Click here to switch to the map view.

The map label for this gene is ilvC

Identifier: 32266703

GI number: 32266703

Start: 1173945

End: 1174970

Strand: Direct

Name: ilvC

Synonym: HH1204

Alternate gene names: 32266703

Gene position: 1173945-1174970 (Clockwise)

Preceding gene: 32266700

Following gene: 32266704

Centisome position: 65.25

GC content: 41.03

Gene sequence:

>1026_bases
ATGGCATTAAAAGTGTATTACGACAAAGATTGTGATTTAGGACTTATTCAAAAGAAAAAAGTTGCAGTGATTGGCTTTGG
TTCACAAGGGCACGCTCACGCAGAAAACTTACGAGATTCTGGCGTTGAGGTAATTATCGGATTGTATCGCGGTGGCTCTA
GCTGGGTAAAAGCTGAAGCAAAGGGTTTTAAGGTGCTTGAAGTGAGTGAGGCAACAAAAGTTGCTGATGTGATTATGATA
TTAATCCCTGATGAATTGCAAGCTGATGTGTTTGCCAAAGATATTTTACCCTCTTTAAGCGAAGATAAAATTATTGCATT
TGGGCACGGATTCAATATCCATTTTGGGCAAATCAAAGCTCCAAAGGGTGTAGGTGTGATTATGGTTGCACCAAAAGCCC
CGGGTCATACCGTTCGTAGTGAATTTGTAAAAGGTGGCGGAATCCCTGATTTAATTGCTGTAGAGCAAGATACAAGCAGA
GGAGATGCCAAAGCGATTGCACTAAGTTATGCAAGTGCGATTGGAGGAGGGCGCAGTGGCATTATTGAAACGACTTTTAA
AGATGAGACAGAGACAGATTTATTTGGTGAGCAAGCTGTGCTTTGCGGTGGTGTAACGAGCCTTGTTAAAGCTGGATTTG
AAACTTTGGTTGAGGCAGGCTATCCTGAAGAAATGGCGTATTTTGAGTGTTTGCACGAACTAAAGCTAATTGTGGATTTG
ATTTATGAGGGTGGCTTGGCAAATATGCGCTATTCTATCTCAAATACCGCAGAATATGGCGATATGGTAAGTGGTCCGCG
TGTGATTAATGAAGAATCTAAAAAAGCAATGAAGCAGATTCTAAAAGATATTCAAGAAGGGCGATTTGCTAAAGATTTTA
TATTGGAGCGTAAAGCAGGATATGCGAGAATGAATGCAGAGCGAAAAAATCTAGCAAATCATAAAATTGAGCAAGTCGGT
GGCAGACTCCGCGCAATGATGCCGTGGATTGGTGCAAATAAATTGGTAGATAAGGAGAGAAACTAA

Upstream 100 bases:

>100_bases
AGCCTTTGACTTGGTGGCTTAATTATAACTAAGTTTGTTTTAACTATAATTGAGCCTTTAATTTAAAATAGCGGCTAAAC
TGCTAGAAAGGAAATGTATA

Downstream 100 bases:

>100_bases
ATAAAACTCCCACTTGCAATGAACTTGCAACATTAAAATTGTTTATAGTATAAAATACTTTATAAAAGGAGGGCATAGAA
TCTAAGGAGTAAGAATGACA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MALKVYYDKDCDLGLIQKKKVAVIGFGSQGHAHAENLRDSGVEVIIGLYRGGSSWVKAEAKGFKVLEVSEATKVADVIMI
LIPDELQADVFAKDILPSLSEDKIIAFGHGFNIHFGQIKAPKGVGVIMVAPKAPGHTVRSEFVKGGGIPDLIAVEQDTSR
GDAKAIALSYASAIGGGRSGIIETTFKDETETDLFGEQAVLCGGVTSLVKAGFETLVEAGYPEEMAYFECLHELKLIVDL
IYEGGLANMRYSISNTAEYGDMVSGPRVINEESKKAMKQILKDIQEGRFAKDFILERKAGYARMNAERKNLANHKIEQVG
GRLRAMMPWIGANKLVDKERN

Sequences:

>Translated_341_residues
MALKVYYDKDCDLGLIQKKKVAVIGFGSQGHAHAENLRDSGVEVIIGLYRGGSSWVKAEAKGFKVLEVSEATKVADVIMI
LIPDELQADVFAKDILPSLSEDKIIAFGHGFNIHFGQIKAPKGVGVIMVAPKAPGHTVRSEFVKGGGIPDLIAVEQDTSR
GDAKAIALSYASAIGGGRSGIIETTFKDETETDLFGEQAVLCGGVTSLVKAGFETLVEAGYPEEMAYFECLHELKLIVDL
IYEGGLANMRYSISNTAEYGDMVSGPRVINEESKKAMKQILKDIQEGRFAKDFILERKAGYARMNAERKNLANHKIEQVG
GRLRAMMPWIGANKLVDKERN
>Mature_340_residues
ALKVYYDKDCDLGLIQKKKVAVIGFGSQGHAHAENLRDSGVEVIIGLYRGGSSWVKAEAKGFKVLEVSEATKVADVIMIL
IPDELQADVFAKDILPSLSEDKIIAFGHGFNIHFGQIKAPKGVGVIMVAPKAPGHTVRSEFVKGGGIPDLIAVEQDTSRG
DAKAIALSYASAIGGGRSGIIETTFKDETETDLFGEQAVLCGGVTSLVKAGFETLVEAGYPEEMAYFECLHELKLIVDLI
YEGGLANMRYSISNTAEYGDMVSGPRVINEESKKAMKQILKDIQEGRFAKDFILERKAGYARMNAERKNLANHKIEQVGG
RLRAMMPWIGANKLVDKERN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=287, Percent_Identity=34.4947735191638, Blast_Score=142, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=330, Percent_Identity=32.1212121212121, Blast_Score=130, Evalue=4e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_HELHP (Q7VGW6)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860735.1
- ProteinModelPortal:   Q7VGW6
- SMR:   Q7VGW6
- GeneID:   1492892
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH1204
- NMPDR:   fig|235279.1.peg.1204
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   HHEP235279:HH_1204-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37098; Mature: 36967

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: ACT_SITE 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKVYYDKDCDLGLIQKKKVAVIGFGSQGHAHAENLRDSGVEVIIGLYRGGSSWVKAEA
CEEEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCEEEECC
KGFKVLEVSEATKVADVIMILIPDELQADVFAKDILPSLSEDKIIAFGHGFNIHFGQIKA
CCCEEEEECCHHHHEEEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEECEEEC
PKGVGVIMVAPKAPGHTVRSEFVKGGGIPDLIAVEQDTSRGDAKAIALSYASAIGGGRSG
CCCCEEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
IIETTFKDETETDLFGEQAVLCGGVTSLVKAGFETLVEAGYPEEMAYFECLHELKLIVDL
EEEECCCCCCCHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
IYEGGLANMRYSISNTAEYGDMVSGPRVINEESKKAMKQILKDIQEGRFAKDFILERKAG
HHCCCCCCEEEECCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
YARMNAERKNLANHKIEQVGGRLRAMMPWIGANKLVDKERN
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALKVYYDKDCDLGLIQKKKVAVIGFGSQGHAHAENLRDSGVEVIIGLYRGGSSWVKAEA
EEEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCEEEECC
KGFKVLEVSEATKVADVIMILIPDELQADVFAKDILPSLSEDKIIAFGHGFNIHFGQIKA
CCCEEEEECCHHHHEEEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEECEEEC
PKGVGVIMVAPKAPGHTVRSEFVKGGGIPDLIAVEQDTSRGDAKAIALSYASAIGGGRSG
CCCCEEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
IIETTFKDETETDLFGEQAVLCGGVTSLVKAGFETLVEAGYPEEMAYFECLHELKLIVDL
EEEECCCCCCCHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
IYEGGLANMRYSISNTAEYGDMVSGPRVINEESKKAMKQILKDIQEGRFAKDFILERKAG
HHCCCCCCEEEECCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
YARMNAERKNLANHKIEQVGGRLRAMMPWIGANKLVDKERN
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954