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The map label for this gene is cadA [H]

Identifier: 32266085

GI number: 32266085

Start: 562622

End: 564709

Strand: Direct

Name: cadA [H]

Synonym: HH0586

Alternate gene names: 32266085

Gene position: 562622-564709 (Clockwise)

Preceding gene: 32266083

Following gene: 32266088

Centisome position: 31.27

GC content: 36.59

Gene sequence:

>2088_bases
ATGAAGCAGCATATTCTTATACTTAAAGGTATTGATTGCGCAAATTGTGCACAGCGCATAGAAGATGCACTCAATGCACT
CCCAAATACAAAAGAAGCTAATATTGATTTTAGCACGAATATGCTTTATATCTATACAGATAATCTCACAAAAGTTATAC
ACACTATCACACATATAGAACCACAAGTGAGCGTATTAGAAACATCTTCATCTTATATCTCTCCACTACAAGAAGATACA
AAACATTCACACGAATTACTCTCTATAAGTATTTTTATAGCCATATTCATCTTTTGTATGGCTGCACTTCATATAGATTC
TCTATATATTCCTCCCATTGTTGCTTATATTTTACTTAGTATAGTTTATATAGGTTCAGGAATACCTATATTTAGCGCAA
CTTGGAGAAATTGCAAAAATAAACTATTTTTTGATGAACACTCCCTTATGCTTTTTGCCACACTCGCAGCATTGTGTATT
GGTGAGATAAGCGAAGCTGTAGCAGTTATGCTTTTTTTTCGTGTAGGTGAATTTTTAGAATCTCTTGCAGTGCAAAAATC
TAAACGCTCTATCAATGCACTTTTGCAAATTATGCCTGATATAGCACACAAAAAGCATAATGACACTTTACAAGACTTGC
ACCCACAAGAATTGAGTGTAGGAGATATTATCGTTATTAAGGTAGGAGAAAAAATCCCCACTGATGGCATAGTGCTTAAA
GGAAAAAGTTATTTAGATATGCGCTCAATTAATGGAGAGAGCGTGCCTGTGAGTATAAATGAGGGGCAAAGTATTATCGC
AGGAGCAATCAATACAACTGCTATGCTTGAAGTGCGCGTAGAAAAACCCTTTAAAGATTCTCATATTGCTAAAATTGCCA
AGCTTACACAGGAAGCAAGCGCAAATAAAGCCAAAACGCAAAAAGTAATTACTTCTTTTGCTCGTATTTATACGCCTATT
ATTTTTTTTCTTTCTCTAAGTCTCGCTCTTATCCCACCTCTTTTTGATGAACAATGGCACGAATGGGTTTATCGCGCACT
TGTAGTAATGATGATAAGCTGTCCTTGTGCACTTGTTATTGCTGTGCCTTTGGGATACTTCGCTGCCATTGGGCAAGCAA
GTGCCAAAGGGATTTTATTTAAAGGCTCAACTTACCTTGAAACCCTTGCTCAAGTAAAAAATATTATCTTTGATAAAACA
GGAACGCTTACGCTTGGCACATTTGAAATTCTTAGTATTGTGCCAAATGAAGGCTACACGCAGCAAGACTTACTTGAAAT
TGCTTCATTAGCAGAACAAAACTCAAATCACCCAATAGCTACTTGTATCAAAAATCACCTTAACACAATGTGCCATATAG
AATCTTATGAGGAAATAAGTGGTAAGGGTGTGCGACTTTTGAGTGATAAAGGCGAGATTCTCGCAGGAAATGCTGCGCTT
ATGCAGGAAAATCATATCTCCTTTACACCTATACATACACCCCATACAACCATATATGTCGCACTTAAAGGAACTTATGT
GGGGCATATCCTTATCGGAGATAAAATTAAAGAGGGAATAAAAGATGATTTAAAAATGCTCAAACACTATGGTATAAAAC
ATTTCGCAATTCTTAGTGGAGATAATCAAACCAATGTAGATTGCCTTGCTAAAGAGCTAGGTATATCTCACGCTTATGGG
AATCTTTTACCCGCACAAAAAGAACAAAAACTAGCTGAATTTATGGAACAATGGCAGGAAAAAATTGCATTTGTGGGTGA
TGGCATTAATGATGCAATAGTGCTTAGACGCAGTGATGTGGGCATAAGTATCAATACCGGAGAAACTAGTAATGATATTA
GCAAAGAAAGTGCGGATATCATTTTACAACATAATTCGCTTCAAGGGCTTGTGCAAGCATTTAAAATCGCTCATCATACA
CGCTCTATTACTTGGCAAAATATTAGCTTTGCACTAGCAAGCAAACTCGTGCTGATTATTTTGAGTATAATGGGCATAGC
AAATATGTGGCTTGCTGTATTTGGTGATGTCGGCATAGCACTTTTAGCACTTTTGAATGCTATGCGCCCTCCACGCTCTA
AAAATTAA

Upstream 100 bases:

>100_bases
TTTTATTCTGTTCTCATTTATTTTATACATATACCCCCTATATGTATATTTACAAATTTATGCCATAATCATATCTATTT
ATAGAATATAAGGATTTTTT

Downstream 100 bases:

>100_bases
GCCTTTGCATTCCAAGTATGTTTTCTTTATTTTTTATTTGTTAATTCCATTACGCATCTGCTCTTTAAAAAACTTTTTAT
CCTATCGTGCAAATTCAACC

Product: cation transport ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MKQHILILKGIDCANCAQRIEDALNALPNTKEANIDFSTNMLYIYTDNLTKVIHTITHIEPQVSVLETSSSYISPLQEDT
KHSHELLSISIFIAIFIFCMAALHIDSLYIPPIVAYILLSIVYIGSGIPIFSATWRNCKNKLFFDEHSLMLFATLAALCI
GEISEAVAVMLFFRVGEFLESLAVQKSKRSINALLQIMPDIAHKKHNDTLQDLHPQELSVGDIIVIKVGEKIPTDGIVLK
GKSYLDMRSINGESVPVSINEGQSIIAGAINTTAMLEVRVEKPFKDSHIAKIAKLTQEASANKAKTQKVITSFARIYTPI
IFFLSLSLALIPPLFDEQWHEWVYRALVVMMISCPCALVIAVPLGYFAAIGQASAKGILFKGSTYLETLAQVKNIIFDKT
GTLTLGTFEILSIVPNEGYTQQDLLEIASLAEQNSNHPIATCIKNHLNTMCHIESYEEISGKGVRLLSDKGEILAGNAAL
MQENHISFTPIHTPHTTIYVALKGTYVGHILIGDKIKEGIKDDLKMLKHYGIKHFAILSGDNQTNVDCLAKELGISHAYG
NLLPAQKEQKLAEFMEQWQEKIAFVGDGINDAIVLRRSDVGISINTGETSNDISKESADIILQHNSLQGLVQAFKIAHHT
RSITWQNISFALASKLVLIILSIMGIANMWLAVFGDVGIALLALLNAMRPPRSKN

Sequences:

>Translated_695_residues
MKQHILILKGIDCANCAQRIEDALNALPNTKEANIDFSTNMLYIYTDNLTKVIHTITHIEPQVSVLETSSSYISPLQEDT
KHSHELLSISIFIAIFIFCMAALHIDSLYIPPIVAYILLSIVYIGSGIPIFSATWRNCKNKLFFDEHSLMLFATLAALCI
GEISEAVAVMLFFRVGEFLESLAVQKSKRSINALLQIMPDIAHKKHNDTLQDLHPQELSVGDIIVIKVGEKIPTDGIVLK
GKSYLDMRSINGESVPVSINEGQSIIAGAINTTAMLEVRVEKPFKDSHIAKIAKLTQEASANKAKTQKVITSFARIYTPI
IFFLSLSLALIPPLFDEQWHEWVYRALVVMMISCPCALVIAVPLGYFAAIGQASAKGILFKGSTYLETLAQVKNIIFDKT
GTLTLGTFEILSIVPNEGYTQQDLLEIASLAEQNSNHPIATCIKNHLNTMCHIESYEEISGKGVRLLSDKGEILAGNAAL
MQENHISFTPIHTPHTTIYVALKGTYVGHILIGDKIKEGIKDDLKMLKHYGIKHFAILSGDNQTNVDCLAKELGISHAYG
NLLPAQKEQKLAEFMEQWQEKIAFVGDGINDAIVLRRSDVGISINTGETSNDISKESADIILQHNSLQGLVQAFKIAHHT
RSITWQNISFALASKLVLIILSIMGIANMWLAVFGDVGIALLALLNAMRPPRSKN
>Mature_695_residues
MKQHILILKGIDCANCAQRIEDALNALPNTKEANIDFSTNMLYIYTDNLTKVIHTITHIEPQVSVLETSSSYISPLQEDT
KHSHELLSISIFIAIFIFCMAALHIDSLYIPPIVAYILLSIVYIGSGIPIFSATWRNCKNKLFFDEHSLMLFATLAALCI
GEISEAVAVMLFFRVGEFLESLAVQKSKRSINALLQIMPDIAHKKHNDTLQDLHPQELSVGDIIVIKVGEKIPTDGIVLK
GKSYLDMRSINGESVPVSINEGQSIIAGAINTTAMLEVRVEKPFKDSHIAKIAKLTQEASANKAKTQKVITSFARIYTPI
IFFLSLSLALIPPLFDEQWHEWVYRALVVMMISCPCALVIAVPLGYFAAIGQASAKGILFKGSTYLETLAQVKNIIFDKT
GTLTLGTFEILSIVPNEGYTQQDLLEIASLAEQNSNHPIATCIKNHLNTMCHIESYEEISGKGVRLLSDKGEILAGNAAL
MQENHISFTPIHTPHTTIYVALKGTYVGHILIGDKIKEGIKDDLKMLKHYGIKHFAILSGDNQTNVDCLAKELGISHAYG
NLLPAQKEQKLAEFMEQWQEKIAFVGDGINDAIVLRRSDVGISINTGETSNDISKESADIILQHNSLQGLVQAFKIAHHT
RSITWQNISFALASKLVLIILSIMGIANMWLAVFGDVGIALLALLNAMRPPRSKN

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=594, Percent_Identity=26.2626262626263, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI115529486, Length=810, Percent_Identity=24.6913580246914, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI55743073, Length=521, Percent_Identity=26.295585412668, Blast_Score=173, Evalue=6e-43,
Organism=Escherichia coli, GI1789879, Length=700, Percent_Identity=30.4285714285714, Blast_Score=315, Evalue=5e-87,
Organism=Escherichia coli, GI1786691, Length=683, Percent_Identity=23.4260614934114, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786914, Length=510, Percent_Identity=25.2941176470588, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17556548, Length=574, Percent_Identity=27.1777003484321, Blast_Score=168, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6320475, Length=545, Percent_Identity=28.9908256880734, Blast_Score=203, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6319772, Length=521, Percent_Identity=25.9117082533589, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI221329854, Length=403, Percent_Identity=27.2952853598015, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 76649; Mature: 76649

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQHILILKGIDCANCAQRIEDALNALPNTKEANIDFSTNMLYIYTDNLTKVIHTITHIE
CCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEECCEEEEEECCHHHHHHHHHHCC
PQVSVLETSSSYISPLQEDTKHSHELLSISIFIAIFIFCMAALHIDSLYIPPIVAYILLS
CCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IVYIGSGIPIFSATWRNCKNKLFFDEHSLMLFATLAALCIGEISEAVAVMLFFRVGEFLE
HHHHCCCCCCHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAVQKSKRSINALLQIMPDIAHKKHNDTLQDLHPQELSVGDIIVIKVGEKIPTDGIVLK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEEEECCCCCCCCEEEC
GKSYLDMRSINGESVPVSINEGQSIIAGAINTTAMLEVRVEKPFKDSHIAKIAKLTQEAS
CCCCEEEECCCCCEEEEEECCCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHC
ANKAKTQKVITSFARIYTPIIFFLSLSLALIPPLFDEQWHEWVYRALVVMMISCPCALVI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHH
AVPLGYFAAIGQASAKGILFKGSTYLETLAQVKNIIFDKTGTLTLGTFEILSIVPNEGYT
HHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEECCEEEHEECCCCCCC
QQDLLEIASLAEQNSNHPIATCIKNHLNTMCHIESYEEISGKGVRLLSDKGEILAGNAAL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCHHHHCCCCEEEECCCCCEEECCHHH
MQENHISFTPIHTPHTTIYVALKGTYVGHILIGDKIKEGIKDDLKMLKHYGIKHFAILSG
EECCCCEECCCCCCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEEEC
DNQTNVDCLAKELGISHAYGNLLPAQKEQKLAEFMEQWQEKIAFVGDGINDAIVLRRSDV
CCCCCHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
GISINTGETSNDISKESADIILQHNSLQGLVQAFKIAHHTRSITWQNISFALASKLVLII
CEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHH
LSIMGIANMWLAVFGDVGIALLALLNAMRPPRSKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKQHILILKGIDCANCAQRIEDALNALPNTKEANIDFSTNMLYIYTDNLTKVIHTITHIE
CCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEECCEEEEEECCHHHHHHHHHHCC
PQVSVLETSSSYISPLQEDTKHSHELLSISIFIAIFIFCMAALHIDSLYIPPIVAYILLS
CCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IVYIGSGIPIFSATWRNCKNKLFFDEHSLMLFATLAALCIGEISEAVAVMLFFRVGEFLE
HHHHCCCCCCHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAVQKSKRSINALLQIMPDIAHKKHNDTLQDLHPQELSVGDIIVIKVGEKIPTDGIVLK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEEEECCCCCCCCEEEC
GKSYLDMRSINGESVPVSINEGQSIIAGAINTTAMLEVRVEKPFKDSHIAKIAKLTQEAS
CCCCEEEECCCCCEEEEEECCCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHC
ANKAKTQKVITSFARIYTPIIFFLSLSLALIPPLFDEQWHEWVYRALVVMMISCPCALVI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHH
AVPLGYFAAIGQASAKGILFKGSTYLETLAQVKNIIFDKTGTLTLGTFEILSIVPNEGYT
HHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEECCEEEHEECCCCCCC
QQDLLEIASLAEQNSNHPIATCIKNHLNTMCHIESYEEISGKGVRLLSDKGEILAGNAAL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCHHHHCCCCEEEECCCCCEEECCHHH
MQENHISFTPIHTPHTTIYVALKGTYVGHILIGDKIKEGIKDDLKMLKHYGIKHFAILSG
EECCCCEECCCCCCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEEEC
DNQTNVDCLAKELGISHAYGNLLPAQKEQKLAEFMEQWQEKIAFVGDGINDAIVLRRSDV
CCCCCHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
GISINTGETSNDISKESADIILQHNSLQGLVQAFKIAHHTRSITWQNISFALASKLVLII
CEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHH
LSIMGIANMWLAVFGDVGIALLALLNAMRPPRSKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]