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The map label for this gene is accC

Identifier: 32265694

GI number: 32265694

Start: 187204

End: 188568

Strand: Direct

Name: accC

Synonym: HH0195

Alternate gene names: 32265694

Gene position: 187204-188568 (Clockwise)

Preceding gene: 32265693

Following gene: 32265695

Centisome position: 10.41

GC content: 39.56

Gene sequence:

>1365_bases
ATGAGTGTAAAACAACGAAAGATTCAAAAGATTCTCATTGCAAATCGTGGTGAGATTGCCCTGCGTGCTATTAGAACAAT
CCAAGAAATGGGCAAAGAGGCTATTGCTATTTACTCCACTGCTGATAAAGACACATATTACCTTGATGTAGCTGATGCAA
AAATTTGTGTAGGCGGAGACAAATCAAGTGAAAGCTACCTCAATATCCCTGCTATAATGAGTGCAGCTGAACTTCTTAAA
GCTGATGCAATTTTTCCGGGTTATGGATTTTTAAGTGAAAATCAAAATTTTGTAGAAATTTGCTCTCATCATAGCATAGA
ATTTATTGGTCCAACAGCTGATGTTATGGTCCTTATGAGTGATAAGTCAAAAGCAAAAGATGTAATGAAGGAAGCAGGTG
TACCTGTGATCTTAGGAAGCGATGGGGCTTTAAAAGATTATAAAGAAGCACAAAAAATCGCCGATGAAATTGGGTATCCC
GTGATTCTCAAAGCTGCAGCAGGTGGTGGTGGAAGAGGTATGCGTGTGGTTGAAAAACCTGAAATGCTAAAGAATCTCTA
CCTTGCAGCAGAATCTGAAGCAGTGAGCGCATTTGGCGATGGCACAATTTATATGGAAAAATTTATCCGCAATCCCAAAC
ATATTGAAGTGCAGATTCTCGCAGATAAGCACGGAAATGTTTTACACATTGGTGAGCGTGATTGTTCTGCACAGAGACGA
CAACAAAAACTTATTGAAGAATCCCCTGCGGTAGTGCTCAAACCTGAAGTGCGTCAAAGACTACTTCAAACTGCTGTCAA
AGCAGCTCAATATATTAAATATGTAGGTGCTGGAACTTTTGAGTTTTTGCTTGATGCAAATTATGAGGATTTTTATTTTA
TGGAGATGAATACGCGTTTGCAAGTAGAACACACTGTGAGCGAAATGGTAAGCGGACTTGACTTAGTAGAGTGGATGATA
CGCATTGCAGAGGGTGAAAAGCTTCCAAGCCAAGAAAGCATTAGTTTTAAAGGGCATTCTATTGAATGTCGCATTACAGC
CGAAGACCCAGAGAAGTTTTATCCTTGCCCGGGAAAAATTACCAAATGGGTAGCGCCCGGTGGAGCAAATGTGCGACTTG
ATACTCACGCTTATGGAGGATATAGTGTGCCAATGCATTATGATTCTATGATTGGCAAACTTATCGTGTGGGGCGAGGAT
AGAAATCAAGCTATCAATCGTATGCACCGCGCTTTAAAGGAATTTTGCATTGAAGGAATTAAGACAACTTTGCCTTTCCA
TATAAAAATGATGAAAAATCAAGATTTCCTTGCTTCCAAGATTCATACTAAGTATCTGGAACAAAATATGCTTGATACAG
AATGA

Upstream 100 bases:

>100_bases
GGAATTTGATTGTAAGGTTGTTTCAATAGAAGTAAATGACGGGCAACCCGTAGAATTTAGCACAAATCTCATTAAAGTTG
AAAAACTCTAAGGTGATATA

Downstream 100 bases:

>100_bases
TTGGGCGGGATAATTTTATAAAGGAGTGAGTATGAAAATCAACGCAAATACAACACAAAAACTCGCCAAAGAGGAAATGA
AAAAAAAAGATATACAAGAA

Product: biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSVKQRKIQKILIANRGEIALRAIRTIQEMGKEAIAIYSTADKDTYYLDVADAKICVGGDKSSESYLNIPAIMSAAELLK
ADAIFPGYGFLSENQNFVEICSHHSIEFIGPTADVMVLMSDKSKAKDVMKEAGVPVILGSDGALKDYKEAQKIADEIGYP
VILKAAAGGGGRGMRVVEKPEMLKNLYLAAESEAVSAFGDGTIYMEKFIRNPKHIEVQILADKHGNVLHIGERDCSAQRR
QQKLIEESPAVVLKPEVRQRLLQTAVKAAQYIKYVGAGTFEFLLDANYEDFYFMEMNTRLQVEHTVSEMVSGLDLVEWMI
RIAEGEKLPSQESISFKGHSIECRITAEDPEKFYPCPGKITKWVAPGGANVRLDTHAYGGYSVPMHYDSMIGKLIVWGED
RNQAINRMHRALKEFCIEGIKTTLPFHIKMMKNQDFLASKIHTKYLEQNMLDTE

Sequences:

>Translated_454_residues
MSVKQRKIQKILIANRGEIALRAIRTIQEMGKEAIAIYSTADKDTYYLDVADAKICVGGDKSSESYLNIPAIMSAAELLK
ADAIFPGYGFLSENQNFVEICSHHSIEFIGPTADVMVLMSDKSKAKDVMKEAGVPVILGSDGALKDYKEAQKIADEIGYP
VILKAAAGGGGRGMRVVEKPEMLKNLYLAAESEAVSAFGDGTIYMEKFIRNPKHIEVQILADKHGNVLHIGERDCSAQRR
QQKLIEESPAVVLKPEVRQRLLQTAVKAAQYIKYVGAGTFEFLLDANYEDFYFMEMNTRLQVEHTVSEMVSGLDLVEWMI
RIAEGEKLPSQESISFKGHSIECRITAEDPEKFYPCPGKITKWVAPGGANVRLDTHAYGGYSVPMHYDSMIGKLIVWGED
RNQAINRMHRALKEFCIEGIKTTLPFHIKMMKNQDFLASKIHTKYLEQNMLDTE
>Mature_453_residues
SVKQRKIQKILIANRGEIALRAIRTIQEMGKEAIAIYSTADKDTYYLDVADAKICVGGDKSSESYLNIPAIMSAAELLKA
DAIFPGYGFLSENQNFVEICSHHSIEFIGPTADVMVLMSDKSKAKDVMKEAGVPVILGSDGALKDYKEAQKIADEIGYPV
ILKAAAGGGGRGMRVVEKPEMLKNLYLAAESEAVSAFGDGTIYMEKFIRNPKHIEVQILADKHGNVLHIGERDCSAQRRQ
QKLIEESPAVVLKPEVRQRLLQTAVKAAQYIKYVGAGTFEFLLDANYEDFYFMEMNTRLQVEHTVSEMVSGLDLVEWMIR
IAEGEKLPSQESISFKGHSIECRITAEDPEKFYPCPGKITKWVAPGGANVRLDTHAYGGYSVPMHYDSMIGKLIVWGEDR
NQAINRMHRALKEFCIEGIKTTLPFHIKMMKNQDFLASKIHTKYLEQNMLDTE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=44.7427293064877, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI65506442, Length=446, Percent_Identity=45.067264573991, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=45.1685393258427, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI295821183, Length=446, Percent_Identity=45.067264573991, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI106049528, Length=451, Percent_Identity=44.3458980044346, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI106049295, Length=451, Percent_Identity=44.3458980044346, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI106049292, Length=451, Percent_Identity=44.3458980044346, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=32.4165029469548, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=32.4165029469548, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=32.4165029469548, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=32.4165029469548, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=32.4165029469548, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI134142062, Length=512, Percent_Identity=30.2734375, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI18105007, Length=270, Percent_Identity=24.0740740740741, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=50.7865168539326, Blast_Score=438, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71987519, Length=444, Percent_Identity=44.5945945945946, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562816, Length=454, Percent_Identity=44.0528634361233, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567343, Length=446, Percent_Identity=42.3766816143498, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71997168, Length=514, Percent_Identity=28.4046692607004, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=514, Percent_Identity=28.4046692607004, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=28.0808080808081, Blast_Score=213, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319685, Length=439, Percent_Identity=40.0911161731207, Blast_Score=342, Evalue=7e-95,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=43.75, Blast_Score=334, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=44.4196428571429, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=34.051724137931, Blast_Score=240, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6324343, Length=517, Percent_Identity=32.1083172147002, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24651757, Length=452, Percent_Identity=44.6902654867257, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI281363050, Length=454, Percent_Identity=43.8325991189427, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652224, Length=454, Percent_Identity=43.8325991189427, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652222, Length=454, Percent_Identity=43.8325991189427, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652220, Length=454, Percent_Identity=43.8325991189427, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652218, Length=454, Percent_Identity=43.8325991189427, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652212, Length=454, Percent_Identity=43.8325991189427, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652210, Length=454, Percent_Identity=43.8325991189427, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652214, Length=454, Percent_Identity=43.8325991189427, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921944, Length=454, Percent_Identity=43.8325991189427, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652216, Length=454, Percent_Identity=43.8325991189427, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24651759, Length=407, Percent_Identity=44.2260442260442, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24586458, Length=505, Percent_Identity=32.2772277227723, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI161076409, Length=505, Percent_Identity=32.2772277227723, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI161076407, Length=505, Percent_Identity=32.2772277227723, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24586460, Length=505, Percent_Identity=32.2772277227723, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50773; Mature: 50642

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKQRKIQKILIANRGEIALRAIRTIQEMGKEAIAIYSTADKDTYYLDVADAKICVGGD
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCEEEECCC
KSSESYLNIPAIMSAAELLKADAIFPGYGFLSENQNFVEICSHHSIEFIGPTADVMVLMS
CCCCCEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCEEEEEEC
DKSKAKDVMKEAGVPVILGSDGALKDYKEAQKIADEIGYPVILKAAAGGGGRGMRVVEKP
CCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCH
EMLKNLYLAAESEAVSAFGDGTIYMEKFIRNPKHIEVQILADKHGNVLHIGERDCSAQRR
HHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHH
QQKLIEESPAVVLKPEVRQRLLQTAVKAAQYIKYVGAGTFEFLLDANYEDFYFMEMNTRL
HHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCEE
QVEHTVSEMVSGLDLVEWMIRIAEGEKLPSQESISFKGHSIECRITAEDPEKFYPCPGKI
EHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEEEEECCCCHHCCCCCCCC
TKWVAPGGANVRLDTHAYGGYSVPMHYDSMIGKLIVWGEDRNQAINRMHRALKEFCIEGI
EEEECCCCCEEEEEEECCCCEECCEEHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHH
KTTLPFHIKMMKNQDFLASKIHTKYLEQNMLDTE
HHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVKQRKIQKILIANRGEIALRAIRTIQEMGKEAIAIYSTADKDTYYLDVADAKICVGGD
CCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCEEEECCC
KSSESYLNIPAIMSAAELLKADAIFPGYGFLSENQNFVEICSHHSIEFIGPTADVMVLMS
CCCCCEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCEEEEEEC
DKSKAKDVMKEAGVPVILGSDGALKDYKEAQKIADEIGYPVILKAAAGGGGRGMRVVEKP
CCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCH
EMLKNLYLAAESEAVSAFGDGTIYMEKFIRNPKHIEVQILADKHGNVLHIGERDCSAQRR
HHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHH
QQKLIEESPAVVLKPEVRQRLLQTAVKAAQYIKYVGAGTFEFLLDANYEDFYFMEMNTRL
HHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCEE
QVEHTVSEMVSGLDLVEWMIRIAEGEKLPSQESISFKGHSIECRITAEDPEKFYPCPGKI
EHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEEEEECCCCHHCCCCCCCC
TKWVAPGGANVRLDTHAYGGYSVPMHYDSMIGKLIVWGEDRNQAINRMHRALKEFCIEGI
EEEECCCCCEEEEEEECCCCEECCEEHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHH
KTTLPFHIKMMKNQDFLASKIHTKYLEQNMLDTE
HHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]