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The map label for this gene is emrA [H]

Identifier: 29348203

GI number: 29348203

Start: 3464845

End: 3465936

Strand: Reverse

Name: emrA [H]

Synonym: BT_2794

Alternate gene names: 29348203

Gene position: 3465936-3464845 (Counterclockwise)

Preceding gene: 29348204

Following gene: 29348202

Centisome position: 55.36

GC content: 45.42

Gene sequence:

>1092_bases
ATGGAAACAATGGACAATAATACAATCTCCAGTACGCATCAGGAGAAAGCTAAGAAAATGAGAAAATTACGCCGCTGGCA
GATTATAGTAAGTCTGTTTGGAGTTGCTGTGATTGTTTGGGGAGTAATTGAAATTGTTTTTCTCTTTCTGGGCTATAAGC
AGACGGAAACCAGCAATGATGCGCAGATAGAGCAATATGTGTCACCTGTCAATCTGCGTGCATCGGGCTATATTAATAAG
ATTTATTTTACGGAACATCAGCAGGTACGTAAAGGTGATACCTTGCTGGTGCTGGACGACCGCGAATATAAAATCCGGGT
GATGGAAGCTGAGGCTGCATTGAAGGATGCGCAGGCAGGCGCCACTGTGATAAATGCTACCTTGCAGACTACACAAACGA
CTGCATCTGTGTATGATGCGTCTATAGCTGAAATAGAAATCCGGCTAGCAAAACTGGAGAAAGACCGTCAGCGGTATGAA
AATTTGGTCAAACGAAATGCGGCGACACCTATCCAGTTGGAACAGATTACAACAGAGTATGAAGCTACCTTTAAGAAGCT
GGAAGCAACCAGGCGCCAGCGGGAGGCGGCTCTTTCGGGAGTGAATGAAGTATCTCACCGTCGTGAGAATACGGAAGCTG
CCATCCAGCGTGCTACGGCTGCGCTTGAAATGGCACGGCTGAATCTTTCGTATACGGTTGTACTGGCTCCTTGCGATGGC
AAGTTAGGCAGACGTTCTCTGGAAGAAGGGCAGTTCATTACAGCAGGGCAATGCATTACATATATTCTGCCCGATACACA
AAAATGGATTATTGCTAATTATAAAGAAACGCAGATAGAGAATCTCCGCATCGGGCAGGAGGTGGCTATCACGGTAGATG
CTATCAGTAAGAAAGAGTTTACAGGCAAAGTGACTGCTATTTCCGGAGCGACAGGTTCTAAATATTCGTTGGTGCCGACT
GACAATTCTGCCGGAAACTTTGTGAAAATACAGCAGCGTATCCCTGTCCGTATTGATTTTACGGATTTATCGAAGGAAGA
TAATGATAAGCTGGCGGCGGGTATGATGGTAGTAGTAAAAGCTAAACTCTGA

Upstream 100 bases:

>100_bases
TGCACATTATAATTATCGGGTGACCAACCTGATGTTACTGAAACTAACCGGACAGATCTCATCCTTGTTCAAATAACAGA
TAACTAATTGAATCATTCAT

Downstream 100 bases:

>100_bases
TAGCCATGCCTTCGTGTCCTAGAAATTATCCTTTTTACAATTGGGTGCCCAAACCGATAGGTATTATTATTCTGCTGTTC
TTTTTCCTGCCGATTCTTTC

Product: putative multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
METMDNNTISSTHQEKAKKMRKLRRWQIIVSLFGVAVIVWGVIEIVFLFLGYKQTETSNDAQIEQYVSPVNLRASGYINK
IYFTEHQQVRKGDTLLVLDDREYKIRVMEAEAALKDAQAGATVINATLQTTQTTASVYDASIAEIEIRLAKLEKDRQRYE
NLVKRNAATPIQLEQITTEYEATFKKLEATRRQREAALSGVNEVSHRRENTEAAIQRATAALEMARLNLSYTVVLAPCDG
KLGRRSLEEGQFITAGQCITYILPDTQKWIIANYKETQIENLRIGQEVAITVDAISKKEFTGKVTAISGATGSKYSLVPT
DNSAGNFVKIQQRIPVRIDFTDLSKEDNDKLAAGMMVVVKAKL

Sequences:

>Translated_363_residues
METMDNNTISSTHQEKAKKMRKLRRWQIIVSLFGVAVIVWGVIEIVFLFLGYKQTETSNDAQIEQYVSPVNLRASGYINK
IYFTEHQQVRKGDTLLVLDDREYKIRVMEAEAALKDAQAGATVINATLQTTQTTASVYDASIAEIEIRLAKLEKDRQRYE
NLVKRNAATPIQLEQITTEYEATFKKLEATRRQREAALSGVNEVSHRRENTEAAIQRATAALEMARLNLSYTVVLAPCDG
KLGRRSLEEGQFITAGQCITYILPDTQKWIIANYKETQIENLRIGQEVAITVDAISKKEFTGKVTAISGATGSKYSLVPT
DNSAGNFVKIQQRIPVRIDFTDLSKEDNDKLAAGMMVVVKAKL
>Mature_363_residues
METMDNNTISSTHQEKAKKMRKLRRWQIIVSLFGVAVIVWGVIEIVFLFLGYKQTETSNDAQIEQYVSPVNLRASGYINK
IYFTEHQQVRKGDTLLVLDDREYKIRVMEAEAALKDAQAGATVINATLQTTQTTASVYDASIAEIEIRLAKLEKDRQRYE
NLVKRNAATPIQLEQITTEYEATFKKLEATRRQREAALSGVNEVSHRRENTEAAIQRATAALEMARLNLSYTVVLAPCDG
KLGRRSLEEGQFITAGQCITYILPDTQKWIIANYKETQIENLRIGQEVAITVDAISKKEFTGKVTAISGATGSKYSLVPT
DNSAGNFVKIQQRIPVRIDFTDLSKEDNDKLAAGMMVVVKAKL

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=338, Percent_Identity=28.9940828402367, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788711, Length=289, Percent_Identity=28.719723183391, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1790519, Length=307, Percent_Identity=27.0358306188925, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790012, Length=306, Percent_Identity=24.5098039215686, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40746; Mature: 40746

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METMDNNTISSTHQEKAKKMRKLRRWQIIVSLFGVAVIVWGVIEIVFLFLGYKQTETSND
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AQIEQYVSPVNLRASGYINKIYFTEHQQVRKGDTLLVLDDREYKIRVMEAEAALKDAQAG
HHHHHHCCCCCEEECCCEEEEEEECCHHHCCCCEEEEEECCCEEEEEEEHHHHHHHHHCC
ATVINATLQTTQTTASVYDASIAEIEIRLAKLEKDRQRYENLVKRNAATPIQLEQITTEY
CEEEEEEHHHHHHHHHHHHCHHHHEEEHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHH
EATFKKLEATRRQREAALSGVNEVSHRRENTEAAIQRATAALEMARLNLSYTVVLAPCDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
KLGRRSLEEGQFITAGQCITYILPDTQKWIIANYKETQIENLRIGQEVAITVDAISKKEF
CCCCCCHHCCCEEEECCEEEEEECCCCEEEEECCCHHHHHHEECCCEEEEEEEECCCCCC
TGKVTAISGATGSKYSLVPTDNSAGNFVKIQQRIPVRIDFTDLSKEDNDKLAAGMMVVVK
CCEEEEEECCCCCEEEEEECCCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHCEEEEEE
AKL
ECC
>Mature Secondary Structure
METMDNNTISSTHQEKAKKMRKLRRWQIIVSLFGVAVIVWGVIEIVFLFLGYKQTETSND
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AQIEQYVSPVNLRASGYINKIYFTEHQQVRKGDTLLVLDDREYKIRVMEAEAALKDAQAG
HHHHHHCCCCCEEECCCEEEEEEECCHHHCCCCEEEEEECCCEEEEEEEHHHHHHHHHCC
ATVINATLQTTQTTASVYDASIAEIEIRLAKLEKDRQRYENLVKRNAATPIQLEQITTEY
CEEEEEEHHHHHHHHHHHHCHHHHEEEHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHH
EATFKKLEATRRQREAALSGVNEVSHRRENTEAAIQRATAALEMARLNLSYTVVLAPCDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
KLGRRSLEEGQFITAGQCITYILPDTQKWIIANYKETQIENLRIGQEVAITVDAISKKEF
CCCCCCHHCCCEEEECCEEEEEECCCCEEEEECCCHHHHHHEECCCEEEEEEEECCCCCC
TGKVTAISGATGSKYSLVPTDNSAGNFVKIQQRIPVRIDFTDLSKEDNDKLAAGMMVVVK
CCEEEEEECCCCCEEEEEECCCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHCEEEEEE
AKL
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]