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The map label for this gene is frr

Identifier: 32265940

GI number: 32265940

Start: 421749

End: 422306

Strand: Direct

Name: frr

Synonym: HH0441

Alternate gene names: 32265940

Gene position: 421749-422306 (Clockwise)

Preceding gene: 32265939

Following gene: 32265941

Centisome position: 23.44

GC content: 36.02

Gene sequence:

>558_bases
ATGCTTAATGAGATTTTTAAAAATGCTAAGTCCCATATGGATAAGAGCATAGAATCTTTGCGTAGGGATTTTAGCACACT
CCGCAGTGGTAAAGTAAGCGTAAATATCTTAGACAATGTTCGCGTAGATTATTATGGCACGCCCACACCCCTTAATCAAG
TAGGCTCAGTTATTGCACAAGATGCTACAACAATTATCATTACCCCTTGGGAAAAACCGCTAATAAAAGATATTGAAAAA
TCTATTCAAGAAGCAAATATTGGCGTGAATCCAAATAGTGATAGCGAATGTGTCAAGCTCTTTTTTCCTCCTATGACACA
AGAGCAACGCAAAGAAATAGCCAAAAATGCTAGATCTATGGGTGAAAAAGCCAAGGTTGCTATCCGCAATATCCGACAAG
ATGCAAACAATGCTATCAAAAAGCTAGAAAAAGATAAAAGCATTACTGAAGATGAGAATAAAAAAGCACTTGAAGAAATT
CAAAGATATACCGATGAATTTGTCAAAAAATGCGATGAAATGCTCAAACACAAAGAAGAAGAGGTGATGAAAGTATAG

Upstream 100 bases:

>100_bases
AAAACCCTTTTATTCTTAACGAAAATGTTGCTCCCTCTGCCCCACTCTTACAACAAGAGCCTGTTCAAGGACAAAATGAA
AAATAAGTTAAAGGAAAATA

Downstream 100 bases:

>100_bases
CAATGAGTGAAGTTATAGGCATTAAACACAATCAACATATTTATGACCTCTGCACAGCAGATGAACTTGGCATTACTGGG
GATTCTATTAGTTTTGATAA

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MLNEIFKNAKSHMDKSIESLRRDFSTLRSGKVSVNILDNVRVDYYGTPTPLNQVGSVIAQDATTIIITPWEKPLIKDIEK
SIQEANIGVNPNSDSECVKLFFPPMTQEQRKEIAKNARSMGEKAKVAIRNIRQDANNAIKKLEKDKSITEDENKKALEEI
QRYTDEFVKKCDEMLKHKEEEVMKV

Sequences:

>Translated_185_residues
MLNEIFKNAKSHMDKSIESLRRDFSTLRSGKVSVNILDNVRVDYYGTPTPLNQVGSVIAQDATTIIITPWEKPLIKDIEK
SIQEANIGVNPNSDSECVKLFFPPMTQEQRKEIAKNARSMGEKAKVAIRNIRQDANNAIKKLEKDKSITEDENKKALEEI
QRYTDEFVKKCDEMLKHKEEEVMKV
>Mature_185_residues
MLNEIFKNAKSHMDKSIESLRRDFSTLRSGKVSVNILDNVRVDYYGTPTPLNQVGSVIAQDATTIIITPWEKPLIKDIEK
SIQEANIGVNPNSDSECVKLFFPPMTQEQRKEIAKNARSMGEKAKVAIRNIRQDANNAIKKLEKDKSITEDENKKALEEI
QRYTDEFVKKCDEMLKHKEEEVMKV

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Escherichia coli, GI1786368, Length=184, Percent_Identity=39.6739130434783, Blast_Score=165, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24661488, Length=179, Percent_Identity=26.2569832402235, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_HELHP (Q7VJ10)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_859972.1
- ProteinModelPortal:   Q7VJ10
- SMR:   Q7VJ10
- GeneID:   1493495
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0441
- NMPDR:   fig|235279.1.peg.441
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- ProtClustDB:   PRK00083
- BioCyc:   HHEP235279:HH_0441-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 21213; Mature: 21213

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNEIFKNAKSHMDKSIESLRRDFSTLRSGKVSVNILDNVRVDYYGTPTPLNQVGSVIAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCCCHHHHHHHHHC
DATTIIITPWEKPLIKDIEKSIQEANIGVNPNSDSECVKLFFPPMTQEQRKEIAKNARSM
CCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
GEKAKVAIRNIRQDANNAIKKLEKDKSITEDENKKALEEIQRYTDEFVKKCDEMLKHKEE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVMKV
HHHCC
>Mature Secondary Structure
MLNEIFKNAKSHMDKSIESLRRDFSTLRSGKVSVNILDNVRVDYYGTPTPLNQVGSVIAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCCCHHHHHHHHHC
DATTIIITPWEKPLIKDIEKSIQEANIGVNPNSDSECVKLFFPPMTQEQRKEIAKNARSM
CCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
GEKAKVAIRNIRQDANNAIKKLEKDKSITEDENKKALEEIQRYTDEFVKKCDEMLKHKEE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVMKV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954