| Definition | Bacillus anthracis str. Ames, complete genome. |
|---|---|
| Accession | NC_003997 |
| Length | 5,227,293 |
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The map label for this gene is coaBC [H]
Identifier: 30263872
GI number: 30263872
Start: 3686419
End: 3687624
Strand: Reverse
Name: coaBC [H]
Synonym: BA_4007
Alternate gene names: 30263872
Gene position: 3687624-3686419 (Counterclockwise)
Preceding gene: 30263873
Following gene: 30263871
Centisome position: 70.55
GC content: 37.98
Gene sequence:
>1206_bases ATGCTAAAAGGGAAAAAGATACTTTTATGTGTAACAGGAGGCATTGCGGTCTTTAAAGCGGCTGCGTTAACGAGTAAATT GACACAAGCTGGTGCTATTGTAAAAGTAATGATGAGTGAGTCAGCAGTGAAGTTTGTTACACCTCTTACATTCCAGGCAC TTTCTCGTCATGATGTATATACGGATACATTCGATGAGAAAGATTCAGCTGTTATTGCTCATATCGATTTAGCAGATTGG GCAGATGTTGTACTTGTTGCACCTGCTACAGCCAATTGTATTGGAAAGCTAGCTAACGGCATTGCAGATGATATGATTAC AACTACTTTGTTAGCTACTACAGCCCCAGTGTGGATTGCACCTGCTATGAATGTGCATATGTATGAAAATAAAATTGTTC AAAAAAATATGATGACGTTAAAAACGTTAGGATATACATTTATTGAGCCTGGAGAAGGTTTTTTAGCGTGTGGTTATGTA GCGAAGGGAAGATTAGAAGAACCTGAAGCGATTATTGCACGGTTAGAAGAGGCTTTTTCAGAACAAAAACCATTGCAAGG AAAAAGGATATTAATAACTGCTGGTCCAACTCGTGAAAAGATTGACCCAGTCCGTTTTATGACTAATTTTTCTTCTGGAA AAATGGGATATGCGATTGCGGAAGTGGCAGTGAACTTAGGCGCTGAAGTCATACTCGTTTCTGGACCGACAGCATTAAAT CCACCATTACATGTAACTACAGTGCAAGTGGAATCTGCACAAGATATGTTAGAGGCAGTCATTCAACATTATCAAAACGT AGATGTTGTCATTAAAACAGCAGCAGTTGCAGATTATCGTCCGAAATATGTACATGATAATAAAATGAAAAAGAAAAATG GCGATGCTGTAATTGAACTCGAGAGAACAGTAGATATTTTAAAAACGTTAGGTGAGATGAAGGACAAACAGTTACTTATC GGTTTTGCGGCTGAAACGACAAACGTAGAGGAATATGCAACGAAAAAATTACGTGAGAAAAATGCGAATATGATTGTTGC AAACGACGTAAAGGCGCAAGGAGCTGGATTTGGTACAGACACGAACATTGTAACAATGTATAGAAAAGATGGAGAAGTTA TAGAGTTGCCACTTTTAACGAAGAAAGAGGTTGCTCGTGAAATATTAAAGCAAATTGAAATGATGTTAGAAGATGATCGT CTATGA
Upstream 100 bases:
>100_bases AGGTTGTTATTTTTTTACGATAGGGAAGAAATATTGATACTGATGAGCTGATAATTTTGTTTCAGTATTATAAGTTTGAA AAAGAAAGAGGACGAGCCAT
Downstream 100 bases:
>100_bases AATTTGCAAGTGTAATTGTTGATGTACCTGCACGTCAGACAGATCGACCATTTGATTATATTATCCCTAAAAAATGGGAA GATATTGTCCAGACAGGCAT
Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 401; Mature: 401
Protein sequence:
>401_residues MLKGKKILLCVTGGIAVFKAAALTSKLTQAGAIVKVMMSESAVKFVTPLTFQALSRHDVYTDTFDEKDSAVIAHIDLADW ADVVLVAPATANCIGKLANGIADDMITTTLLATTAPVWIAPAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYV AKGRLEEPEAIIARLEEAFSEQKPLQGKRILITAGPTREKIDPVRFMTNFSSGKMGYAIAEVAVNLGAEVILVSGPTALN PPLHVTTVQVESAQDMLEAVIQHYQNVDVVIKTAAVADYRPKYVHDNKMKKKNGDAVIELERTVDILKTLGEMKDKQLLI GFAAETTNVEEYATKKLREKNANMIVANDVKAQGAGFGTDTNIVTMYRKDGEVIELPLLTKKEVAREILKQIEMMLEDDR L
Sequences:
>Translated_401_residues MLKGKKILLCVTGGIAVFKAAALTSKLTQAGAIVKVMMSESAVKFVTPLTFQALSRHDVYTDTFDEKDSAVIAHIDLADW ADVVLVAPATANCIGKLANGIADDMITTTLLATTAPVWIAPAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYV AKGRLEEPEAIIARLEEAFSEQKPLQGKRILITAGPTREKIDPVRFMTNFSSGKMGYAIAEVAVNLGAEVILVSGPTALN PPLHVTTVQVESAQDMLEAVIQHYQNVDVVIKTAAVADYRPKYVHDNKMKKKNGDAVIELERTVDILKTLGEMKDKQLLI GFAAETTNVEEYATKKLREKNANMIVANDVKAQGAGFGTDTNIVTMYRKDGEVIELPLLTKKEVAREILKQIEMMLEDDR L >Mature_401_residues MLKGKKILLCVTGGIAVFKAAALTSKLTQAGAIVKVMMSESAVKFVTPLTFQALSRHDVYTDTFDEKDSAVIAHIDLADW ADVVLVAPATANCIGKLANGIADDMITTTLLATTAPVWIAPAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYV AKGRLEEPEAIIARLEEAFSEQKPLQGKRILITAGPTREKIDPVRFMTNFSSGKMGYAIAEVAVNLGAEVILVSGPTALN PPLHVTTVQVESAQDMLEAVIQHYQNVDVVIKTAAVADYRPKYVHDNKMKKKNGDAVIELERTVDILKTLGEMKDKQLLI GFAAETTNVEEYATKKLREKNANMIVANDVKAQGAGFGTDTNIVTMYRKDGEVIELPLLTKKEVAREILKQIEMMLEDDR L
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=183, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=8e-19, Organism=Escherichia coli, GI87082301, Length=395, Percent_Identity=43.0379746835443, Blast_Score=291, Evalue=6e-80, Organism=Caenorhabditis elegans, GI17560194, Length=166, Percent_Identity=34.9397590361446, Blast_Score=96, Evalue=3e-20, Organism=Saccharomyces cerevisiae, GI6322762, Length=179, Percent_Identity=30.7262569832402, Blast_Score=84, Evalue=5e-17, Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=29.1005291005291, Blast_Score=83, Evalue=3e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 43891; Mature: 43891
Theoretical pI: Translated: 6.02; Mature: 6.02
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 4.2 %Met (Translated Protein) 5.0 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 4.2 %Met (Mature Protein) 5.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLKGKKILLCVTGGIAVFKAAALTSKLTQAGAIVKVMMSESAVKFVTPLTFQALSRHDVY CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCHHEEEHHCCCHHHHHCCHHHHHHHCCCCC TDTFDEKDSAVIAHIDLADWADVVLVAPATANCIGKLANGIADDMITTTLLATTAPVWIA CCCCCCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE PAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYVAKGRLEEPEAIIARLEEAFS CCCEEEEHHHHHHHHHHHHHHHCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHHH EQKPLQGKRILITAGPTREKIDPVRFMTNFSSGKMGYAIAEVAVNLGAEVILVSGPTALN HCCCCCCCEEEEEECCCCCCCCHHHHEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCC PPLHVTTVQVESAQDMLEAVIQHYQNVDVVIKTAAVADYRPKYVHDNKMKKKNGDAVIEL CCEEEEEEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEE ERTVDILKTLGEMKDKQLLIGFAAETTNVEEYATKKLREKNANMIVANDVKAQGAGFGTD HHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC TNIVTMYRKDGEVIELPLLTKKEVAREILKQIEMMLEDDRL CCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCC >Mature Secondary Structure MLKGKKILLCVTGGIAVFKAAALTSKLTQAGAIVKVMMSESAVKFVTPLTFQALSRHDVY CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCHHEEEHHCCCHHHHHCCHHHHHHHCCCCC TDTFDEKDSAVIAHIDLADWADVVLVAPATANCIGKLANGIADDMITTTLLATTAPVWIA CCCCCCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE PAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYVAKGRLEEPEAIIARLEEAFS CCCEEEEHHHHHHHHHHHHHHHCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHHH EQKPLQGKRILITAGPTREKIDPVRFMTNFSSGKMGYAIAEVAVNLGAEVILVSGPTALN HCCCCCCCEEEEEECCCCCCCCHHHHEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCC PPLHVTTVQVESAQDMLEAVIQHYQNVDVVIKTAAVADYRPKYVHDNKMKKKNGDAVIEL CCEEEEEEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEE ERTVDILKTLGEMKDKQLLIGFAAETTNVEEYATKKLREKNANMIVANDVKAQGAGFGTD HHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC TNIVTMYRKDGEVIELPLLTKKEVAREILKQIEMMLEDDRL CCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9534248; 9384377 [H]