Click here to switch to the map view.

The map label for this gene is hisB

Identifier: 32266824

GI number: 32266824

Start: 1284326

End: 1284937

Strand: Direct

Name: hisB

Synonym: HH1325

Alternate gene names: 32266824

Gene position: 1284326-1284937 (Clockwise)

Preceding gene: 32266823

Following gene: 32266825

Centisome position: 71.39

GC content: 39.22

Gene sequence:

>612_bases
ATGCAGGAAAGAATGGCAAAAAATGTTATAGAGATTTCGCGCACAACAAAAGAAACAGACATTAGCTTGAAACTTCTTGT
TTATGGCAATGGTAACGCACAGATTCAAAGTGGAATAGGCTTTTTTGACCATATGTTGCAATCGCTGACCAAACACTCCC
TTATAGATTTGGAGCTTGCGTGTAAAGGTGATACATTTATTGATGGGCATCATAGCGTAGAAGATTGTGGGATTGTATTA
GGGCAAGGATTAGCTCAAGGCATTTACCCTGCAGCAGGTATTGAACGATTTGGCAATGCAAGTATAGTAATGGATGAAGC
GTGTGTGGAGTGTGATATTGATGTGAGCAATCGTGCCTTTCTTGTCTTTGAAACAAATGCCTATAAACTGCCATTCAAAG
GTAGAGTAGGCGAACTTGATGTAGAATTGGTTGAGGAGTTTTTCCGTGCACTTTGTTTTAATGCTCATTTGAGTGCACAT
ATTGTCCTTAAACGAGGCAAAAATCTTCATCATATTATTGAAGCGATGTTTAAAGCTTTTGGTGTATCTTTGCGCCGCGC
ACTCACATTAAATCCAAGAATCCTCACTCCATCAACAAAAGGTGTATTATGA

Upstream 100 bases:

>100_bases
CAAAGTGAACAAGAAGCGCGTGATTTCTTAAAAAAGAATACGCAGATTCAAGGAGGATTTTTTATCCGTGACTAAAAAAG
AAAAACTAAAGGAGTGAGGT

Downstream 100 bases:

>100_bases
TAAAACTTTTAGTCTTTGATGTTGATGGGACATTAAGTGATGGTAAAGTGTATTATTCGCAATCGGGAGAAGAAATAAAA
AGTTTTAGCACGCGTGATGG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MQERMAKNVIEISRTTKETDISLKLLVYGNGNAQIQSGIGFFDHMLQSLTKHSLIDLELACKGDTFIDGHHSVEDCGIVL
GQGLAQGIYPAAGIERFGNASIVMDEACVECDIDVSNRAFLVFETNAYKLPFKGRVGELDVELVEEFFRALCFNAHLSAH
IVLKRGKNLHHIIEAMFKAFGVSLRRALTLNPRILTPSTKGVL

Sequences:

>Translated_203_residues
MQERMAKNVIEISRTTKETDISLKLLVYGNGNAQIQSGIGFFDHMLQSLTKHSLIDLELACKGDTFIDGHHSVEDCGIVL
GQGLAQGIYPAAGIERFGNASIVMDEACVECDIDVSNRAFLVFETNAYKLPFKGRVGELDVELVEEFFRALCFNAHLSAH
IVLKRGKNLHHIIEAMFKAFGVSLRRALTLNPRILTPSTKGVL
>Mature_203_residues
MQERMAKNVIEISRTTKETDISLKLLVYGNGNAQIQSGIGFFDHMLQSLTKHSLIDLELACKGDTFIDGHHSVEDCGIVL
GQGLAQGIYPAAGIERFGNASIVMDEACVECDIDVSNRAFLVFETNAYKLPFKGRVGELDVELVEEFFRALCFNAHLSAH
IVLKRGKNLHHIIEAMFKAFGVSLRRALTLNPRILTPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=193, Percent_Identity=41.9689119170984, Blast_Score=147, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324776, Length=169, Percent_Identity=39.6449704142012, Blast_Score=132, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_HELHP (Q7VGJ6)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860856.1
- ProteinModelPortal:   Q7VGJ6
- SMR:   Q7VGJ6
- GeneID:   1493013
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1325
- NMPDR:   fig|235279.1.peg.1325
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   HHEP235279:HH_1325-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22433; Mature: 22433

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQERMAKNVIEISRTTKETDISLKLLVYGNGNAQIQSGIGFFDHMLQSLTKHSLIDLELA
CCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCEEEECCCCHHHHHHHHHHHCCEEEEEEE
CKGDTFIDGHHSVEDCGIVLGQGLAQGIYPAAGIERFGNASIVMDEACVECDIDVSNRAF
ECCCEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECHHEEECCCCCCCEE
LVFETNAYKLPFKGRVGELDVELVEEFFRALCFNAHLSAHIVLKRGKNLHHIIEAMFKAF
EEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHH
GVSLRRALTLNPRILTPSTKGVL
CHHHHHEEECCCEEECCCCCCCC
>Mature Secondary Structure
MQERMAKNVIEISRTTKETDISLKLLVYGNGNAQIQSGIGFFDHMLQSLTKHSLIDLELA
CCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCEEEECCCCHHHHHHHHHHHCCEEEEEEE
CKGDTFIDGHHSVEDCGIVLGQGLAQGIYPAAGIERFGNASIVMDEACVECDIDVSNRAF
ECCCEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEECHHEEECCCCCCCEE
LVFETNAYKLPFKGRVGELDVELVEEFFRALCFNAHLSAHIVLKRGKNLHHIIEAMFKAF
EEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHH
GVSLRRALTLNPRILTPSTKGVL
CHHHHHEEECCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954