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The map label for this gene is clpP

Identifier: 32266066

GI number: 32266066

Start: 545690

End: 546280

Strand: Direct

Name: clpP

Synonym: HH0567

Alternate gene names: 32266066

Gene position: 545690-546280 (Clockwise)

Preceding gene: 32266065

Following gene: 32266067

Centisome position: 30.33

GC content: 35.53

Gene sequence:

>591_bases
ATGAGTAGTTATATTCCTTATGTCATTGAACGCACAGGACGCGGTGAGAGAAGCTATGATATTTATTCACGGCTTTTAAA
AGACCGCATAATCTTACTAAGTGGCGAAATTAACGACCATATAGCTTCCTCAATCGTAGCACAACTACTTTTCTTAGAAG
CTGAAGACCCAGAAAAAGATATTAATTTTTATATTAATTCCCCCGGTGGTGTTATCACAAGTGCTTTTAGCATTTATGAC
ACAATGAATTATATCCATTCTGATATTAGCACTATTTGCATTGGACAAGCCGCATCCGCAGGAGCATTTTTGTTAAGCTC
TGGCACAAAAGGAAAACGCTTTTCTCTGCCAAACTCACGGATTATGATTCACCAACCTCTTGGTGGTGCGCAAGGACAAG
CCACAGATATTGAAATACAGGCAAGAGAAATTTTACGATTAAAAAAGATACTTAATGAAATTATGGCTCACAACACAGGA
CAAAAAATTGAAAAAATTACTCAAGATACTGAAAGAGACTTTTTTATGAGCGGAGAAGAAGCTAAAAAATATGGATTAGT
TGATGAAATTTTGACAAAAAGTTTGAAATAA

Upstream 100 bases:

>100_bases
CTATTAAAATGACTATGCTTGAAGATAGAGTATTACACTATTTGCTTGATAAAAAATTTGAAGAAAGCAAGGCAAATACT
AATGCTCAAAAGGATAATCA

Downstream 100 bases:

>100_bases
TGAATATGAAAAGGGAGAGATATGAATTTAGATGAATTAGATTTAGATGGAAACAATGATTTTTTTGGGAATCTTGATGA
TGTAGGTTTAGAAGGCGTTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MSSYIPYVIERTGRGERSYDIYSRLLKDRIILLSGEINDHIASSIVAQLLFLEAEDPEKDINFYINSPGGVITSAFSIYD
TMNYIHSDISTICIGQAASAGAFLLSSGTKGKRFSLPNSRIMIHQPLGGAQGQATDIEIQAREILRLKKILNEIMAHNTG
QKIEKITQDTERDFFMSGEEAKKYGLVDEILTKSLK

Sequences:

>Translated_196_residues
MSSYIPYVIERTGRGERSYDIYSRLLKDRIILLSGEINDHIASSIVAQLLFLEAEDPEKDINFYINSPGGVITSAFSIYD
TMNYIHSDISTICIGQAASAGAFLLSSGTKGKRFSLPNSRIMIHQPLGGAQGQATDIEIQAREILRLKKILNEIMAHNTG
QKIEKITQDTERDFFMSGEEAKKYGLVDEILTKSLK
>Mature_195_residues
SSYIPYVIERTGRGERSYDIYSRLLKDRIILLSGEINDHIASSIVAQLLFLEAEDPEKDINFYINSPGGVITSAFSIYDT
MNYIHSDISTICIGQAASAGAFLLSSGTKGKRFSLPNSRIMIHQPLGGAQGQATDIEIQAREILRLKKILNEIMAHNTGQ
KIEKITQDTERDFFMSGEEAKKYGLVDEILTKSLK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=58.5106382978723, Blast_Score=237, Evalue=6e-63,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=69.4736842105263, Blast_Score=285, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17538017, Length=188, Percent_Identity=56.3829787234042, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI20129427, Length=187, Percent_Identity=56.6844919786096, Blast_Score=231, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_HELHP (Q7VIN7)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860098.1
- ProteinModelPortal:   Q7VIN7
- SMR:   Q7VIN7
- MEROPS:   S14.001
- GeneID:   1493621
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0567
- NMPDR:   fig|235279.1.peg.567
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   PRK00277
- BioCyc:   HHEP235279:HH_0567-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21852; Mature: 21721

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 99-99 ACT_SITE 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSYIPYVIERTGRGERSYDIYSRLLKDRIILLSGEINDHIASSIVAQLLFLEAEDPEKD
CCCCCCHHEECCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCC
INFYINSPGGVITSAFSIYDTMNYIHSDISTICIGQAASAGAFLLSSGTKGKRFSLPNSR
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEECCCCE
IMIHQPLGGAQGQATDIEIQAREILRLKKILNEIMAHNTGQKIEKITQDTERDFFMSGEE
EEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHH
AKKYGLVDEILTKSLK
HHHHCCHHHHHHHCCC
>Mature Secondary Structure 
SSYIPYVIERTGRGERSYDIYSRLLKDRIILLSGEINDHIASSIVAQLLFLEAEDPEKD
CCCCCHHEECCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCC
INFYINSPGGVITSAFSIYDTMNYIHSDISTICIGQAASAGAFLLSSGTKGKRFSLPNSR
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEECCCCE
IMIHQPLGGAQGQATDIEIQAREILRLKKILNEIMAHNTGQKIEKITQDTERDFFMSGEE
EEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHH
AKKYGLVDEILTKSLK
HHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954