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The map label for this gene is fhuB [H]

Identifier: 30263434

GI number: 30263434

Start: 3241398

End: 3242432

Strand: Reverse

Name: fhuB [H]

Synonym: BA_3534

Alternate gene names: 30263434

Gene position: 3242432-3241398 (Counterclockwise)

Preceding gene: 30263436

Following gene: 30263433

Centisome position: 62.03

GC content: 39.9

Gene sequence:

>1035_bases
ATGTTACATAAGTCTACTATACGTGCTGGCAATAACCGCTGGATACACATTAAGTTTATATGTTTTATGAGCTTAACAAT
TATATGTTTAATTGGATCTATATTTTTGGCCGTCGCATTTGGTGCAAAGGATATTCATTTGCAAACGGTGTGGACAGCGG
TTTTTGATTACAATCCGAAATTAACGCAGCATCAAATCATTTACGAATTAAGGCTCCCAAGGGTAATTGGCGCAGCAGTT
GTAGGAGCGGCTTTTGCGGTCGCTGGGGCTGTTATGCAAGGAGTAACACGAAATCCTTTAGCTGATGCAGGTGTGCTTGG
CATAAATGCAGGTGCGATGTTTGTAGTAGCACTTAGTTTTGCCTTTTTCCCGCATATGCCGTATTCCTATTTGATGGTTG
TTTCCTTTATTGGAGCGGTTTTAAGTACAGTACTCATTTTTATTATCGGATCAGCAACAGCAGGCGGATTAACACCGATG
AGGTTAACGATCGCTGGGGCAGTTATGGCAGCACTTTTACATTCATTAAGTTCAGGTGTTGCAATTTATTATGACTTAAG
TCAAGATTTAGCGTTTTGGTACGCTGGTGGTGTTGCAGGGGTTAAGTGGGAACACTTGAAATTTTTAGTTCCTATTATTT
TTATAACGATTGTTTTTGCGACAGTGTTAGGGCGGTCTATTTCACTCATATCAATGGGGGATGATGTCGCTACGAATTTA
GGTGTGAAAACGAATCGAACGAGGATACTTGGAATGATTATAGTAGTTATTCTAGCAGGTGTTTCTGTTTCAGCTGTTGG
TTCTATTGGATTTGTAGGACTCGTTATCCCGCATATTGCTAGAAAAATAGTTGGTGTGAATTATCGACTCATTATTCCTA
TGTCAGCATTATTAGGAGCTATGTTATTAGTTTTAGCTGACCTAGGGGCAAGAACAGTAAACCCTCCTAAAGAACTTGCG
ATAGGGATTATGGTAGCTCTCATTGGAGTTCCGTTTTTCCTATATATAGCACGTAAAGTTGGGAGGGAACTATAA

Upstream 100 bases:

>100_bases
AAGTGGGGATATAATATCTAAATGAAAATGATAATTATTATCAATATTAATTATAAATAAAAAATAATTATAAAAAACAA
CTGAATATAAAGGATGAAAC

Downstream 100 bases:

>100_bases
GTGAAGAAGATTTTAAACACAGATAAGAAGAGAGCTATTACTGTAACTACAATATTTGGTTGTATTGGTATCGCTGTCAT
TTTAATTAGTTTAAATACAG

Product: iron compound ABC transporter, permease protein

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLHKSTIRAGNNRWIHIKFICFMSLTIICLIGSIFLAVAFGAKDIHLQTVWTAVFDYNPKLTQHQIIYELRLPRVIGAAV
VGAAFAVAGAVMQGVTRNPLADAGVLGINAGAMFVVALSFAFFPHMPYSYLMVVSFIGAVLSTVLIFIIGSATAGGLTPM
RLTIAGAVMAALLHSLSSGVAIYYDLSQDLAFWYAGGVAGVKWEHLKFLVPIIFITIVFATVLGRSISLISMGDDVATNL
GVKTNRTRILGMIIVVILAGVSVSAVGSIGFVGLVIPHIARKIVGVNYRLIIPMSALLGAMLLVLADLGARTVNPPKELA
IGIMVALIGVPFFLYIARKVGREL

Sequences:

>Translated_344_residues
MLHKSTIRAGNNRWIHIKFICFMSLTIICLIGSIFLAVAFGAKDIHLQTVWTAVFDYNPKLTQHQIIYELRLPRVIGAAV
VGAAFAVAGAVMQGVTRNPLADAGVLGINAGAMFVVALSFAFFPHMPYSYLMVVSFIGAVLSTVLIFIIGSATAGGLTPM
RLTIAGAVMAALLHSLSSGVAIYYDLSQDLAFWYAGGVAGVKWEHLKFLVPIIFITIVFATVLGRSISLISMGDDVATNL
GVKTNRTRILGMIIVVILAGVSVSAVGSIGFVGLVIPHIARKIVGVNYRLIIPMSALLGAMLLVLADLGARTVNPPKELA
IGIMVALIGVPFFLYIARKVGREL
>Mature_344_residues
MLHKSTIRAGNNRWIHIKFICFMSLTIICLIGSIFLAVAFGAKDIHLQTVWTAVFDYNPKLTQHQIIYELRLPRVIGAAV
VGAAFAVAGAVMQGVTRNPLADAGVLGINAGAMFVVALSFAFFPHMPYSYLMVVSFIGAVLSTVLIFIIGSATAGGLTPM
RLTIAGAVMAALLHSLSSGVAIYYDLSQDLAFWYAGGVAGVKWEHLKFLVPIIFITIVFATVLGRSISLISMGDDVATNL
GVKTNRTRILGMIIVVILAGVSVSAVGSIGFVGLVIPHIARKIVGVNYRLIIPMSALLGAMLLVLADLGARTVNPPKELA
IGIMVALIGVPFFLYIARKVGREL

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786805, Length=303, Percent_Identity=35.973597359736, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1790740, Length=292, Percent_Identity=34.9315068493151, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1790741, Length=290, Percent_Identity=33.7931034482759, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1786804, Length=259, Percent_Identity=31.6602316602317, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788004, Length=280, Percent_Identity=33.2142857142857, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786347, Length=323, Percent_Identity=29.4117647058824, Blast_Score=114, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36651; Mature: 36651

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHKSTIRAGNNRWIHIKFICFMSLTIICLIGSIFLAVAFGAKDIHLQTVWTAVFDYNPK
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
LTQHQIIYELRLPRVIGAAVVGAAFAVAGAVMQGVTRNPLADAGVLGINAGAMFVVALSF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHH
AFFPHMPYSYLMVVSFIGAVLSTVLIFIIGSATAGGLTPMRLTIAGAVMAALLHSLSSGV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCE
AIYYDLSQDLAFWYAGGVAGVKWEHLKFLVPIIFITIVFATVLGRSISLISMGDDVATNL
EEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCC
GVKTNRTRILGMIIVVILAGVSVSAVGSIGFVGLVIPHIARKIVGVNYRLIIPMSALLGA
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHH
MLLVLADLGARTVNPPKELAIGIMVALIGVPFFLYIARKVGREL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLHKSTIRAGNNRWIHIKFICFMSLTIICLIGSIFLAVAFGAKDIHLQTVWTAVFDYNPK
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
LTQHQIIYELRLPRVIGAAVVGAAFAVAGAVMQGVTRNPLADAGVLGINAGAMFVVALSF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHH
AFFPHMPYSYLMVVSFIGAVLSTVLIFIIGSATAGGLTPMRLTIAGAVMAALLHSLSSGV
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCE
AIYYDLSQDLAFWYAGGVAGVKWEHLKFLVPIIFITIVFATVLGRSISLISMGDDVATNL
EEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCC
GVKTNRTRILGMIIVVILAGVSVSAVGSIGFVGLVIPHIARKIVGVNYRLIIPMSALLGA
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHH
MLLVLADLGARTVNPPKELAIGIMVALIGVPFFLYIARKVGREL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]