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The map label for this gene is argH

Identifier: 32267217

GI number: 32267217

Start: 1643182

End: 1644600

Strand: Direct

Name: argH

Synonym: HH1718

Alternate gene names: 32267217

Gene position: 1643182-1644600 (Clockwise)

Preceding gene: 32267216

Following gene: 32267218

Centisome position: 91.33

GC content: 39.46

Gene sequence:

>1419_bases
ATGGCAAAATTATGGGGAGGACGCTTTGAATTAGATTCAAGCGCGCTTTTAGAGGAATTTAACGCTTCAATTTTCTTTGA
TAAGCAGCTATGGCAAGAAGATATAAAAGGTTCAAAAGCTCACGCAAAAATGCTTCATAAAATTGGCGTTTTGAGTGAGG
AAGAAACACAAGAAATTATCAATGGACTTGAAATTATTGCACAGCGCATTAGTAGAGGTGAGTTTGTATTTAATGCAAGT
GATGAAGATATACATATGGCAATAGAATCTGCTCTTACTGCACTTATTGGTGATGTAGGTAAAAAGCTTCATACTGCGCG
TAGCCGTAATGACCAAGTGGCACTTGATTTTAGGTTATATGTGTTAAAAAGCAATAAGGAGATTGTTAATTTGCTTTTAG
AGCTTATGGCATCTATCCTTGCAATAGCAAAAGTGCATACTAGCACGATTATGCCGGGTATGACGCATTTACAACACGCA
CAACCGATTAATTTTGGTTTTGCTCTTGTAGCGTGGGCGTGTAATTTTAAACGAGATGTGGAACGATTATTGAGTGATTA
TACGCGCAATAATAAATGTCCGCTTGGTAGTGGTGCATTAGCAGGCACACCTTATGGCAATGATAGAATCTTCCTTACCC
AAGAGTTAGGGTTTGACGAACCTACGCTTAATGCAATGGATTCAGTAAGTGATAGAGATTTTGCCCTTGATATGCTTTAT
TCCCTTTCTATGATAATGATGCACATTTCTCGTGTGGCAGAGGAGCTTGTGCTGTGGAGTAGCTCGGAATTTAAATTTAT
CTCTTTAAGTGATGAATATGCTACGGGAAGCTCTATAATGCCACAAAAAAAGAATCCTGATGTGCCTGAACTTTTGCGCG
GAAAGAGTGGGCGCGTGTATGGGGAGCTTATGGGACTGCTTTGTGTAATGAAAGGATTACCCTTTGCTTATAATAAAGAT
ACGCAAGAGGATAAAGAGGGCGTGTTTGATGCACTTAAAAATGTGGGGCTTTGCCTTAGAATCCTCAAAGAATGTCTTAA
AACTATGAGTATTCACCCTGAAAATATGTATAAAATGGCGAAAATTGGACATTTGAGTGCTACTGATTTGGCAGATTTTT
TAGTGCGTGAGTGTGGTGTGGCATTCCGTGATGCACATCATATCACCGGGCAAGTCGTAGCGTATGCAGAGAGCAAAGGT
GTAGATATAAGCGATTTATCCGAAAAAGAGATTATGGGTGTAGATTCTCGGATTAAACAAGGTGTAAAAGCTGTGCTGTG
TTTAGAGTATTCTATGAATGCACGTAATACTCTTGGTGGCACAGCAGTAACACAAACTTGTCATCAAATTGAGGTGCTTG
AATCTTTTGTGCGTGAGCAAATGGCGTGTTTGCAAGTAGGAAGGAGTAAAAATGAGTGA

Upstream 100 bases:

>100_bases
AAAAGCCATACATTTTTTAGAATCTTTAATGAGATTCCCACACTTTTAGTTATTGTGATTGTCTTTTTGGCAGTGTGTAA
GCCATTTTAGGAGATGATAA

Downstream 100 bases:

>100_bases
AAAACAAGAACAAATTGTAAATATGTTTAATGATATTGCTCCGAGCTATGATAGGGCAAATCGCGTGATGAGTTTGGGTA
TTGATGTGAGTTGGCGTAAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MAKLWGGRFELDSSALLEEFNASIFFDKQLWQEDIKGSKAHAKMLHKIGVLSEEETQEIINGLEIIAQRISRGEFVFNAS
DEDIHMAIESALTALIGDVGKKLHTARSRNDQVALDFRLYVLKSNKEIVNLLLELMASILAIAKVHTSTIMPGMTHLQHA
QPINFGFALVAWACNFKRDVERLLSDYTRNNKCPLGSGALAGTPYGNDRIFLTQELGFDEPTLNAMDSVSDRDFALDMLY
SLSMIMMHISRVAEELVLWSSSEFKFISLSDEYATGSSIMPQKKNPDVPELLRGKSGRVYGELMGLLCVMKGLPFAYNKD
TQEDKEGVFDALKNVGLCLRILKECLKTMSIHPENMYKMAKIGHLSATDLADFLVRECGVAFRDAHHITGQVVAYAESKG
VDISDLSEKEIMGVDSRIKQGVKAVLCLEYSMNARNTLGGTAVTQTCHQIEVLESFVREQMACLQVGRSKNE

Sequences:

>Translated_472_residues
MAKLWGGRFELDSSALLEEFNASIFFDKQLWQEDIKGSKAHAKMLHKIGVLSEEETQEIINGLEIIAQRISRGEFVFNAS
DEDIHMAIESALTALIGDVGKKLHTARSRNDQVALDFRLYVLKSNKEIVNLLLELMASILAIAKVHTSTIMPGMTHLQHA
QPINFGFALVAWACNFKRDVERLLSDYTRNNKCPLGSGALAGTPYGNDRIFLTQELGFDEPTLNAMDSVSDRDFALDMLY
SLSMIMMHISRVAEELVLWSSSEFKFISLSDEYATGSSIMPQKKNPDVPELLRGKSGRVYGELMGLLCVMKGLPFAYNKD
TQEDKEGVFDALKNVGLCLRILKECLKTMSIHPENMYKMAKIGHLSATDLADFLVRECGVAFRDAHHITGQVVAYAESKG
VDISDLSEKEIMGVDSRIKQGVKAVLCLEYSMNARNTLGGTAVTQTCHQIEVLESFVREQMACLQVGRSKNE
>Mature_471_residues
AKLWGGRFELDSSALLEEFNASIFFDKQLWQEDIKGSKAHAKMLHKIGVLSEEETQEIINGLEIIAQRISRGEFVFNASD
EDIHMAIESALTALIGDVGKKLHTARSRNDQVALDFRLYVLKSNKEIVNLLLELMASILAIAKVHTSTIMPGMTHLQHAQ
PINFGFALVAWACNFKRDVERLLSDYTRNNKCPLGSGALAGTPYGNDRIFLTQELGFDEPTLNAMDSVSDRDFALDMLYS
LSMIMMHISRVAEELVLWSSSEFKFISLSDEYATGSSIMPQKKNPDVPELLRGKSGRVYGELMGLLCVMKGLPFAYNKDT
QEDKEGVFDALKNVGLCLRILKECLKTMSIHPENMYKMAKIGHLSATDLADFLVRECGVAFRDAHHITGQVVAYAESKGV
DISDLSEKEIMGVDSRIKQGVKAVLCLEYSMNARNTLGGTAVTQTCHQIEVLESFVREQMACLQVGRSKNE

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=461, Percent_Identity=44.468546637744, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI68303542, Length=461, Percent_Identity=44.468546637744, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI68303549, Length=461, Percent_Identity=41.8655097613883, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI68303547, Length=461, Percent_Identity=41.8655097613883, Blast_Score=358, Evalue=6e-99,
Organism=Escherichia coli, GI1790398, Length=448, Percent_Identity=41.2946428571429, Blast_Score=347, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6321806, Length=460, Percent_Identity=43.695652173913, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=38.7308533916849, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=38.7308533916849, Blast_Score=346, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_HELHP (Q7VFF8)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_861249.1
- ProteinModelPortal:   Q7VFF8
- SMR:   Q7VFF8
- GeneID:   1492265
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1718
- NMPDR:   fig|235279.1.peg.1718
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- BioCyc:   HHEP235279:HH_1718-MONOMER
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52593; Mature: 52462

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLWGGRFELDSSALLEEFNASIFFDKQLWQEDIKGSKAHAKMLHKIGVLSEEETQEII
CCCCCCCCEECCHHHHHHHCCCCEEECHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHH
NGLEIIAQRISRGEFVFNASDEDIHMAIESALTALIGDVGKKLHTARSRNDQVALDFRLY
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
VLKSNKEIVNLLLELMASILAIAKVHTSTIMPGMTHLQHAQPINFGFALVAWACNFKRDV
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCHHHHH
ERLLSDYTRNNKCPLGSGALAGTPYGNDRIFLTQELGFDEPTLNAMDSVSDRDFALDMLY
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHH
SLSMIMMHISRVAEELVLWSSSEFKFISLSDEYATGSSIMPQKKNPDVPELLRGKSGRVY
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCHH
GELMGLLCVMKGLPFAYNKDTQEDKEGVFDALKNVGLCLRILKECLKTMSIHPENMYKMA
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KIGHLSATDLADFLVRECGVAFRDAHHITGQVVAYAESKGVDISDLSEKEIMGVDSRIKQ
HHCCCCHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCCCCCHHCCCHHHHHCCHHHHHH
GVKAVLCLEYSMNARNTLGGTAVTQTCHQIEVLESFVREQMACLQVGRSKNE
HHHEEEHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AKLWGGRFELDSSALLEEFNASIFFDKQLWQEDIKGSKAHAKMLHKIGVLSEEETQEII
CCCCCCCEECCHHHHHHHCCCCEEECHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHH
NGLEIIAQRISRGEFVFNASDEDIHMAIESALTALIGDVGKKLHTARSRNDQVALDFRLY
HHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
VLKSNKEIVNLLLELMASILAIAKVHTSTIMPGMTHLQHAQPINFGFALVAWACNFKRDV
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCHHHHH
ERLLSDYTRNNKCPLGSGALAGTPYGNDRIFLTQELGFDEPTLNAMDSVSDRDFALDMLY
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHH
SLSMIMMHISRVAEELVLWSSSEFKFISLSDEYATGSSIMPQKKNPDVPELLRGKSGRVY
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCHH
GELMGLLCVMKGLPFAYNKDTQEDKEGVFDALKNVGLCLRILKECLKTMSIHPENMYKMA
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KIGHLSATDLADFLVRECGVAFRDAHHITGQVVAYAESKGVDISDLSEKEIMGVDSRIKQ
HHCCCCHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCCCCCHHCCCHHHHHCCHHHHHH
GVKAVLCLEYSMNARNTLGGTAVTQTCHQIEVLESFVREQMACLQVGRSKNE
HHHEEEHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954