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The map label for this gene is ech3

Identifier: 304570502

GI number: 304570502

Start: 3180828

End: 3181655

Strand: Direct

Name: ech3

Synonym: NA

Alternate gene names: 304570502

Gene position: 3180828-3181655 (Clockwise)

Preceding gene: 45658464

Following gene: 45658467

Centisome position: 74.37

GC content: 40.1

Gene sequence:

>828_bases
ATGAAAACCCATTTTGAATTTTTTGAAATCGTTCCAAAACCAGAAGACAAAACTGCTATCCTTTATCTCAATAGACCCGA
AAAAAGAAACGCAATGAACTGGCCTTTTTGGAGAGATCTGCCAGATACAATCGAAGAAATTAACTCGAATCCGGATATTC
ATTCGTTTGTGATCGCCGCAAGAGGTAAATCTTTCTCCACCGGTTTAGATCTGGATTCTTTTATCCAACAGTTCGGAAGT
ATAATCCAAGCTCCCTTAGGTAGCGATCGAAGAAAGTTCTTTGATCTCATTTTAAAAATGCAAAAAGGAATCAATGCAGT
TTACGATTCCCCTAAACCTTCCATCGCAGCGGTTCAAAAACATTGTATCGGTGGCGGTTTAGATCTGATCTCCGCCTGCG
ATATTCGTTATGCTACCGTGGACGCGTCTATCTCTCTTAGAGAAGCAAAAGTAGCGATTGTCGCAGATATGGGTTCTATC
AACAGACTTCCTTCTATCATCGGACAAGGTCATACAAGAGAATTGGCCTTAACCGGAAAAGACATAGACGGACCAGAAGC
AGAAAGGATAGGACTTGTTACTAAAGTATTTTCAACCGAAGAAGAAATGATGAACGCAGCTCTTGCAACTGCAAAAGAAA
TCGCTGAAAATCCTAAAATAGTCGTATCCGGAATTAAAGACGTAATGAGATATTCTGAAGGAAAACCGTTAGACGCCGGT
TTAAATTATGTTGCTCTTTGGAATTCTAGCTTTTTAGATTCCGCAGATTTTAGAGGAGCAATGCAATCTTTTCGGGAACG
CAAACGCCCCGTCTATAATCAATCTTAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:
NA

Sequences:

>Translated_275_residues
MKTHFEFFEIVPKPEDKTAILYLNRPEKRNAMNWPFWRDLPDTIEEINSNPDIHSFVIAARGKSFSTGLDLDSFIQQFGS
IIQAPLGSDRRKFFDLILKMQKGINAVYDSPKPSIAAVQKHCIGGGLDLISACDIRYATVDASISLREAKVAIVADMGSI
NRLPSIIGQGHTRELALTGKDIDGPEAERIGLVTKVFSTEEEMMNAALATAKEIAENPKIVVSGIKDVMRYSEGKPLDAG
LNYVALWNSSFLDSADFRGAMQSFRERKRPVYNQS
>Mature_275_residues
MKTHFEFFEIVPKPEDKTAILYLNRPEKRNAMNWPFWRDLPDTIEEINSNPDIHSFVIAARGKSFSTGLDLDSFIQQFGS
IIQAPLGSDRRKFFDLILKMQKGINAVYDSPKPSIAAVQKHCIGGGLDLISACDIRYATVDASISLREAKVAIVADMGSI
NRLPSIIGQGHTRELALTGKDIDGPEAERIGLVTKVFSTEEEMMNAALATAKEIAENPKIVVSGIKDVMRYSEGKPLDAG
LNYVALWNSSFLDSADFRGAMQSFRERKRPVYNQS

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=251, Percent_Identity=41.0358565737052, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI194097323, Length=273, Percent_Identity=27.1062271062271, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=26.3565891472868, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI31542718, Length=258, Percent_Identity=24.8062015503876, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI157694516, Length=218, Percent_Identity=23.394495412844, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI213417737, Length=218, Percent_Identity=23.394495412844, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI221142681, Length=257, Percent_Identity=28.0155642023346, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787659, Length=262, Percent_Identity=25.1908396946565, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790281, Length=187, Percent_Identity=28.3422459893048, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787660, Length=267, Percent_Identity=25.8426966292135, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788682, Length=202, Percent_Identity=27.7227722772277, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082183, Length=261, Percent_Identity=24.5210727969349, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=254, Percent_Identity=33.4645669291339, Blast_Score=170, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17534483, Length=255, Percent_Identity=34.1176470588235, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI25145438, Length=261, Percent_Identity=25.2873563218391, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17554946, Length=256, Percent_Identity=25.390625, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17560910, Length=250, Percent_Identity=25.6, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17540714, Length=212, Percent_Identity=28.7735849056604, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=214, Percent_Identity=26.6355140186916, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25141363, Length=187, Percent_Identity=28.3422459893048, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144276, Length=258, Percent_Identity=25.968992248062, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508953, Length=259, Percent_Identity=25.8687258687259, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508951, Length=258, Percent_Identity=25.968992248062, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920382, Length=253, Percent_Identity=33.596837944664, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI20129971, Length=269, Percent_Identity=25.2788104089219, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653477, Length=269, Percent_Identity=25.2788104089219, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653139, Length=261, Percent_Identity=27.9693486590038, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21357171, Length=212, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583165, Length=227, Percent_Identity=25.5506607929515, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24650670, Length=207, Percent_Identity=23.1884057971014, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19921018, Length=197, Percent_Identity=28.9340101522843, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 30573; Mature: 30573

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHFEFFEIVPKPEDKTAILYLNRPEKRNAMNWPFWRDLPDTIEEINSNPDIHSFVIAA
CCCCCCHHEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHEEEEEE
RGKSFSTGLDLDSFIQQFGSIIQAPLGSDRRKFFDLILKMQKGINAVYDSPKPSIAAVQK
CCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHH
HCIGGGLDLISACDIRYATVDASISLREAKVAIVADMGSINRLPSIIGQGHTRELALTGK
HHCCCCHHHHHHCCEEEEEECCCEEECHHEEEEEECCCCHHHHHHHHCCCCCEEEEEECC
DIDGPEAERIGLVTKVFSTEEEMMNAALATAKEIAENPKIVVSGIKDVMRYSEGKPLDAG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCHHC
LNYVALWNSSFLDSADFRGAMQSFRERKRPVYNQS
CCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKTHFEFFEIVPKPEDKTAILYLNRPEKRNAMNWPFWRDLPDTIEEINSNPDIHSFVIAA
CCCCCCHHEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHEEEEEE
RGKSFSTGLDLDSFIQQFGSIIQAPLGSDRRKFFDLILKMQKGINAVYDSPKPSIAAVQK
CCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHH
HCIGGGLDLISACDIRYATVDASISLREAKVAIVADMGSINRLPSIIGQGHTRELALTGK
HHCCCCHHHHHHCCEEEEEECCCEEECHHEEEEEECCCCHHHHHHHHCCCCCEEEEEECC
DIDGPEAERIGLVTKVFSTEEEMMNAALATAKEIAENPKIVVSGIKDVMRYSEGKPLDAG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCHHC
LNYVALWNSSFLDSADFRGAMQSFRERKRPVYNQS
CCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA