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The map label for this gene is adk

Identifier: 32267270

GI number: 32267270

Start: 1693612

End: 1694184

Strand: Direct

Name: adk

Synonym: HH1771

Alternate gene names: 32267270

Gene position: 1693612-1694184 (Clockwise)

Preceding gene: 32267268

Following gene: 32267271

Centisome position: 94.13

GC content: 36.82

Gene sequence:

>573_bases
ATGAAAAAGTTGTTTTTAATTATTGGTGCGCCCGGTTCGGGAAAGACGACAGATGCACAAATCATTGCAAGAGATAATGC
GGATTCTATCGTGCATTATTCCACGGGAGATTTATTACGCGAAGAAGTTGCAAGTGGTAGTGAATATGGGAAAACCATTG
ATAGTTTTATTAGTAAGGGCAATCTTGTCCCACTTGATATTGTAGTTGGCACAATTATTAATGCCATAGCAAATGCGCCC
AAAGATGTTATCATTATTGATGGCTATCCTCGTAGCATAGAGCAAATGGAAGCCCTTGATGAAAAACTTAAAGCACAAAA
TCAAGTGCAATTAGTGAGCGTAATAGAAGTTGAAGTAAGTGAATCTGTCGCAAGAGAGAGAGTGTTAGGACGGGCAAGAG
GTGCAGATGATAATGTAGAAGTATTTAATAATCGTATGCAAGTGTATCTCACGCCACTTAAAGATATTGAGACATTTTAT
AGTAAGCAAAAAGTGCTTCATAAAATTAATGGTGAGCGTATGATTGAGGAAATCGTAAGTGAAATGGAAAGTTTTATTAA
AGGGAAAATGTAA

Upstream 100 bases:

>100_bases
GTCATTTGAATATTTGAAATCATATTATATCTTAAGATTTTAAAGCTATAATCTTTTTTAAAAATATTTTTTGTCCATTA
AAGTTTTAAGGAGAATAGTT

Downstream 100 bases:

>100_bases
TACTTTAAAATAATGTTTTAAAATTATATTCTTCACTTTTATGTTTTTTTATACTTAAAATAGTAGAATCCTTACTTTAA
TTCTAAATGGAAAGTAGAGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MKKLFLIIGAPGSGKTTDAQIIARDNADSIVHYSTGDLLREEVASGSEYGKTIDSFISKGNLVPLDIVVGTIINAIANAP
KDVIIIDGYPRSIEQMEALDEKLKAQNQVQLVSVIEVEVSESVARERVLGRARGADDNVEVFNNRMQVYLTPLKDIETFY
SKQKVLHKINGERMIEEIVSEMESFIKGKM

Sequences:

>Translated_190_residues
MKKLFLIIGAPGSGKTTDAQIIARDNADSIVHYSTGDLLREEVASGSEYGKTIDSFISKGNLVPLDIVVGTIINAIANAP
KDVIIIDGYPRSIEQMEALDEKLKAQNQVQLVSVIEVEVSESVARERVLGRARGADDNVEVFNNRMQVYLTPLKDIETFY
SKQKVLHKINGERMIEEIVSEMESFIKGKM
>Mature_190_residues
MKKLFLIIGAPGSGKTTDAQIIARDNADSIVHYSTGDLLREEVASGSEYGKTIDSFISKGNLVPLDIVVGTIINAIANAP
KDVIIIDGYPRSIEQMEALDEKLKAQNQVQLVSVIEVEVSESVARERVLGRARGADDNVEVFNNRMQVYLTPLKDIETFY
SKQKVLHKINGERMIEEIVSEMESFIKGKM

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502011, Length=190, Percent_Identity=31.5789473684211, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI28144899, Length=189, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI28144897, Length=189, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI7706497, Length=192, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4502013, Length=199, Percent_Identity=29.1457286432161, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI7524346, Length=199, Percent_Identity=29.1457286432161, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI19923437, Length=215, Percent_Identity=27.4418604651163, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI310110345, Length=96, Percent_Identity=35.4166666666667, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI53832003, Length=96, Percent_Identity=35.4166666666667, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI8051579, Length=96, Percent_Identity=35.4166666666667, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI53832001, Length=96, Percent_Identity=35.4166666666667, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1786680, Length=127, Percent_Identity=34.6456692913386, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=32.4324324324324, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17533833, Length=187, Percent_Identity=31.0160427807487, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=31.8918918918919, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17552384, Length=128, Percent_Identity=40.625, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17537943, Length=193, Percent_Identity=28.4974093264249, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322828, Length=193, Percent_Identity=30.5699481865285, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320432, Length=202, Percent_Identity=29.7029702970297, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321018, Length=201, Percent_Identity=29.8507462686567, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221459597, Length=186, Percent_Identity=29.0322580645161, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21356893, Length=186, Percent_Identity=29.0322580645161, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI17737899, Length=220, Percent_Identity=30.4545454545455, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24645822, Length=220, Percent_Identity=30.4545454545455, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22026816, Length=216, Percent_Identity=27.3148148148148, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24663208, Length=186, Percent_Identity=29.5698924731183, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17647141, Length=186, Percent_Identity=29.5698924731183, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_HELHP (Q7VFA6)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_861302.1
- ProteinModelPortal:   Q7VFA6
- GeneID:   1492318
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1771
- NMPDR:   fig|235279.1.peg.1771
- HOGENOM:   HBG630208
- OMA:   IVHYSTG
- ProtClustDB:   PRK00279
- BioCyc:   HHEP235279:HH_1771-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 21041; Mature: 21041

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLFLIIGAPGSGKTTDAQIIARDNADSIVHYSTGDLLREEVASGSEYGKTIDSFISKG
CCEEEEEEECCCCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHCCHHHHHHHHHHHHCC
NLVPLDIVVGTIINAIANAPKDVIIIDGYPRSIEQMEALDEKLKAQNQVQLVSVIEVEVS
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ESVARERVLGRARGADDNVEVFNNRMQVYLTPLKDIETFYSKQKVLHKINGERMIEEIVS
HHHHHHHHHHHHCCCCCCHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
EMESFIKGKM
HHHHHHCCCC
>Mature Secondary Structure
MKKLFLIIGAPGSGKTTDAQIIARDNADSIVHYSTGDLLREEVASGSEYGKTIDSFISKG
CCEEEEEEECCCCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHCCHHHHHHHHHHHHCC
NLVPLDIVVGTIINAIANAPKDVIIIDGYPRSIEQMEALDEKLKAQNQVQLVSVIEVEVS
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ESVARERVLGRARGADDNVEVFNNRMQVYLTPLKDIETFYSKQKVLHKINGERMIEEIVS
HHHHHHHHHHHHCCCCCCHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
EMESFIKGKM
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954