Click here to switch to the map view.

The map label for this gene is accB

Identifier: 32265693

GI number: 32265693

Start: 186721

End: 187194

Strand: Direct

Name: accB

Synonym: HH0194

Alternate gene names: 32265693

Gene position: 186721-187194 (Clockwise)

Preceding gene: 32265690

Following gene: 32265694

Centisome position: 10.38

GC content: 39.03

Gene sequence:

>474_bases
ATGAATTTGCAAGAAATCAAAAAGATTATGGAATTATTTGACAACAGCGGCATAGCTAAATTTAGTATTAAACAAGAGGG
TTTTGAACTCAAACTCCAAAAAGCAGGTGCGTGTGGCTCGGTTACAGCTGTTACTCAAGCACCTATGCAAGTTATTTCTC
AATCTCCTGTGGCAGGAGAATCTGTTCCTACAGCAGTGCCTACACAAACACCTACTCCATCAAAAGATACAAGCGGACAT
TTTATTACTTCGCCAATGGTAGGGACATTTTATCGTTCTCCTAGTCCGGGGGCAGCTCCTTATGTTAATGTCGGCGATAC
CATTAAAAAGGGGCAGACGGTTGCTATTATTGAAGCAATGAAGATTATGAATGAAATTGAAGCGGAATTTGATTGTAAGG
TTGTTTCAATAGAAGTAAATGACGGGCAACCCGTAGAATTTAGCACAAATCTCATTAAAGTTGAAAAACTCTAA

Upstream 100 bases:

>100_bases
ATCCCATTACTATTACCTCACTAATCTTGCAAAAACTTTGTTATCTTAGAAAAATTGTGATATTATAGCAGATTAAATTT
TACAGATGAAAGGTGCAATG

Downstream 100 bases:

>100_bases
GGTGATATAATGAGTGTAAAACAACGAAAGATTCAAAAGATTCTCATTGCAAATCGTGGTGAGATTGCCCTGCGTGCTAT
TAGAACAATCCAAGAAATGG

Product: biotin carboxyl carrier protein

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MNLQEIKKIMELFDNSGIAKFSIKQEGFELKLQKAGACGSVTAVTQAPMQVISQSPVAGESVPTAVPTQTPTPSKDTSGH
FITSPMVGTFYRSPSPGAAPYVNVGDTIKKGQTVAIIEAMKIMNEIEAEFDCKVVSIEVNDGQPVEFSTNLIKVEKL

Sequences:

>Translated_157_residues
MNLQEIKKIMELFDNSGIAKFSIKQEGFELKLQKAGACGSVTAVTQAPMQVISQSPVAGESVPTAVPTQTPTPSKDTSGH
FITSPMVGTFYRSPSPGAAPYVNVGDTIKKGQTVAIIEAMKIMNEIEAEFDCKVVSIEVNDGQPVEFSTNLIKVEKL
>Mature_157_residues
MNLQEIKKIMELFDNSGIAKFSIKQEGFELKLQKAGACGSVTAVTQAPMQVISQSPVAGESVPTAVPTQTPTPSKDTSGH
FITSPMVGTFYRSPSPGAAPYVNVGDTIKKGQTVAIIEAMKIMNEIEAEFDCKVVSIEVNDGQPVEFSTNLIKVEKL

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=156, Percent_Identity=38.4615384615385, Blast_Score=117, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 16822; Mature: 16822

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQEIKKIMELFDNSGIAKFSIKQEGFELKLQKAGACGSVTAVTQAPMQVISQSPVAGE
CCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCC
SVPTAVPTQTPTPSKDTSGHFITSPMVGTFYRSPSPGAAPYVNVGDTIKKGQTVAIIEAM
CCCCCCCCCCCCCCCCCCCCEEECCCEEHEECCCCCCCCCEEECCCCHHCCCEEHHHHHH
KIMNEIEAEFDCKVVSIEVNDGQPVEFSTNLIKVEKL
HHHHHHCCCCCCEEEEEECCCCCCEEEECCEEEEECC
>Mature Secondary Structure
MNLQEIKKIMELFDNSGIAKFSIKQEGFELKLQKAGACGSVTAVTQAPMQVISQSPVAGE
CCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCC
SVPTAVPTQTPTPSKDTSGHFITSPMVGTFYRSPSPGAAPYVNVGDTIKKGQTVAIIEAM
CCCCCCCCCCCCCCCCCCCCEEECCCEEHEECCCCCCCCCEEECCCCHHCCCEEHHHHHH
KIMNEIEAEFDCKVVSIEVNDGQPVEFSTNLIKVEKL
HHHHHHCCCCCCEEEEEECCCCCCEEEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]