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The map label for this gene is hemH [H]

Identifier: 30995475

GI number: 30995475

Start: 1798692

End: 1799564

Strand: Direct

Name: hemH [H]

Synonym: HI1726

Alternate gene names: 30995475

Gene position: 1798692-1799564 (Clockwise)

Preceding gene: 16273611

Following gene: 16273613

Centisome position: 98.28

GC content: 38.37

Gene sequence:

>873_bases
ATGACACAACAACTCCCCATTTTAAGTCTAAAAAAAATCTATTCAGGCAAAGTACGCGATCTCTATGAAATCGATGATAA
ACGCATGCTAATGGTTACTTCTGACCGCTTATCTGCCTTTGATGTTATTTTAGATGATCCCATTCCACGAAAAGGCGAAA
TCCTAACTCAAATTTCCAATTTTTGGTTTAATAAACTTGCTCACATTATGCCCAATCATTTCACTGGCGACAGCGTTTAT
GATGTGTTACCAAAAGAAGAAGCGGATTTAATCAGAGATCGCGCCGTCGTATGTAAACGTTTGAATCCCATTAAAATTGA
ATCTATCGTACGTGGTTATTTAACTGGCAGTGGTTTAAAAGATTACAAACAAACTGGCACGATTTGCGGATTAAAATTGC
CTGAAGGCTTGGTGGAAGCGAGTAAATTACCCGAAGCTATTTTCACGCCATCAAGCAAAGAAGAAGTTGGCAACCACGAT
ATAAATATTAGCTATGCCGAATGCGAAAAACTTATCGGGGCTGATTTAGCCGCACAAGTAAAAGAAAAAGCTATCGCACT
TTATACCGTGGCTGCAGAATATGCACTCACTAAAGGGATTATTATTTGTGACACAAAATTTGAATTTGGTTTAGATGAAA
ATGGCACGCTCACTTTAATGGACGAAGTATTAACGCCAGATTCTAGCCGTTTTTGGTCTGTGGATACTTACCAAGCAGGA
ACAAATCCCCCATCATTCGATAAACAATTTGTGCGCGATTGGTTAGAAAATAGCGGCTGGAATAAACAAGCTCCCGCACC
AAAAGTGCCAGAAAATATTATTCAGAAAACCGTTGATAAATATCAAGAGGCACTGGATTTATTAACAAAATGA

Upstream 100 bases:

>100_bases
ATTTTTATTTCTTTTTAAAAAATAGCAAACGTTTGCTTTATTTGATTTAAAAGTGCGGTACAATACGCGCCAGTTTTTAC
TTTCATACAGGTGCAAAACG

Downstream 100 bases:

>100_bases
AAATTAGGATTTTTTATGCACAAAGCTAAATAAAGATTTTTGCTTTTAATGCACAAAACACTAGACAAAGAGGAAAAGTG
CGGTTATACTCTATAGAATT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MTQQLPILSLKKIYSGKVRDLYEIDDKRMLMVTSDRLSAFDVILDDPIPRKGEILTQISNFWFNKLAHIMPNHFTGDSVY
DVLPKEEADLIRDRAVVCKRLNPIKIESIVRGYLTGSGLKDYKQTGTICGLKLPEGLVEASKLPEAIFTPSSKEEVGNHD
INISYAECEKLIGADLAAQVKEKAIALYTVAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQAG
TNPPSFDKQFVRDWLENSGWNKQAPAPKVPENIIQKTVDKYQEALDLLTK

Sequences:

>Translated_290_residues
MTQQLPILSLKKIYSGKVRDLYEIDDKRMLMVTSDRLSAFDVILDDPIPRKGEILTQISNFWFNKLAHIMPNHFTGDSVY
DVLPKEEADLIRDRAVVCKRLNPIKIESIVRGYLTGSGLKDYKQTGTICGLKLPEGLVEASKLPEAIFTPSSKEEVGNHD
INISYAECEKLIGADLAAQVKEKAIALYTVAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQAG
TNPPSFDKQFVRDWLENSGWNKQAPAPKVPENIIQKTVDKYQEALDLLTK
>Mature_289_residues
TQQLPILSLKKIYSGKVRDLYEIDDKRMLMVTSDRLSAFDVILDDPIPRKGEILTQISNFWFNKLAHIMPNHFTGDSVYD
VLPKEEADLIRDRAVVCKRLNPIKIESIVRGYLTGSGLKDYKQTGTICGLKLPEGLVEASKLPEAIFTPSSKEEVGNHDI
NISYAECEKLIGADLAAQVKEKAIALYTVAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQAGT
NPPSFDKQFVRDWLENSGWNKQAPAPKVPENIIQKTVDKYQEALDLLTK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=287, Percent_Identity=46.6898954703833, Blast_Score=262, Evalue=6e-71,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 32582; Mature: 32450

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQLPILSLKKIYSGKVRDLYEIDDKRMLMVTSDRLSAFDVILDDPIPRKGEILTQISN
CCCCCCHHHHHHHHCCCCHHHHHCCCCEEEEEECCCHHHHHHEECCCCCCCHHHHHHHHH
FWFNKLAHIMPNHFTGDSVYDVLPKEEADLIRDRAVVCKRLNPIKIESIVRGYLTGSGLK
HHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCH
DYKQTGTICGLKLPEGLVEASKLPEAIFTPSSKEEVGNHDINISYAECEKLIGADLAAQV
HHHHCCCEEECCCCHHHHHHHHCCHHHCCCCCHHHCCCCCCEEEHHHHHHHHCCHHHHHH
KEKAIALYTVAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQAG
HHHHHHHHHHHHHHHHHCCEEEEECCEECCCCCCCCEEEEHHHHCCCCCCEEEEECCCCC
TNPPSFDKQFVRDWLENSGWNKQAPAPKVPENIIQKTVDKYQEALDLLTK
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQQLPILSLKKIYSGKVRDLYEIDDKRMLMVTSDRLSAFDVILDDPIPRKGEILTQISN
CCCCCHHHHHHHHCCCCHHHHHCCCCEEEEEECCCHHHHHHEECCCCCCCHHHHHHHHH
FWFNKLAHIMPNHFTGDSVYDVLPKEEADLIRDRAVVCKRLNPIKIESIVRGYLTGSGLK
HHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCH
DYKQTGTICGLKLPEGLVEASKLPEAIFTPSSKEEVGNHDINISYAECEKLIGADLAAQV
HHHHCCCEEECCCCHHHHHHHHCCHHHCCCCCHHHCCCCCCEEEHHHHHHHHCCHHHHHH
KEKAIALYTVAAEYALTKGIIICDTKFEFGLDENGTLTLMDEVLTPDSSRFWSVDTYQAG
HHHHHHHHHHHHHHHHHCCEEEEECCEECCCCCCCCEEEEHHHHCCCCCCEEEEECCCCC
TNPPSFDKQFVRDWLENSGWNKQAPAPKVPENIIQKTVDKYQEALDLLTK
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA