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The map label for this gene is ubiE

Identifier: 32267218

GI number: 32267218

Start: 1644593

End: 1645324

Strand: Direct

Name: ubiE

Synonym: HH1719

Alternate gene names: 32267218

Gene position: 1644593-1645324 (Clockwise)

Preceding gene: 32267217

Following gene: 32267219

Centisome position: 91.41

GC content: 37.3

Gene sequence:

>732_bases
ATGAGTGAAAAACAAGAACAAATTGTAAATATGTTTAATGATATTGCTCCGAGCTATGATAGGGCAAATCGCGTGATGAG
TTTGGGTATTGATGTGAGTTGGCGTAAAGAGGCTTGCAAGAAAGCTTATGAGGCTTTGGGCAAAGATGAAATTCAGTGTG
TGCTTGATGTGGCGTGTGGCACAGGTGATATGTTATTGCATTGGCATAATGAGGCACAAAAGGCACATAAACATATCACA
CAAATGCGTGGAATTGACCCTTCTAGTGGTATGCTTGATGTAGCTAGAAAGAAACTTACACCATTTTTTACATCTGATAC
TTTAATGCTTGATATTGGCGAAGCAAAGGCATTATGTGTAGAATCCCAAAGTGTAGATATTCTCTCAATTGCTTATGGAT
TACGCAATGTCGTAGAGCTTGATAAAGCACTTGATGAATTTGTGCGTGTGCTTAAAAGTGGGGGTGTTCTTGTAATTTTA
GAATTTATGAACAACAAGCCTAGAGGGTTACTTGATATATTTATGCGCTTTTATACGCGCAAGATTCTTCCTGTAGTGGG
GGGGATTATTTCTCGTAATTATGGAGCCTATAAGTATTTACCAAATTCTATTGAGGGTTTTGTAAGCAGCGAAGAACTTG
CAAATAAACTCTTACAGAGGGGAGTGAAAAGTTATTTTATTAAAGGATATAGTGCTAATATTTCTACACTCTATGTAGGA
GTGAAGGTATAA

Upstream 100 bases:

>100_bases
CTTGGTGGCACAGCAGTAACACAAACTTGTCATCAAATTGAGGTGCTTGAATCTTTTGTGCGTGAGCAAATGGCGTGTTT
GCAAGTAGGAAGGAGTAAAA

Downstream 100 bases:

>100_bases
ATGCGTAAAAGTGATTTAAAAAATTTATTTTAGTAACAAAGTTATTCTTTTGCTTTACTTTTTAAGGGGTTATTTACAAA
AATATCTTACCATAAGAAAG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSEKQEQIVNMFNDIAPSYDRANRVMSLGIDVSWRKEACKKAYEALGKDEIQCVLDVACGTGDMLLHWHNEAQKAHKHIT
QMRGIDPSSGMLDVARKKLTPFFTSDTLMLDIGEAKALCVESQSVDILSIAYGLRNVVELDKALDEFVRVLKSGGVLVIL
EFMNNKPRGLLDIFMRFYTRKILPVVGGIISRNYGAYKYLPNSIEGFVSSEELANKLLQRGVKSYFIKGYSANISTLYVG
VKV

Sequences:

>Translated_243_residues
MSEKQEQIVNMFNDIAPSYDRANRVMSLGIDVSWRKEACKKAYEALGKDEIQCVLDVACGTGDMLLHWHNEAQKAHKHIT
QMRGIDPSSGMLDVARKKLTPFFTSDTLMLDIGEAKALCVESQSVDILSIAYGLRNVVELDKALDEFVRVLKSGGVLVIL
EFMNNKPRGLLDIFMRFYTRKILPVVGGIISRNYGAYKYLPNSIEGFVSSEELANKLLQRGVKSYFIKGYSANISTLYVG
VKV
>Mature_242_residues
SEKQEQIVNMFNDIAPSYDRANRVMSLGIDVSWRKEACKKAYEALGKDEIQCVLDVACGTGDMLLHWHNEAQKAHKHITQ
MRGIDPSSGMLDVARKKLTPFFTSDTLMLDIGEAKALCVESQSVDILSIAYGLRNVVELDKALDEFVRVLKSGGVLVILE
FMNNKPRGLLDIFMRFYTRKILPVVGGIISRNYGAYKYLPNSIEGFVSSEELANKLLQRGVKSYFIKGYSANISTLYVGV
KV

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=271, Percent_Identity=29.520295202952, Blast_Score=108, Evalue=3e-24,
Organism=Escherichia coli, GI48994983, Length=243, Percent_Identity=28.8065843621399, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17557039, Length=248, Percent_Identity=26.6129032258064, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323526, Length=249, Percent_Identity=29.718875502008, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24641702, Length=254, Percent_Identity=27.9527559055118, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27226; Mature: 27095

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKQEQIVNMFNDIAPSYDRANRVMSLGIDVSWRKEACKKAYEALGKDEIQCVLDVACG
CCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCC
TGDMLLHWHNEAQKAHKHITQMRGIDPSSGMLDVARKKLTPFFTSDTLMLDIGEAKALCV
CCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCEEEE
ESQSVDILSIAYGLRNVVELDKALDEFVRVLKSGGVLVILEFMNNKPRGLLDIFMRFYTR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCHHHHHHHHHHHH
KILPVVGGIISRNYGAYKYLPNSIEGFVSSEELANKLLQRGVKSYFIKGYSANISTLYVG
HHHHHHHHHHHCCCCCHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
VKV
EEC
>Mature Secondary Structure 
SEKQEQIVNMFNDIAPSYDRANRVMSLGIDVSWRKEACKKAYEALGKDEIQCVLDVACG
CHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCC
TGDMLLHWHNEAQKAHKHITQMRGIDPSSGMLDVARKKLTPFFTSDTLMLDIGEAKALCV
CCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCEEEE
ESQSVDILSIAYGLRNVVELDKALDEFVRVLKSGGVLVILEFMNNKPRGLLDIFMRFYTR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCHHHHHHHHHHHH
KILPVVGGIISRNYGAYKYLPNSIEGFVSSEELANKLLQRGVKSYFIKGYSANISTLYVG
HHHHHHHHHHHCCCCCHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
VKV
EEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA