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The map label for this gene is ykuU [H]

Identifier: 308513291

GI number: 308513291

Start: 956555

End: 957097

Strand: Reverse

Name: ykuU [H]

Synonym: NA

Alternate gene names: 308513291

Gene position: 957097-956555 (Counterclockwise)

Preceding gene: 39996000

Following gene: 39995996

Centisome position: 25.09

GC content: 63.17

Gene sequence:

>543_bases
ATGGTCCAGAGCGAGCCGGAACGGGCCATGGTGGGTGAGCCGGCCCCGGCGTTCTCGCTTGAGGCGGTGGTCAACAAGGA
GTTCAAGCGGGTCAATCTGGCCGACTACCGGGGCAAGTGGGTGGTTCTCTTCTTCTACCCGGGCGACTTCACCTTTGTCT
GCCCCACCGAGATCAGGGGCTTCAACGCCGCCGTGGACCGTTTCACCGAACTGAACGCTGTCGTGCTCGGCGCCTCAGTG
GACAGCAAGTTCTCTCACTTGGCCTGGATCAACCGGGGCGACCTGGGCGACCTCAAGTTCCCGCTGCTGGCCGACAACAA
GAAGGAAGCCACCATCCGCTACGGTATCCTGGACGAAAAGGAAGGAGTCGCGCTGCGCGGGCTCTTCATCATCGACCCCA
ATGGCGTCCTCCAGTACCAGGTGGTCCAGACCCCGTCGGTGGGCAGGAGCGTGGAGGAGACCATCCGGGTCCTGGAGGCG
CTCCAGACCGGCGAACTCTGCCCCCTGGGCTGGAAGCCGGGCGAGAAGACCATCAAAAAGTAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: thioredoxin peroxidase

Products: an alcohol; H2O; NAD [C]

Alternate protein names: NA

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:
NA

Sequences:

>Translated_180_residues
MVQSEPERAMVGEPAPAFSLEAVVNKEFKRVNLADYRGKWVVLFFYPGDFTFVCPTEIRGFNAAVDRFTELNAVVLGASV
DSKFSHLAWINRGDLGDLKFPLLADNKKEATIRYGILDEKEGVALRGLFIIDPNGVLQYQVVQTPSVGRSVEETIRVLEA
LQTGELCPLGWKPGEKTIKK
>Mature_180_residues
MVQSEPERAMVGEPAPAFSLEAVVNKEFKRVNLADYRGKWVVLFFYPGDFTFVCPTEIRGFNAAVDRFTELNAVVLGASV
DSKFSHLAWINRGDLGDLKFPLLADNKKEATIRYGILDEKEGVALRGLFIIDPNGVLQYQVVQTPSVGRSVEETIRVLEA
LQTGELCPLGWKPGEKTIKK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=179, Percent_Identity=54.7486033519553, Blast_Score=189, Evalue=1e-48,
Organism=Homo sapiens, GI4505591, Length=181, Percent_Identity=50.828729281768, Blast_Score=186, Evalue=7e-48,
Organism=Homo sapiens, GI32455266, Length=181, Percent_Identity=50.828729281768, Blast_Score=186, Evalue=7e-48,
Organism=Homo sapiens, GI32455264, Length=181, Percent_Identity=50.828729281768, Blast_Score=186, Evalue=7e-48,
Organism=Homo sapiens, GI5802974, Length=186, Percent_Identity=50.5376344086022, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI32483377, Length=173, Percent_Identity=53.1791907514451, Blast_Score=180, Evalue=5e-46,
Organism=Homo sapiens, GI5453549, Length=180, Percent_Identity=48.3333333333333, Blast_Score=176, Evalue=7e-45,
Organism=Homo sapiens, GI33188454, Length=85, Percent_Identity=58.8235294117647, Blast_Score=106, Evalue=9e-24,
Organism=Homo sapiens, GI4758638, Length=187, Percent_Identity=31.0160427807487, Blast_Score=81, Evalue=4e-16,
Organism=Escherichia coli, GI1786822, Length=167, Percent_Identity=34.7305389221557, Blast_Score=117, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI193204376, Length=180, Percent_Identity=53.3333333333333, Blast_Score=197, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI32565831, Length=180, Percent_Identity=53.3333333333333, Blast_Score=197, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17554494, Length=172, Percent_Identity=48.8372093023256, Blast_Score=171, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25153706, Length=189, Percent_Identity=26.984126984127, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=179, Percent_Identity=49.1620111731844, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320661, Length=179, Percent_Identity=47.4860335195531, Blast_Score=157, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319407, Length=194, Percent_Identity=30.9278350515464, Blast_Score=95, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17157991, Length=174, Percent_Identity=52.2988505747126, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24641739, Length=174, Percent_Identity=52.2988505747126, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24656348, Length=184, Percent_Identity=50.5434782608696, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17864676, Length=184, Percent_Identity=50.5434782608696, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17738015, Length=189, Percent_Identity=51.3227513227513, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21357347, Length=177, Percent_Identity=44.0677966101695, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17975518, Length=168, Percent_Identity=32.1428571428571, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24652434, Length=168, Percent_Identity=32.1428571428571, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24652436, Length=168, Percent_Identity=32.1428571428571, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24581278, Length=183, Percent_Identity=28.9617486338798, Blast_Score=90, Evalue=8e-19,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: 1.6.4.- [C]

Molecular weight: Translated: 20032; Mature: 20032

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQSEPERAMVGEPAPAFSLEAVVNKEFKRVNLADYRGKWVVLFFYPGDFTFVCPTEIRG
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEEECCHHCCC
FNAAVDRFTELNAVVLGASVDSKFSHLAWINRGDLGDLKFPLLADNKKEATIRYGILDEK
CHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCEECCEEECCCCCEEEEEEEEECC
EGVALRGLFIIDPNGVLQYQVVQTPSVGRSVEETIRVLEALQTGELCPLGWKPGEKTIKK
CCEEEEEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MVQSEPERAMVGEPAPAFSLEAVVNKEFKRVNLADYRGKWVVLFFYPGDFTFVCPTEIRG
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEEECCHHCCC
FNAAVDRFTELNAVVLGASVDSKFSHLAWINRGDLGDLKFPLLADNKKEATIRYGILDEK
CHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCEECCEEECCCCCEEEEEEEEECC
EGVALRGLFIIDPNGVLQYQVVQTPSVGRSVEETIRVLEALQTGELCPLGWKPGEKTIKK
CCEEEEEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ROOH; Proton; NADH [C]

Specific reaction: ROOH + Proton + NADH = an alcohol + H2O + NAD [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]