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The map label for this gene is tmk

Identifier: 32266861

GI number: 32266861

Start: 1317785

End: 1318372

Strand: Direct

Name: tmk

Synonym: HH1362

Alternate gene names: 32266861

Gene position: 1317785-1318372 (Clockwise)

Preceding gene: 32266860

Following gene: 32266862

Centisome position: 73.25

GC content: 35.88

Gene sequence:

>588_bases
ATGTATGTAGCAATTGAAGGCGTAGATACTTGTGGTAAAAGCACACAGATTCAATTACTCAAAGCGTATTACCCACAAGC
TGTTTTTACCAAAGAGCCCGGTGGCAGTATTATTGGTGAGCATATACGAGATCTTGTGCTTTTTGCGCCTAAAAAATATG
GTTTTACACTTGATGAACGGGCAGAGTTAATGTTATTTCTTGCTGATAGAGCACAGCATTATGCTCAAGTCCTTCTTCCG
CACAAAGATAAACTTATTATTTCCGATAGAAGTGTTATATCGGGTATAGCGTATGCAAAGAGTATTGATATAGCACAAAG
TATAGCCCTTAATGATTTTGTTTTGCGTGGTATGTTACCCGATTTAGTAGTCATTTTGGAGCTTGATGAGAAAAGCCTGA
AAGAAAGGATTGAGAGCAAAAGCCACGATAATATTGAAAGTAGAGGCATTTCATATATGCTTGAGATTCAAAAATGCTTT
AAAAATGTCGTTACCCAAATGAATCTTAAATATATAGTGCTTGATGCTACACAGGATAAAGAAAGGATTTGTGCCCAAAT
TAGAGAGCATATCAATATTTTAGTGTAA

Upstream 100 bases:

>100_bases
GTTCAATCATTGAACATAATGGAGCATTTTCTCACCTTGTGCCAAAAAATGCTGCTGATTTTATTTATTCACTTTATACC
AAACATAAAAGAGGTATGTA

Downstream 100 bases:

>100_bases
CTTATGAAATGTCTTGTATGTGAGAAATGGAGCTTTAAAATTATTTGTGAAGAATGCCTTGCGCGTATTCCTCTCGTGCC
TCGTTATAGAATCTTGCAAA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MYVAIEGVDTCGKSTQIQLLKAYYPQAVFTKEPGGSIIGEHIRDLVLFAPKKYGFTLDERAELMLFLADRAQHYAQVLLP
HKDKLIISDRSVISGIAYAKSIDIAQSIALNDFVLRGMLPDLVVILELDEKSLKERIESKSHDNIESRGISYMLEIQKCF
KNVVTQMNLKYIVLDATQDKERICAQIREHINILV

Sequences:

>Translated_195_residues
MYVAIEGVDTCGKSTQIQLLKAYYPQAVFTKEPGGSIIGEHIRDLVLFAPKKYGFTLDERAELMLFLADRAQHYAQVLLP
HKDKLIISDRSVISGIAYAKSIDIAQSIALNDFVLRGMLPDLVVILELDEKSLKERIESKSHDNIESRGISYMLEIQKCF
KNVVTQMNLKYIVLDATQDKERICAQIREHINILV
>Mature_195_residues
MYVAIEGVDTCGKSTQIQLLKAYYPQAVFTKEPGGSIIGEHIRDLVLFAPKKYGFTLDERAELMLFLADRAQHYAQVLLP
HKDKLIISDRSVISGIAYAKSIDIAQSIALNDFVLRGMLPDLVVILELDEKSLKERIESKSHDNIESRGISYMLEIQKCF
KNVVTQMNLKYIVLDATQDKERICAQIREHINILV

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=205, Percent_Identity=28.780487804878, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_HELHP (Q7VGF9)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860893.1
- ProteinModelPortal:   Q7VGF9
- SMR:   Q7VGF9
- GeneID:   1493050
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1362
- NMPDR:   fig|235279.1.peg.1362
- HOGENOM:   HBG626009
- OMA:   EKLLTIQ
- ProtClustDB:   PRK00698
- BioCyc:   HHEP235279:HH_1362-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22126; Mature: 22126

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVAIEGVDTCGKSTQIQLLKAYYPQAVFTKEPGGSIIGEHIRDLVLFAPKKYGFTLDER
CEEEEECCCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
AELMLFLADRAQHYAQVLLPHKDKLIISDRSVISGIAYAKSIDIAQSIALNDFVLRGMLP
HHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DLVVILELDEKSLKERIESKSHDNIESRGISYMLEIQKCFKNVVTQMNLKYIVLDATQDK
CEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCH
ERICAQIREHINILV
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MYVAIEGVDTCGKSTQIQLLKAYYPQAVFTKEPGGSIIGEHIRDLVLFAPKKYGFTLDER
CEEEEECCCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
AELMLFLADRAQHYAQVLLPHKDKLIISDRSVISGIAYAKSIDIAQSIALNDFVLRGMLP
HHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DLVVILELDEKSLKERIESKSHDNIESRGISYMLEIQKCFKNVVTQMNLKYIVLDATQDK
CEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCH
ERICAQIREHINILV
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954