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The map label for this gene is cfrA

Identifier: 32266220

GI number: 32266220

Start: 699209

End: 701395

Strand: Direct

Name: cfrA

Synonym: HH0721

Alternate gene names: 32266220

Gene position: 699209-701395 (Clockwise)

Preceding gene: 32266210

Following gene: 32266221

Centisome position: 38.86

GC content: 37.63

Gene sequence:

>2187_bases
ATGATAACGATAAGTAGAATATTAATATGTGGAGGGGTAACCTGCTGTCTATGTCTTTTTGGATATGCCGATGAGATAGG
CAATGAAACTTTTTCGGATACGACAGAATCTACAAAAGAAAAGTCATCTTCAAGTGCAACGCGCAATGTCAAATTACAAA
AATCTATCGTTACTGCTGCTTCAGGGAGTGAGAAAAATGTAATTGATGCTCCAGCATCTGTAAATATTATTACCAAAGAA
GAATTAGAGCAAAAACCTTATAGAGACTTAGGCGAAGCTCTCAAAGAAGTGCCCGGCGTGAGCCTTGATGAAACCTCCAA
CAAACTCGGTGCTTCTGCTATTTCTATTCGTGGTATGCCTTCAGGTTATACACTTTTTTTAGTTGATGGCTTAAGGCAAA
ATCCTAGCGGCGATGTAGCTACTGCAAATTTAGGTGCTGGTGTGTATAACACTTTTATCCCTCCAATGGGTGCTATTGAG
CGTATTGAAGTTATCAAGGGACCTATGAGCACACTCTATGGAAGTGATGCGATAGGGGGTGTTGTAAATATCATCACTAA
ACCTATTACAGATAAATGGCACACTTCTTTTCAATCTCAAATCATTGTGCCCCAATCCTCTACTTTTGGTAATACTTATC
AAAACTCACTTTGGACACAAGGTGGGCTTACAAAACACTTAGGGCTAACTTTTAGGGTGCGTCAAATTCATAAAAATCCA
AGCGATAGACCCAAAAATGATTTAGGGCAAGATGTTTCTACTTTTTTTGGCACAAAATTTTCATTACTTAATGTCGGCAC
AAGGCTCACTTGGCTACCTGATAGTAAAAATATGCTCTATGCCGATGTAGATTACACAACATCAAACTATGATAATCGCA
AAGGAGAAATAGGAACACTTGGTGTAGATGTTAACGGGAGAGGAGGCTATGAAAAAAATGTGGGTGTAGATAAGATTCTC
GGGGCTATTGGACATAAAGGCTCTTATGATTTTGGGACTTGGAAAAATACCCTGCAATTTATGCGAACAAACAATACGGG
AAGACTTGTAGCAGGCAATACTAACTCTCCAAATATTGGTAAAAATAGAGATATTGCTTCTAATGATGTGATCGCCGACA
CGCGACTTTTGCTTCCTTTAGGAGAAAGCAATATTTTAAATGTCGGCGCAGAATATCGCTTTGAGAATTATTACGATTTA
GCTGCTACTCCTGCAAGTCATAATCGCCATACTTTCGCACTTTTTGCTGAAGATGAATATAATATCTTTGAACCGCTTAC
TTTTACTCTCGGAGCGAGGTATAATCATAATGATAAGTTTGGCTCAAATATCAGTCCGCGCGCATATCTTGTATATGAGA
TTCTTGATGGTTTTGCTCTTAAAGGCGGAGTAGCCACAGGATATAAAGCTCCTTATGCCAATCAACTCATTGACGCGGTA
TATGGCTATGGAAGTCAAGGCACACTTGCTTTTTTAGGTAATCCAAACCTTAAACCAGAAACTTCAGTGAGCTATGAAAT
AGGCACTATTTTTGATGGGAGATATATTGATTTTTCTTTAATGTTTTTCCGCTCAAATTTTAAAGACAAAATTGAAAACA
CAAGGGTGAATAAAAATGCAAATGGTGCTTTTTATGAAATTACTTGCCAAAATTACGGAGGAACAAATACTCAATGTAAT
CTCGCTATTAATGCAGATAGTGCATTTTCTCAAGGTGTAGAATCTAGCTTTGGCATTAAACCCATTTATGGCGTAGGATT
TGATGTGGCTTATACCTTTGTGGATTCTGAAATTACTTCAGGAAGCAATAAAGGCAGACCTCTTTCAAGTGTGGCAAAGC
ACAACATCGTGTCTAAGCTTATCTTTACACATAAGAAATTCCATCTTTATGTGCAAGGGCAACACAAAGCAGGGTTGCTT
AACACAAATGCATTAGGCAATACACCAGATGCCATAGCAATTAGAAATATACTTGGTGGCACATACTACAAACCTTATAC
GATTGTTAATCTCGGTTTAGGTTATAAAATTACAGAATCTATCCGCTTAAATGGTGGTGTGTATAATCTCTTTGATACAA
ATTTTATTGATTTTAGGAATTATAGTGCTAGTGGCAATGTCAATATGCACGGAGCTTATATTCAAGAGGGGCGCAGATAT
TGGGCAAATATCACACTTGATTTTTAA

Upstream 100 bases:

>100_bases
TCTTTACATTTTAGTGATTATTCCTATAATAAATTTTATTTTAAGTTTTGTATGCTAAAATCTCACTTCACAAAAAATAA
TTTGCATAAAAGGGGATAAA

Downstream 100 bases:

>100_bases
ACTATTCAAGTTTAGTTTAATCTTTGAGAATATATAATTCTTGCAAATTATCTAATGATTCGTGATAATTTACCTATATA
ATACTTACAGGAGTTTAAAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 728; Mature: 728

Protein sequence:

>728_residues
MITISRILICGGVTCCLCLFGYADEIGNETFSDTTESTKEKSSSSATRNVKLQKSIVTAASGSEKNVIDAPASVNIITKE
ELEQKPYRDLGEALKEVPGVSLDETSNKLGASAISIRGMPSGYTLFLVDGLRQNPSGDVATANLGAGVYNTFIPPMGAIE
RIEVIKGPMSTLYGSDAIGGVVNIITKPITDKWHTSFQSQIIVPQSSTFGNTYQNSLWTQGGLTKHLGLTFRVRQIHKNP
SDRPKNDLGQDVSTFFGTKFSLLNVGTRLTWLPDSKNMLYADVDYTTSNYDNRKGEIGTLGVDVNGRGGYEKNVGVDKIL
GAIGHKGSYDFGTWKNTLQFMRTNNTGRLVAGNTNSPNIGKNRDIASNDVIADTRLLLPLGESNILNVGAEYRFENYYDL
AATPASHNRHTFALFAEDEYNIFEPLTFTLGARYNHNDKFGSNISPRAYLVYEILDGFALKGGVATGYKAPYANQLIDAV
YGYGSQGTLAFLGNPNLKPETSVSYEIGTIFDGRYIDFSLMFFRSNFKDKIENTRVNKNANGAFYEITCQNYGGTNTQCN
LAINADSAFSQGVESSFGIKPIYGVGFDVAYTFVDSEITSGSNKGRPLSSVAKHNIVSKLIFTHKKFHLYVQGQHKAGLL
NTNALGNTPDAIAIRNILGGTYYKPYTIVNLGLGYKITESIRLNGGVYNLFDTNFIDFRNYSASGNVNMHGAYIQEGRRY
WANITLDF

Sequences:

>Translated_728_residues
MITISRILICGGVTCCLCLFGYADEIGNETFSDTTESTKEKSSSSATRNVKLQKSIVTAASGSEKNVIDAPASVNIITKE
ELEQKPYRDLGEALKEVPGVSLDETSNKLGASAISIRGMPSGYTLFLVDGLRQNPSGDVATANLGAGVYNTFIPPMGAIE
RIEVIKGPMSTLYGSDAIGGVVNIITKPITDKWHTSFQSQIIVPQSSTFGNTYQNSLWTQGGLTKHLGLTFRVRQIHKNP
SDRPKNDLGQDVSTFFGTKFSLLNVGTRLTWLPDSKNMLYADVDYTTSNYDNRKGEIGTLGVDVNGRGGYEKNVGVDKIL
GAIGHKGSYDFGTWKNTLQFMRTNNTGRLVAGNTNSPNIGKNRDIASNDVIADTRLLLPLGESNILNVGAEYRFENYYDL
AATPASHNRHTFALFAEDEYNIFEPLTFTLGARYNHNDKFGSNISPRAYLVYEILDGFALKGGVATGYKAPYANQLIDAV
YGYGSQGTLAFLGNPNLKPETSVSYEIGTIFDGRYIDFSLMFFRSNFKDKIENTRVNKNANGAFYEITCQNYGGTNTQCN
LAINADSAFSQGVESSFGIKPIYGVGFDVAYTFVDSEITSGSNKGRPLSSVAKHNIVSKLIFTHKKFHLYVQGQHKAGLL
NTNALGNTPDAIAIRNILGGTYYKPYTIVNLGLGYKITESIRLNGGVYNLFDTNFIDFRNYSASGNVNMHGAYIQEGRRY
WANITLDF
>Mature_728_residues
MITISRILICGGVTCCLCLFGYADEIGNETFSDTTESTKEKSSSSATRNVKLQKSIVTAASGSEKNVIDAPASVNIITKE
ELEQKPYRDLGEALKEVPGVSLDETSNKLGASAISIRGMPSGYTLFLVDGLRQNPSGDVATANLGAGVYNTFIPPMGAIE
RIEVIKGPMSTLYGSDAIGGVVNIITKPITDKWHTSFQSQIIVPQSSTFGNTYQNSLWTQGGLTKHLGLTFRVRQIHKNP
SDRPKNDLGQDVSTFFGTKFSLLNVGTRLTWLPDSKNMLYADVDYTTSNYDNRKGEIGTLGVDVNGRGGYEKNVGVDKIL
GAIGHKGSYDFGTWKNTLQFMRTNNTGRLVAGNTNSPNIGKNRDIASNDVIADTRLLLPLGESNILNVGAEYRFENYYDL
AATPASHNRHTFALFAEDEYNIFEPLTFTLGARYNHNDKFGSNISPRAYLVYEILDGFALKGGVATGYKAPYANQLIDAV
YGYGSQGTLAFLGNPNLKPETSVSYEIGTIFDGRYIDFSLMFFRSNFKDKIENTRVNKNANGAFYEITCQNYGGTNTQCN
LAINADSAFSQGVESSFGIKPIYGVGFDVAYTFVDSEITSGSNKGRPLSSVAKHNIVSKLIFTHKKFHLYVQGQHKAGLL
NTNALGNTPDAIAIRNILGGTYYKPYTIVNLGLGYKITESIRLNGGVYNLFDTNFIDFRNYSASGNVNMHGAYIQEGRRY
WANITLDF

Specific function: Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=699, Percent_Identity=31.9027181688126, Blast_Score=282, Evalue=5e-77,
Organism=Escherichia coli, GI1786798, Length=758, Percent_Identity=27.7044854881267, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1790405, Length=132, Percent_Identity=34.0909090909091, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1787723, Length=136, Percent_Identity=30.8823529411765, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 79693; Mature: 79693

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITISRILICGGVTCCLCLFGYADEIGNETFSDTTESTKEKSSSSATRNVKLQKSIVTAA
CEEEEEEHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEEEEEHHEEEEC
SGSEKNVIDAPASVNIITKEELEQKPYRDLGEALKEVPGVSLDETSNKLGASAISIRGMP
CCCCCCEEECCCEEEEEEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCC
SGYTLFLVDGLRQNPSGDVATANLGAGVYNTFIPPMGAIERIEVIKGPMSTLYGSDAIGG
CCEEEEEEECCCCCCCCCEEEEECCCCHHHHCCCCCCHHHHHHHHHCCHHHHCCCHHHHH
VVNIITKPITDKWHTSFQSQIIVPQSSTFGNTYQNSLWTQGGLTKHLGLTFRVRQIHKNP
HHHHHHCCCCCHHHCCCCCEEEEECCCCCCCCHHHCCCCCCCCHHHCCCEEEEEEHHCCC
SDRPKNDLGQDVSTFFGTKFSLLNVGTRLTWLPDSKNMLYADVDYTTSNYDNRKGEIGTL
CCCCCHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEE
GVDVNGRGGYEKNVGVDKILGAIGHKGSYDFGTWKNTLQFMRTNNTGRLVAGNTNSPNIG
EEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHEEEEECCCCEEEECCCCCCCCC
KNRDIASNDVIADTRLLLPLGESNILNVGAEYRFENYYDLAATPASHNRHTFALFAEDEY
CCCCCCCCCEEECCEEEEECCCCCEEECCCCCCCCCEEEEECCCCCCCCEEEEEEECCCC
NIFEPLTFTLGARYNHNDKFGSNISPRAYLVYEILDGFALKGGVATGYKAPYANQLIDAV
CCCCCEEEEEECEECCCCCCCCCCCCCCEEEEEHHCCCEECCCCCCCCCCCHHHHHHHHH
YGYGSQGTLAFLGNPNLKPETSVSYEIGTIFDGRYIDFSLMFFRSNFKDKIENTRVNKNA
HCCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCEEEEEEEEEHHCCHHHHHHCCCCCCC
NGAFYEITCQNYGGTNTQCNLAINADSAFSQGVESSFGIKPIYGVGFDVAYTFVDSEITS
CCEEEEEEEECCCCCCCEEEEEECCCHHHHHCCCCCCCCCEEECCCCEEEEEEECCHHCC
GSNKGRPLSSVAKHNIVSKLIFTHKKFHLYVQGQHKAGLLNTNALGNTPDAIAIRNILGG
CCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCEEECCCCCCCCCHHHHHHHHCC
TYYKPYTIVNLGLGYKITESIRLNGGVYNLFDTNFIDFRNYSASGNVNMHGAYIQEGRRY
CCCCCEEEEEECCCEEEEEEEEECCCEEEECCCCEEEEECCCCCCCEEECHHHHHCCCEE
WANITLDF
EEEEEEEC
>Mature Secondary Structure
MITISRILICGGVTCCLCLFGYADEIGNETFSDTTESTKEKSSSSATRNVKLQKSIVTAA
CEEEEEEHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEEEEEHHEEEEC
SGSEKNVIDAPASVNIITKEELEQKPYRDLGEALKEVPGVSLDETSNKLGASAISIRGMP
CCCCCCEEECCCEEEEEEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCC
SGYTLFLVDGLRQNPSGDVATANLGAGVYNTFIPPMGAIERIEVIKGPMSTLYGSDAIGG
CCEEEEEEECCCCCCCCCEEEEECCCCHHHHCCCCCCHHHHHHHHHCCHHHHCCCHHHHH
VVNIITKPITDKWHTSFQSQIIVPQSSTFGNTYQNSLWTQGGLTKHLGLTFRVRQIHKNP
HHHHHHCCCCCHHHCCCCCEEEEECCCCCCCCHHHCCCCCCCCHHHCCCEEEEEEHHCCC
SDRPKNDLGQDVSTFFGTKFSLLNVGTRLTWLPDSKNMLYADVDYTTSNYDNRKGEIGTL
CCCCCHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEE
GVDVNGRGGYEKNVGVDKILGAIGHKGSYDFGTWKNTLQFMRTNNTGRLVAGNTNSPNIG
EEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHEEEEECCCCEEEECCCCCCCCC
KNRDIASNDVIADTRLLLPLGESNILNVGAEYRFENYYDLAATPASHNRHTFALFAEDEY
CCCCCCCCCEEECCEEEEECCCCCEEECCCCCCCCCEEEEECCCCCCCCEEEEEEECCCC
NIFEPLTFTLGARYNHNDKFGSNISPRAYLVYEILDGFALKGGVATGYKAPYANQLIDAV
CCCCCEEEEEECEECCCCCCCCCCCCCCEEEEEHHCCCEECCCCCCCCCCCHHHHHHHHH
YGYGSQGTLAFLGNPNLKPETSVSYEIGTIFDGRYIDFSLMFFRSNFKDKIENTRVNKNA
HCCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCEEEEEEEEEHHCCHHHHHHCCCCCCC
NGAFYEITCQNYGGTNTQCNLAINADSAFSQGVESSFGIKPIYGVGFDVAYTFVDSEITS
CCEEEEEEEECCCCCCCEEEEEECCCHHHHHCCCCCCCCCEEECCCCEEEEEEECCHHCC
GSNKGRPLSSVAKHNIVSKLIFTHKKFHLYVQGQHKAGLLNTNALGNTPDAIAIRNILGG
CCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCEEECCCCCCCCCHHHHHHHHCC
TYYKPYTIVNLGLGYKITESIRLNGGVYNLFDTNFIDFRNYSASGNVNMHGAYIQEGRRY
CCCCCEEEEEECCCEEEEEEEEECCCEEEECCCCEEEEECCCCCCCEEECHHHHHCCCEE
WANITLDF
EEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1406279; 2174861 [H]