAFCSGGDQKIRGDYGGYKDDSGVHHLNVLDFQR
HHHHHHHHHCCCCCCCCEEEEECCCCCHHCCCCCCEECCCCCCCCCCCCCEEEEHHHHHH
DIRTCPKPVIASVAGWAVGGGHVLHMMCDLTIAAENAQFGQTGPKVGSFDGGWGASYMAR
HHHHCCHHHHHHHHHHCCCCHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
IVGQKKAREIWFLCRFYDAQEALDMGLVNTVVPVEELEKETVRWCREVLQHSPMALRCLK
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
AALNADCDGQAGLQELAGNATMMFYMTDEGQEGRNAFNEKRRPDFNKFPRNP
HHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]