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The map label for this gene is ipaH_2

Identifier: 30062414

GI number: 30062414

Start: 913648

End: 915474

Strand: Reverse

Name: ipaH_2

Synonym: S0934

Alternate gene names: 30062414

Gene position: 915474-913648 (Counterclockwise)

Preceding gene: 30062419

Following gene: 30062412

Centisome position: 19.9

GC content: 46.41

Gene sequence:

>1827_bases
ATGCGAGAAATTAATATGCTCAGAAACATTTCATCCTGTTTATTTCCACATATCAGCACAATTACATCCCCCAACCATTA
TTTGTCCGAATGGGATGATTGGGAGAAACAGGGGTTACCGGAAGAACAGCGTACTGAGGCGGTAAGAAGACTTCGTGCAT
GTCTTACCTCTAAGGGGCATAAACTGGACCTGCGAGCCTTGGCGCTTTCCTCGCTACCTGTACTCCCTGCTTGCATTAAA
AAGCTTGATGTGAGCTGTAATAAATTAACCATCCTTACTGATTTACCTGAAAATATTAAAGAACTTATTGCAAGAGATAA
TTTCTTAACACATATATCTGCATTACCACATTATCTAATAACTTTGGATGTGTCCGAAAATCAATTAGAGAATCTGCCGT
TATTACCAGACACCATCAAATCACTAAGCGCAGAGTATAATAGGTTATCCACACTGCCTTCATTACCCTTGAATTTAAAA
AAACTTGAGGTTAGGAACAACGAACTGCAAACTCTTCCATCTCTGCCTTCTAATCTTAAGATACTTAAGGTTGCGCACAA
CCATCTTACTGAACTGCCCCCTTTACCTAGGAGACTGCAACTTCTTTTTGCATATAGCAATAGATTAAGCAACTTACCAA
ACATCCAAGAAAATATTATCATGAGAAGATTTTTTTATTTTGAAAACAACCAAATAACTACAATCCCGACAAATCTTTTT
CGTTTAGATCCTCATATAACTATTGAGATTGCAAATAACCCCTTATCAGATCAAACTCTGCTATTCTTAATACAGCAAAC
TTCGGTTCCAAATTTTAACGGGCCTCAGTTTCGTATTTCCCTGTCAGACCAAAACAGACTGTTTTTACGCCAGATGTTGC
CGCAAAATTTACATTCGCGCCATATCAGAGTCATCACTGAAGGGGGGCAGAACTTTCAGATCCCCCCTCTTCCCGAAACT
GTGGCAGCCTGGTTTCCTGAAGCAGATCGTCGGGAGGTTTCTACACAATGGACTTCTTTTTCCACCGAGGAGAATTCCCG
GGCATTCTCCGCGTTCCTTGACCGCCTTTCCGATACCGTCTCTGCACGCAATACCTCCGGATTCCGTGAACAGGTCGCTG
CATGGCTGGAAAAACTCAGTGCCTCTGCGGAGCTTCGACAGCAGTCTTTCGCTGTTGCTGCTGATGCCACTGAGAGCTGT
GAGGACCGTGTCGCGCTCACATGGAACAATCTCCGGAAAACCCTCCTGGTCCATCAGGCATCTGAAGGCCTTTTCGATAA
TGATACCGGCGCTCTGCTCTCCCTGGGCAGGGAAATGTTCCGCCTCGAAATTCTGGAGGACATTGCCCGGGATAAAGTCA
GAACTCTCCATTTTGTGGATGAGATAGAAGTCTACCTGGCCTTCCAGACCATGCTCGCAGAGAAACTTCAGCTCTCCACT
GCCGTGAAGGAAATGCGTTTCTATGGCGTGTCGGGAGTGACAGCAAATGACCTCCGCACTGCCGAAGCCATGGTCAGAAG
CCGTGAAGAGAATGAATTTACGGACTGGTTCTCCCTCTGGGGACCATGGCATGCTGTACTGAAGCGTACGGAAGCTGACC
GCTGGGCGCAGGCAGAAGAGCAGAAGTATGAGATGCTGGAGAATGAGTACCCTCAGAGGGTGGCTGACCGGCTGAAAGCA
TCCGGTCTGAGCGATGATGCGGATGCGGAGAGGGAAGCAGGAGCACAGGTGATGCGTGAGACTGAACAGCAGATTTACCG
TCAGCTGACTGACGAGGTACTGGCCCTGCGATTGTCTGAAAACGGCTCACAACTGCACCATTCATAA

Upstream 100 bases:

>100_bases
ATATAACACTCATTCCCTTATGGCGAATATTCTGAAACACCCTCCTCATTAGGAGAGATACATTAAATACAATTTATTCA
CAATCTAATTCCATATCCAT

Downstream 100 bases:

>100_bases
TCACATCGCATAAACCACAGACCGGACTGACTCCGGAAAAACAGAGGCCCGCCCCCGGGCCTCCCCGGATTCATCCGTTT
CCCTGTTCAGCCTGACAGCA

Product: invasion plasmid antigen

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MREINMLRNISSCLFPHISTITSPNHYLSEWDDWEKQGLPEEQRTEAVRRLRACLTSKGHKLDLRALALSSLPVLPACIK
KLDVSCNKLTILTDLPENIKELIARDNFLTHISALPHYLITLDVSENQLENLPLLPDTIKSLSAEYNRLSTLPSLPLNLK
KLEVRNNELQTLPSLPSNLKILKVAHNHLTELPPLPRRLQLLFAYSNRLSNLPNIQENIIMRRFFYFENNQITTIPTNLF
RLDPHITIEIANNPLSDQTLLFLIQQTSVPNFNGPQFRISLSDQNRLFLRQMLPQNLHSRHIRVITEGGQNFQIPPLPET
VAAWFPEADRREVSTQWTSFSTEENSRAFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESC
EDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLST
AVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYPQRVADRLKA
SGLSDDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS

Sequences:

>Translated_608_residues
MREINMLRNISSCLFPHISTITSPNHYLSEWDDWEKQGLPEEQRTEAVRRLRACLTSKGHKLDLRALALSSLPVLPACIK
KLDVSCNKLTILTDLPENIKELIARDNFLTHISALPHYLITLDVSENQLENLPLLPDTIKSLSAEYNRLSTLPSLPLNLK
KLEVRNNELQTLPSLPSNLKILKVAHNHLTELPPLPRRLQLLFAYSNRLSNLPNIQENIIMRRFFYFENNQITTIPTNLF
RLDPHITIEIANNPLSDQTLLFLIQQTSVPNFNGPQFRISLSDQNRLFLRQMLPQNLHSRHIRVITEGGQNFQIPPLPET
VAAWFPEADRREVSTQWTSFSTEENSRAFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESC
EDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLST
AVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYPQRVADRLKA
SGLSDDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS
>Mature_608_residues
MREINMLRNISSCLFPHISTITSPNHYLSEWDDWEKQGLPEEQRTEAVRRLRACLTSKGHKLDLRALALSSLPVLPACIK
KLDVSCNKLTILTDLPENIKELIARDNFLTHISALPHYLITLDVSENQLENLPLLPDTIKSLSAEYNRLSTLPSLPLNLK
KLEVRNNELQTLPSLPSNLKILKVAHNHLTELPPLPRRLQLLFAYSNRLSNLPNIQENIIMRRFFYFENNQITTIPTNLF
RLDPHITIEIANNPLSDQTLLFLIQQTSVPNFNGPQFRISLSDQNRLFLRQMLPQNLHSRHIRVITEGGQNFQIPPLPET
VAAWFPEADRREVSTQWTSFSTEENSRAFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESC
EDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLST
AVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYPQRVADRLKA
SGLSDDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSQLHHS

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway [H]

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm (Probable). Note=Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 7 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 69764; Mature: 69764

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREINMLRNISSCLFPHISTITSPNHYLSEWDDWEKQGLPEEQRTEAVRRLRACLTSKGH
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCC
KLDLRALALSSLPVLPACIKKLDVSCNKLTILTDLPENIKELIARDNFLTHISALPHYLI
EEEHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCHHHHHHHHCCCEEE
TLDVSENQLENLPLLPDTIKSLSAEYNRLSTLPSLPLNLKKLEVRNNELQTLPSLPSNLK
EEECCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHCCCCCCCCE
ILKVAHNHLTELPPLPRRLQLLFAYSNRLSNLPNIQENIIMRRFFYFENNQITTIPTNLF
EEEEHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCEEEEECCHHE
RLDPHITIEIANNPLSDQTLLFLIQQTSVPNFNGPQFRISLSDQNRLFLRQMLPQNLHSR
EECCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCC
HIRVITEGGQNFQIPPLPETVAAWFPEADRREVSTQWTSFSTEENSRAFSAFLDRLSDTV
EEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
SARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEHHHHHHHHHHHHH
SEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLST
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEE
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKYEMLENEYPQRVADRLKASGLSDDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSE
HHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NGSQLHHS
CCCCCCCC
>Mature Secondary Structure
MREINMLRNISSCLFPHISTITSPNHYLSEWDDWEKQGLPEEQRTEAVRRLRACLTSKGH
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCC
KLDLRALALSSLPVLPACIKKLDVSCNKLTILTDLPENIKELIARDNFLTHISALPHYLI
EEEHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCHHHHHHHHCCCEEE
TLDVSENQLENLPLLPDTIKSLSAEYNRLSTLPSLPLNLKKLEVRNNELQTLPSLPSNLK
EEECCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHCCCCCCCCE
ILKVAHNHLTELPPLPRRLQLLFAYSNRLSNLPNIQENIIMRRFFYFENNQITTIPTNLF
EEEEHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCEEEEECCHHE
RLDPHITIEIANNPLSDQTLLFLIQQTSVPNFNGPQFRISLSDQNRLFLRQMLPQNLHSR
EECCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCC
HIRVITEGGQNFQIPPLPETVAAWFPEADRREVSTQWTSFSTEENSRAFSAFLDRLSDTV
EEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
SARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEHHHHHHHHHHHHH
SEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLST
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEE
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKYEMLENEYPQRVADRLKASGLSDDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSE
HHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NGSQLHHS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11115111; 11292750; 12384590; 1690703 [H]