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The map label for this gene is ftsI [H]

Identifier: 326423736

GI number: 326423736

Start: 599575

End: 601305

Strand: Reverse

Name: ftsI [H]

Synonym: NA

Alternate gene names: 326423736

Gene position: 601305-599575 (Counterclockwise)

Preceding gene: 27364046

Following gene: 326423735

Centisome position: 18.32

GC content: 51.47

Gene sequence:

>1731_bases
ATGATGGGTAAAAAGAGCAAAACCACCGTCAAACCCAAAGAGAGTGAGCAAGGGACATCTTTGCTTATCCGCTGGCGTTT
CCATTTAGTCCTAGGATTTGTTTTCCTCGCGTTTGCTGCGCTTGTTGTTCGTCTTGCATTTATTCAAGTCATTGAGCCTG
ACAACCTTATTCGTGAAGGGGATCTGCGTTCTATCCGTGTGAAAGCCCTTCCGTCCGCGCGAGGTATCATCTCCGATCGC
AATGGTGAACCTTTAGCGGTCAGTGTTCCCGTTGAAGCTGTCTGGGCCGATCCGGTGACGATTTTCAAAGAAAAGGCGCT
GGATAACAAACAGCGTTGGTATGCGTTAGCCGATGTGTTGGGGCTGCAGCGTGAAGAATTGATTGAACGTATCGAGCGCA
ATGAAAGCCGCCGCTTCATCTACTTGCAGCGCCAAGTGAGCCCCGCGATGGCGAACTACATACGCGAGCTTAAAATTCCA
GGCGTGGGGCTGAAATCAGAATCGCGCCGCTATTATCCCGCTGGTGAAGTGAGTGCTCATTTAGTGGGTGTAACGGGTAT
CGATGGTCACGGCCTTGAAGGGGTGGAACGCAGTTACGATAACTGGTTGACTGGTGAAGCGGGTAAACAGACGATTCGTA
AAGACCGTTATGGCCGAGTGGTGGAAAACATTGCCTATGAAGACAGGCAAGAAGGCAAGTCACTTGAACTCACCATTGAT
CAGCGTCTCCAAGCCATTGCTTATCGCGCCATCAAACAGGCGGTGGCCGATCACCGTGCGACTTCTGGTTCGGCAGTGAT
GTTGGATGTAAAAACCGGCGCCGTGTTGGCGATGGTCAACGCGCCTTCTTACAACCCAAACAATCGCAGTGATTGGCAAA
GCTACAAGATGCGTAACCGCATCATCACCGATTCGTTGGAGCCTGGCTCCACGGTGAAGCCTTTTGTGATTCTTGCCGCG
CTGGAAAACGGCGTTGCCACCAAAGACACGGTGATCGACACGGGCAACGGCATTCTCCAAGTCGGTGGCAGTCGAGTACG
AGATACGAGTAAGGTCGGTAAAGCGGACCTGACCGAAATCCTCAAAAAATCCAGTAATATCGGCGTGACAAAACTGTCGA
TGGAAATGCCCGTGGAAGCGATTCTCGGCATGTATAACTCGGTTGGGCTTGGAGAGCCTTCTGGGTTAAATCTTGTTGGC
GAAGTGACCGGTATTTTCCCTACTCGTTCGCGTTGGTCTCCGATTGAGAGAGCGACGCTGTCGTTTGGGTACGGTCTGTC
TATCACTCCGATTCAATTGGCTCATGCCTACGCAACCTTGGGCAATGAAGGTATGTACGAGCCGATCCACATCATCAAAA
GCAACGACCGTGATATGGCGAAGCAAGTGGTGTCCAAACAACACGCTCGTGAAGTGCTCAATATGCTTGAAACCGTGACG
CAAAAAGGCGGCTCAGCCAGACGAGCGGCCGTTCCGGGTTACCGGGTTGGGGCGAAAACGGGGACATCACGTAAAGCAAC
GGCTGGTGGGTATAGCGATGAGTACATCACCTACACGGCGGGGATTGCGCCAGTTAGCGATCCGAGAATTGCTTTGGTCG
TGGTGGTCAATGAACCACAAGGGGATGATTACTATGGTGGTTCCGTTGCTTCCCCTGTTTTTTCAGAAATTATGAAAGGT
GCGCTGCAAATTTTGAATGTGGCACCCGATGAAAATGCATTCCAGAACTAG

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: cell division protein FtsI

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:
NA

Sequences:

>Translated_576_residues
MMGKKSKTTVKPKESEQGTSLLIRWRFHLVLGFVFLAFAALVVRLAFIQVIEPDNLIREGDLRSIRVKALPSARGIISDR
NGEPLAVSVPVEAVWADPVTIFKEKALDNKQRWYALADVLGLQREELIERIERNESRRFIYLQRQVSPAMANYIRELKIP
GVGLKSESRRYYPAGEVSAHLVGVTGIDGHGLEGVERSYDNWLTGEAGKQTIRKDRYGRVVENIAYEDRQEGKSLELTID
QRLQAIAYRAIKQAVADHRATSGSAVMLDVKTGAVLAMVNAPSYNPNNRSDWQSYKMRNRIITDSLEPGSTVKPFVILAA
LENGVATKDTVIDTGNGILQVGGSRVRDTSKVGKADLTEILKKSSNIGVTKLSMEMPVEAILGMYNSVGLGEPSGLNLVG
EVTGIFPTRSRWSPIERATLSFGYGLSITPIQLAHAYATLGNEGMYEPIHIIKSNDRDMAKQVVSKQHAREVLNMLETVT
QKGGSARRAAVPGYRVGAKTGTSRKATAGGYSDEYITYTAGIAPVSDPRIALVVVVNEPQGDDYYGGSVASPVFSEIMKG
ALQILNVAPDENAFQN
>Mature_576_residues
MMGKKSKTTVKPKESEQGTSLLIRWRFHLVLGFVFLAFAALVVRLAFIQVIEPDNLIREGDLRSIRVKALPSARGIISDR
NGEPLAVSVPVEAVWADPVTIFKEKALDNKQRWYALADVLGLQREELIERIERNESRRFIYLQRQVSPAMANYIRELKIP
GVGLKSESRRYYPAGEVSAHLVGVTGIDGHGLEGVERSYDNWLTGEAGKQTIRKDRYGRVVENIAYEDRQEGKSLELTID
QRLQAIAYRAIKQAVADHRATSGSAVMLDVKTGAVLAMVNAPSYNPNNRSDWQSYKMRNRIITDSLEPGSTVKPFVILAA
LENGVATKDTVIDTGNGILQVGGSRVRDTSKVGKADLTEILKKSSNIGVTKLSMEMPVEAILGMYNSVGLGEPSGLNLVG
EVTGIFPTRSRWSPIERATLSFGYGLSITPIQLAHAYATLGNEGMYEPIHIIKSNDRDMAKQVVSKQHAREVLNMLETVT
QKGGSARRAAVPGYRVGAKTGTSRKATAGGYSDEYITYTAGIAPVSDPRIALVVVVNEPQGDDYYGGSVASPVFSEIMKG
ALQILNVAPDENAFQN

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=568, Percent_Identity=50.1760563380282, Blast_Score=596, Evalue=1e-171,
Organism=Escherichia coli, GI1786854, Length=622, Percent_Identity=27.0096463022508, Blast_Score=160, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63095; Mature: 63095

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGKKSKTTVKPKESEQGTSLLIRWRFHLVLGFVFLAFAALVVRLAFIQVIEPDNLIREG
CCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DLRSIRVKALPSARGIISDRNGEPLAVSVPVEAVWADPVTIFKEKALDNKQRWYALADVL
CCCEEEEEECCCCCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHCCCHHHHHHHHHHH
GLQREELIERIERNESRRFIYLQRQVSPAMANYIRELKIPGVGLKSESRRYYPAGEVSAH
CCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEE
LVGVTGIDGHGLEGVERSYDNWLTGEAGKQTIRKDRYGRVVENIAYEDRQEGKSLELTID
EEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHH
QRLQAIAYRAIKQAVADHRATSGSAVMLDVKTGAVLAMVNAPSYNPNNRSDWQSYKMRNR
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHH
IITDSLEPGSTVKPFVILAALENGVATKDTVIDTGNGILQVGGSRVRDTSKVGKADLTEI
HCCCCCCCCCCCCCEEEEEEHHCCCCCCCCEEECCCCEEEECCCHHCCHHHCCHHHHHHH
LKKSSNIGVTKLSMEMPVEAILGMYNSVGLGEPSGLNLVGEVTGIFPTRSRWSPIERATL
HHCCCCCCEEEEEHHCCHHHHHHHHHCCCCCCCCCCEEEEHHHCCCCCCCCCCCHHHHHH
SFGYGLSITPIQLAHAYATLGNEGMYEPIHIIKSNDRDMAKQVVSKQHAREVLNMLETVT
EECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
QKGGSARRAAVPGYRVGAKTGTSRKATAGGYSDEYITYTAGIAPVSDPRIALVVVVNEPQ
HCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCC
GDDYYGGSVASPVFSEIMKGALQILNVAPDENAFQN
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MMGKKSKTTVKPKESEQGTSLLIRWRFHLVLGFVFLAFAALVVRLAFIQVIEPDNLIREG
CCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DLRSIRVKALPSARGIISDRNGEPLAVSVPVEAVWADPVTIFKEKALDNKQRWYALADVL
CCCEEEEEECCCCCCCCCCCCCCCEEEECCCCEEECCHHHHHHHHHCCCHHHHHHHHHHH
GLQREELIERIERNESRRFIYLQRQVSPAMANYIRELKIPGVGLKSESRRYYPAGEVSAH
CCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEE
LVGVTGIDGHGLEGVERSYDNWLTGEAGKQTIRKDRYGRVVENIAYEDRQEGKSLELTID
EEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHH
QRLQAIAYRAIKQAVADHRATSGSAVMLDVKTGAVLAMVNAPSYNPNNRSDWQSYKMRNR
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHH
IITDSLEPGSTVKPFVILAALENGVATKDTVIDTGNGILQVGGSRVRDTSKVGKADLTEI
HCCCCCCCCCCCCCEEEEEEHHCCCCCCCCEEECCCCEEEECCCHHCCHHHCCHHHHHHH
LKKSSNIGVTKLSMEMPVEAILGMYNSVGLGEPSGLNLVGEVTGIFPTRSRWSPIERATL
HHCCCCCCEEEEEHHCCHHHHHHHHHCCCCCCCCCCEEEEHHHCCCCCCCCCCCHHHHHH
SFGYGLSITPIQLAHAYATLGNEGMYEPIHIIKSNDRDMAKQVVSKQHAREVLNMLETVT
EECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
QKGGSARRAAVPGYRVGAKTGTSRKATAGGYSDEYITYTAGIAPVSDPRIALVVVVNEPQ
HCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCC
GDDYYGGSVASPVFSEIMKGALQILNVAPDENAFQN
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]