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The map label for this gene is bioA

Identifier: 32266709

GI number: 32266709

Start: 1179847

End: 1181160

Strand: Direct

Name: bioA

Synonym: HH1210

Alternate gene names: 32266709

Gene position: 1179847-1181160 (Clockwise)

Preceding gene: 32266705

Following gene: 32266716

Centisome position: 65.58

GC content: 37.06

Gene sequence:

>1314_bases
ATGCTAGATTTAAAAGCATTGGATTTGGCGCATATTTGGCATCCTTGCACACAAATGAAAGACCACGAAACGTTGCCTCT
TATTCCTATCAAATCAGCAAAAGGTGTATATTTATATGATTTTGAAGGAAAGGCATTTATTGATGGTATCAGTAGTTGGT
GGGTGAATCTTTTTGGGCATTGCAATCCTTTTATCAATGCTGCAATTACGAAACAATTACAACAATTGGAGCATATTATT
TTGGCAGGTTTCTCACACGAGGGAATCATTCGCTATTCAGAGAAATTATGTGCTTTGCTTCCGCAGAGCTTGCAAAAATG
TTTTTATGCCGATAATGGCTCAAGTGCCATTGAAGTAGCTCTGAAAATGAGTTTTCATAGCCATTATAATGCAGGAAATA
AAGATAAAAACGCATTTTTATCCCTTAGTAATGCTTATCACGGCGAAACTTTAGGAGCTTTAAGCGTAGGTGATGTCGCA
TTATATAAAAGCACTTATCAGCCTCTTTTACTTGAATGTTTAAGCGCACCTGTGCCACGAGGTATATGGAATCCCGATGA
TGGCACAATAAGTGGAGATTATCATATGGAACTTGAAGCATTGGAGGAAATTTTAAAACATCACGCTCATCGCATTTGTG
CATTTATACTTGAGCCATTATTGCAATGTGCTGGTGGTATGAATATGTATCCCGCAGCTTATATTAAAGAAGCGTGTGCA
TTAGCAAGGAAGCATAATATTCATATTATCTTTGATGAAATTGCCGTAGGATTTGGGCGCACAGGCAGTATGTTTGCTTT
AGAGCAATGTGATGTAACGCCTGATTTTCTCTGTCTTTCTAAGGGTATTACAGGAGGATATCTTCCTTTATCTGTTGTGG
TTACAAGCAATAATATCTATGAGGGATTCTATGCTCCTTATGAGGAACAAAAAGCATTTTTGCACTCTCATAGCTACACA
GGTAATGCTTTAGCTATAGCAGCTGCAAATGCCGTATTAGACATTTTTGAGCAAGATGATATTATATTTTCTAATCATTC
TTTAAGTGTTGCCATAGTCAAGCGGTGGTCTATGCTCGCAAAGCATAAAAAAGTAGGGAATCTACGAGTATGCGGAATGG
TGTTTGCATTTGATTTGCAAGGTTGTAAGCTTAAAAGAGCTGGTTTATATGTGTATGAAAACGCACTTGCAAAAGGCGTG
TTATTGCGTCCTTTGGGAAATACAATTTATTTTATGCCACCTTATGTGATAAATCTTGAAATTGCTGAATATGTATGCAA
TGTGCTTGATGCAATCTTAGAAGATGATTTCTAA

Upstream 100 bases:

>100_bases
AAATGAGGTTTTGATAGGCATAATATTCCTTGTGTTAAGAGATGTGATTAGATGTTTTGGAGTAAAATTATATCTTAAAT
TATTATATAAAGGTTGAGTT

Downstream 100 bases:

>100_bases
TTTATAATAATTTTTGAATATAAGGTGTAAGCTCATAAGAGAGTGCATTTGCAGCAGAATCCAAAGTTTGAGTTGTATAA
GATTCTATATGCACAAGTGG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MLDLKALDLAHIWHPCTQMKDHETLPLIPIKSAKGVYLYDFEGKAFIDGISSWWVNLFGHCNPFINAAITKQLQQLEHII
LAGFSHEGIIRYSEKLCALLPQSLQKCFYADNGSSAIEVALKMSFHSHYNAGNKDKNAFLSLSNAYHGETLGALSVGDVA
LYKSTYQPLLLECLSAPVPRGIWNPDDGTISGDYHMELEALEEILKHHAHRICAFILEPLLQCAGGMNMYPAAYIKEACA
LARKHNIHIIFDEIAVGFGRTGSMFALEQCDVTPDFLCLSKGITGGYLPLSVVVTSNNIYEGFYAPYEEQKAFLHSHSYT
GNALAIAAANAVLDIFEQDDIIFSNHSLSVAIVKRWSMLAKHKKVGNLRVCGMVFAFDLQGCKLKRAGLYVYENALAKGV
LLRPLGNTIYFMPPYVINLEIAEYVCNVLDAILEDDF

Sequences:

>Translated_437_residues
MLDLKALDLAHIWHPCTQMKDHETLPLIPIKSAKGVYLYDFEGKAFIDGISSWWVNLFGHCNPFINAAITKQLQQLEHII
LAGFSHEGIIRYSEKLCALLPQSLQKCFYADNGSSAIEVALKMSFHSHYNAGNKDKNAFLSLSNAYHGETLGALSVGDVA
LYKSTYQPLLLECLSAPVPRGIWNPDDGTISGDYHMELEALEEILKHHAHRICAFILEPLLQCAGGMNMYPAAYIKEACA
LARKHNIHIIFDEIAVGFGRTGSMFALEQCDVTPDFLCLSKGITGGYLPLSVVVTSNNIYEGFYAPYEEQKAFLHSHSYT
GNALAIAAANAVLDIFEQDDIIFSNHSLSVAIVKRWSMLAKHKKVGNLRVCGMVFAFDLQGCKLKRAGLYVYENALAKGV
LLRPLGNTIYFMPPYVINLEIAEYVCNVLDAILEDDF
>Mature_437_residues
MLDLKALDLAHIWHPCTQMKDHETLPLIPIKSAKGVYLYDFEGKAFIDGISSWWVNLFGHCNPFINAAITKQLQQLEHII
LAGFSHEGIIRYSEKLCALLPQSLQKCFYADNGSSAIEVALKMSFHSHYNAGNKDKNAFLSLSNAYHGETLGALSVGDVA
LYKSTYQPLLLECLSAPVPRGIWNPDDGTISGDYHMELEALEEILKHHAHRICAFILEPLLQCAGGMNMYPAAYIKEACA
LARKHNIHIIFDEIAVGFGRTGSMFALEQCDVTPDFLCLSKGITGGYLPLSVVVTSNNIYEGFYAPYEEQKAFLHSHSYT
GNALAIAAANAVLDIFEQDDIIFSNHSLSVAIVKRWSMLAKHKKVGNLRVCGMVFAFDLQGCKLKRAGLYVYENALAKGV
LLRPLGNTIYFMPPYVINLEIAEYVCNVLDAILEDDF

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=426, Percent_Identity=28.6384976525822, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=28.5353535353535, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI13994255, Length=367, Percent_Identity=29.700272479564, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI226442705, Length=427, Percent_Identity=27.4004683840749, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI24119277, Length=431, Percent_Identity=29.0023201856148, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI4557809, Length=415, Percent_Identity=26.5060240963855, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI284507298, Length=226, Percent_Identity=28.3185840707965, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786991, Length=439, Percent_Identity=34.8519362186788, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI145693181, Length=399, Percent_Identity=27.5689223057644, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789759, Length=393, Percent_Identity=25.9541984732824, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=25.5050505050505, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=29.6912114014252, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789016, Length=354, Percent_Identity=28.5310734463277, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786349, Length=315, Percent_Identity=25.3968253968254, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI32564660, Length=432, Percent_Identity=27.3148148148148, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=425, Percent_Identity=24.4705882352941, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71992977, Length=432, Percent_Identity=25, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI25144274, Length=246, Percent_Identity=28.0487804878049, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324386, Length=466, Percent_Identity=33.4763948497854, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=27.2511848341232, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6324432, Length=417, Percent_Identity=24.220623501199, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=29.8876404494382, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI161085790, Length=446, Percent_Identity=29.372197309417, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI21356575, Length=437, Percent_Identity=25.4004576659039, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21357415, Length=413, Percent_Identity=28.0871670702179, Blast_Score=118, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48537; Mature: 48537

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKALDLAHIWHPCTQMKDHETLPLIPIKSAKGVYLYDFEGKAFIDGISSWWVNLFGH
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHC
CNPFINAAITKQLQQLEHIILAGFSHEGIIRYSEKLCALLPQSLQKCFYADNGSSAIEVA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEE
LKMSFHSHYNAGNKDKNAFLSLSNAYHGETLGALSVGDVALYKSTYQPLLLECLSAPVPR
EEEHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCC
GIWNPDDGTISGDYHMELEALEEILKHHAHRICAFILEPLLQCAGGMNMYPAAYIKEACA
CCCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LARKHNIHIIFDEIAVGFGRTGSMFALEQCDVTPDFLCLSKGITGGYLPLSVVVTSNNIY
HHHHCCEEEEEEHHHHCCCCCCCEEEEEECCCCCCHHHHHCCCCCCCCEEEEEEECCCEE
EGFYAPYEEQKAFLHSHSYTGNALAIAAANAVLDIFEQDDIIFSNHSLSVAIVKRWSMLA
CCCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCCCEEEECCCEEEHHHHHHHHHH
KHKKVGNLRVCGMVFAFDLQGCKLKRAGLYVYENALAKGVLLRPLGNTIYFMPPYVINLE
HHHCCCCEEEEEEEEEEECCCCEEECCCEEEEHHHHHCCEEEEECCCEEEECCCEEEEEE
IAEYVCNVLDAILEDDF
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDLKALDLAHIWHPCTQMKDHETLPLIPIKSAKGVYLYDFEGKAFIDGISSWWVNLFGH
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHC
CNPFINAAITKQLQQLEHIILAGFSHEGIIRYSEKLCALLPQSLQKCFYADNGSSAIEVA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEE
LKMSFHSHYNAGNKDKNAFLSLSNAYHGETLGALSVGDVALYKSTYQPLLLECLSAPVPR
EEEHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCC
GIWNPDDGTISGDYHMELEALEEILKHHAHRICAFILEPLLQCAGGMNMYPAAYIKEACA
CCCCCCCCEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LARKHNIHIIFDEIAVGFGRTGSMFALEQCDVTPDFLCLSKGITGGYLPLSVVVTSNNIY
HHHHCCEEEEEEHHHHCCCCCCCEEEEEECCCCCCHHHHHCCCCCCCCEEEEEEECCCEE
EGFYAPYEEQKAFLHSHSYTGNALAIAAANAVLDIFEQDDIIFSNHSLSVAIVKRWSMLA
CCCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCCCEEEECCCEEEHHHHHHHHHH
KHKKVGNLRVCGMVFAFDLQGCKLKRAGLYVYENALAKGVLLRPLGNTIYFMPPYVINLE
HHHCCCCEEEEEEEEEEECCCCEEECCCEEEEHHHHHCCEEEEECCCEEEECCCEEEEEE
IAEYVCNVLDAILEDDF
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]