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The map label for this gene is folP

Identifier: 32266120

GI number: 32266120

Start: 598966

End: 600015

Strand: Direct

Name: folP

Synonym: HH0621

Alternate gene names: 32266120

Gene position: 598966-600015 (Clockwise)

Preceding gene: 32266119

Following gene: 32266121

Centisome position: 33.29

GC content: 35.9

Gene sequence:

>1050_bases
ATGAGCAAAAAAGCACATATTTTTGGTTTTGAAATCACTGGCTTAAGCTTTGAAGCAGTCAATATTCTTAAACAAGAAGC
TTTAAGTGTGGGTGGGGATTGTGCTACGCCAAGAGATACTATTGCCCATAAAGGCAAACATATTGCTCTGCTCATTGCCA
CTAGATCTCAACTTGAAAAAATCATTGCAAAACTCTCTATACAACCCTTTGGCTTAAAGACACTTAAAAGCCTTCTTCAA
GGACATCTTAAAACACAATCTGCTGTGCCCTCCCTTATGGCAATTATTAATGCCACGCCTGATAGTTTTTATAAGCATTC
ACAAACAGAAGGAGAACAAGCTATAAAAAGAATAAATACACTTTTAGAAAAAGAAGTAGATATTATTGATATTGGTGCGG
CAAGTTCTCGTCCGGGCAGTGAGTTAATAGAATCTGATGAAGAAATTGCTCGTTTAAAACCCATTGTAGAATATATTGCT
ACACATAAACTCTACGAAAAAGTATGTTTTAGTATTGATACTTATAACCCGCAAACTGCTGATTATGCACTTTCTCGTGG
ATTTAAAATGATTAATGATGTGAGTGGATTCTCTAACGCACAAATGATACAAGTTGCTACAAAATACAATGCCCGAGTAG
TCTTAATGCACACTAAAGGCACACCCGAAACTATGCAAAGCCTCACAGATAGCTACACTCATCTTTTTAATGATATAGAT
TGTTTTTTTGAGCATAAAATTGCTTTATTAAACGATGCAGGCATAACAGATATTATCCTTGATATTGGCTTTGGCTTTGC
TAAAGATACCTCGCAAAATATTGCTCTAATCAAAGATTTGGCACATTTTTTGCACTTTGGATTCCCATTACTTGTTGGAG
CTAGCCGTAAAAATACTATCGGACAAATCACAGGGAAAAAAGTAGAAAATCGATTAGCTGGCACACTTGCGCTACATCTT
TTTGCCTTACAAAATGGAGCAAGTATTTTGCGCATACACGATGAAGATGAGCATATTGATATGCTTAAAATGTATAAGGC
GATGCAATGA

Upstream 100 bases:

>100_bases
AAAAACAAAAGAATAAACAATGATAGTACAGAGAATCTACCCTCAATCTATTCCTCAAAAAATCCAAGCAATAGGCGCAG
ATGCCATAGGACAAAAGATT

Downstream 100 bases:

>100_bases
ATGAACCTAGAGATTTAAAATCCGTTAAGGCATTTTTACTGCGACACGGACATACCAAAGAAGAAATAGAGCGTCTTGAT
AAAGAAAGCGTTATAAATCT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MSKKAHIFGFEITGLSFEAVNILKQEALSVGGDCATPRDTIAHKGKHIALLIATRSQLEKIIAKLSIQPFGLKTLKSLLQ
GHLKTQSAVPSLMAIINATPDSFYKHSQTEGEQAIKRINTLLEKEVDIIDIGAASSRPGSELIESDEEIARLKPIVEYIA
THKLYEKVCFSIDTYNPQTADYALSRGFKMINDVSGFSNAQMIQVATKYNARVVLMHTKGTPETMQSLTDSYTHLFNDID
CFFEHKIALLNDAGITDIILDIGFGFAKDTSQNIALIKDLAHFLHFGFPLLVGASRKNTIGQITGKKVENRLAGTLALHL
FALQNGASILRIHDEDEHIDMLKMYKAMQ

Sequences:

>Translated_349_residues
MSKKAHIFGFEITGLSFEAVNILKQEALSVGGDCATPRDTIAHKGKHIALLIATRSQLEKIIAKLSIQPFGLKTLKSLLQ
GHLKTQSAVPSLMAIINATPDSFYKHSQTEGEQAIKRINTLLEKEVDIIDIGAASSRPGSELIESDEEIARLKPIVEYIA
THKLYEKVCFSIDTYNPQTADYALSRGFKMINDVSGFSNAQMIQVATKYNARVVLMHTKGTPETMQSLTDSYTHLFNDID
CFFEHKIALLNDAGITDIILDIGFGFAKDTSQNIALIKDLAHFLHFGFPLLVGASRKNTIGQITGKKVENRLAGTLALHL
FALQNGASILRIHDEDEHIDMLKMYKAMQ
>Mature_348_residues
SKKAHIFGFEITGLSFEAVNILKQEALSVGGDCATPRDTIAHKGKHIALLIATRSQLEKIIAKLSIQPFGLKTLKSLLQG
HLKTQSAVPSLMAIINATPDSFYKHSQTEGEQAIKRINTLLEKEVDIIDIGAASSRPGSELIESDEEIARLKPIVEYIAT
HKLYEKVCFSIDTYNPQTADYALSRGFKMINDVSGFSNAQMIQVATKYNARVVLMHTKGTPETMQSLTDSYTHLFNDIDC
FFEHKIALLNDAGITDIILDIGFGFAKDTSQNIALIKDLAHFLHFGFPLLVGASRKNTIGQITGKKVENRLAGTLALHLF
ALQNGASILRIHDEDEHIDMLKMYKAMQ

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=261, Percent_Identity=37.1647509578544, Blast_Score=174, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6324073, Length=300, Percent_Identity=29.3333333333333, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 38601; Mature: 38470

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKAHIFGFEITGLSFEAVNILKQEALSVGGDCATPRDTIAHKGKHIALLIATRSQLEK
CCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECHHHHHH
IIAKLSIQPFGLKTLKSLLQGHLKTQSAVPSLMAIINATPDSFYKHSQTEGEQAIKRINT
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHH
LLEKEVDIIDIGAASSRPGSELIESDEEIARLKPIVEYIATHKLYEKVCFSIDTYNPQTA
HHHCCCCEEEECCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DYALSRGFKMINDVSGFSNAQMIQVATKYNARVVLMHTKGTPETMQSLTDSYTHLFNDID
HHHHHCCHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
CFFEHKIALLNDAGITDIILDIGFGFAKDTSQNIALIKDLAHFLHFGFPLLVGASRKNTI
HHHHHHEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHEECCCCCCCH
GQITGKKVENRLAGTLALHLFALQNGASILRIHDEDEHIDMLKMYKAMQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SKKAHIFGFEITGLSFEAVNILKQEALSVGGDCATPRDTIAHKGKHIALLIATRSQLEK
CCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECHHHHHH
IIAKLSIQPFGLKTLKSLLQGHLKTQSAVPSLMAIINATPDSFYKHSQTEGEQAIKRINT
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHH
LLEKEVDIIDIGAASSRPGSELIESDEEIARLKPIVEYIATHKLYEKVCFSIDTYNPQTA
HHHCCCCEEEECCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DYALSRGFKMINDVSGFSNAQMIQVATKYNARVVLMHTKGTPETMQSLTDSYTHLFNDID
HHHHHCCHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
CFFEHKIALLNDAGITDIILDIGFGFAKDTSQNIALIKDLAHFLHFGFPLLVGASRKNTI
HHHHHHEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHEECCCCCCCH
GQITGKKVENRLAGTLALHLFALQNGASILRIHDEDEHIDMLKMYKAMQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]