Click here to switch to the map view.

The map label for this gene is lon

Identifier: 32266344

GI number: 32266344

Start: 819983

End: 822391

Strand: Direct

Name: lon

Synonym: HH0845

Alternate gene names: 32266344

Gene position: 819983-822391 (Clockwise)

Preceding gene: 32266343

Following gene: 32266348

Centisome position: 45.58

GC content: 37.28

Gene sequence:

>2409_bases
ATGAATACTTTAAATAATGAATTTCCCATACTTATGCCCTTAATTGTTGAAGATGAACTTTTTATTTATCCCTTTATGAT
TGCGCCACTTTTTATTAACGATGAAAATAATATCAAAGCTGCAGATAAAGCTATAAAAGGTAATAGCCTTGTATTTATTA
GCTCTATACGCAATGATGATAAGCAAACATTTTACGATGTTGGCGTAATTGGTTCAATTATGCGCAAAGTCGCTCTCCCT
GATGGACGTGTTAAATTGCTTTTTAAAGGCTTATATCGTGGCAAAATACTTCAAATCATTCAAACCCCTAAAGAACCTAT
ACAAGTAGAAGTAGATTTAATTGCCTATAAAGAATATGAAAATGATAAAATGAACGCTCTTTTGCAAGTGCTGCGCGAAA
AAGTCCGTCATCTTGCAAATCTAGATGGGCATTTTCCACCTGATTTACTCAAAAGTATAGAGGAAAATCACGAACCAAAT
CGCATTGTGGATTTAATCGCTTCAGCTATGCGCCTCTCTACGCAACAAGCCTATACACTTTTTGCAAAAGATGATGTTGA
AGAACGAGTATTAGGCTTGATTGAATATATTATTGAAGAAATAGAAGCTCAAAAGCTCCAAAAAGAGATTAAAAACAAAG
TCCATAATAAAATGGAACAAGTCAATAAAGAGTATTTTCTCAAAGAACAATTAAAGCAAATTCAAAAAGAGCTTGGAACA
GATAACACTCGCGATGAAGAAATGGAACAATACACCCAAAAGCTCAATAGCCTCAAACCTTATATGAGCGAAAACGCTTT
CAAAGAAGTGCAAAAACAAATCAAGCGTCTCTCTCGTATGCACCAAGATAGCGGTGATGCAAATATTTTGCAAAATTATG
TTGAATGGGTGCTTGAGATTCCATTTGGGCAATATGCTAATCAAAAACTTTCTATTGAAAATGTCGCTAAACAGCTTGAT
ATAGACCATTATTCGTTGCAAAAGCCAAAAGAACGCATTGTAGAATATTTCGCGGTAAAAGAGCTAATGGCACAACGCAC
ACAAAATACGCAAGGAGTGACCTCTAAGCCAAAACGAGGCAAAAAATCTAAGACAGAAAACACAGATAAATATGAAAAAG
GCACTATTTTATGTTTCTATGGACCGCCGGGTGTAGGAAAAACAAGCCTTGCAAACTCTATTGCAAAAGCTATTAAGCGT
GAGCTTGTGCGCATTGCACTTGGAGGGCTAGAAGATGTCAATGAGTTACGAGGACATCGTCGCACTTATATTGGAGCAAT
GCCCGGACGCATCACACAAGGACTTATTGAAGCAAAAGAAATGAATCCCGTCATTGTGCTTGATGAAATTGATAAAGTTG
GTAGAAGTTATAGGGGCGACCCTACAAGTGTGTTGCTTGAGATTCTAGACCCAGAGCAAAACCACGCTTTTAGGGATTAT
TACACAAATTTTGATATTGACCTCTCACAAGTTATTTTTATTGCCACTGCAAATGATATTTCTACTATTCCCGCACCATT
GCGCGATAGAATGGAATTTATTGCCGTATCTTCCTACACGCCGCAGGAAAAATTTGAAATCGCCAAAAAATATTTGATTC
CCCAAGAATTAAAAAAACACGGCTTAAAACCCGAAGAGCTCAAAATTTCTACACCTACGCTTAAACTTATTATTGAAAAA
TACACGCGCGAAGCAGGAGTGCGCAATCTACGTCATAAAATCGCACAAATTATGCGCAAAGTTGCAACTATTATTTTAAA
AGGTGAAAAATCTATCACCCTCACACCACAGAATCTAGGGCAATTTCTTGATAAAATTGTGTTTGAAATTTCACCTACAG
ATAAAAAAAATATGGTTGGCATTGTCAATGGGTTAGCTTGGACAAGTGTAGGCGGCGATGTGCTTAAGATTGAAGCAGTG
AAAATTAAAGGCAAAGGCATACTTACGCTTACAGGGAGTTTAGGCGATGTAATGAAAGAATCTGCACACATCGCACACTC
CGTGGTAAAAGTCTTGCTTGATAAAAAAATATTAAAACACAGCGCAAAAGCGCCCATTTATCAGCATTATGATATTCATC
TTCACGTCCCAGAAGGTGCAACACCAAAAGATGGACCAAGTGCGGGTATTGCTATGGCGTGCGTTATTGCTTCAATCCTT
ACAGATTCTAAAATTGATACAAGTGTGGCGATGACAGGCGAACTCACATTAAGAGGCAATGTTCTACCTATCGGTGGTTT
GCGCGAGAAACTCATTGCTGCGCATAAAGCTGGCATTAAAACTGCACTTATTCCACAAAAAAATTATGAACGCGATTTAA
AAGATATTCCCCAAGAAGTGCTTAAAAAGCTTAAAATCATTGGCGTGAGTGATATTAAAGAAGTGCTTGATATGGCTCTT
GTGAAATAA

Upstream 100 bases:

>100_bases
AATACTTAAGTCGCAATGATGAAGAGCTTTTTACAAATCTTAAACCCAAACCCTCACATATCCCGTGGTATGTAAGAATC
TTTAATTGGTAGGAGAAAGA

Downstream 100 bases:

>100_bases
GATATTTTGAGGTAATTTTGCCCAAATGCACTCGATTTTCTACTTATTCTACTTTGATGTCAAGTTTATGGAGTAGATTC
TTTAAGCACTTTAAATTATA

Product: ATP-dependent protease LA

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 802; Mature: 802

Protein sequence:

>802_residues
MNTLNNEFPILMPLIVEDELFIYPFMIAPLFINDENNIKAADKAIKGNSLVFISSIRNDDKQTFYDVGVIGSIMRKVALP
DGRVKLLFKGLYRGKILQIIQTPKEPIQVEVDLIAYKEYENDKMNALLQVLREKVRHLANLDGHFPPDLLKSIEENHEPN
RIVDLIASAMRLSTQQAYTLFAKDDVEERVLGLIEYIIEEIEAQKLQKEIKNKVHNKMEQVNKEYFLKEQLKQIQKELGT
DNTRDEEMEQYTQKLNSLKPYMSENAFKEVQKQIKRLSRMHQDSGDANILQNYVEWVLEIPFGQYANQKLSIENVAKQLD
IDHYSLQKPKERIVEYFAVKELMAQRTQNTQGVTSKPKRGKKSKTENTDKYEKGTILCFYGPPGVGKTSLANSIAKAIKR
ELVRIALGGLEDVNELRGHRRTYIGAMPGRITQGLIEAKEMNPVIVLDEIDKVGRSYRGDPTSVLLEILDPEQNHAFRDY
YTNFDIDLSQVIFIATANDISTIPAPLRDRMEFIAVSSYTPQEKFEIAKKYLIPQELKKHGLKPEELKISTPTLKLIIEK
YTREAGVRNLRHKIAQIMRKVATIILKGEKSITLTPQNLGQFLDKIVFEISPTDKKNMVGIVNGLAWTSVGGDVLKIEAV
KIKGKGILTLTGSLGDVMKESAHIAHSVVKVLLDKKILKHSAKAPIYQHYDIHLHVPEGATPKDGPSAGIAMACVIASIL
TDSKIDTSVAMTGELTLRGNVLPIGGLREKLIAAHKAGIKTALIPQKNYERDLKDIPQEVLKKLKIIGVSDIKEVLDMAL
VK

Sequences:

>Translated_802_residues
MNTLNNEFPILMPLIVEDELFIYPFMIAPLFINDENNIKAADKAIKGNSLVFISSIRNDDKQTFYDVGVIGSIMRKVALP
DGRVKLLFKGLYRGKILQIIQTPKEPIQVEVDLIAYKEYENDKMNALLQVLREKVRHLANLDGHFPPDLLKSIEENHEPN
RIVDLIASAMRLSTQQAYTLFAKDDVEERVLGLIEYIIEEIEAQKLQKEIKNKVHNKMEQVNKEYFLKEQLKQIQKELGT
DNTRDEEMEQYTQKLNSLKPYMSENAFKEVQKQIKRLSRMHQDSGDANILQNYVEWVLEIPFGQYANQKLSIENVAKQLD
IDHYSLQKPKERIVEYFAVKELMAQRTQNTQGVTSKPKRGKKSKTENTDKYEKGTILCFYGPPGVGKTSLANSIAKAIKR
ELVRIALGGLEDVNELRGHRRTYIGAMPGRITQGLIEAKEMNPVIVLDEIDKVGRSYRGDPTSVLLEILDPEQNHAFRDY
YTNFDIDLSQVIFIATANDISTIPAPLRDRMEFIAVSSYTPQEKFEIAKKYLIPQELKKHGLKPEELKISTPTLKLIIEK
YTREAGVRNLRHKIAQIMRKVATIILKGEKSITLTPQNLGQFLDKIVFEISPTDKKNMVGIVNGLAWTSVGGDVLKIEAV
KIKGKGILTLTGSLGDVMKESAHIAHSVVKVLLDKKILKHSAKAPIYQHYDIHLHVPEGATPKDGPSAGIAMACVIASIL
TDSKIDTSVAMTGELTLRGNVLPIGGLREKLIAAHKAGIKTALIPQKNYERDLKDIPQEVLKKLKIIGVSDIKEVLDMAL
VK
>Mature_802_residues
MNTLNNEFPILMPLIVEDELFIYPFMIAPLFINDENNIKAADKAIKGNSLVFISSIRNDDKQTFYDVGVIGSIMRKVALP
DGRVKLLFKGLYRGKILQIIQTPKEPIQVEVDLIAYKEYENDKMNALLQVLREKVRHLANLDGHFPPDLLKSIEENHEPN
RIVDLIASAMRLSTQQAYTLFAKDDVEERVLGLIEYIIEEIEAQKLQKEIKNKVHNKMEQVNKEYFLKEQLKQIQKELGT
DNTRDEEMEQYTQKLNSLKPYMSENAFKEVQKQIKRLSRMHQDSGDANILQNYVEWVLEIPFGQYANQKLSIENVAKQLD
IDHYSLQKPKERIVEYFAVKELMAQRTQNTQGVTSKPKRGKKSKTENTDKYEKGTILCFYGPPGVGKTSLANSIAKAIKR
ELVRIALGGLEDVNELRGHRRTYIGAMPGRITQGLIEAKEMNPVIVLDEIDKVGRSYRGDPTSVLLEILDPEQNHAFRDY
YTNFDIDLSQVIFIATANDISTIPAPLRDRMEFIAVSSYTPQEKFEIAKKYLIPQELKKHGLKPEELKISTPTLKLIIEK
YTREAGVRNLRHKIAQIMRKVATIILKGEKSITLTPQNLGQFLDKIVFEISPTDKKNMVGIVNGLAWTSVGGDVLKIEAV
KIKGKGILTLTGSLGDVMKESAHIAHSVVKVLLDKKILKHSAKAPIYQHYDIHLHVPEGATPKDGPSAGIAMACVIASIL
TDSKIDTSVAMTGELTLRGNVLPIGGLREKLIAAHKAGIKTALIPQKNYERDLKDIPQEVLKKLKIIGVSDIKEVLDMAL
VK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=716, Percent_Identity=37.4301675977654, Blast_Score=499, Evalue=1e-141,
Organism=Homo sapiens, GI31377667, Length=866, Percent_Identity=35.796766743649, Blast_Score=475, Evalue=1e-134,
Organism=Escherichia coli, GI1786643, Length=801, Percent_Identity=40.6991260923845, Blast_Score=577, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17505831, Length=698, Percent_Identity=37.6790830945559, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17556486, Length=656, Percent_Identity=33.2317073170732, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319449, Length=694, Percent_Identity=35.8789625360231, Blast_Score=436, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24666867, Length=711, Percent_Identity=37.4120956399437, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI221513036, Length=711, Percent_Identity=37.4120956399437, Blast_Score=469, Evalue=1e-132,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90611; Mature: 90611

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLNNEFPILMPLIVEDELFIYPFMIAPLFINDENNIKAADKAIKGNSLVFISSIRNDD
CCCCCCCCCEEEEEEECCCHHEEEHHHEEEEECCCCCCCHHHHHCCCCCEEEEECCCCCC
KQTFYDVGVIGSIMRKVALPDGRVKLLFKGLYRGKILQIIQTPKEPIQVEVDLIAYKEYE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCC
NDKMNALLQVLREKVRHLANLDGHFPPDLLKSIEENHEPNRIVDLIASAMRLSTQQAYTL
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEE
FAKDDVEERVLGLIEYIIEEIEAQKLQKEIKNKVHNKMEQVNKEYFLKEQLKQIQKELGT
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DNTRDEEMEQYTQKLNSLKPYMSENAFKEVQKQIKRLSRMHQDSGDANILQNYVEWVLEI
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
PFGQYANQKLSIENVAKQLDIDHYSLQKPKERIVEYFAVKELMAQRTQNTQGVTSKPKRG
CCCHHCCCCCCHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
KKSKTENTDKYEKGTILCFYGPPGVGKTSLANSIAKAIKRELVRIALGGLEDVNELRGHR
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCH
RTYIGAMPGRITQGLIEAKEMNPVIVLDEIDKVGRSYRGDPTSVLLEILDPEQNHAFRDY
HHEECCCCCHHHHHHHHHHHCCCEEEEECHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHH
YTNFDIDLSQVIFIATANDISTIPAPLRDRMEFIAVSSYTPQEKFEIAKKYLIPQELKKH
CCCCCCCHHHEEEEEECCCCCCCCCCHHHHHHHHEECCCCCHHHHHHHHHHCCHHHHHHC
GLKPEELKISTPTLKLIIEKYTREAGVRNLRHKIAQIMRKVATIILKGEKSITLTPQNLG
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECHHHHH
QFLDKIVFEISPTDKKNMVGIVNGLAWTSVGGDVLKIEAVKIKGKGILTLTGSLGDVMKE
HHHHHHHHHCCCCCCCCHHHHHHCHHHHCCCCCEEEEEEEEEECCEEEEEECCHHHHHHH
SAHIAHSVVKVLLDKKILKHSAKAPIYQHYDIHLHVPEGATPKDGPSAGIAMACVIASIL
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
TDSKIDTSVAMTGELTLRGNVLPIGGLREKLIAAHKAGIKTALIPQKNYERDLKDIPQEV
HCCCCCCCEEEEEEEEEECCEEECCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
LKKLKIIGVSDIKEVLDMALVK
HHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTLNNEFPILMPLIVEDELFIYPFMIAPLFINDENNIKAADKAIKGNSLVFISSIRNDD
CCCCCCCCCEEEEEEECCCHHEEEHHHEEEEECCCCCCCHHHHHCCCCCEEEEECCCCCC
KQTFYDVGVIGSIMRKVALPDGRVKLLFKGLYRGKILQIIQTPKEPIQVEVDLIAYKEYE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCC
NDKMNALLQVLREKVRHLANLDGHFPPDLLKSIEENHEPNRIVDLIASAMRLSTQQAYTL
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEE
FAKDDVEERVLGLIEYIIEEIEAQKLQKEIKNKVHNKMEQVNKEYFLKEQLKQIQKELGT
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DNTRDEEMEQYTQKLNSLKPYMSENAFKEVQKQIKRLSRMHQDSGDANILQNYVEWVLEI
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
PFGQYANQKLSIENVAKQLDIDHYSLQKPKERIVEYFAVKELMAQRTQNTQGVTSKPKRG
CCCHHCCCCCCHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
KKSKTENTDKYEKGTILCFYGPPGVGKTSLANSIAKAIKRELVRIALGGLEDVNELRGHR
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCH
RTYIGAMPGRITQGLIEAKEMNPVIVLDEIDKVGRSYRGDPTSVLLEILDPEQNHAFRDY
HHEECCCCCHHHHHHHHHHHCCCEEEEECHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHH
YTNFDIDLSQVIFIATANDISTIPAPLRDRMEFIAVSSYTPQEKFEIAKKYLIPQELKKH
CCCCCCCHHHEEEEEECCCCCCCCCCHHHHHHHHEECCCCCHHHHHHHHHHCCHHHHHHC
GLKPEELKISTPTLKLIIEKYTREAGVRNLRHKIAQIMRKVATIILKGEKSITLTPQNLG
CCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECHHHHH
QFLDKIVFEISPTDKKNMVGIVNGLAWTSVGGDVLKIEAVKIKGKGILTLTGSLGDVMKE
HHHHHHHHHCCCCCCCCHHHHHHCHHHHCCCCCEEEEEEEEEECCEEEEEECCHHHHHHH
SAHIAHSVVKVLLDKKILKHSAKAPIYQHYDIHLHVPEGATPKDGPSAGIAMACVIASIL
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
TDSKIDTSVAMTGELTLRGNVLPIGGLREKLIAAHKAGIKTALIPQKNYERDLKDIPQEV
HCCCCCCCEEEEEEEEEECCEEECCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
LKKLKIIGVSDIKEVLDMALVK
HHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA