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The map label for this gene is galM

Identifier: 16272759

GI number: 16272759

Start: 868882

End: 869904

Strand: Reverse

Name: galM

Synonym: HI0818

Alternate gene names: 16272759

Gene position: 869904-868882 (Counterclockwise)

Preceding gene: 30995403

Following gene: 16272758

Centisome position: 47.53

GC content: 39.2

Gene sequence:

>1023_bases
ATGTTAGAACAAACCACTTTTAATGCGCCTGATGGTGCACCTTATCAGCTTATAACCCTGCAAAATGAAAATGGGATGCG
TGTTCAATTTATGGATTGGGGCGCAACTTGGCTTTCTTGTAAAGTGCCAGTAAATGACACATTACGCGAGGTTTTATTGG
GTTGTAAGGTAGATAATTATCCCACTCATCAAAGCTATTTAGGCGCAAGCGTAGGGCGTTATGCAAATCGTATTGCAAAT
GCACAATTTGAATTGAATGGCGAACTTATTAAATTAAGTAGTAATCAAGGTAAACATCAGCTTCATGGTGGAGAGGGCTT
TGATAAACGCCGTTGGAACATTCAAGAGTGCGGTGAGAATTTTGTGTGTTTTTCATTACATTCAGTGGATGGTGATCAAG
GTTTTCCTGGTAATGTGGATGTGTCTGTAACCTATACGCTAACAGGTGATAATAGCGTAAAAATTGAATATGCAGGGATG
TGCGATAAGGATACTGCATTGAACCTAACGAATCATACTTATTTCAATTTAGAAAATGCAGAGCAAGGCAGTGACGTGCG
TGAACATACATTACGTTTAAATGCTGATTTTTATCTGCCTGTAGATAATGAGGGGATTCCTAATTCTCCATTAAAGCACG
TGGTGAATACAAGTTTTGACTTCCGTATTGCTAAACCCATCAAGCAAGATTTTTTACAAGGGGATCAGCAAGCAACAAAG
GGTTACGATCATTCCTTTATTGTCAATAAAGCTTGGCAAAAGCCTTGTGTGTTACTAACCTCTCCAACTGGCGATTTAAG
TTTGGAAGTAAGAACCTCGCAAGCTGCATTGCAGGTTTATACGGGTAATTATCTTGCAGGTACACCAACGAGAAATGGCG
AATTATATGCCGATTTTTCTGGCATAGCACTAGAAACTCAATGTTTACCAGATACGCCAAATCATCCTGAATGGCAAAAT
TACGGCGGAATTCAAAAAGCAGGCGGGCGATATTATCAATGGACAGAGTTTAAATTTAAATAA

Upstream 100 bases:

>100_bases
TAAAATTATTGCGGATAATTACGAGAAAACGACTGGTTTAAAAGAAACTTTTTATGTGTGTACCGCATCACAAGGTGTTC
GAGTGATTTAAGAGAAAATA

Downstream 100 bases:

>100_bases
GCCATTATTTATAATAAAAATGTCATTACAAGATCTATAAATCAGGTTCATTTCTAGCGTTAAAAGCTGTGACGCACCAC
CAGCCTCTTAATCTAATTTA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MLEQTTFNAPDGAPYQLITLQNENGMRVQFMDWGATWLSCKVPVNDTLREVLLGCKVDNYPTHQSYLGASVGRYANRIAN
AQFELNGELIKLSSNQGKHQLHGGEGFDKRRWNIQECGENFVCFSLHSVDGDQGFPGNVDVSVTYTLTGDNSVKIEYAGM
CDKDTALNLTNHTYFNLENAEQGSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFSGIALETQCLPDTPNHPEWQN
YGGIQKAGGRYYQWTEFKFK

Sequences:

>Translated_340_residues
MLEQTTFNAPDGAPYQLITLQNENGMRVQFMDWGATWLSCKVPVNDTLREVLLGCKVDNYPTHQSYLGASVGRYANRIAN
AQFELNGELIKLSSNQGKHQLHGGEGFDKRRWNIQECGENFVCFSLHSVDGDQGFPGNVDVSVTYTLTGDNSVKIEYAGM
CDKDTALNLTNHTYFNLENAEQGSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFSGIALETQCLPDTPNHPEWQN
YGGIQKAGGRYYQWTEFKFK
>Mature_340_residues
MLEQTTFNAPDGAPYQLITLQNENGMRVQFMDWGATWLSCKVPVNDTLREVLLGCKVDNYPTHQSYLGASVGRYANRIAN
AQFELNGELIKLSSNQGKHQLHGGEGFDKRRWNIQECGENFVCFSLHSVDGDQGFPGNVDVSVTYTLTGDNSVKIEYAGM
CDKDTALNLTNHTYFNLENAEQGSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFSGIALETQCLPDTPNHPEWQN
YGGIQKAGGRYYQWTEFKFK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family

Homologues:

Organism=Homo sapiens, GI20270355, Length=324, Percent_Identity=37.037037037037, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1786971, Length=345, Percent_Identity=50.4347826086956, Blast_Score=331, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17557428, Length=331, Percent_Identity=29.607250755287, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI115533334, Length=331, Percent_Identity=29.607250755287, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324399, Length=347, Percent_Identity=27.6657060518732, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322004, Length=357, Percent_Identity=27.7310924369748, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319493, Length=329, Percent_Identity=25.531914893617, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24659048, Length=340, Percent_Identity=35, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24668278, Length=311, Percent_Identity=32.7974276527331, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24583720, Length=317, Percent_Identity=30.9148264984227, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24668282, Length=315, Percent_Identity=29.8412698412698, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24641876, Length=339, Percent_Identity=25.9587020648968, Blast_Score=114, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GALM_HAEIN (P31765)

Other databases:

- EMBL:   L42023
- EMBL:   X65934
- PIR:   C64096
- RefSeq:   NP_438978.1
- ProteinModelPortal:   P31765
- SMR:   P31765
- GeneID:   949661
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0818
- NMPDR:   fig|71421.1.peg.786
- TIGR:   HI_0818
- HOGENOM:   HBG703640
- OMA:   SPNHPDW
- ProtClustDB:   PRK11055
- BioCyc:   HINF71421:HI_0818-MONOMER
- BRENDA:   5.1.3.3
- GO:   GO:0005737
- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718
- Gene3D:   G3DSA:2.70.98.10
- PANTHER:   PTHR10091
- TIGRFAMs:   TIGR02636

Pfam domain/function: PF01263 Aldose_epim; SSF74650 Gal_mut_like

EC number: =5.1.3.3

Molecular weight: Translated: 38103; Mature: 38103

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: ACT_SITE 172-172 ACT_SITE 305-305 BINDING 77-77 BINDING 243-243

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQTTFNAPDGAPYQLITLQNENGMRVQFMDWGATWLSCKVPVNDTLREVLLGCKVDNY
CCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCC
PTHQSYLGASVGRYANRIANAQFELNGELIKLSSNQGKHQLHGGEGFDKRRWNIQECGEN
CCHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCCEEECCCCCCCCCCCCHHHHCCC
FVCFSLHSVDGDQGFPGNVDVSVTYTLTGDNSVKIEYAGMCDKDTALNLTNHTYFNLENA
EEEEEEEECCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCEEEECCCEEEEECCC
EQGSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
CCCCCCCCEEEEECCEEEEECCCCCCCCCHHHHHHCCCCCEEECCHHHHHHHCCCHHHHC
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFS
CCCCEEEEECCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCEEECCCCCCCEEEEECC
GIALETQCLPDTPNHPEWQNYGGIQKAGGRYYQWTEFKFK
CEEEEEEECCCCCCCCCCCCCCCHHHCCCCEEEEEEEEEC
>Mature Secondary Structure
MLEQTTFNAPDGAPYQLITLQNENGMRVQFMDWGATWLSCKVPVNDTLREVLLGCKVDNY
CCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCC
PTHQSYLGASVGRYANRIANAQFELNGELIKLSSNQGKHQLHGGEGFDKRRWNIQECGEN
CCHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCCEEECCCCCCCCCCCCHHHHCCC
FVCFSLHSVDGDQGFPGNVDVSVTYTLTGDNSVKIEYAGMCDKDTALNLTNHTYFNLENA
EEEEEEEECCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCEEEECCCEEEEECCC
EQGSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
CCCCCCCCEEEEECCEEEEECCCCCCCCCHHHHHHCCCCCEEECCHHHHHHHCCCHHHHC
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFS
CCCCEEEEECCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCEEECCCCCCCEEEEECC
GIALETQCLPDTPNHPEWQNYGGIQKAGGRYYQWTEFKFK
CEEEEEEECCCCCCCCCCCCCCCHHHCCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 1282642