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The map label for this gene is galK [H]

Identifier: 30995403

GI number: 30995403

Start: 869914

End: 871068

Strand: Reverse

Name: galK [H]

Synonym: HI0819

Alternate gene names: 30995403

Gene position: 871068-869914 (Counterclockwise)

Preceding gene: 16272761

Following gene: 16272759

Centisome position: 47.6

GC content: 41.3

Gene sequence:

>1155_bases
ATGACCCCAATCCAAAATGCTCAACAAATTTTCAATAGACAGCATAAAAATTTGCCAGAAATTACCGTCTATGCGCCTGG
CAGAGTAAATATCATCGGCGAACATACCGACTACAACGACGGCTTTGTTATGCCTTGCGCAATTAATTTTGGTACGGCCG
TTTCTGGTACAAAACGAGATGATCATATTTGGAATGTTTATGCTGCAGATCTTGATGAAACTGATGAATTTTCTCTCAAT
GTTGAAATTCCTAAGAGTGAACACAAATGGGCTAATTACGTGCGTGGGGTGGTAAAATTTATCCAAGAACGTTACCCAGA
TTTTCAACAAGGTGCAAATTTAGTGATTTCTGGTAATGTGCCGCTTTCTTCTGGATTAAGTTCATCTGCAGCGTTAGAAG
TTGCGGTGGGTAAATTCTGCCAACAACTTGGCGATTTACCGCTTTCTCACACGGATATTGCATTGAATGGGCAAAAGGCT
GAAAACCAATTTGTCGGTGCTAATTGTGGCAATATGGATCAGTTAATTTCCGCACTTGGGCAGGAAAATCACTTACTGAT
GATCGATTGTCGTAGTCTTGAAACCACGCCAACACCAGTGCCACAAGATGTCGCCGTGATTATTGTGAATTCAAACGTAC
CGCACGATTTAGTAACAGGCGAATACAATACTCGCCGTCAGCAATGTGAAGAGGCAGCAAAATTTTTTGGCGTGAAAGCA
TTACGAGATGTTTCAGTTGAGCAATTCCAAAAAAGAGAAGCGGAATTGACCGCACTTTCTCCGTTAGCAGCAAAACGTGC
TCGTCATGTCGTAACAGAAAATCAACGAGTACTTGATGCAGTGGAAGCATTGAAGAACAATGATTTGACTTGTTTAGGTA
AACTAATGGAAGCATCTCACGATTCAATGCGTGATGATTTTGAAATCACCGTGCCACAAATTGATTATTTAGTTGAATTG
GCTCAACTTGTTATTGGCAAAAGTGGCGGTGCACGTATGACGGGCGGCGGTTTTGGTGGCTGTATTGTCGCACTTGCACC
GCATGATAAAGTCGATTCAGTTCGTAAAATTATTGCGGATAATTACGAGAAAACGACTGGTTTAAAAGAAACTTTTTATG
TGTGTACCGCATCACAAGGTGTTCGAGTGATTTAA

Upstream 100 bases:

>100_bases
CATTATAAAGAAAGAACTAAATAATATAGTCAGTCTCCCTCTTTAGCTTTAGCAAAGAGGGGTGCAGATCGAGTATAGAT
TTAATATAAAGGATAGAAAT

Downstream 100 bases:

>100_bases
GAGAAAATAATGTTAGAACAAACCACTTTTAATGCGCCTGATGGTGCACCTTATCAGCTTATAACCCTGCAAAATGAAAA
TGGGATGCGTGTTCAATTTA

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MTPIQNAQQIFNRQHKNLPEITVYAPGRVNIIGEHTDYNDGFVMPCAINFGTAVSGTKRDDHIWNVYAADLDETDEFSLN
VEIPKSEHKWANYVRGVVKFIQERYPDFQQGANLVISGNVPLSSGLSSSAALEVAVGKFCQQLGDLPLSHTDIALNGQKA
ENQFVGANCGNMDQLISALGQENHLLMIDCRSLETTPTPVPQDVAVIIVNSNVPHDLVTGEYNTRRQQCEEAAKFFGVKA
LRDVSVEQFQKREAELTALSPLAAKRARHVVTENQRVLDAVEALKNNDLTCLGKLMEASHDSMRDDFEITVPQIDYLVEL
AQLVIGKSGGARMTGGGFGGCIVALAPHDKVDSVRKIIADNYEKTTGLKETFYVCTASQGVRVI

Sequences:

>Translated_384_residues
MTPIQNAQQIFNRQHKNLPEITVYAPGRVNIIGEHTDYNDGFVMPCAINFGTAVSGTKRDDHIWNVYAADLDETDEFSLN
VEIPKSEHKWANYVRGVVKFIQERYPDFQQGANLVISGNVPLSSGLSSSAALEVAVGKFCQQLGDLPLSHTDIALNGQKA
ENQFVGANCGNMDQLISALGQENHLLMIDCRSLETTPTPVPQDVAVIIVNSNVPHDLVTGEYNTRRQQCEEAAKFFGVKA
LRDVSVEQFQKREAELTALSPLAAKRARHVVTENQRVLDAVEALKNNDLTCLGKLMEASHDSMRDDFEITVPQIDYLVEL
AQLVIGKSGGARMTGGGFGGCIVALAPHDKVDSVRKIIADNYEKTTGLKETFYVCTASQGVRVI
>Mature_383_residues
TPIQNAQQIFNRQHKNLPEITVYAPGRVNIIGEHTDYNDGFVMPCAINFGTAVSGTKRDDHIWNVYAADLDETDEFSLNV
EIPKSEHKWANYVRGVVKFIQERYPDFQQGANLVISGNVPLSSGLSSSAALEVAVGKFCQQLGDLPLSHTDIALNGQKAE
NQFVGANCGNMDQLISALGQENHLLMIDCRSLETTPTPVPQDVAVIIVNSNVPHDLVTGEYNTRRQQCEEAAKFFGVKAL
RDVSVEQFQKREAELTALSPLAAKRARHVVTENQRVLDAVEALKNNDLTCLGKLMEASHDSMRDDFEITVPQIDYLVELA
QLVIGKSGGARMTGGGFGGCIVALAPHDKVDSVRKIIADNYEKTTGLKETFYVCTASQGVRVI

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=393, Percent_Identity=41.9847328244275, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI48527957, Length=409, Percent_Identity=31.7848410757946, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI4503897, Length=407, Percent_Identity=31.4496314496315, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1786972, Length=382, Percent_Identity=57.5916230366492, Blast_Score=430, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71989053, Length=419, Percent_Identity=27.2076372315036, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320212, Length=246, Percent_Identity=26.8292682926829, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319494, Length=243, Percent_Identity=30.4526748971193, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24661292, Length=441, Percent_Identity=27.437641723356, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21355577, Length=441, Percent_Identity=27.437641723356, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24661285, Length=441, Percent_Identity=27.437641723356, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42132; Mature: 42001

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPIQNAQQIFNRQHKNLPEITVYAPGRVNIIGEHTDYNDGFVMPCAINFGTAVSGTKRD
CCCCCHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCC
DHIWNVYAADLDETDEFSLNVEIPKSEHKWANYVRGVVKFIQERYPDFQQGANLVISGNV
CCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCEEEECCC
PLSSGLSSSAALEVAVGKFCQQLGDLPLSHTDIALNGQKAENQFVGANCGNMDQLISALG
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHC
QENHLLMIDCRSLETTPTPVPQDVAVIIVNSNVPHDLVTGEYNTRRQQCEEAAKFFGVKA
CCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHHH
LRDVSVEQFQKREAELTALSPLAAKRARHVVTENQRVLDAVEALKNNDLTCLGKLMEASH
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCC
DSMRDDFEITVPQIDYLVELAQLVIGKSGGARMTGGGFGGCIVALAPHDKVDSVRKIIAD
CCCCCCCEEECCHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECCCCHHHHHHHHHHC
NYEKTTGLKETFYVCTASQGVRVI
CCHHHCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
TPIQNAQQIFNRQHKNLPEITVYAPGRVNIIGEHTDYNDGFVMPCAINFGTAVSGTKRD
CCCCHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCC
DHIWNVYAADLDETDEFSLNVEIPKSEHKWANYVRGVVKFIQERYPDFQQGANLVISGNV
CCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCEEEECCC
PLSSGLSSSAALEVAVGKFCQQLGDLPLSHTDIALNGQKAENQFVGANCGNMDQLISALG
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHC
QENHLLMIDCRSLETTPTPVPQDVAVIIVNSNVPHDLVTGEYNTRRQQCEEAAKFFGVKA
CCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHHH
LRDVSVEQFQKREAELTALSPLAAKRARHVVTENQRVLDAVEALKNNDLTCLGKLMEASH
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCC
DSMRDDFEITVPQIDYLVELAQLVIGKSGGARMTGGGFGGCIVALAPHDKVDSVRKIIAD
CCCCCCCEEECCHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECCCCHHHHHHHHHHC
NYEKTTGLKETFYVCTASQGVRVI
CCHHHCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA