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The map label for this gene is aslA [H]

Identifier: 29348742

GI number: 29348742

Start: 4287822

End: 4289357

Strand: Reverse

Name: aslA [H]

Synonym: BT_3333

Alternate gene names: 29348742

Gene position: 4289357-4287822 (Counterclockwise)

Preceding gene: 29348743

Following gene: 29348741

Centisome position: 68.52

GC content: 53.06

Gene sequence:

>1536_bases
ATGAAGAATGTCTCACGTTTACTACCGCTATTGCCCGGTATAGCCCTGCTGACCGGATGCAATCAGAAAGTACAAAAAGA
CAACGGACAAAACTCACAAAAGCCTAACATTATTTATATATTCGCGGACGACCTTGGCATAGGTGACCTTAGCTGCTACG
GAGCGACAAAGGTCAGTACTCCCCATATCGACCGCCTTGCCGGACAGGGCGTACAGTTCACCAACGCCTATGCAACTTCC
GCCACCAGTACCCCTTCCCGCTTCGGACTCCTGACAGGCATGTACCCGTGGCGACAGGAGAACACAGGCATCGCCCCCGG
AAACTCGGAACTAATCATCGACACCGCCTGCGTCACCATGGCCGATATGCTGAAAGAAGCAGGTTACGCCACCGGAGTTG
TCGGCAAATGGCATCTTGGACTCGGTCCGAAGGGAGGCACCGACTTCAACGGCCACATCACCCCCAACGCCCAAAGTATC
GGCTTCGACTACGAGTTCGTGATTCCGGCAACCGTAGACCGTGTCCCCTGTGTATTCGTCGAGAACGGACACGTGGTAGG
ACTCGACCCGAACGACCCGATCACAGTGAACTACGAGCATAAAGTAGGCGACTGGCCTACAGGCGAAGAGAACCCGGAAC
TCGTAAAACTAAAACCCAGTCAGGGACATAACAATACGATAATCAACGGCATCCCCCGCATCGGCTGGATGACCGGAGGT
AAGTCCGCTCTCTGGAAAGACGAGGACATCGCCGACATCATCACCAATAAAGCAAAAAGCTTCATCGTCTCCCATAAGGA
AGAACCTTTCTTCTTATATATGGGTACGCAGGACGTACACGTACCGCGCGTCCCACATCCCCGCTTCGCCGGGAAAAGCG
GTCTGGGAACCCGCGGAGACGTAATCCTGCAACTCGACTGGACCATCGGAGAGATCATGAACACCCTCGACAGCCTCCAG
CTGACGGACAACACCATCCTGATATTCACCAGCGACAATGGCCCCGTCATCGACGACGGCTACCAGGACCAAGCCTTTGA
ACGTCTCAACGGACATACCCCGATGGGTATTTACCGTGGTGGAAAGTACAGCGCTTACGAAGCCGGAACCCGCATTCCGT
TCATCGTCCGCTGGCCTGCCAAAGTGAAGCCGAACAAGCAACAGGCTCTCTTCTCACAAATCGATATCTTTGCCTCACTT
GCCGCTTTACTGAAACAACCGCTTCCGGAAGACGCAGCTCCTGACAGTCAGGAACATCTGAACACGCTTCTGGGAAAAGA
CTACACCAGTCGTGAATACATCGTACAGCAAAATCTCAATAATACGCTCGCCATCGTGAAAGGACAATGGAAGTACATCG
AACCGAGTGACGCCCCCGCCATCGAATACTGGACAAAAATGGAACTGGGCAATGACAGGCATCCCCAGCTGTACGATTTA
TCCGCCGATCCATCGGAGAAAAACAATGTAGCGAAACAGCATCCGGAAGTTGTCAGGGAGCTGTCCGAACTGCTTGAATC
GGTAAAGACAAGATAA

Upstream 100 bases:

>100_bases
AATGGACTATTTTGTATCACACCTGTACATTCCTGCTCACTCATTTCCGCCAATCCTCTTATCTTTGTGTTCAGTAATCA
CTCCATAAAAGACCAACATT

Downstream 100 bases:

>100_bases
CCAATGAGAATAGCAGATTTGTATTATTTTGTATCAATCTTGAATAATTCTATCCATATGAGAACAATCAATGCGTATAT
CTTTGCCATCGTAAATTCAA

Product: arylsulfatase A

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MKNVSRLLPLLPGIALLTGCNQKVQKDNGQNSQKPNIIYIFADDLGIGDLSCYGATKVSTPHIDRLAGQGVQFTNAYATS
ATSTPSRFGLLTGMYPWRQENTGIAPGNSELIIDTACVTMADMLKEAGYATGVVGKWHLGLGPKGGTDFNGHITPNAQSI
GFDYEFVIPATVDRVPCVFVENGHVVGLDPNDPITVNYEHKVGDWPTGEENPELVKLKPSQGHNNTIINGIPRIGWMTGG
KSALWKDEDIADIITNKAKSFIVSHKEEPFFLYMGTQDVHVPRVPHPRFAGKSGLGTRGDVILQLDWTIGEIMNTLDSLQ
LTDNTILIFTSDNGPVIDDGYQDQAFERLNGHTPMGIYRGGKYSAYEAGTRIPFIVRWPAKVKPNKQQALFSQIDIFASL
AALLKQPLPEDAAPDSQEHLNTLLGKDYTSREYIVQQNLNNTLAIVKGQWKYIEPSDAPAIEYWTKMELGNDRHPQLYDL
SADPSEKNNVAKQHPEVVRELSELLESVKTR

Sequences:

>Translated_511_residues
MKNVSRLLPLLPGIALLTGCNQKVQKDNGQNSQKPNIIYIFADDLGIGDLSCYGATKVSTPHIDRLAGQGVQFTNAYATS
ATSTPSRFGLLTGMYPWRQENTGIAPGNSELIIDTACVTMADMLKEAGYATGVVGKWHLGLGPKGGTDFNGHITPNAQSI
GFDYEFVIPATVDRVPCVFVENGHVVGLDPNDPITVNYEHKVGDWPTGEENPELVKLKPSQGHNNTIINGIPRIGWMTGG
KSALWKDEDIADIITNKAKSFIVSHKEEPFFLYMGTQDVHVPRVPHPRFAGKSGLGTRGDVILQLDWTIGEIMNTLDSLQ
LTDNTILIFTSDNGPVIDDGYQDQAFERLNGHTPMGIYRGGKYSAYEAGTRIPFIVRWPAKVKPNKQQALFSQIDIFASL
AALLKQPLPEDAAPDSQEHLNTLLGKDYTSREYIVQQNLNNTLAIVKGQWKYIEPSDAPAIEYWTKMELGNDRHPQLYDL
SADPSEKNNVAKQHPEVVRELSELLESVKTR
>Mature_511_residues
MKNVSRLLPLLPGIALLTGCNQKVQKDNGQNSQKPNIIYIFADDLGIGDLSCYGATKVSTPHIDRLAGQGVQFTNAYATS
ATSTPSRFGLLTGMYPWRQENTGIAPGNSELIIDTACVTMADMLKEAGYATGVVGKWHLGLGPKGGTDFNGHITPNAQSI
GFDYEFVIPATVDRVPCVFVENGHVVGLDPNDPITVNYEHKVGDWPTGEENPELVKLKPSQGHNNTIINGIPRIGWMTGG
KSALWKDEDIADIITNKAKSFIVSHKEEPFFLYMGTQDVHVPRVPHPRFAGKSGLGTRGDVILQLDWTIGEIMNTLDSLQ
LTDNTILIFTSDNGPVIDDGYQDQAFERLNGHTPMGIYRGGKYSAYEAGTRIPFIVRWPAKVKPNKQQALFSQIDIFASL
AALLKQPLPEDAAPDSQEHLNTLLGKDYTSREYIVQQNLNNTLAIVKGQWKYIEPSDAPAIEYWTKMELGNDRHPQLYDL
SADPSEKNNVAKQHPEVVRELSELLESVKTR

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=489, Percent_Identity=31.0838445807771, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI146229329, Length=489, Percent_Identity=31.0838445807771, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI6005990, Length=489, Percent_Identity=31.0838445807771, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI146229324, Length=489, Percent_Identity=31.0838445807771, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI31742482, Length=574, Percent_Identity=29.2682926829268, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI71852584, Length=525, Percent_Identity=26.6666666666667, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI157266309, Length=536, Percent_Identity=27.4253731343284, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI4503899, Length=441, Percent_Identity=29.4784580498866, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI45430057, Length=512, Percent_Identity=27.34375, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI146229327, Length=400, Percent_Identity=28.25, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI71852586, Length=338, Percent_Identity=28.1065088757396, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI53831991, Length=283, Percent_Identity=28.9752650176678, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI38569405, Length=535, Percent_Identity=25.2336448598131, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI58743319, Length=143, Percent_Identity=41.2587412587413, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI38569407, Length=393, Percent_Identity=27.4809160305344, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI59797060, Length=523, Percent_Identity=24.8565965583174, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI109389362, Length=126, Percent_Identity=38.8888888888889, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI39930577, Length=234, Percent_Identity=26.0683760683761, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790233, Length=513, Percent_Identity=25.7309941520468, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI87081924, Length=428, Percent_Identity=24.2990654205607, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790112, Length=112, Percent_Identity=35.7142857142857, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559078, Length=293, Percent_Identity=30.0341296928328, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI115533416, Length=510, Percent_Identity=24.3137254901961, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI115533418, Length=488, Percent_Identity=23.7704918032787, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24666109, Length=365, Percent_Identity=28.7671232876712, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281366397, Length=462, Percent_Identity=27.0562770562771, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI281366395, Length=462, Percent_Identity=27.0562770562771, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24666163, Length=462, Percent_Identity=27.0562770562771, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24666175, Length=412, Percent_Identity=26.9417475728155, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281363223, Length=110, Percent_Identity=40, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 56324; Mature: 56324

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00061 ADH_SHORT ; PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVSRLLPLLPGIALLTGCNQKVQKDNGQNSQKPNIIYIFADDLGIGDLSCYGATKVST
CCCHHHHHHHHCHHHHHHCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCC
PHIDRLAGQGVQFTNAYATSATSTPSRFGLLTGMYPWRQENTGIAPGNSELIIDTACVTM
CCHHHHHCCCCEEECCEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHH
ADMLKEAGYATGVVGKWHLGLGPKGGTDFNGHITPNAQSIGFDYEFVIPATVDRVPCVFV
HHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEECCCCHHCCCCEEEEECCCCCCCCEEEE
ENGHVVGLDPNDPITVNYEHKVGDWPTGEENPELVKLKPSQGHNNTIINGIPRIGWMTGG
ECCEEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCEECCCCCCEEECCC
KSALWKDEDIADIITNKAKSFIVSHKEEPFFLYMGTQDVHVPRVPHPRFAGKSGLGTRGD
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
VILQLDWTIGEIMNTLDSLQLTDNTILIFTSDNGPVIDDGYQDQAFERLNGHTPMGIYRG
EEEEECCCHHHHHHHHHCEEECCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEEC
GKYSAYEAGTRIPFIVRWPAKVKPNKQQALFSQIDIFASLAALLKQPLPEDAAPDSQEHL
CCEEHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
NTLLGKDYTSREYIVQQNLNNTLAIVKGQWKYIEPSDAPAIEYWTKMELGNDRHPQLYDL
HHHHCCCCCCCHHHHHCCCCCEEEEEECCEEEECCCCCCHHHHEEEECCCCCCCCEEEEC
SADPSEKNNVAKQHPEVVRELSELLESVKTR
CCCCCCCCCHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNVSRLLPLLPGIALLTGCNQKVQKDNGQNSQKPNIIYIFADDLGIGDLSCYGATKVST
CCCHHHHHHHHCHHHHHHCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCC
PHIDRLAGQGVQFTNAYATSATSTPSRFGLLTGMYPWRQENTGIAPGNSELIIDTACVTM
CCHHHHHCCCCEEECCEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHH
ADMLKEAGYATGVVGKWHLGLGPKGGTDFNGHITPNAQSIGFDYEFVIPATVDRVPCVFV
HHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEECCCCHHCCCCEEEEECCCCCCCCEEEE
ENGHVVGLDPNDPITVNYEHKVGDWPTGEENPELVKLKPSQGHNNTIINGIPRIGWMTGG
ECCEEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCEECCCCCCEEECCC
KSALWKDEDIADIITNKAKSFIVSHKEEPFFLYMGTQDVHVPRVPHPRFAGKSGLGTRGD
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
VILQLDWTIGEIMNTLDSLQLTDNTILIFTSDNGPVIDDGYQDQAFERLNGHTPMGIYRG
EEEEECCCHHHHHHHHHCEEECCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEEC
GKYSAYEAGTRIPFIVRWPAKVKPNKQQALFSQIDIFASLAALLKQPLPEDAAPDSQEHL
CCEEHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
NTLLGKDYTSREYIVQQNLNNTLAIVKGQWKYIEPSDAPAIEYWTKMELGNDRHPQLYDL
HHHHCCCCCCCHHHHHCCCCCEEEEEECCEEEECCCCCCHHHHEEEECCCCCCCCEEEEC
SADPSEKNNVAKQHPEVVRELSELLESVKTR
CCCCCCCCCHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]