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The map label for this gene is loN [H]

Identifier: 30264538

GI number: 30264538

Start: 4276826

End: 4279147

Strand: Reverse

Name: loN [H]

Synonym: BA_4702

Alternate gene names: 30264538

Gene position: 4279147-4276826 (Counterclockwise)

Preceding gene: 30264539

Following gene: 30264537

Centisome position: 81.86

GC content: 39.15

Gene sequence:

>2322_bases
ATGAATACGAATGAAAGAATCGTACCCCTCCTACCATTAAGAGGCGTTCTCGTATATCCAACGATGGTTCTGCATCTTGA
TGTAGGACGTGATAAATCGATACAAGCACTAGAGCAGGCGGCAATGGATGAAAATATCATCTTTTTAGCAATGCAAAAAG
AAATGAATATCGATGATCCGAAAGAAGATGACATATATAGTGTAGGTACAGTGGCGAAAGTGAAGCAAATGTTAAAATTG
CCGAACGGTACGCTTCGTGTCCTTGTAGAAGGTTTACATAGAGCAGAAGTAGTAGAGTTTATCGAAGAAGAAAATGTAGT
GCAAGTTTCTATTAAAACGGTAACTGAAGAAGTGGAAGCTGATTTAGAAGAGAAAGCACTTATGCGTACATTACTGGAGC
ATTTCGAACAATATATTAAAGTTTCGAAAAAAGTTTCAAATGAAACATTTGCAACGGTAGCTGATGTAGAAGAGCCAGGA
AGATTAGTGGATTTAATTGCTTCTCACTTGCCAATTAAAACGAAGCAGAAACAAGAGATTTTAGAAATCATATCTGTGAA
AGAACGATTACATACACTTATTTCAATTATTCAAGATGAACAAGAATTACTTAGTTTAGAAAAGAAAATTGGACAAAAAG
TGAAACGTTCAATGGAGCGCACGCAAAAAGAATATTTCTTGCGTGAGCAAATGAAGGCGATTCAAACTGAACTTGGCGAT
AAAGAAGGCAAGGGCGGGGAAGTTGAAGAACTTCGTGAGAAAATTGAACAGTCAGGAATGCCTGAAGAAACAATGAAGGC
TGCGCTGAAAGAATTAGATCGTTATGAAAAGTTACCAGCAAGTTCTGCGGAGAGCGGTGTTATTCGCAATTATATGGATT
GGTTATTAGCACTTCCGTGGACAGACGCAACGGAAGATATGATTGATCTTGCTCATTCGGAAGAGATTTTAAACAAAGAT
CATTACGGTCTTGAGAAAGTGAAAGAGCGCGTACTGGAATATTTAGCGGTACAGAAGTTAACGAATTCATTAAAAGGGCC
TATCCTTTGTTTAGTAGGGCCACCTGGGGTCGGAAAAACTTCGTTAGCGCGTTCTATTGCGACATCATTAAATCGTAATT
TTGTCCGTGTATCCCTTGGTGGTGTGCGTGATGAATCTGAAATTCGTGGTCACCGTCGTACGTACGTTGGAGCAATGCCA
GGACGCATTATTCAAGGTATGAAAAAGGCAAAATCAGTTAATCCAGTCTTCTTATTAGATGAGATTGATAAAATGTCTAA
CGATTTCCGTGGAGATCCTTCAGCAGCATTACTTGAAGTGTTAGATCCAGAACAAAACCATAACTTCAGTGATCATTATA
TTGAAGAACCATATGATCTATCGAAAGTTATGTTTGTAGCAACTGCGAATACACTTTCAAGTATTCCAGGTCCATTACTT
GACCGTATGGAAATTATTTCGATTGCTGGCTATACAGAACTTGAAAAAGTTCATATTGCTCGTGAACATTTATTGCCGAA
ACAATTACAAGAGCATGGCTTACGAAAAGGTAATTTACAAGTACGTGATGAAGCGCTTCTTGAAATTATTCGCTATTATA
CACGTGAGGCTGGTGTTCGTACACTAGAGCGCCAAATTGCAAAGGTTTGTCGTAAAGTAGCAAAAATTATCGTTACAGCA
GAACGTAAGCGTATTGTAGTAACAGAGAAAAACGTTGTTGATTTACTTGGTAAGCACATATTCCGTTATGGGCAAGCTGA
AAAAACAGACCAAGTTGGTATGGCGACGGGTTTAGCGTATACGGCAGCAGGCGGCGATACACTGGCGATTGAAGTGTCCG
TAGCGCCAGGTAAAGGGAAATTAATTTTAACAGGGAAACTTGGGGATGTTATGAAAGAATCCGCACAAGCAGCGTTTAGC
TATATTCGTTCTCGTGCAGAAGAGCTTCAGATTGATCCGAATTTCCATGAGAAAAATGATATTCATATTCATGTTCCAGA
AGGAGCAGTTCCAAAAGATGGACCGTCAGCAGGTATTACGATGGCAACGGCACTTATTTCTGCGTTAACAGGTATTCCTG
TAAGTAAAGAAGTGGGGATGACAGGTGAAATTACACTTCGTGGTCGTGTATTACCGATTGGTGGTTTAAAAGAAAAAACA
TTAAGTGCTCACCGCGCAGGTTTAACAAAAATTATTTTACCGGCGGAAAATGAGAAAGATTTAGATGATATTCCAGAGAG
CGTAAAAGAAAACCTTACGTTTGTGCTTGCATCTCATTTAGATGAAGTATTGGAGCACGCATTAGTAGGAGTGAAACAAT
GA

Upstream 100 bases:

>100_bases
ATTTACAGTTGCGGAGAATCTCGGCAATTGCATCTAGATGTATTGTAATATAAAATGGTTGAACAGGAGTTTAATTTATT
ATGGAGGTGCTATGTCTAGT

Downstream 100 bases:

>100_bases
AAGTAACAAAAGCAGACATTGTAATTAGTGCTGTTAAACCAGAACAATATCCAGACGGTGACTTACCAGAAATCGCATTA
GCAGGTCGTTCAAATGTCGG

Product: ATP-dependent protease La 1

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNIDDPKEDDIYSVGTVAKVKQMLKL
PNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEEVEADLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVEEPG
RLVDLIASHLPIKTKQKQEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTELGD
KEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALPWTDATEDMIDLAHSEEILNKD
HYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMP
GRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLSSIPGPLL
DRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKVCRKVAKIIVTA
ERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAAFS
YIRSRAEELQIDPNFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLKEKT
LSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ

Sequences:

>Translated_773_residues
MNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNIDDPKEDDIYSVGTVAKVKQMLKL
PNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEEVEADLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVEEPG
RLVDLIASHLPIKTKQKQEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTELGD
KEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALPWTDATEDMIDLAHSEEILNKD
HYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMP
GRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLSSIPGPLL
DRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKVCRKVAKIIVTA
ERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAAFS
YIRSRAEELQIDPNFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLKEKT
LSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ
>Mature_773_residues
MNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNIDDPKEDDIYSVGTVAKVKQMLKL
PNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEEVEADLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVEEPG
RLVDLIASHLPIKTKQKQEILEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTELGD
KEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALPWTDATEDMIDLAHSEEILNKD
HYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMP
GRIIQGMKKAKSVNPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLSSIPGPLL
DRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKVCRKVAKIIVTA
ERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAYTAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAAFS
YIRSRAEELQIDPNFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLKEKT
LSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=780, Percent_Identity=41.7948717948718, Blast_Score=586, Evalue=1e-167,
Organism=Homo sapiens, GI21396489, Length=692, Percent_Identity=42.9190751445087, Blast_Score=556, Evalue=1e-158,
Organism=Escherichia coli, GI1786643, Length=767, Percent_Identity=53.7157757496741, Blast_Score=836, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=702, Percent_Identity=39.8860398860399, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17556486, Length=785, Percent_Identity=36.4331210191083, Blast_Score=479, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319449, Length=715, Percent_Identity=38.041958041958, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24666867, Length=698, Percent_Identity=43.5530085959885, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI221513036, Length=698, Percent_Identity=43.5530085959885, Blast_Score=561, Evalue=1e-160,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 86214; Mature: 86214

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNIDDP
CCCCCCEEEECCCCCHHHHCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KEDDIYSVGTVAKVKQMLKLPNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEEVEA
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHH
DLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVEEPGRLVDLIASHLPIKTKQKQEI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHH
LEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTELGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALPW
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
TDATEDMIDLAHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKT
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
SLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAKSVNPVFLLD
HHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHEECCCCHHHHHHHHHHCCCCCEEEHH
EIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLSSIPGPLL
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEEHHHHHHCCCHHH
DRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGVR
HHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
TLERQIAKVCRKVAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAY
HHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEE
TAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAAFSYIRSRAEELQIDPNFHEKND
EECCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLKEKT
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCHHHH
LSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNTNERIVPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAMDENIIFLAMQKEMNIDDP
CCCCCCEEEECCCCCHHHHCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KEDDIYSVGTVAKVKQMLKLPNGTLRVLVEGLHRAEVVEFIEEENVVQVSIKTVTEEVEA
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHH
DLEEKALMRTLLEHFEQYIKVSKKVSNETFATVADVEEPGRLVDLIASHLPIKTKQKQEI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHH
LEIISVKERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTELGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KEGKGGEVEELREKIEQSGMPEETMKAALKELDRYEKLPASSAESGVIRNYMDWLLALPW
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
TDATEDMIDLAHSEEILNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKT
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
SLARSIATSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAKSVNPVFLLD
HHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHEECCCCHHHHHHHHHHCCCCCEEEHH
EIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLSSIPGPLL
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEEHHHHHHCCCHHH
DRMEIISIAGYTELEKVHIAREHLLPKQLQEHGLRKGNLQVRDEALLEIIRYYTREAGVR
HHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
TLERQIAKVCRKVAKIIVTAERKRIVVTEKNVVDLLGKHIFRYGQAEKTDQVGMATGLAY
HHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEE
TAAGGDTLAIEVSVAPGKGKLILTGKLGDVMKESAQAAFSYIRSRAEELQIDPNFHEKND
EECCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLKEKT
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCHHHH
LSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLASHLDEVLEHALVGVKQ
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA