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The map label for this gene is thyX

Identifier: 304570497

GI number: 304570497

Start: 2695022

End: 2696596

Strand: Direct

Name: thyX

Synonym: NA

Alternate gene names: 304570497

Gene position: 2695022-2696596 (Clockwise)

Preceding gene: 45658077

Following gene: 45658083

Centisome position: 63.01

GC content: 38.22

Gene sequence:

>1575_bases
ATGCCAGCCCAAAAACCAATCGTTTCACTTCTAGATCATAGTAAAGATCCATTCAATCTATCTATAGCCACTGCAAGAAC
CTGTTATTCTTCTAAAGGTATCCTTCTTCCTTCCGATATGATCACTTCGGAAAAGTCGATAGAGATCCGAGATAAAGTCG
CCAAATCCACTAAAAAAGCGGGACATCTTACCACTCGTCAACATCCACAGTTTATATTTACGTTGGACAAAGTATCCAGA
CAATTCGTTTGGTCTTTTCTACATTCACATCCATTTTATAATTCCGAACAAGTTTCTCAAAGATACGTGGAAGTAAAAAA
AGAGAATTACTACATCCCACCCGAACTCGACGGAAAACTTTTAGAACTTTATTTAGATGCCGTAGACTTTGCAAGTCAGT
CTTACTTTTCTTACACGGAAGCGTTACATCCTTTTATCCAAGAAGAATACTTTCAGATTTATAAGGCCCGTGCCAACTAT
CCAGACAAGTGGCAAACTCCAATCAAAAAGAAATGTTTGGAAGTAGCACGTTATCTGCTACCTCTAGGAACATTTACATA
TCTATATCACTCCGTTAACGGACTTACTCTACATCGTTACTATAGATTGATGAATTCCTACGACGTTCCAAACGAACAAA
GAGCCGTTATTACGGAAATGATCAATCAAGTTCGAGCAATCGATCCTTTATACGCCGACGAAATGGACGATCCGGTTCCT
CTCGAAGAAACCACAGAATATCGTTATTTCGACTCCATGTTTGGAAATGGTAAGAGAGAATTTCATCCGGAAACCGCTTC
TACTTTTGTAAAAGAATTTGATTTGGAGTTAGGAGAAAGATATTCTAAACTAGTCTCTCATTCTTCCAACGGCCCTGAAA
TTTTAGCTCAATCGGTTCGCTCTATATTAGGAATTCCTAAATCAATTCTTAACGACCAAGACGCAATTGATTTGGTTTTA
AATCCCGCAAAGAACAGACATCTTACTTCTACTTTGAATGAAAGTTCCATGAGTCCGATTACAAGGGCGCTTTTTAACGT
TCAGTATTCTTTTCAAAAAAGAATCTCCCATACTGCAGACAGTCAAGATCAAAGACATAGAATGGTTCCTGGAGGAAGAC
CTGTTTTAATGTCTCAATATGCAGGTATTCCTGATTATATAACCCCTTTTGTAGTTCAAAAATATCCTGAACTCAAAGAA
AAATACGACGTAGTTCATAGAGAAATTTTTGAAAAACTAAATCGTTTTTTAGAAGCGGGAGGTTCCCCCGAACACGGAAC
GTATCTTTTGCCGAATAGTTTTCCAATTCGTTTTTACGAAAGTGGAGACCTACTCAACCTTCATCATAAATGGAGATCTA
GAACTTGTTATAACGCTCAGGAAGAAATTTTTCAAGCCTCAGTAGATGAATTGACGGACGTAATGAAAGTCCACCCTCAG
ATAGCAAAATGGATCAAAGCACCTTGTTGGATACGTTTACAAGGAGAAGTCAAACCTTATTGTCCAGAAGGAGATCACTA
CTGTGGAACTCAGGTTTGGAAAAGAGAGTTGTCCGAATATTCCAGAGTGATTTAG

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:
NA

Sequences:

>Translated_524_residues
MPAQKPIVSLLDHSKDPFNLSIATARTCYSSKGILLPSDMITSEKSIEIRDKVAKSTKKAGHLTTRQHPQFIFTLDKVSR
QFVWSFLHSHPFYNSEQVSQRYVEVKKENYYIPPELDGKLLELYLDAVDFASQSYFSYTEALHPFIQEEYFQIYKARANY
PDKWQTPIKKKCLEVARYLLPLGTFTYLYHSVNGLTLHRYYRLMNSYDVPNEQRAVITEMINQVRAIDPLYADEMDDPVP
LEETTEYRYFDSMFGNGKREFHPETASTFVKEFDLELGERYSKLVSHSSNGPEILAQSVRSILGIPKSILNDQDAIDLVL
NPAKNRHLTSTLNESSMSPITRALFNVQYSFQKRISHTADSQDQRHRMVPGGRPVLMSQYAGIPDYITPFVVQKYPELKE
KYDVVHREIFEKLNRFLEAGGSPEHGTYLLPNSFPIRFYESGDLLNLHHKWRSRTCYNAQEEIFQASVDELTDVMKVHPQ
IAKWIKAPCWIRLQGEVKPYCPEGDHYCGTQVWKRELSEYSRVI
>Mature_523_residues
PAQKPIVSLLDHSKDPFNLSIATARTCYSSKGILLPSDMITSEKSIEIRDKVAKSTKKAGHLTTRQHPQFIFTLDKVSRQ
FVWSFLHSHPFYNSEQVSQRYVEVKKENYYIPPELDGKLLELYLDAVDFASQSYFSYTEALHPFIQEEYFQIYKARANYP
DKWQTPIKKKCLEVARYLLPLGTFTYLYHSVNGLTLHRYYRLMNSYDVPNEQRAVITEMINQVRAIDPLYADEMDDPVPL
EETTEYRYFDSMFGNGKREFHPETASTFVKEFDLELGERYSKLVSHSSNGPEILAQSVRSILGIPKSILNDQDAIDLVLN
PAKNRHLTSTLNESSMSPITRALFNVQYSFQKRISHTADSQDQRHRMVPGGRPVLMSQYAGIPDYITPFVVQKYPELKEK
YDVVHREIFEKLNRFLEAGGSPEHGTYLLPNSFPIRFYESGDLLNLHHKWRSRTCYNAQEEIFQASVDELTDVMKVHPQI
AKWIKAPCWIRLQGEVKPYCPEGDHYCGTQVWKRELSEYSRVI

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 60924; Mature: 60793

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAQKPIVSLLDHSKDPFNLSIATARTCYSSKGILLPSDMITSEKSIEIRDKVAKSTKKA
CCCCHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHH
GHLTTRQHPQFIFTLDKVSRQFVWSFLHSHPFYNSEQVSQRYVEVKKENYYIPPELDGKL
CCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEECCCCCCHHH
LELYLDAVDFASQSYFSYTEALHPFIQEEYFQIYKARANYPDKWQTPIKKKCLEVARYLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
PLGTFTYLYHSVNGLTLHRYYRLMNSYDVPNEQRAVITEMINQVRAIDPLYADEMDDPVP
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
LEETTEYRYFDSMFGNGKREFHPETASTFVKEFDLELGERYSKLVSHSSNGPEILAQSVR
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SILGIPKSILNDQDAIDLVLNPAKNRHLTSTLNESSMSPITRALFNVQYSFQKRISHTAD
HHHCCCHHHCCCCCCCHHEECCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SQDQRHRMVPGGRPVLMSQYAGIPDYITPFVVQKYPELKEKYDVVHREIFEKLNRFLEAG
CCHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
GSPEHGTYLLPNSFPIRFYESGDLLNLHHKWRSRTCYNAQEEIFQASVDELTDVMKVHPQ
CCCCCCEEECCCCCCEEEECCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IAKWIKAPCWIRLQGEVKPYCPEGDHYCGTQVWKRELSEYSRVI
HHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAQKPIVSLLDHSKDPFNLSIATARTCYSSKGILLPSDMITSEKSIEIRDKVAKSTKKA
CCCHHHHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHH
GHLTTRQHPQFIFTLDKVSRQFVWSFLHSHPFYNSEQVSQRYVEVKKENYYIPPELDGKL
CCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEECCCCCCHHH
LELYLDAVDFASQSYFSYTEALHPFIQEEYFQIYKARANYPDKWQTPIKKKCLEVARYLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
PLGTFTYLYHSVNGLTLHRYYRLMNSYDVPNEQRAVITEMINQVRAIDPLYADEMDDPVP
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
LEETTEYRYFDSMFGNGKREFHPETASTFVKEFDLELGERYSKLVSHSSNGPEILAQSVR
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SILGIPKSILNDQDAIDLVLNPAKNRHLTSTLNESSMSPITRALFNVQYSFQKRISHTAD
HHHCCCHHHCCCCCCCHHEECCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SQDQRHRMVPGGRPVLMSQYAGIPDYITPFVVQKYPELKEKYDVVHREIFEKLNRFLEAG
CCHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
GSPEHGTYLLPNSFPIRFYESGDLLNLHHKWRSRTCYNAQEEIFQASVDELTDVMKVHPQ
CCCCCCEEECCCCCCEEEECCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IAKWIKAPCWIRLQGEVKPYCPEGDHYCGTQVWKRELSEYSRVI
HHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]