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The map label for this gene is guaB

Identifier: 32266201

GI number: 32266201

Start: 682096

End: 683541

Strand: Direct

Name: guaB

Synonym: HH0702

Alternate gene names: 32266201

Gene position: 682096-683541 (Clockwise)

Preceding gene: 32266200

Following gene: 32266202

Centisome position: 37.91

GC content: 38.17

Gene sequence:

>1446_bases
ATGAAAATTAAACAAAAAGCTCTCACATTTGAAGATGTTTTACTTATCCCTGCATATTCCGAAATTCTCCCTCAAGAAGT
TAATACTCAAACTCTTTTAAGCAAAAATATTTCACTTAATGTTCCCCTTGTAAGTGCTGCAATGGATACAGTTACAGAAT
GTCGCACTGCCATTGCTATGGCAAGACTTGGCGGCATTGGTATTATCCACAAAAATATGGATATTGATTCACAAGTAGAA
CAAATCAAACGCGTGAAAAAAAGTGAAAGCGGCGTTATTATTGACCCTATTTATATCCGAGCAAACAACACACTTGCTGA
TGCAAAATCAATTACAGATAATTATAAAATCTCTGGTGTGCCTGTTGTTGATGAATATGGCAAACTCATTGGTATTCTCA
CTAATCGTGATATGCGCTTTGAACAAGATTTAAGTAAATATGTAGGCGATTTAATGACAAAAGATTCCCTAGTTACAGCA
AAAGTAGGCACCACACTTGAGGAAGCAAAAGAGATTATGCACAAAAATAGAATTGAAAAGCTCCCAATTGTTGATGAAAA
CTATATGCTTAAAGGACTTATTACTATTAAAGATATTCAAAAACGTATAGAATACCCTAATTCCTGCAAGGATAGCTTTG
GACGATTAAAGGTTGGCGCAGCTATTGGAGTAAAGCAATTTGAAAGAGCACAAGCACTTGCTGATGCAGGAGCTGATGTG
CTAGTGCTTGATTCTGCACACGGACATTCTATTAATGTTCTTAAAACTTTAGAAAAAATCAAATCCAAGCTCACCATTGA
TATTGTTGTTGGCAATGTCGTTACACCACAAGCCACACAAGATCTTATTAATGCAGGAGCTGATGCAGTAAAAGTAGGTA
TTGGACCGGGTAGTATTTGCACCACTCGCATTGTTGCTGGCGTGGGAATGCCTCAAATTTCAGCTATTGATGATTGCTCT
CAAATAGCCCAAAAACATAAAATCCCTATTATTGCTGATGGCGGTATAAAATATTCAGGAGATATCGCTAAAGCTTTAGC
AGTTGGTGCTTCAAGTGTAATGATAGGAAGTCTTCTTGCGGGCACTGAAGAATCTCCGGGTGATCTTATTATCTATCAAG
GCAGACAATATAAAATTTATCGTGGTATGGGAAGTATAGGTGCAATGACACGAGGAAGCTCGGATAGATATTTCCAAGAG
GGCACAGCGCAAGATAAACTTGTGCCCGAAGGTGTAGAAGGAAGAGTTCCTTATCGCGGAAAAGTAAGTGATGTAATTCA
TCAACTTATCGGTGGATTAAAATCGTCAATGGGCTATCTAGGCAGTAAAGACATTCAATCCTTATGGGAAAGGGCAGAGT
TTGTAGAAATTACCTCTGCTGGGCTTAGAGAATCTCACGTGCATGATGTAGATATCACCAAAGAAGCACCAAATTATCAC
GGCTAA

Upstream 100 bases:

>100_bases
ATGCAGTTTATTGGTGCAAAATTCAAAGAACAGAACATTCTCAATATTGCCTATGGATTAGAAAAAGAAATAAACAATTA
ATTTTATAAAGGAGTAAAAT

Downstream 100 bases:

>100_bases
AAGGAATAAAATGGCAGATTCTAAAAAGCAAAAAATCATTTCGCAAACTAACACCGAAAATAAAAAAAACGAAATAACAC
AAGAAGAAGACTTTGAGGAT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKIKQKALTFEDVLLIPAYSEILPQEVNTQTLLSKNISLNVPLVSAAMDTVTECRTAIAMARLGGIGIIHKNMDIDSQVE
QIKRVKKSESGVIIDPIYIRANNTLADAKSITDNYKISGVPVVDEYGKLIGILTNRDMRFEQDLSKYVGDLMTKDSLVTA
KVGTTLEEAKEIMHKNRIEKLPIVDENYMLKGLITIKDIQKRIEYPNSCKDSFGRLKVGAAIGVKQFERAQALADAGADV
LVLDSAHGHSINVLKTLEKIKSKLTIDIVVGNVVTPQATQDLINAGADAVKVGIGPGSICTTRIVAGVGMPQISAIDDCS
QIAQKHKIPIIADGGIKYSGDIAKALAVGASSVMIGSLLAGTEESPGDLIIYQGRQYKIYRGMGSIGAMTRGSSDRYFQE
GTAQDKLVPEGVEGRVPYRGKVSDVIHQLIGGLKSSMGYLGSKDIQSLWERAEFVEITSAGLRESHVHDVDITKEAPNYH
G

Sequences:

>Translated_481_residues
MKIKQKALTFEDVLLIPAYSEILPQEVNTQTLLSKNISLNVPLVSAAMDTVTECRTAIAMARLGGIGIIHKNMDIDSQVE
QIKRVKKSESGVIIDPIYIRANNTLADAKSITDNYKISGVPVVDEYGKLIGILTNRDMRFEQDLSKYVGDLMTKDSLVTA
KVGTTLEEAKEIMHKNRIEKLPIVDENYMLKGLITIKDIQKRIEYPNSCKDSFGRLKVGAAIGVKQFERAQALADAGADV
LVLDSAHGHSINVLKTLEKIKSKLTIDIVVGNVVTPQATQDLINAGADAVKVGIGPGSICTTRIVAGVGMPQISAIDDCS
QIAQKHKIPIIADGGIKYSGDIAKALAVGASSVMIGSLLAGTEESPGDLIIYQGRQYKIYRGMGSIGAMTRGSSDRYFQE
GTAQDKLVPEGVEGRVPYRGKVSDVIHQLIGGLKSSMGYLGSKDIQSLWERAEFVEITSAGLRESHVHDVDITKEAPNYH
G
>Mature_481_residues
MKIKQKALTFEDVLLIPAYSEILPQEVNTQTLLSKNISLNVPLVSAAMDTVTECRTAIAMARLGGIGIIHKNMDIDSQVE
QIKRVKKSESGVIIDPIYIRANNTLADAKSITDNYKISGVPVVDEYGKLIGILTNRDMRFEQDLSKYVGDLMTKDSLVTA
KVGTTLEEAKEIMHKNRIEKLPIVDENYMLKGLITIKDIQKRIEYPNSCKDSFGRLKVGAAIGVKQFERAQALADAGADV
LVLDSAHGHSINVLKTLEKIKSKLTIDIVVGNVVTPQATQDLINAGADAVKVGIGPGSICTTRIVAGVGMPQISAIDDCS
QIAQKHKIPIIADGGIKYSGDIAKALAVGASSVMIGSLLAGTEESPGDLIIYQGRQYKIYRGMGSIGAMTRGSSDRYFQE
GTAQDKLVPEGVEGRVPYRGKVSDVIHQLIGGLKSSMGYLGSKDIQSLWERAEFVEITSAGLRESHVHDVDITKEAPNYH
G

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=480, Percent_Identity=40.2083333333333, Blast_Score=324, Evalue=9e-89,
Organism=Homo sapiens, GI217035146, Length=453, Percent_Identity=39.7350993377483, Blast_Score=318, Evalue=8e-87,
Organism=Homo sapiens, GI34328928, Length=453, Percent_Identity=39.7350993377483, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI34328930, Length=453, Percent_Identity=39.7350993377483, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI156616279, Length=453, Percent_Identity=39.7350993377483, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI217035152, Length=449, Percent_Identity=39.6436525612472, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI217035148, Length=453, Percent_Identity=39.2935982339956, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI217035150, Length=453, Percent_Identity=37.3068432671082, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI50541956, Length=258, Percent_Identity=36.8217054263566, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541954, Length=258, Percent_Identity=36.8217054263566, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541952, Length=258, Percent_Identity=36.8217054263566, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI50541948, Length=258, Percent_Identity=36.8217054263566, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI156104880, Length=244, Percent_Identity=36.4754098360656, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1788855, Length=484, Percent_Identity=54.9586776859504, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1786293, Length=345, Percent_Identity=30.7246376811594, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=34.8547717842324, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=36.0655737704918, Blast_Score=238, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17560440, Length=251, Percent_Identity=36.2549800796813, Blast_Score=169, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322012, Length=482, Percent_Identity=39.8340248962656, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6323464, Length=482, Percent_Identity=41.49377593361, Blast_Score=320, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6323585, Length=482, Percent_Identity=39.6265560165975, Blast_Score=317, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6319352, Length=337, Percent_Identity=40.0593471810089, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=43.2203389830509, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=38.8773388773389, Blast_Score=308, Evalue=8e-84,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=38.8773388773389, Blast_Score=308, Evalue=8e-84,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=39.1799544419134, Blast_Score=273, Evalue=2e-73,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52035; Mature: 52035

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKQKALTFEDVLLIPAYSEILPQEVNTQTLLSKNISLNVPLVSAAMDTVTECRTAIAM
CCCHHHHCCHHHEEEECCHHHHCCCCCCHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHH
ARLGGIGIIHKNMDIDSQVEQIKRVKKSESGVIIDPIYIRANNTLADAKSITDNYKISGV
HHHCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHCCCCCEECCC
PVVDEYGKLIGILTNRDMRFEQDLSKYVGDLMTKDSLVTAKVGTTLEEAKEIMHKNRIEK
CCHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHHHCCCC
LPIVDENYMLKGLITIKDIQKRIEYPNSCKDSFGRLKVGAAIGVKQFERAQALADAGADV
CCCCCCCCEEEEEEHHHHHHHHCCCCCCHHHHHCCEEECHHHHHHHHHHHHHHHHCCCCE
LVLDSAHGHSINVLKTLEKIKSKLTIDIVVGNVVTPQATQDLINAGADAVKVGIGPGSIC
EEEECCCCCCHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHH
TTRIVAGVGMPQISAIDDCSQIAQKHKIPIIADGGIKYSGDIAKALAVGASSVMIGSLLA
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHHC
GTEESPGDLIIYQGRQYKIYRGMGSIGAMTRGSSDRYFQEGTAQDKLVPEGVEGRVPYRG
CCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCC
KVSDVIHQLIGGLKSSMGYLGSKDIQSLWERAEFVEITSAGLRESHVHDVDITKEAPNYH
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
G
C
>Mature Secondary Structure
MKIKQKALTFEDVLLIPAYSEILPQEVNTQTLLSKNISLNVPLVSAAMDTVTECRTAIAM
CCCHHHHCCHHHEEEECCHHHHCCCCCCHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHH
ARLGGIGIIHKNMDIDSQVEQIKRVKKSESGVIIDPIYIRANNTLADAKSITDNYKISGV
HHHCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHCCCCCEECCC
PVVDEYGKLIGILTNRDMRFEQDLSKYVGDLMTKDSLVTAKVGTTLEEAKEIMHKNRIEK
CCHHHHCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHHHCCCC
LPIVDENYMLKGLITIKDIQKRIEYPNSCKDSFGRLKVGAAIGVKQFERAQALADAGADV
CCCCCCCCEEEEEEHHHHHHHHCCCCCCHHHHHCCEEECHHHHHHHHHHHHHHHHCCCCE
LVLDSAHGHSINVLKTLEKIKSKLTIDIVVGNVVTPQATQDLINAGADAVKVGIGPGSIC
EEEECCCCCCHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHH
TTRIVAGVGMPQISAIDDCSQIAQKHKIPIIADGGIKYSGDIAKALAVGASSVMIGSLLA
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHHC
GTEESPGDLIIYQGRQYKIYRGMGSIGAMTRGSSDRYFQEGTAQDKLVPEGVEGRVPYRG
CCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCC
KVSDVIHQLIGGLKSSMGYLGSKDIQSLWERAEFVEITSAGLRESHVHDVDITKEAPNYH
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]