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The map label for this gene is acdA [H]

Identifier: 32267012

GI number: 32267012

Start: 1452401

End: 1453534

Strand: Direct

Name: acdA [H]

Synonym: HH1513

Alternate gene names: 32267012

Gene position: 1452401-1453534 (Clockwise)

Preceding gene: 32267011

Following gene: 32267013

Centisome position: 80.73

GC content: 40.48

Gene sequence:

>1134_bases
ATGTTAAGTTTGGAAAACTTAGAACAAAAAGCAGCGGAGTTTGGTAAGGTATTTGTTGCTCCTCATACAGAATCTATTGA
CAAAGAAGCAAGATTCCCAAAAGAAGCCTATGATGAGCTCAAAAAGCAAGGGTTTATGGGGCTACTTGTGCCTAAAGAGT
ATGGCGGAAGCGGTGGAAATTGCTCTCATCACGCTTTAACTTGTTATACTTTAGCACAATTTGATGCTTCTACTGCACTT
TGTTATATGATGCACAATGTTGCAACGGCTTGTATTGCAACTTTTGGGACAAAGGGGCAAAAAGAGGAATTTTTGCCAAA
AATAGCAAAAGGGGAGATTTCTTTTGCTCTTGCTTATAGTGAAAGTGGCTCTGGGACACACTTTGGTTTGCCTGATATAA
CAGAGACAGAAGCGGGAGAGTATAGAATCTTAAAAGGGCGCAAAAGCTTTGTAACTTCGGCTCAACAAGCTAACTATTAT
CTTACTTATACAAATTCTTGCAAGGTAAATGGTGGTAAAAATAATTGGATTACACCCAATAATGTGGAGGGTATTTATCA
CGAAGAGGGCGTGTGGAATGGGTTAGGTATGCGCGGAAATGTCTCAAAACCTGTGCAATATAATGATGTGAAGCTTCATA
CAAAACAATATTTGCTAGGCAAAGACGGAGAGGGTGAAGCGCAAGCTGGAGTTGTAGCAATGTATTTTGTCGTGGGGCTT
GGAGCGGTGTATAGCGGTGTGGGAAAGGCTTCTTATGAATGCGCACTTAGTCATTGTAAGAGTAGAAAATATACTGATGG
CTCCTCTTTGGCAGATAAAGAGTTAGTGAGAATCCATATCGCAGAACTCTATACCAAAACGCAAAGCCAAATTGCACTTG
TTTATGAGGCTGCAAGGGCATTTGATAATAAAGAATCTGATGCAATGTGCAAAATATTTGCGTGTAGGATTAACGCCACA
CATCTTGTTATGGATATTTGTGCTCTTGCAATGCGACTTGGTGGAGGAAAAGCTTATAGTAAGATCTTACCACTAGAGCG
ATATTTGCGAGATGCGTTCGCTTCACAAGTAATGGCGCCAAGTCTTGATATTTTACAAGTGTGGCTCTCTGATGCACTTT
TACCAAAGGAGTAA

Upstream 100 bases:

>100_bases
GAAAAATCGCACAAAGCGGCTTGTGGAATGTGGCATTGATGAGGAACTTGCCCTTGATTTAAGCAGGGCTCATACACCTA
ATTTTATGTAAGGAGAAAAT

Downstream 100 bases:

>100_bases
ATATGAAGTCAATTTTAGTAGGTGCAGTGGCGTATGCGCCACAAATTGTCCCTATTTGGGATACGATTAGGGAATATGCT
AATGATTATTTTAAAGATAT

Product: hypothetical protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MLSLENLEQKAAEFGKVFVAPHTESIDKEARFPKEAYDELKKQGFMGLLVPKEYGGSGGNCSHHALTCYTLAQFDASTAL
CYMMHNVATACIATFGTKGQKEEFLPKIAKGEISFALAYSESGSGTHFGLPDITETEAGEYRILKGRKSFVTSAQQANYY
LTYTNSCKVNGGKNNWITPNNVEGIYHEEGVWNGLGMRGNVSKPVQYNDVKLHTKQYLLGKDGEGEAQAGVVAMYFVVGL
GAVYSGVGKASYECALSHCKSRKYTDGSSLADKELVRIHIAELYTKTQSQIALVYEAARAFDNKESDAMCKIFACRINAT
HLVMDICALAMRLGGGKAYSKILPLERYLRDAFASQVMAPSLDILQVWLSDALLPKE

Sequences:

>Translated_377_residues
MLSLENLEQKAAEFGKVFVAPHTESIDKEARFPKEAYDELKKQGFMGLLVPKEYGGSGGNCSHHALTCYTLAQFDASTAL
CYMMHNVATACIATFGTKGQKEEFLPKIAKGEISFALAYSESGSGTHFGLPDITETEAGEYRILKGRKSFVTSAQQANYY
LTYTNSCKVNGGKNNWITPNNVEGIYHEEGVWNGLGMRGNVSKPVQYNDVKLHTKQYLLGKDGEGEAQAGVVAMYFVVGL
GAVYSGVGKASYECALSHCKSRKYTDGSSLADKELVRIHIAELYTKTQSQIALVYEAARAFDNKESDAMCKIFACRINAT
HLVMDICALAMRLGGGKAYSKILPLERYLRDAFASQVMAPSLDILQVWLSDALLPKE
>Mature_377_residues
MLSLENLEQKAAEFGKVFVAPHTESIDKEARFPKEAYDELKKQGFMGLLVPKEYGGSGGNCSHHALTCYTLAQFDASTAL
CYMMHNVATACIATFGTKGQKEEFLPKIAKGEISFALAYSESGSGTHFGLPDITETEAGEYRILKGRKSFVTSAQQANYY
LTYTNSCKVNGGKNNWITPNNVEGIYHEEGVWNGLGMRGNVSKPVQYNDVKLHTKQYLLGKDGEGEAQAGVVAMYFVVGL
GAVYSGVGKASYECALSHCKSRKYTDGSSLADKELVRIHIAELYTKTQSQIALVYEAARAFDNKESDAMCKIFACRINAT
HLVMDICALAMRLGGGKAYSKILPLERYLRDAFASQVMAPSLDILQVWLSDALLPKE

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=356, Percent_Identity=27.5280898876405, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4557233, Length=380, Percent_Identity=25, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=24.4094488188976, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI7656849, Length=382, Percent_Identity=23.5602094240838, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI21361497, Length=364, Percent_Identity=26.3736263736264, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI226958414, Length=350, Percent_Identity=24, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI76496475, Length=392, Percent_Identity=24.234693877551, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4557235, Length=392, Percent_Identity=24.234693877551, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4557231, Length=386, Percent_Identity=25.1295336787565, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI187960098, Length=386, Percent_Identity=25.1295336787565, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1786223, Length=358, Percent_Identity=23.7430167597765, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17533517, Length=380, Percent_Identity=25, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17508101, Length=347, Percent_Identity=26.5129682997118, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17506239, Length=353, Percent_Identity=25.2124645892351, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=25.7294429708223, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71990804, Length=290, Percent_Identity=28.2758620689655, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=28.3088235294118, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985184, Length=354, Percent_Identity=22.5988700564972, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17534899, Length=389, Percent_Identity=22.879177377892, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=23.9473684210526, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32563615, Length=235, Percent_Identity=25.1063829787234, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71985192, Length=286, Percent_Identity=23.4265734265734, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17570075, Length=364, Percent_Identity=21.4285714285714, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17505929, Length=348, Percent_Identity=21.264367816092, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646207, Length=384, Percent_Identity=27.6041666666667, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21355753, Length=392, Percent_Identity=26.530612244898, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=23.2, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281363737, Length=360, Percent_Identity=25, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24666513, Length=353, Percent_Identity=22.3796033994334, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24660351, Length=372, Percent_Identity=20.6989247311828, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41330; Mature: 41330

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLENLEQKAAEFGKVFVAPHTESIDKEARFPKEAYDELKKQGFMGLLVPKEYGGSGGN
CCCHHHHHHHHHHHCEEEECCCCCCCCHHHCCCHHHHHHHHHCCCEEEEEEHHCCCCCCC
CSHHALTCYTLAQFDASTALCYMMHNVATACIATFGTKGQKEEFLPKIAKGEISFALAYS
CCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEC
ESGSGTHFGLPDITETEAGEYRILKGRKSFVTSAQQANYYLTYTNSCKVNGGKNNWITPN
CCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCEEEEEECEEEECCCCCCCCCCC
NVEGIYHEEGVWNGLGMRGNVSKPVQYNDVKLHTKQYLLGKDGEGEAQAGVVAMYFVVGL
CCCCEEECCCCCCCCCCCCCCCCCCEECCEEEEHHHHEECCCCCCCHHHHHHHHHHHHHH
GAVYSGVGKASYECALSHCKSRKYTDGSSLADKELVRIHIAELYTKTQSQIALVYEAARA
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDNKESDAMCKIFACRINATHLVMDICALAMRLGGGKAYSKILPLERYLRDAFASQVMAP
HCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCC
SLDILQVWLSDALLPKE
CHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLSLENLEQKAAEFGKVFVAPHTESIDKEARFPKEAYDELKKQGFMGLLVPKEYGGSGGN
CCCHHHHHHHHHHHCEEEECCCCCCCCHHHCCCHHHHHHHHHCCCEEEEEEHHCCCCCCC
CSHHALTCYTLAQFDASTALCYMMHNVATACIATFGTKGQKEEFLPKIAKGEISFALAYS
CCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEC
ESGSGTHFGLPDITETEAGEYRILKGRKSFVTSAQQANYYLTYTNSCKVNGGKNNWITPN
CCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCEEEEEECEEEECCCCCCCCCCC
NVEGIYHEEGVWNGLGMRGNVSKPVQYNDVKLHTKQYLLGKDGEGEAQAGVVAMYFVVGL
CCCCEEECCCCCCCCCCCCCCCCCCEECCEEEEHHHHEECCCCCCCHHHHHHHHHHHHHH
GAVYSGVGKASYECALSHCKSRKYTDGSSLADKELVRIHIAELYTKTQSQIALVYEAARA
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDNKESDAMCKIFACRINATHLVMDICALAMRLGGGKAYSKILPLERYLRDAFASQVMAP
HCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCC
SLDILQVWLSDALLPKE
CHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]