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The map label for this gene is murC [H]

Identifier: 29348856

GI number: 29348856

Start: 4440190

End: 4441593

Strand: Reverse

Name: murC [H]

Synonym: BT_3447

Alternate gene names: 29348856

Gene position: 4441593-4440190 (Counterclockwise)

Preceding gene: 29348857

Following gene: 29348855

Centisome position: 70.95

GC content: 48.72

Gene sequence:

>1404_bases
ATGAATATTGAAACGATCAAATCAGTCTACTTTGTCGGTGCCGGAGGCATCGGTATGAGTGCGCTTGTCCGCTATTTCCT
TTCCAAAGGAAAAGTGGTAGCCGGATACGACCGCACCCCGACTCCATTGACTGAAAACCTCATCGCCGAAGGCGCACAAA
TACATTACGAAGAAAACGTACGACTGATTCCGGAAGCCTGCAAAGACAAAGAAAGCACTTTAGTCGTATTGACCCCCGCC
GTTCCGCAGGAACACGAAGAATTGGTTTATTTCCGCAACAACGGATTCGAAATACAAAAACGCGCGCAAGTACTGGGAAC
GATCACTCATTCCAGCAAAGGTCTGTGTGTAGCCGGCACTCATGGCAAGACAACCACTTCTACCATGACCGCCCACCTAT
TCCACCAATCGCACATAGAATGTACCGCTTTCCTCGGAGGCATCTCCAAGAATTACGGCACCAATCTGCTACTCTCTCAG
AAAAGCCCTTATACCGTCATCGAAGCAGACGAGTTCGACCGCTCTTTCCATTGGCTGTCCCCTTATATGTCTGTCATCAC
TGCCACAGACCCCGATCATCTGGACATCTACGGAACAGAAAAGGCATACCTCGAAAGCTTCGAACATTATACAACACTGA
TCCAGCCGGGCGGTGCACTGATTATCCGAAAAGGTATCTCACTACAACCGAAAGTACAGGCCGGAGTCCGTGTCTATACC
TATTCGCGTGACGAAGGAGACTTCCACGCCGAGAATATCCGCATCGGAAACGGTGAAATCTTCATCGACTTCGTTGCCCC
CGACACACGTATCAACAATATCCAACTGGGAGTTCCGGTAAGCATTAACATCGAGAATGGTGTAGCCGCCATGGCACTCG
CCCACCTCAACGGAGTGACCGACGAAGAGATCAGACAAGGAATGAACAGCTTCCGCGGTGTAGACCGCCGGTTCGATTTC
AAGATCAAGAATGACCAGGTAGTCTTTCTGAGCGACTACGCCCATCATCCCTCTGAAATCAAACAGAGCGTGCTGTCTAT
CCGCGAACTCTATAAAGACAAGAAGATCACAGCCATCTTCCAGCCGCACCTGTACACCCGTACCCGCGACTTCTATCAGG
ACTTTGCCGATAGCCTGTCACTACTGGACGAAGTCATTCTGGTAGACATCTATCCGGCTCGTGAGACACCGATCCCCGGT
GTCACCAGCAAGCTGATATACGACAACCTCCGTCCGGGCATCGAAAAAAGTATGTGCAAAAAGGAAGAAATACTGAACAT
TCTGAAAGATAAAAACATTGAAGTATTAATAACTCTGGGAGCCGGAGACATAGACAATTATGTCCCCGAAATAAAGAAAG
AACTGGAAAAAATGAAGAACGAAGAGCGAAGAACGAAGAACTAA

Upstream 100 bases:

>100_bases
CGACTTTGGGGGTCATCCCCAATTAAAGGTAGTACCGACTCTGATTAAAACTTGAAATGTTACTTGGAACAAGAATTATA
AAAAGAAACAGTATAAAGAA

Downstream 100 bases:

>100_bases
GAATTTCTACGCTACATCATACAGTCGCGCAGCCAATTCTCAATTCTTCATTTTCAATTTTCAATTCTCAATTAAATAAA
AACTATGGTAAAGAGAATCC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MNIETIKSVYFVGAGGIGMSALVRYFLSKGKVVAGYDRTPTPLTENLIAEGAQIHYEENVRLIPEACKDKESTLVVLTPA
VPQEHEELVYFRNNGFEIQKRAQVLGTITHSSKGLCVAGTHGKTTTSTMTAHLFHQSHIECTAFLGGISKNYGTNLLLSQ
KSPYTVIEADEFDRSFHWLSPYMSVITATDPDHLDIYGTEKAYLESFEHYTTLIQPGGALIIRKGISLQPKVQAGVRVYT
YSRDEGDFHAENIRIGNGEIFIDFVAPDTRINNIQLGVPVSINIENGVAAMALAHLNGVTDEEIRQGMNSFRGVDRRFDF
KIKNDQVVFLSDYAHHPSEIKQSVLSIRELYKDKKITAIFQPHLYTRTRDFYQDFADSLSLLDEVILVDIYPARETPIPG
VTSKLIYDNLRPGIEKSMCKKEEILNILKDKNIEVLITLGAGDIDNYVPEIKKELEKMKNEERRTKN

Sequences:

>Translated_467_residues
MNIETIKSVYFVGAGGIGMSALVRYFLSKGKVVAGYDRTPTPLTENLIAEGAQIHYEENVRLIPEACKDKESTLVVLTPA
VPQEHEELVYFRNNGFEIQKRAQVLGTITHSSKGLCVAGTHGKTTTSTMTAHLFHQSHIECTAFLGGISKNYGTNLLLSQ
KSPYTVIEADEFDRSFHWLSPYMSVITATDPDHLDIYGTEKAYLESFEHYTTLIQPGGALIIRKGISLQPKVQAGVRVYT
YSRDEGDFHAENIRIGNGEIFIDFVAPDTRINNIQLGVPVSINIENGVAAMALAHLNGVTDEEIRQGMNSFRGVDRRFDF
KIKNDQVVFLSDYAHHPSEIKQSVLSIRELYKDKKITAIFQPHLYTRTRDFYQDFADSLSLLDEVILVDIYPARETPIPG
VTSKLIYDNLRPGIEKSMCKKEEILNILKDKNIEVLITLGAGDIDNYVPEIKKELEKMKNEERRTKN
>Mature_467_residues
MNIETIKSVYFVGAGGIGMSALVRYFLSKGKVVAGYDRTPTPLTENLIAEGAQIHYEENVRLIPEACKDKESTLVVLTPA
VPQEHEELVYFRNNGFEIQKRAQVLGTITHSSKGLCVAGTHGKTTTSTMTAHLFHQSHIECTAFLGGISKNYGTNLLLSQ
KSPYTVIEADEFDRSFHWLSPYMSVITATDPDHLDIYGTEKAYLESFEHYTTLIQPGGALIIRKGISLQPKVQAGVRVYT
YSRDEGDFHAENIRIGNGEIFIDFVAPDTRINNIQLGVPVSINIENGVAAMALAHLNGVTDEEIRQGMNSFRGVDRRFDF
KIKNDQVVFLSDYAHHPSEIKQSVLSIRELYKDKKITAIFQPHLYTRTRDFYQDFADSLSLLDEVILVDIYPARETPIPG
VTSKLIYDNLRPGIEKSMCKKEEILNILKDKNIEVLITLGAGDIDNYVPEIKKELEKMKNEERRTKN

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=480, Percent_Identity=28.75, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1790680, Length=289, Percent_Identity=26.643598615917, Blast_Score=99, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 52554; Mature: 52554

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIETIKSVYFVGAGGIGMSALVRYFLSKGKVVAGYDRTPTPLTENLIAEGAQIHYEENV
CCHHHEEEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCEEEEECCC
RLIPEACKDKESTLVVLTPAVPQEHEELVYFRNNGFEIQKRAQVLGTITHSSKGLCVAGT
EECCHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHEEEEECCCCEEEECC
HGKTTTSTMTAHLFHQSHIECTAFLGGISKNYGTNLLLSQKSPYTVIEADEFDRSFHWLS
CCCCCHHHHHHHHHHHCCCEEEEHHCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHH
PYMSVITATDPDHLDIYGTEKAYLESFEHYTTLIQPGGALIIRKGISLQPKVQAGVRVYT
HHHHHEECCCCCCEEEEECHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCCCEEEEE
YSRDEGDFHAENIRIGNGEIFIDFVAPDTRINNIQLGVPVSINIENGVAAMALAHLNGVT
EECCCCCEEECEEEECCCEEEEEEECCCCEECEEEECCEEEEEECCCHHHHHHHHHCCCC
DEEIRQGMNSFRGVDRRFDFKIKNDQVVFLSDYAHHPSEIKQSVLSIRELYKDKKITAIF
HHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEE
QPHLYTRTRDFYQDFADSLSLLDEVILVDIYPARETPIPGVTSKLIYDNLRPGIEKSMCK
CCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHH
KEEILNILKDKNIEVLITLGAGDIDNYVPEIKKELEKMKNEERRTKN
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIETIKSVYFVGAGGIGMSALVRYFLSKGKVVAGYDRTPTPLTENLIAEGAQIHYEENV
CCHHHEEEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCEEEEECCC
RLIPEACKDKESTLVVLTPAVPQEHEELVYFRNNGFEIQKRAQVLGTITHSSKGLCVAGT
EECCHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHEEEEECCCCEEEECC
HGKTTTSTMTAHLFHQSHIECTAFLGGISKNYGTNLLLSQKSPYTVIEADEFDRSFHWLS
CCCCCHHHHHHHHHHHCCCEEEEHHCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHH
PYMSVITATDPDHLDIYGTEKAYLESFEHYTTLIQPGGALIIRKGISLQPKVQAGVRVYT
HHHHHEECCCCCCEEEEECHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCCCEEEEE
YSRDEGDFHAENIRIGNGEIFIDFVAPDTRINNIQLGVPVSINIENGVAAMALAHLNGVT
EECCCCCEEECEEEECCCEEEEEEECCCCEECEEEECCEEEEEECCCHHHHHHHHHCCCC
DEEIRQGMNSFRGVDRRFDFKIKNDQVVFLSDYAHHPSEIKQSVLSIRELYKDKKITAIF
HHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEE
QPHLYTRTRDFYQDFADSLSLLDEVILVDIYPARETPIPGVTSKLIYDNLRPGIEKSMCK
CCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHH
KEEILNILKDKNIEVLITLGAGDIDNYVPEIKKELEKMKNEERRTKN
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA