| Definition | Helicobacter hepaticus ATCC 51449 chromosome, complete genome. |
|---|---|
| Accession | NC_004917 |
| Length | 1,799,146 |
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The map label for this gene is gyrB
Identifier: 32266626
GI number: 32266626
Start: 1095901
End: 1098219
Strand: Direct
Name: gyrB
Synonym: HH1127
Alternate gene names: 32266626
Gene position: 1095901-1098219 (Clockwise)
Preceding gene: 32266625
Following gene: 32266638
Centisome position: 60.91
GC content: 34.33
Gene sequence:
>2319_bases ATGGAAAAAAAAGAATATCAAGCAAGTAATATTAAAGTTTTAAAAGGCTTAGAAGCTGTCCGAAAACGCCCTGGTATGTA TATTGGTGATACAAACTCTGGTGGATTGCATCATATGATTTATGAAGTAGTAGATAATTCAATAGATGAAGCTATGGCAG GGTATTGTGATAAAATCAATATTACTCTCACTATGGAAGGCAGTGCTATTATTGAAGATAATGGACGCGGAATCCCAGTA GATATTCATCCTACTGAAAATCTTCCTGCAGCCACACTCGTTCTTACAACACTTCACGCAGGTGGAAAGTTTGACCAGGA TACTTACAAAGTTTCTGGCGGATTACACGGAGTAGGTGTAAGTGTAGTGAATGCTCTTTCTAAACGTCTTATTATGACTA TCAAAAAAAATGGACATATTTATCGTCAAGAGTTTGCTAAAGGTATCCCTCAAAGCGATTTAGAAGTTATCGGTAATACT AAAAAACACGGCACCACCATTGAGTTCTTCCCTGATGGAGAAGTAATGGAAGTGCTTGAATTTGATAAAGATATTCTTGT TCGTAGATTCAAAGAAATGGCATATCTTAACCATAATATTACCATTCAATTTAAAGATGAACGCACACAATTTGAAGAAA TCTATCACTTTGAAGGGGGGCTAAAACAATTTATTCAAGATGTAAATAAAAAGCCACTTATTTCATCAATTATAAGTTTT GAGGCTACAGAGCAAGAGAGTGAAATTGAAATCGCTCTTGCTTATAATGAAGGCTATGATGAAAAACTTTTAAGTTTTGT AAATAATATTCGCACACCTGATGGAGGAACACACGAGGCAGGATTTAGAGCAGGATTGAGCCGTGCGATTATGAATTATA TTGAAGCAAATGCAAATGCACGTGAAAAAGATGCAAAAGTAAGTGGTGAAGATGTGCGTGAAGGGCTTGTGGCGATTATT TCTACTAAAATTATTGATCCTCAATTTGAAGGACAAACTAAAGGCAAACTTGGAAGCTCTTTTGTTAAGCCTATTGTGCA AAAGCTCACTTATGAAAAACTTTCAAAATTCTTTGAAGAAAATCCTAATGAAGCTAAGGCTATTATGCAAAAAGCTATTA TGGCGGCGCGCGGGAGAGAGGCTGCTAAAAAAGCTCGTGATTTAACGCGTAAGAAAGAAAGTTTTTCTGTTGGCACTTTG CCCGGTAAGCTTGCAGATTGCCAAAGTAAAGATCCGAGTGTGTCAGAAATTTATCTTGTAGAAGGTGATAGTGCTGGTGG AAGTGCAAAACAAGGACGTGATAGGACTTTCCAAGCAATCTTGCCATTGCGTGGAAAAATTCTTAATGTTGAAAAATCTC GTCTTGATAAGATTTTGAAATCTGATGAAATTAAAAATATGATTACTGCTTTTGGTTGTGGTATAGGTGAAGAATTTAAT ATAGAAAAATTGCGTTATCACAAAATTATTATTATGACAGATGCAGATGTTGATGGAAGCCATATACAAACGCTTTTAAT GACATTTTTCTATCGTTATTTAAAACCCTTAGTCGAAAATGGACATATTTATATTGCTCAACCGCCACTTTATCGTTATA AAAAGGGCAAAAAAGAAATATATCTTAAAGATGAACGTGCTTTAAGCGAATACTTAATTGAAAATGGCATTGAAAATTTC AAGTTTGAGGGTGTTGGTAACCGTGAATTACTTGAGATTCTTAAATTTATTTCACATTATCGTTCAATCCTCAAGGAGCT AGAAAAACGTTATCCGATGATTGAAGTTGTGCGTTATTTGGTTGAAAATGAGCAGTTTGATACATTAGAGCTTAAAGCAT TAAGTCAAAATATAGAATCTTATCTTATAAGCAAAGAATGCAATATTTTAAATAAAACAACTGCACAGGAACAAATTACG CTTTATGTGCAAACAAAAGTTGGACTTGTAGAGCTTAGCATTAATGACACACTTTTTATGGATAATTTCTTCCAAGAAGC ACGATTTATTTATAAGAAAATTGCCGATAGAGATTTAGGATTTTTAAATGATGAAGATATGATTGTTTTCTTAGAGAGAA TTGAGGAAAGTGCAAAAAAAGATGCTTATATCCAAAGATACAAAGGTTTAGGAGAGATGAATCCAGATCAATTATGGGAA ACAACAATGATTCCACAAAATCGCACACTTTTGCGTGTTAAAATTGATAATGACATAAACACTGATGAAATTTTCACACT TTTTATGGGTGATGAGGTAGAGCCACGAAGAGCTTATATACAAGAGCACGCTAAAGATGTAAAACACCTTGATGTGTAG
Upstream 100 bases:
>100_bases TATTAATGAACCAAATACACCATTTGTAGTAATGAGTGAGAATTTTTCAACTGTTATTATGCCTGTGATTCTCTAAAATT AAAAAACGGAGCTCATATCA
Downstream 100 bases:
>100_bases ATTCTACAGAATCTAATTAGTTTTTATACTCTCATCATTCATAATCTCTATAATCTCGTTCATATCATAGTTTTTTAGTT TTGATTCTAGCTCTGTAAAG
Product: DNA gyrase subunit B
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 772; Mature: 772
Protein sequence:
>772_residues MEKKEYQASNIKVLKGLEAVRKRPGMYIGDTNSGGLHHMIYEVVDNSIDEAMAGYCDKINITLTMEGSAIIEDNGRGIPV DIHPTENLPAATLVLTTLHAGGKFDQDTYKVSGGLHGVGVSVVNALSKRLIMTIKKNGHIYRQEFAKGIPQSDLEVIGNT KKHGTTIEFFPDGEVMEVLEFDKDILVRRFKEMAYLNHNITIQFKDERTQFEEIYHFEGGLKQFIQDVNKKPLISSIISF EATEQESEIEIALAYNEGYDEKLLSFVNNIRTPDGGTHEAGFRAGLSRAIMNYIEANANAREKDAKVSGEDVREGLVAII STKIIDPQFEGQTKGKLGSSFVKPIVQKLTYEKLSKFFEENPNEAKAIMQKAIMAARGREAAKKARDLTRKKESFSVGTL PGKLADCQSKDPSVSEIYLVEGDSAGGSAKQGRDRTFQAILPLRGKILNVEKSRLDKILKSDEIKNMITAFGCGIGEEFN IEKLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLKPLVENGHIYIAQPPLYRYKKGKKEIYLKDERALSEYLIENGIENF KFEGVGNRELLEILKFISHYRSILKELEKRYPMIEVVRYLVENEQFDTLELKALSQNIESYLISKECNILNKTTAQEQIT LYVQTKVGLVELSINDTLFMDNFFQEARFIYKKIADRDLGFLNDEDMIVFLERIEESAKKDAYIQRYKGLGEMNPDQLWE TTMIPQNRTLLRVKIDNDINTDEIFTLFMGDEVEPRRAYIQEHAKDVKHLDV
Sequences:
>Translated_772_residues MEKKEYQASNIKVLKGLEAVRKRPGMYIGDTNSGGLHHMIYEVVDNSIDEAMAGYCDKINITLTMEGSAIIEDNGRGIPV DIHPTENLPAATLVLTTLHAGGKFDQDTYKVSGGLHGVGVSVVNALSKRLIMTIKKNGHIYRQEFAKGIPQSDLEVIGNT KKHGTTIEFFPDGEVMEVLEFDKDILVRRFKEMAYLNHNITIQFKDERTQFEEIYHFEGGLKQFIQDVNKKPLISSIISF EATEQESEIEIALAYNEGYDEKLLSFVNNIRTPDGGTHEAGFRAGLSRAIMNYIEANANAREKDAKVSGEDVREGLVAII STKIIDPQFEGQTKGKLGSSFVKPIVQKLTYEKLSKFFEENPNEAKAIMQKAIMAARGREAAKKARDLTRKKESFSVGTL PGKLADCQSKDPSVSEIYLVEGDSAGGSAKQGRDRTFQAILPLRGKILNVEKSRLDKILKSDEIKNMITAFGCGIGEEFN IEKLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLKPLVENGHIYIAQPPLYRYKKGKKEIYLKDERALSEYLIENGIENF KFEGVGNRELLEILKFISHYRSILKELEKRYPMIEVVRYLVENEQFDTLELKALSQNIESYLISKECNILNKTTAQEQIT LYVQTKVGLVELSINDTLFMDNFFQEARFIYKKIADRDLGFLNDEDMIVFLERIEESAKKDAYIQRYKGLGEMNPDQLWE TTMIPQNRTLLRVKIDNDINTDEIFTLFMGDEVEPRRAYIQEHAKDVKHLDV >Mature_772_residues MEKKEYQASNIKVLKGLEAVRKRPGMYIGDTNSGGLHHMIYEVVDNSIDEAMAGYCDKINITLTMEGSAIIEDNGRGIPV DIHPTENLPAATLVLTTLHAGGKFDQDTYKVSGGLHGVGVSVVNALSKRLIMTIKKNGHIYRQEFAKGIPQSDLEVIGNT KKHGTTIEFFPDGEVMEVLEFDKDILVRRFKEMAYLNHNITIQFKDERTQFEEIYHFEGGLKQFIQDVNKKPLISSIISF EATEQESEIEIALAYNEGYDEKLLSFVNNIRTPDGGTHEAGFRAGLSRAIMNYIEANANAREKDAKVSGEDVREGLVAII STKIIDPQFEGQTKGKLGSSFVKPIVQKLTYEKLSKFFEENPNEAKAIMQKAIMAARGREAAKKARDLTRKKESFSVGTL PGKLADCQSKDPSVSEIYLVEGDSAGGSAKQGRDRTFQAILPLRGKILNVEKSRLDKILKSDEIKNMITAFGCGIGEEFN IEKLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLKPLVENGHIYIAQPPLYRYKKGKKEIYLKDERALSEYLIENGIENF KFEGVGNRELLEILKFISHYRSILKELEKRYPMIEVVRYLVENEQFDTLELKALSQNIESYLISKECNILNKTTAQEQIT LYVQTKVGLVELSINDTLFMDNFFQEARFIYKKIADRDLGFLNDEDMIVFLERIEESAKKDAYIQRYKGLGEMNPDQLWE TTMIPQNRTLLRVKIDNDINTDEIFTLFMGDEVEPRRAYIQEHAKDVKHLDV
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0187
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=570, Percent_Identity=25.6140350877193, Blast_Score=133, Evalue=7e-31, Organism=Homo sapiens, GI19913406, Length=571, Percent_Identity=24.8686514886165, Blast_Score=124, Evalue=4e-28, Organism=Escherichia coli, GI48994957, Length=804, Percent_Identity=46.2686567164179, Blast_Score=699, Evalue=0.0, Organism=Escherichia coli, GI1789408, Length=563, Percent_Identity=40.4973357015986, Blast_Score=399, Evalue=1e-112, Organism=Caenorhabditis elegans, GI212645845, Length=500, Percent_Identity=26.6, Blast_Score=145, Evalue=9e-35, Organism=Caenorhabditis elegans, GI17535065, Length=564, Percent_Identity=24.822695035461, Blast_Score=135, Evalue=7e-32, Organism=Caenorhabditis elegans, GI212645657, Length=195, Percent_Identity=28.7179487179487, Blast_Score=70, Evalue=4e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=561, Percent_Identity=26.5597147950089, Blast_Score=119, Evalue=1e-27, Organism=Drosophila melanogaster, GI17136538, Length=497, Percent_Identity=24.748490945674, Blast_Score=116, Evalue=5e-26,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003594 - InterPro: IPR011557 - InterPro: IPR020568 - InterPro: IPR014721 - InterPro: IPR001241 - InterPro: IPR013759 - InterPro: IPR002288 - InterPro: IPR013506 - InterPro: IPR013760 - InterPro: IPR018522 - InterPro: IPR006171 [H]
Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 87912; Mature: 87912
Theoretical pI: Translated: 5.84; Mature: 5.84
Prosite motif: PS00177 TOPOISOMERASE_II
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEKKEYQASNIKVLKGLEAVRKRPGMYIGDTNSGGLHHMIYEVVDNSIDEAMAGYCDKIN CCCCHHCCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCHHHHHHHCCCCEEE ITLTMEGSAIIEDNGRGIPVDIHPTENLPAATLVLTTLHAGGKFDQDTYKVSGGLHGVGV EEEEECCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHH SVVNALSKRLIMTIKKNGHIYRQEFAKGIPQSDLEVIGNTKKHGTTIEFFPDGEVMEVLE HHHHHHHHHHEEEEECCCCCHHHHHHCCCCCCHHHHHCCCCCCCCEEEECCCCHHHHHHH FDKDILVRRFKEMAYLNHNITIQFKDERTQFEEIYHFEGGLKQFIQDVNKKPLISSIISF CCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH EATEQESEIEIALAYNEGYDEKLLSFVNNIRTPDGGTHEAGFRAGLSRAIMNYIEANANA HCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC REKDAKVSGEDVREGLVAIISTKIIDPQFEGQTKGKLGSSFVKPIVQKLTYEKLSKFFEE CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC NPNEAKAIMQKAIMAARGREAAKKARDLTRKKESFSVGTLPGKLADCQSKDPSVSEIYLV CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEE EGDSAGGSAKQGRDRTFQAILPLRGKILNVEKSRLDKILKSDEIKNMITAFGCGIGEEFN ECCCCCCCCCCCCCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC IEKLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLKPLVENGHIYIAQPPLYRYKKGKKEI CCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCCEE YLKDERALSEYLIENGIENFKFEGVGNRELLEILKFISHYRSILKELEKRYPMIEVVRYL EEEHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH VENEQFDTLELKALSQNIESYLISKECNILNKTTAQEQITLYVQTKVGLVELSINDTLFM HCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEEEEECEEEEEECCCCHHH DNFFQEARFIYKKIADRDLGFLNDEDMIVFLERIEESAKKDAYIQRYKGLGEMNPDQLWE HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH TTMIPQNRTLLRVKIDNDINTDEIFTLFMGDEVEPRRAYIQEHAKDVKHLDV HHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCC >Mature Secondary Structure MEKKEYQASNIKVLKGLEAVRKRPGMYIGDTNSGGLHHMIYEVVDNSIDEAMAGYCDKIN CCCCHHCCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCHHHHHHHCCCCEEE ITLTMEGSAIIEDNGRGIPVDIHPTENLPAATLVLTTLHAGGKFDQDTYKVSGGLHGVGV EEEEECCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHH SVVNALSKRLIMTIKKNGHIYRQEFAKGIPQSDLEVIGNTKKHGTTIEFFPDGEVMEVLE HHHHHHHHHHEEEEECCCCCHHHHHHCCCCCCHHHHHCCCCCCCCEEEECCCCHHHHHHH FDKDILVRRFKEMAYLNHNITIQFKDERTQFEEIYHFEGGLKQFIQDVNKKPLISSIISF CCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH EATEQESEIEIALAYNEGYDEKLLSFVNNIRTPDGGTHEAGFRAGLSRAIMNYIEANANA HCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC REKDAKVSGEDVREGLVAIISTKIIDPQFEGQTKGKLGSSFVKPIVQKLTYEKLSKFFEE CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC NPNEAKAIMQKAIMAARGREAAKKARDLTRKKESFSVGTLPGKLADCQSKDPSVSEIYLV CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEE EGDSAGGSAKQGRDRTFQAILPLRGKILNVEKSRLDKILKSDEIKNMITAFGCGIGEEFN ECCCCCCCCCCCCCCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC IEKLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLKPLVENGHIYIAQPPLYRYKKGKKEI CCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCCEE YLKDERALSEYLIENGIENFKFEGVGNRELLEILKFISHYRSILKELEKRYPMIEVVRYL EEEHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH VENEQFDTLELKALSQNIESYLISKECNILNKTTAQEQITLYVQTKVGLVELSINDTLFM HCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEEEEECEEEEEECCCCHHH DNFFQEARFIYKKIADRDLGFLNDEDMIVFLERIEESAKKDAYIQRYKGLGEMNPDQLWE HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH TTMIPQNRTLLRVKIDNDINTDEIFTLFMGDEVEPRRAYIQEHAKDVKHLDV HHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10688204 [H]