| Definition | Helicobacter hepaticus ATCC 51449 chromosome, complete genome. |
|---|---|
| Accession | NC_004917 |
| Length | 1,799,146 |
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The map label for this gene is yqhE [C]
Identifier: 32266970
GI number: 32266970
Start: 1413597
End: 1414475
Strand: Direct
Name: yqhE [C]
Synonym: HH1471
Alternate gene names: 32266970
Gene position: 1413597-1414475 (Clockwise)
Preceding gene: 32266969
Following gene: 32266971
Centisome position: 78.57
GC content: 39.7
Gene sequence:
>879_bases TTGGCTAAAAACAATAAAACTCAAGTGATTTTAAATGAATTTTTCACGCTCAATAATGGCAATAAGATTCCAAAACTTGG GCTTGGGACTTGGCGTATTGATGATAATGTGGTAGAAGCGGCGGTGCGAGAGGCTTTTAAGGTGGGTTATCGCCACATTG ACACTGCACAAGCCTATGGCAATGAAAGAGGTGTGGGCGAGGCGGTGAGAAAAAGCAAAATCAAGCGAGAGGAACTTTTT ATCACAAGCAAGATTCGTGCAGAATATAAAGATTATAAAAGCGCGAGTGCTTCCATAGATACTTCTTTAAAAACGATGAA GCTAGATTTCATTGATTTAATGCTTATCCACAGCCCACAGCCTTGGAATAGTTTTAGAAAGGGCGATTATTTTAAAGAAA ATGTAGAAGTCTATAACGCACTAGAGGACGCGCAAAAGGCGGGTAAGGTGCGTTCTATTGGTGTAAGTAACTTTTTGCAA AAAGACTTAGAAAATATCCTCAAAAACTGCAAAACTAAACCCGCAGCAAATCAGATTCTATGCCATATTGGCAACACGCC TTTTACATTGTTGGATTATTGCAAAAAGCAAAATATCCTCGCAGAAGCATATTCGCCTATTGCGCACGGAGAGCTTTTGA AAGACCCTCGCGTGATAGAGTTAGCAAAAAAATACAATGTCAGCCCTGCGCAAATTTGTATCCGCTATACTTTAGAGTTA GGACTTGTTTCTTTGCCAAAGAGCAAAACTCCCAAATATATAGCAGAGAATGCGCAGGTGGATTTCACATTCTCAAAGGC GGATTTACAAACGCTTAAAAAGCTTACCTTTAAGGATTATGGTGAGCATTCATATTTTCCTGTGTTTGGTGGGAAGTGA
Upstream 100 bases:
>100_bases TTCTCACTCTCGGCGAGATTTTCTGAAAACTTCCGCAATGCTAAGCTTAGCAGGTGTAAGTGCGGCATTCATACCAAATC TTTTACAAGGAGCGCAAAAT
Downstream 100 bases:
>100_bases AATAAATAAGCAATGGGAATTAAGCAAAATCCCTTGACAAACACTTAGTATCAGGCTTTATAATTTCAAAATCTATTTTA AGGAGAACAAATGAAAAAAA
Product: aldo-keto reductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 292; Mature: 291
Protein sequence:
>292_residues MAKNNKTQVILNEFFTLNNGNKIPKLGLGTWRIDDNVVEAAVREAFKVGYRHIDTAQAYGNERGVGEAVRKSKIKREELF ITSKIRAEYKDYKSASASIDTSLKTMKLDFIDLMLIHSPQPWNSFRKGDYFKENVEVYNALEDAQKAGKVRSIGVSNFLQ KDLENILKNCKTKPAANQILCHIGNTPFTLLDYCKKQNILAEAYSPIAHGELLKDPRVIELAKKYNVSPAQICIRYTLEL GLVSLPKSKTPKYIAENAQVDFTFSKADLQTLKKLTFKDYGEHSYFPVFGGK
Sequences:
>Translated_292_residues MAKNNKTQVILNEFFTLNNGNKIPKLGLGTWRIDDNVVEAAVREAFKVGYRHIDTAQAYGNERGVGEAVRKSKIKREELF ITSKIRAEYKDYKSASASIDTSLKTMKLDFIDLMLIHSPQPWNSFRKGDYFKENVEVYNALEDAQKAGKVRSIGVSNFLQ KDLENILKNCKTKPAANQILCHIGNTPFTLLDYCKKQNILAEAYSPIAHGELLKDPRVIELAKKYNVSPAQICIRYTLEL GLVSLPKSKTPKYIAENAQVDFTFSKADLQTLKKLTFKDYGEHSYFPVFGGK >Mature_291_residues AKNNKTQVILNEFFTLNNGNKIPKLGLGTWRIDDNVVEAAVREAFKVGYRHIDTAQAYGNERGVGEAVRKSKIKREELFI TSKIRAEYKDYKSASASIDTSLKTMKLDFIDLMLIHSPQPWNSFRKGDYFKENVEVYNALEDAQKAGKVRSIGVSNFLQK DLENILKNCKTKPAANQILCHIGNTPFTLLDYCKKQNILAEAYSPIAHGELLKDPRVIELAKKYNVSPAQICIRYTLELG LVSLPKSKTPKYIAENAQVDFTFSKADLQTLKKLTFKDYGEHSYFPVFGGK
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=288, Percent_Identity=35.0694444444444, Blast_Score=176, Evalue=3e-44, Organism=Homo sapiens, GI5174391, Length=288, Percent_Identity=35.0694444444444, Blast_Score=176, Evalue=3e-44, Organism=Homo sapiens, GI4502049, Length=286, Percent_Identity=40.5594405594406, Blast_Score=169, Evalue=4e-42, Organism=Homo sapiens, GI223468663, Length=289, Percent_Identity=34.9480968858132, Blast_Score=168, Evalue=7e-42, Organism=Homo sapiens, GI5174695, Length=294, Percent_Identity=34.3537414965986, Blast_Score=160, Evalue=2e-39, Organism=Homo sapiens, GI24497583, Length=293, Percent_Identity=35.1535836177474, Blast_Score=155, Evalue=3e-38, Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=35.6115107913669, Blast_Score=155, Evalue=5e-38, Organism=Homo sapiens, GI24497585, Length=290, Percent_Identity=34.4827586206897, Blast_Score=153, Evalue=2e-37, Organism=Homo sapiens, GI5453543, Length=290, Percent_Identity=35.1724137931034, Blast_Score=152, Evalue=4e-37, Organism=Homo sapiens, GI310109920, Length=290, Percent_Identity=35.1724137931034, Blast_Score=151, Evalue=6e-37, Organism=Homo sapiens, GI45446745, Length=290, Percent_Identity=35.1724137931034, Blast_Score=151, Evalue=7e-37, Organism=Homo sapiens, GI4503285, Length=290, Percent_Identity=35.1724137931034, Blast_Score=151, Evalue=7e-37, Organism=Homo sapiens, GI310109922, Length=280, Percent_Identity=36.0714285714286, Blast_Score=150, Evalue=1e-36, Organism=Homo sapiens, GI93277124, Length=295, Percent_Identity=32.2033898305085, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI291291012, Length=287, Percent_Identity=33.1010452961672, Blast_Score=147, Evalue=1e-35, Organism=Homo sapiens, GI300116271, Length=279, Percent_Identity=30.4659498207885, Blast_Score=120, Evalue=1e-27, Organism=Homo sapiens, GI310109924, Length=149, Percent_Identity=38.255033557047, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI207028673, Length=110, Percent_Identity=37.2727272727273, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI310109926, Length=110, Percent_Identity=37.2727272727273, Blast_Score=77, Evalue=1e-14, Organism=Escherichia coli, GI87082198, Length=262, Percent_Identity=41.2213740458015, Blast_Score=182, Evalue=2e-47, Organism=Escherichia coli, GI1786400, Length=254, Percent_Identity=34.251968503937, Blast_Score=138, Evalue=5e-34, Organism=Escherichia coli, GI1788081, Length=271, Percent_Identity=31.7343173431734, Blast_Score=119, Evalue=2e-28, Organism=Escherichia coli, GI48994888, Length=220, Percent_Identity=26.3636363636364, Blast_Score=65, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17537075, Length=305, Percent_Identity=37.3770491803279, Blast_Score=177, Evalue=5e-45, Organism=Caenorhabditis elegans, GI17537077, Length=306, Percent_Identity=36.6013071895425, Blast_Score=174, Evalue=7e-44, Organism=Caenorhabditis elegans, GI17561298, Length=276, Percent_Identity=38.0434782608696, Blast_Score=171, Evalue=4e-43, Organism=Caenorhabditis elegans, GI17564128, Length=310, Percent_Identity=33.8709677419355, Blast_Score=167, Evalue=6e-42, Organism=Caenorhabditis elegans, GI17552492, Length=268, Percent_Identity=33.955223880597, Blast_Score=151, Evalue=5e-37, Organism=Caenorhabditis elegans, GI17566692, Length=289, Percent_Identity=32.1799307958478, Blast_Score=147, Evalue=9e-36, Organism=Caenorhabditis elegans, GI71998625, Length=263, Percent_Identity=33.4600760456274, Blast_Score=146, Evalue=1e-35, Organism=Caenorhabditis elegans, GI17550248, Length=283, Percent_Identity=32.5088339222615, Blast_Score=139, Evalue=2e-33, Organism=Caenorhabditis elegans, GI17562292, Length=289, Percent_Identity=31.4878892733564, Blast_Score=137, Evalue=9e-33, Organism=Caenorhabditis elegans, GI17537079, Length=314, Percent_Identity=28.343949044586, Blast_Score=132, Evalue=3e-31, Organism=Caenorhabditis elegans, GI17561300, Length=252, Percent_Identity=34.5238095238095, Blast_Score=132, Evalue=3e-31, Organism=Caenorhabditis elegans, GI17538386, Length=261, Percent_Identity=33.7164750957854, Blast_Score=130, Evalue=6e-31, Organism=Caenorhabditis elegans, GI17550246, Length=75, Percent_Identity=44, Blast_Score=68, Evalue=5e-12, Organism=Saccharomyces cerevisiae, GI6324694, Length=292, Percent_Identity=35.6164383561644, Blast_Score=177, Evalue=1e-45, Organism=Saccharomyces cerevisiae, GI6320576, Length=305, Percent_Identity=37.0491803278689, Blast_Score=175, Evalue=9e-45, Organism=Saccharomyces cerevisiae, GI6322556, Length=273, Percent_Identity=36.2637362637363, Blast_Score=166, Evalue=3e-42, Organism=Saccharomyces cerevisiae, GI6319625, Length=310, Percent_Identity=36.4516129032258, Blast_Score=157, Evalue=1e-39, Organism=Saccharomyces cerevisiae, GI6321896, Length=306, Percent_Identity=29.4117647058824, Blast_Score=137, Evalue=2e-33, Organism=Saccharomyces cerevisiae, GI6320079, Length=283, Percent_Identity=33.9222614840989, Blast_Score=128, Evalue=1e-30, Organism=Drosophila melanogaster, GI24644950, Length=295, Percent_Identity=34.2372881355932, Blast_Score=188, Evalue=3e-48, Organism=Drosophila melanogaster, GI221378297, Length=316, Percent_Identity=31.9620253164557, Blast_Score=181, Evalue=7e-46, Organism=Drosophila melanogaster, GI45553081, Length=301, Percent_Identity=35.2159468438538, Blast_Score=176, Evalue=1e-44, Organism=Drosophila melanogaster, GI24657054, Length=283, Percent_Identity=38.86925795053, Blast_Score=175, Evalue=4e-44, Organism=Drosophila melanogaster, GI20129731, Length=304, Percent_Identity=34.2105263157895, Blast_Score=171, Evalue=5e-43, Organism=Drosophila melanogaster, GI24663317, Length=280, Percent_Identity=35.7142857142857, Blast_Score=169, Evalue=2e-42, Organism=Drosophila melanogaster, GI21356425, Length=281, Percent_Identity=35.9430604982206, Blast_Score=156, Evalue=1e-38, Organism=Drosophila melanogaster, GI24662789, Length=293, Percent_Identity=31.3993174061433, Blast_Score=156, Evalue=2e-38, Organism=Drosophila melanogaster, GI281366140, Length=270, Percent_Identity=33.7037037037037, Blast_Score=148, Evalue=4e-36, Organism=Drosophila melanogaster, GI24662785, Length=306, Percent_Identity=33.9869281045752, Blast_Score=135, Evalue=4e-32, Organism=Drosophila melanogaster, GI24662781, Length=277, Percent_Identity=35.3790613718412, Blast_Score=134, Evalue=6e-32,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 33070; Mature: 32939
Theoretical pI: Translated: 9.79; Mature: 9.79
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 1.0 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 0.7 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAKNNKTQVILNEFFTLNNGNKIPKLGLGTWRIDDNVVEAAVREAFKVGYRHIDTAQAYG CCCCCCCEEEEEHHEEECCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCC NERGVGEAVRKSKIKREELFITSKIRAEYKDYKSASASIDTSLKTMKLDFIDLMLIHSPQ CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEHHHHHEEEEECCC PWNSFRKGDYFKENVEVYNALEDAQKAGKVRSIGVSNFLQKDLENILKNCKTKPAANQIL CCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHCCCCCCCCCEE CHIGNTPFTLLDYCKKQNILAEAYSPIAHGELLKDPRVIELAKKYNVSPAQICIRYTLEL EEECCCCHHHHHHHHHCCHHHHHHCCHHCCHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH GLVSLPKSKTPKYIAENAQVDFTFSKADLQTLKKLTFKDYGEHSYFPVFGGK HHEECCCCCCCCHHHCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC >Mature Secondary Structure AKNNKTQVILNEFFTLNNGNKIPKLGLGTWRIDDNVVEAAVREAFKVGYRHIDTAQAYG CCCCCCEEEEEHHEEECCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCC NERGVGEAVRKSKIKREELFITSKIRAEYKDYKSASASIDTSLKTMKLDFIDLMLIHSPQ CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEHHHHHEEEEECCC PWNSFRKGDYFKENVEVYNALEDAQKAGKVRSIGVSNFLQKDLENILKNCKTKPAANQIL CCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHCCCCCCCCCEE CHIGNTPFTLLDYCKKQNILAEAYSPIAHGELLKDPRVIELAKKYNVSPAQICIRYTLEL EEECCCCHHHHHHHHHCCHHHHHHCCHHCCHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH GLVSLPKSKTPKYIAENAQVDFTFSKADLQTLKKLTFKDYGEHSYFPVFGGK HHEECCCCCCCCHHHCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA