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The map label for this gene is argJ

Identifier: 32266790

GI number: 32266790

Start: 1251473

End: 1252687

Strand: Direct

Name: argJ

Synonym: HH1291

Alternate gene names: 32266790

Gene position: 1251473-1252687 (Clockwise)

Preceding gene: 32266789

Following gene: 32266791

Centisome position: 69.56

GC content: 40.16

Gene sequence:

>1215_bases
ATGTTTGAGATTATTCCTATTAAAGGTGGTGTCAATGCGCCACAGGGATTCTACGCAGATGGTGTAAGTGCGGGATTAAA
GCCTCCGCTTCCTAATGGTGCTCCTGCACTTGATGTAGCATTTTTATATAGTGAAGATGTGCTCAAGCCCTTTACACTTT
TTACGAGTAATCGTTTTCAAGCAGCTCCCATAACGCATTTTAAACACTTTATAAAAGGCAAAGAGAGTAATTTCGTGCTT
ATTAATACCAAAAATGCAAATGCGATGACAGGAGAGAGAGGGGTGCAAGATGTGTGCGATATTTTATCATCACTTACGCA
AAAATTTCCCTTTATACAAAACCCTATAATGTCAAGCACAGGCGTTATCGGGCAGTATCTCCCTAAAGAGAAAATAATTG
CTTCTTTTGCCTCCTTTGATTTTAATGCTAAGTGTGAAAATGCTCACACTCGTGCTGCTGATGCAATACGCACGACAGAT
GCTTTTAGTAAAGAAATCGCATTAAGGGTGCGACTTGATAATGGTGAGAGCTTTTGTATTGGAGCTATGGCAAAGGGAGC
AGGTATGATACAACCTGCTCTTGCAACTATGCTTTGTTTTATCACAACTGATGCACTTGTACCTCAAAATGAAGGTGATA
GAATCTTGCGTGAATGCGCTAAGACAAGCTTTAATGCTATTAGTGTAGATGGCGATATGAGCACGAATGATTCCGTATTT
TTGTTTGCCAATGGACGCAGTGGGGTATATAATGAAGCGGCTTTCAAAGAAGCATTGAAAATGATTATGCACAAACTTGC
TACTGATATGGTAAGAGATGGCGAAGGTTCTACTAAGCTTGTAGCCTTTGAAGTGTGTGGCGCAAGAGATGAATCACAAG
CTATATGTGCTGCAAAAGCCCTTACAAATTCACTTTTGGTAAAAACTGCTATTTATGGGGAAGATCCAAATTGGGGGAGA
ATTGCCTCAACAATCGGTGCAAGTGGTGTAGAATGCAATGAGGAAAGTTTGAGAATCGCCTTTGATTCTGTGGTAGTATT
TGATAGAGGGCAGATATGTTTTGATGAAGAGAATGAAGCAAGGGCAGCGGCTGTAATGGAACAAGAAAGTTTTAGAATCA
CTTGTGATTTGGGCATAGGTGAGGGACATTTTGTCGCTTATGGTTGTGATTTGGGCTATCGCTATATAGATATTAATGCT
GATTATAGAAGCTAG

Upstream 100 bases:

>100_bases
GTTTCAAGCGAATGCAAACTCCTTGTGATTGGCACAAGTGAAAATATTCGTGCTACCAAACGTTTGATTATGAAAAAGCA
AAAACCAAGAGAGGTTGATT

Downstream 100 bases:

>100_bases
ATTCTGTTGTATTTTTGGAGATTTTAAAAAGTAGTATGATTTTAGAGTAAAAAAATGCGCTATTATTGAAAATATTCTAT
AATAAAGTATTGAATTTGCC

Product: bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein

Products: NA

Alternate protein names: Glutamate N-acetyltransferase; Ornithine acetyltransferase; OATase; Ornithine transacetylase; Amino-acid acetyltransferase; N-acetylglutamate synthase; AGS

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MFEIIPIKGGVNAPQGFYADGVSAGLKPPLPNGAPALDVAFLYSEDVLKPFTLFTSNRFQAAPITHFKHFIKGKESNFVL
INTKNANAMTGERGVQDVCDILSSLTQKFPFIQNPIMSSTGVIGQYLPKEKIIASFASFDFNAKCENAHTRAADAIRTTD
AFSKEIALRVRLDNGESFCIGAMAKGAGMIQPALATMLCFITTDALVPQNEGDRILRECAKTSFNAISVDGDMSTNDSVF
LFANGRSGVYNEAAFKEALKMIMHKLATDMVRDGEGSTKLVAFEVCGARDESQAICAAKALTNSLLVKTAIYGEDPNWGR
IASTIGASGVECNEESLRIAFDSVVVFDRGQICFDEENEARAAAVMEQESFRITCDLGIGEGHFVAYGCDLGYRYIDINA
DYRS

Sequences:

>Translated_404_residues
MFEIIPIKGGVNAPQGFYADGVSAGLKPPLPNGAPALDVAFLYSEDVLKPFTLFTSNRFQAAPITHFKHFIKGKESNFVL
INTKNANAMTGERGVQDVCDILSSLTQKFPFIQNPIMSSTGVIGQYLPKEKIIASFASFDFNAKCENAHTRAADAIRTTD
AFSKEIALRVRLDNGESFCIGAMAKGAGMIQPALATMLCFITTDALVPQNEGDRILRECAKTSFNAISVDGDMSTNDSVF
LFANGRSGVYNEAAFKEALKMIMHKLATDMVRDGEGSTKLVAFEVCGARDESQAICAAKALTNSLLVKTAIYGEDPNWGR
IASTIGASGVECNEESLRIAFDSVVVFDRGQICFDEENEARAAAVMEQESFRITCDLGIGEGHFVAYGCDLGYRYIDINA
DYRS
>Mature_404_residues
MFEIIPIKGGVNAPQGFYADGVSAGLKPPLPNGAPALDVAFLYSEDVLKPFTLFTSNRFQAAPITHFKHFIKGKESNFVL
INTKNANAMTGERGVQDVCDILSSLTQKFPFIQNPIMSSTGVIGQYLPKEKIIASFASFDFNAKCENAHTRAADAIRTTD
AFSKEIALRVRLDNGESFCIGAMAKGAGMIQPALATMLCFITTDALVPQNEGDRILRECAKTSFNAISVDGDMSTNDSVF
LFANGRSGVYNEAAFKEALKMIMHKLATDMVRDGEGSTKLVAFEVCGARDESQAICAAKALTNSLLVKTAIYGEDPNWGR
IASTIGASGVECNEESLRIAFDSVVVFDRGQICFDEENEARAAAVMEQESFRITCDLGIGEGHFVAYGCDLGYRYIDINA
DYRS

Specific function: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate

COG id: COG1364

COG function: function code E; N-acetylglutamate synthase (N-acetylornithine aminotransferase)

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArgJ family

Homologues:

Organism=Saccharomyces cerevisiae, GI6323707, Length=422, Percent_Identity=34.5971563981043, Blast_Score=212, Evalue=7e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGJ_HELHP (Q93EJ3)

Other databases:

- EMBL:   AE017125
- EMBL:   AF358673
- RefSeq:   NP_860822.1
- ProteinModelPortal:   Q93EJ3
- SMR:   Q93EJ3
- MEROPS:   T05.001
- GeneID:   1492979
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1291
- NMPDR:   fig|235279.1.peg.1291
- HOGENOM:   HBG284202
- OMA:   QNRFCAA
- ProtClustDB:   PRK05388
- BioCyc:   HHEP235279:HH_1291-MONOMER
- BRENDA:   2.3.1.1
- BRENDA:   2.3.1.35
- GO:   GO:0005737
- HAMAP:   MF_01106
- InterPro:   IPR002813
- InterPro:   IPR016117
- PANTHER:   PTHR23100
- TIGRFAMs:   TIGR00120

Pfam domain/function: PF01960 ArgJ; SSF56266 Pept_S58_DmpA/Arg_biosyn_ArgJ

EC number: =2.3.1.35; =2.3.1.1

Molecular weight: Translated: 43797; Mature: 43797

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEIIPIKGGVNAPQGFYADGVSAGLKPPLPNGAPALDVAFLYSEDVLKPFTLFTSNRFQ
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCC
AAPITHFKHFIKGKESNFVLINTKNANAMTGERGVQDVCDILSSLTQKFPFIQNPIMSST
CCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
GVIGQYLPKEKIIASFASFDFNAKCENAHTRAADAIRTTDAFSKEIALRVRLDNGESFCI
CCHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEE
GAMAKGAGMIQPALATMLCFITTDALVPQNEGDRILRECAKTSFNAISVDGDMSTNDSVF
EEHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEE
LFANGRSGVYNEAAFKEALKMIMHKLATDMVRDGEGSTKLVAFEVCGARDESQAICAAKA
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHH
LTNSLLVKTAIYGEDPNWGRIASTIGASGVECNEESLRIAFDSVVVFDRGQICFDEENEA
HHHHHEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCEEECCCCCH
RAAAVMEQESFRITCDLGIGEGHFVAYGCDLGYRYIDINADYRS
HHHHHEECCCEEEEEEEECCCCCEEEEEECCCEEEEEECCCCCC
>Mature Secondary Structure
MFEIIPIKGGVNAPQGFYADGVSAGLKPPLPNGAPALDVAFLYSEDVLKPFTLFTSNRFQ
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCC
AAPITHFKHFIKGKESNFVLINTKNANAMTGERGVQDVCDILSSLTQKFPFIQNPIMSST
CCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
GVIGQYLPKEKIIASFASFDFNAKCENAHTRAADAIRTTDAFSKEIALRVRLDNGESFCI
CCHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEE
GAMAKGAGMIQPALATMLCFITTDALVPQNEGDRILRECAKTSFNAISVDGDMSTNDSVF
EEHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEE
LFANGRSGVYNEAAFKEALKMIMHKLATDMVRDGEGSTKLVAFEVCGARDESQAICAAKA
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHH
LTNSLLVKTAIYGEDPNWGRIASTIGASGVECNEESLRIAFDSVVVFDRGQICFDEENEA
HHHHHEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCEEECCCCCH
RAAAVMEQESFRITCDLGIGEGHFVAYGCDLGYRYIDINADYRS
HHHHHEECCCEEEEEEEECCCCCEEEEEECCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954