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The map label for this gene is gluQ

Identifier: 326423863

GI number: 326423863

Start: 1613853

End: 1614764

Strand: Reverse

Name: gluQ

Synonym: NA

Alternate gene names: 326423863

Gene position: 1614764-1613853 (Counterclockwise)

Preceding gene: 27365010

Following gene: 326423862

Centisome position: 49.2

GC content: 46.93

Gene sequence:

>912_bases
ATGCTCCCTTTTTGTTTTGAGATGACATCCATGAGCTACATCGGTCGTTTTGCCCCTTCCCCATCAGGCCCATTGCATTT
TGGCTCTTTGATTGCTGCTTTAGGCAGCTACTTTCAAGCCAAATCTCAACATGGTCAGTGGTTAGTGCGCATTGAAGATC
TCGATCCGCCTCGAGAAATGCCGGGGGCGGCGGATTTGATTTTAAAAACGCTCGAAACTTATCACTTATTTTGGGATGGT
GAAGTGGTTTACCAAAGCCAGCGTCATCACCTCTATCAAGCGCAAATTGACCACTGGCTGCAAAGTGGCCAAGCCTATTA
CTGCCAGTGCAGTCGCAAGCAGATCAAAGAAATGGGTGGCTATTACAACGGCCATTGCCAAGAATTGCATTTGGATGCAG
GGGCTATTCGTCTCAAAATGACGCAGCCAATCACTCATTTTGACGATCTTCGTCATGGGCAGATGCACATTCCTCTCGAA
CTCGCGCAAGAAGATTTCATCATCAAGCGCCGTGATGGTTTGTTTGCCTATAATCTTGCAGTGGTATTGGACGATATCGA
TCAGGGTGTGACCGAAGTGGTGCGTGGCGCTGATTTAATCGAACCAACCGGTCGTCAAATCAGCTTATACCGCATGCTTG
GTCAAGTTCCTGTCCGATATTTGCACTTGCCACTGGCAATGGATAAAAATGGCAACAAACTCTCCAAACAAAATCATGCC
ACTGGCATTGATTTGACACATCCAGCCTCTATGATTCTTGAAGCGATGGCGTTTCTAGGTTTTGCCATTCCCAAAGAACT
TCATCAGGCCAATTTGGATGAAATTCTGCATTGGGGTGTACAAAATTGGCGCTTAAATCAGTTGCCCGAATCGCTAGAAA
TCACGGCGCGATTCTCAAATGGCACGGCGTGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: glutamyl-Q-tRNA synthetase

Products: NA

Alternate protein names: Glu-Q-RSs

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:
NA

Sequences:

>Translated_303_residues
MLPFCFEMTSMSYIGRFAPSPSGPLHFGSLIAALGSYFQAKSQHGQWLVRIEDLDPPREMPGAADLILKTLETYHLFWDG
EVVYQSQRHHLYQAQIDHWLQSGQAYYCQCSRKQIKEMGGYYNGHCQELHLDAGAIRLKMTQPITHFDDLRHGQMHIPLE
LAQEDFIIKRRDGLFAYNLAVVLDDIDQGVTEVVRGADLIEPTGRQISLYRMLGQVPVRYLHLPLAMDKNGNKLSKQNHA
TGIDLTHPASMILEAMAFLGFAIPKELHQANLDEILHWGVQNWRLNQLPESLEITARFSNGTA
>Mature_303_residues
MLPFCFEMTSMSYIGRFAPSPSGPLHFGSLIAALGSYFQAKSQHGQWLVRIEDLDPPREMPGAADLILKTLETYHLFWDG
EVVYQSQRHHLYQAQIDHWLQSGQAYYCQCSRKQIKEMGGYYNGHCQELHLDAGAIRLKMTQPITHFDDLRHGQMHIPLE
LAQEDFIIKRRDGLFAYNLAVVLDDIDQGVTEVVRGADLIEPTGRQISLYRMLGQVPVRYLHLPLAMDKNGNKLSKQNHA
TGIDLTHPASMILEAMAFLGFAIPKELHQANLDEILHWGVQNWRLNQLPESLEITARFSNGTA

Specific function: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble positi

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily

Homologues:

Organism=Homo sapiens, GI134288884, Length=312, Percent_Identity=32.3717948717949, Blast_Score=128, Evalue=8e-30,
Organism=Escherichia coli, GI226510925, Length=308, Percent_Identity=54.5454545454545, Blast_Score=334, Evalue=5e-93,
Organism=Escherichia coli, GI1788743, Length=252, Percent_Identity=35.7142857142857, Blast_Score=140, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71993394, Length=250, Percent_Identity=31.2, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324540, Length=290, Percent_Identity=31.3793103448276, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24665321, Length=260, Percent_Identity=31.5384615384615, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLUQ_VIBVU (Q8DC08)

Other databases:

- EMBL:   AE016795
- EMBL:   AE016795
- RefSeq:   NP_760536.1
- RefSeq:   NP_760537.1
- ProteinModelPortal:   Q8DC08
- SMR:   Q8DC08
- GeneID:   1178560
- GeneID:   1178561
- BioCyc:   VVUL216895:VV1_1646-MONOMER
- BioCyc:   VVUL216895:VV1_1647-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_01428
- InterPro:   IPR022380
- InterPro:   IPR000924
- InterPro:   IPR020058
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10119
- PRINTS:   PR00987
- TIGRFAMs:   TIGR03838

Pfam domain/function: PF00749 tRNA-synt_1c

EC number: NA

Molecular weight: Translated: 34466; Mature: 34466

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 52-52 BINDING 177-177 BINDING 195-195 BINDING 236-236

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPFCFEMTSMSYIGRFAPSPSGPLHFGSLIAALGSYFQAKSQHGQWLVRIEDLDPPREM
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHC
PGAADLILKTLETYHLFWDGEVVYQSQRHHLYQAQIDHWLQSGQAYYCQCSRKQIKEMGG
CCHHHHHHHHHHHHEEEECCEEEEEHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCC
YYNGHCQELHLDAGAIRLKMTQPITHFDDLRHGQMHIPLELAQEDFIIKRRDGLFAYNLA
CCCCCCEEEEECCCEEEEEECCCCHHHHHCCCCCEECCHHHCCCCCEEEECCCEEEEEHH
VVLDDIDQGVTEVVRGADLIEPTGRQISLYRMLGQVPVRYLHLPLAMDKNGNKLSKQNHA
HHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCHHHEEEEEEECCCCCCCCCCCCC
TGIDLTHPASMILEAMAFLGFAIPKELHQANLDEILHWGVQNWRLNQLPESLEITARFSN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHCCCCCEEEEEEECC
GTA
CCC
>Mature Secondary Structure
MLPFCFEMTSMSYIGRFAPSPSGPLHFGSLIAALGSYFQAKSQHGQWLVRIEDLDPPREM
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHC
PGAADLILKTLETYHLFWDGEVVYQSQRHHLYQAQIDHWLQSGQAYYCQCSRKQIKEMGG
CCHHHHHHHHHHHHEEEECCEEEEEHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCC
YYNGHCQELHLDAGAIRLKMTQPITHFDDLRHGQMHIPLELAQEDFIIKRRDGLFAYNLA
CCCCCCEEEEECCCEEEEEECCCCHHHHHCCCCCEECCHHHCCCCCEEEECCCEEEEEHH
VVLDDIDQGVTEVVRGADLIEPTGRQISLYRMLGQVPVRYLHLPLAMDKNGNKLSKQNHA
HHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCHHHEEEEEEECCCCCCCCCCCCC
TGIDLTHPASMILEAMAFLGFAIPKELHQANLDEILHWGVQNWRLNQLPESLEITARFSN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHCCCCCEEEEEEECC
GTA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA