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The map label for this gene is metA

Identifier: 32266136

GI number: 32266136

Start: 616198

End: 617079

Strand: Direct

Name: metA

Synonym: HH0637

Alternate gene names: 32266136

Gene position: 616198-617079 (Clockwise)

Preceding gene: 32266135

Following gene: 32266137

Centisome position: 34.25

GC content: 34.01

Gene sequence:

>882_bases
ATGCCACTCATTATCCCAGAAGATATTCCCGCTTATAAATTCCTCAATCAAAATGCTTTTGTTATGGGTTCTCAAAGGGC
AAAACATCAAGATATTAGAGCATTAGAAGTGCTTATTGTTAATCTTATGCCAACAAAAATAGAGACAGAAAATCAGATTC
TCTCTCTTTTGGCTAACTCTCCTTTGCAGATAAATATTACTCTTCTTTCTACATCAAGCTATATTGGCACAAATACACCC
AAAAGCCATTTGGAGCGCTTTTATGTAAATTTTAGCGAAATCAAAGGACGCAATTTTGATGGAGCAATTGTTACAGGAGC
ACCTATTGAACATTTAGCATTTGAGCAAGTAGCTTATTGGAATGAAATCTCCACAATTATGGATTATCTCAAAAAGCATT
GCACAAGCACACTTTATTTGTGCTGGGGAGCAATGGCAAGTTTATATCACTTTCACAAGATTCCAAAAATTTCACTGCCA
CATAAAGTCTTTGGAATCTTTGCACATCATATTATAGAAAATGATTTACTCCTTAGCGGCTTAGATGAAAATATAAGAAT
CCCTCATTCTAGGCATTCAGGCATTGATGATCAAAAGGTAAGAAAATCGCAACTCAAAATCTTACTTGAAAGTGATATAT
GTGGTATTTGCGCACTTAAAGATGACAAAGACTTTTTTATACTTGGACACCCAGAATATGCCAAAAATACGCTTTTACTT
GAATATGAACGTGATAAACAAAAGGGTTTAGAGATTACACAACCTCTGAATTATTTTAATGATAAAGGAGAACCTGTGCT
TTCTTGGAAATCAAGTGCAAGCGTGCTTTTTTCAAATTGGCTCAATTTTTCTGTATATCAAGATACACCTTTTGTTTTAT
AA

Upstream 100 bases:

>100_bases
CAGGTATCACACCTTGCACTATACGCCTTAGCATTGGTTTAGAATCTGCAGATGATTTAATACAAGATTTAAAAAAAGCT
TTAGAAAAATAAGGAAAACT

Downstream 100 bases:

>100_bases
TTAGTTTATATTTTCATAAATAAGGATTTTTATGCAGCAAGATAAACAAAATACACATCAAAAAAACCCAAAAGTGGGAG
AGATTTATGAGCTATGCAAT

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPLIIPEDIPAYKFLNQNAFVMGSQRAKHQDIRALEVLIVNLMPTKIETENQILSLLANSPLQINITLLSTSSYIGTNTP
KSHLERFYVNFSEIKGRNFDGAIVTGAPIEHLAFEQVAYWNEISTIMDYLKKHCTSTLYLCWGAMASLYHFHKIPKISLP
HKVFGIFAHHIIENDLLLSGLDENIRIPHSRHSGIDDQKVRKSQLKILLESDICGICALKDDKDFFILGHPEYAKNTLLL
EYERDKQKGLEITQPLNYFNDKGEPVLSWKSSASVLFSNWLNFSVYQDTPFVL

Sequences:

>Translated_293_residues
MPLIIPEDIPAYKFLNQNAFVMGSQRAKHQDIRALEVLIVNLMPTKIETENQILSLLANSPLQINITLLSTSSYIGTNTP
KSHLERFYVNFSEIKGRNFDGAIVTGAPIEHLAFEQVAYWNEISTIMDYLKKHCTSTLYLCWGAMASLYHFHKIPKISLP
HKVFGIFAHHIIENDLLLSGLDENIRIPHSRHSGIDDQKVRKSQLKILLESDICGICALKDDKDFFILGHPEYAKNTLLL
EYERDKQKGLEITQPLNYFNDKGEPVLSWKSSASVLFSNWLNFSVYQDTPFVL
>Mature_292_residues
PLIIPEDIPAYKFLNQNAFVMGSQRAKHQDIRALEVLIVNLMPTKIETENQILSLLANSPLQINITLLSTSSYIGTNTPK
SHLERFYVNFSEIKGRNFDGAIVTGAPIEHLAFEQVAYWNEISTIMDYLKKHCTSTLYLCWGAMASLYHFHKIPKISLPH
KVFGIFAHHIIENDLLLSGLDENIRIPHSRHSGIDDQKVRKSQLKILLESDICGICALKDDKDFFILGHPEYAKNTLLLE
YERDKQKGLEITQPLNYFNDKGEPVLSWKSSASVLFSNWLNFSVYQDTPFVL

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family [H]

Homologues:

Organism=Escherichia coli, GI1790443, Length=301, Percent_Identity=45.8471760797342, Blast_Score=263, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005697
- ProDom:   PD037892 [H]

Pfam domain/function: PF04204 HTS [H]

EC number: =2.3.1.46 [H]

Molecular weight: Translated: 33480; Mature: 33349

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLIIPEDIPAYKFLNQNAFVMGSQRAKHQDIRALEVLIVNLMPTKIETENQILSLLANS
CCEECCCCCCHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
PLQINITLLSTSSYIGTNTPKSHLERFYVNFSEIKGRNFDGAIVTGAPIEHLAFEQVAYW
CEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHH
NEISTIMDYLKKHCTSTLYLCWGAMASLYHFHKIPKISLPHKVFGIFAHHIIENDLLLSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEC
LDENIRIPHSRHSGIDDQKVRKSQLKILLESDICGICALKDDKDFFILGHPEYAKNTLLL
CCCCCCCCCCCCCCCCHHHHHHHHHHEEEECCCCEEEEEECCCCEEEEECCCHHCCCEEE
EYERDKQKGLEITQPLNYFNDKGEPVLSWKSSASVLFSNWLNFSVYQDTPFVL
EECCCHHCCCCHHCCHHHHCCCCCEEEEECCCHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure 
PLIIPEDIPAYKFLNQNAFVMGSQRAKHQDIRALEVLIVNLMPTKIETENQILSLLANS
CEECCCCCCHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
PLQINITLLSTSSYIGTNTPKSHLERFYVNFSEIKGRNFDGAIVTGAPIEHLAFEQVAYW
CEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHH
NEISTIMDYLKKHCTSTLYLCWGAMASLYHFHKIPKISLPHKVFGIFAHHIIENDLLLSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEC
LDENIRIPHSRHSGIDDQKVRKSQLKILLESDICGICALKDDKDFFILGHPEYAKNTLLL
CCCCCCCCCCCCCCCCHHHHHHHHHHEEEECCCCEEEEEECCCCEEEEECCCHHCCCEEE
EYERDKQKGLEITQPLNYFNDKGEPVLSWKSSASVLFSNWLNFSVYQDTPFVL
EECCCHHCCCCHHCCHHHHCCCCCEEEEECCCHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]