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The map label for this gene is proC [H]

Identifier: 29349165

GI number: 29349165

Start: 4877565

End: 4878338

Strand: Reverse

Name: proC [H]

Synonym: BT_3757

Alternate gene names: 29349165

Gene position: 4878338-4877565 (Counterclockwise)

Preceding gene: 29349166

Following gene: 29349164

Centisome position: 77.92

GC content: 51.42

Gene sequence:

>774_bases
ATGAAAATAGCTATTATCGGTGCAGGAAACATGGGTGGTTCTATAGCCCGCGGCCTGGCAAAAGGAAGTCTGATAGCAGA
CTCAGATATCATTGTATCCAACCCCAGCGCAGGCAAACTGGAGAAACTGAAAGAAGAATTTCCGGGCATTTCCACCACTC
TGAGCAATACGGAAGCGGCAACGGGAGCAGATGTTGTCATTCTCGCCGTGAAGCCTTGGTTTGTGGAGTCCGTCATGCGC
GAGTTGAAGCTGAAGAGCAAACAGACGCTCGTATCCGTAGCGGCAGGTATCAGTTTTGAAGAACTCGCACACTTTGTGAT
AGCACCGGAGATGCCGATGTTCCGCCTGATTCCGAACACTGCCATCAGCGAACTGGAAAGTATGACGCTTATCGCGGCAC
GCAACACGAACGATGAACAGAACCTGTTTATGCTCCGCCTGTTCAACGAAATGGGAATGGCCATGCTCATCCCCGAAGAT
AAGATAGCCGCCACCACGGCACTGACTTCCTGCGGCATCGCTTACGTATTGAAATACATCCAGGCAGCCATGCAGGCCGG
CATCGAAATGGGCATCCGTCCCAAAGATGCGATGGAAATGGTAGCCCAGTCCGTCAAGGGAGCCGCCGCATTAATTCTGA
ACAATGACACCCACCCCAGCGTGGAAATCGACAAAGTGACTACTCCGGGCGGAATTACGATCAAGGGAATCAACGAACTG
GAACACAACGGATTTACCTCCGCCGTCATCAAAGCGATGAAAGCATCCAAATAA

Upstream 100 bases:

>100_bases
AGCCTCGAACAGAAAAACAGTTCTTATTCAGGCTGCTTTTTGTTTTTTCGCAATTTACCGTTACCTTTGTCTGTAAGAAT
ACATTAAAAAAGAAGCGCAT

Downstream 100 bases:

>100_bases
TACCGCAAAATTATTAATAATCAAAAAACAACCACTTGTATGAATGACCAAATTAAACAGATCGCAGAACGCCTTCGCGG
ATTACGTGACGTACTGGAAC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKIAIIGAGNMGGSIARGLAKGSLIADSDIIVSNPSAGKLEKLKEEFPGISTTLSNTEAATGADVVILAVKPWFVESVMR
ELKLKSKQTLVSVAAGISFEELAHFVIAPEMPMFRLIPNTAISELESMTLIAARNTNDEQNLFMLRLFNEMGMAMLIPED
KIAATTALTSCGIAYVLKYIQAAMQAGIEMGIRPKDAMEMVAQSVKGAAALILNNDTHPSVEIDKVTTPGGITIKGINEL
EHNGFTSAVIKAMKASK

Sequences:

>Translated_257_residues
MKIAIIGAGNMGGSIARGLAKGSLIADSDIIVSNPSAGKLEKLKEEFPGISTTLSNTEAATGADVVILAVKPWFVESVMR
ELKLKSKQTLVSVAAGISFEELAHFVIAPEMPMFRLIPNTAISELESMTLIAARNTNDEQNLFMLRLFNEMGMAMLIPED
KIAATTALTSCGIAYVLKYIQAAMQAGIEMGIRPKDAMEMVAQSVKGAAALILNNDTHPSVEIDKVTTPGGITIKGINEL
EHNGFTSAVIKAMKASK
>Mature_257_residues
MKIAIIGAGNMGGSIARGLAKGSLIADSDIIVSNPSAGKLEKLKEEFPGISTTLSNTEAATGADVVILAVKPWFVESVMR
ELKLKSKQTLVSVAAGISFEELAHFVIAPEMPMFRLIPNTAISELESMTLIAARNTNDEQNLFMLRLFNEMGMAMLIPED
KIAATTALTSCGIAYVLKYIQAAMQAGIEMGIRPKDAMEMVAQSVKGAAALILNNDTHPSVEIDKVTTPGGITIKGINEL
EHNGFTSAVIKAMKASK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=30.4511278195489, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=30.5970149253731, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=30.5970149253731, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI198041662, Length=258, Percent_Identity=29.4573643410853, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1786585, Length=260, Percent_Identity=33.4615384615385, Blast_Score=124, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17569021, Length=260, Percent_Identity=29.6153846153846, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540664, Length=271, Percent_Identity=28.0442804428044, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320861, Length=272, Percent_Identity=28.6764705882353, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648116, Length=266, Percent_Identity=31.9548872180451, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21358587, Length=256, Percent_Identity=29.6875, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24647700, Length=150, Percent_Identity=28, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27323; Mature: 27323

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIIGAGNMGGSIARGLAKGSLIADSDIIVSNPSAGKLEKLKEEFPGISTTLSNTEAA
CEEEEEECCCCCHHHHHHHHCCCEEECCCEEEECCCCCHHHHHHHHCCCCEEECCCCCCC
TGADVVILAVKPWFVESVMRELKLKSKQTLVSVAAGISFEELAHFVIAPEMPMFRLIPNT
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEECCCH
AISELESMTLIAARNTNDEQNLFMLRLFNEMGMAMLIPEDKIAATTALTSCGIAYVLKYI
HHHHHHHEEEEEECCCCCCHHHHHEEEHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
QAAMQAGIEMGIRPKDAMEMVAQSVKGAAALILNNDTHPSVEIDKVTTPGGITIKGINEL
HHHHHHCHHCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEECCCCEEEEECHHH
EHNGFTSAVIKAMKASK
HCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAIIGAGNMGGSIARGLAKGSLIADSDIIVSNPSAGKLEKLKEEFPGISTTLSNTEAA
CEEEEEECCCCCHHHHHHHHCCCEEECCCEEEECCCCCHHHHHHHHCCCCEEECCCCCCC
TGADVVILAVKPWFVESVMRELKLKSKQTLVSVAAGISFEELAHFVIAPEMPMFRLIPNT
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEECCCH
AISELESMTLIAARNTNDEQNLFMLRLFNEMGMAMLIPEDKIAATTALTSCGIAYVLKYI
HHHHHHHEEEEEECCCCCCHHHHHEEEHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
QAAMQAGIEMGIRPKDAMEMVAQSVKGAAALILNNDTHPSVEIDKVTTPGGITIKGINEL
HHHHHHCHHCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEECCCCEEEEECHHH
EHNGFTSAVIKAMKASK
HCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]