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The map label for this gene is ziaA [H]

Identifier: 29347922

GI number: 29347922

Start: 3135864

End: 3137822

Strand: Reverse

Name: ziaA [H]

Synonym: BT_2512

Alternate gene names: 29347922

Gene position: 3137822-3135864 (Counterclockwise)

Preceding gene: 29347924

Following gene: 29347921

Centisome position: 50.12

GC content: 44.92

Gene sequence:

>1959_bases
ATGATTATGGGACATTGTAGTTGTTGCGCACATACACACGAATGTGCACCCGAAAAACATATTGAAAAGAAAGAATCAAT
ATTCGCTGAATATTGGAAAGTGGGACTTTCATTTATCCTGTTGATAAGTGGAATCATCATGAACGCTCTGGAGTTACCTT
TCTTCCGTGAAGGATATTTCTCTCTGATATGGTATGTCGTGGCTTATCTTCCGGTCGGCCTGCCCGTTATGAAAGAGGCT
TGGGAGAGTATGAAGGATAAGGACTATTTCAGTGAGTTTACGCTGATGTTTGTAGCTACGCTTGGAGCGTTTTATATCGG
TGAATATCCGGAGGGAGTAGCGGTGATGTTGTTTTACTCCGTCGGAGAACTGTTTCAGGAGAAGGCTGTTGATAAGGCGA
AGCGTAATATCGGAGCTCTGCTGGATGTCCGTCCGGAAGAAGCGGCAGTAGTCAGAGATGAACGTGTCGTTATTGAGAAT
CCTCAAAGCGTAAAAGTAGGAGAAACAATTGAAATAAAGACAGGAGGAAGAGTTCCTTTGGATGGAATGATGCTCAATGA
GGTAGCTGCTTTCAATACGGCAGCATTGACAGGCGAGAGTGTCCCCCGAAGTATCCGGATGGGTGAGGAAGTACTTGCCG
GAATGATTGTTACCGATAAAGTAATCCGTATCAAGGTGATCAGACCTTTTGATAAAAGTGCTCTTGCCCGTATTCTGGAA
CTTGTTCAGAATGCCTCCGAACGCAAAGCACCGGCAGAACTGTTTATCCGTAAATTTGCCCGTGTTTATACTCCGATTGT
GATAGGGCTGGCGGTTCTGATTGTTTTATTGCCGTTTATTTATTCCTTGATCACTCCCCAGTTCTTATTTACTTTTAATG
ACTGGCTATACAGGGCTTTGGTCTTTCTTGTGATTTCATGCCCGTGCGCTTTGGTGGTCAGTATTCCGTTAGGATACTTC
GGAGGCATCGGGGCAGCTTCCCGGTTGGGAATTTTATTTAAAGGTGGAAATTATCTGGATGCTGTTACGAAGATTAATAC
AGTCGTGTTTGATAAGACGGGAACCCTTACCAAAGGTACGTTTGAAGTACAGTTTTGTAACTGTGAATCCGGTGTATCCG
AAGAAGAATTAATCCGGATGATAGCCTCGGTAGAAAGCAGCAGTACACACCCCATTGCTAAGGCTGTGGTGAATTATGCC
GGACAGCGGGATATCGAGCTTTCCTCTGTAACCGACAGTAAGGAGTATGCAGGTCTCGGACTGGAAGCTGCCGTAAATGG
AATTCAGGTTTTGGCAGGTAATGGGCGTTTGCTTTCAAAATTTCAGATAGAATATCCGCCCGAACTTCTTTCCATTACAG
ATACGATCGTTGTCTGTGCGATAGGAAACAAGTATGCCGGTTATCTGCTATTATCCGACAGTCTGAAAGAGGATGCAAAG
ATCGCCATTCAGAACCTGAAAGCATTGGGAATTCAAAACATTCAGATATTATCCGGTGATAAACAAAGTATTGTTAGTAA
CTTTGCAGAGAAGCTGGGTATTTCGGAAGCCTATGGTGATCTGCTCCCCGATGGGAAAGTGAAGCATTTGGAAGAATTGC
GCCAACATACGGAGAACCAGGTTGCCTTTGTGGGCGACGGCATGAATGATGCTCCGGTACTGGCTTTAAGTAATGTAGGT
ATTGCCATGGGCGGACTAGGCAGTGATGCGGCTATTGAAACGGCTGATGTGGTGATACAGACCGACCAGCCTTCCAAAGT
GGCTGAAGCGATAAAGGTAGGAAAACTGACGCGAAGGATTGTATGGCAGAATATTTCACTGGCGTTTGGTGTGAAACTGC
TGGTACTGATTTTGGGAGCCGGTGGACTGGCTACACTTTGGGAAGCTGTTTTCGCCGATGTTGGTGTAGCACTGATTGCT
ATCATGAATGCCGTAAGGATACAGAAAATGATAAAATAA

Upstream 100 bases:

>100_bases
CCCTTGAACGATATTTATTTGGAGATTGGCTGTGGCGTCTTCTTTTGCAACTTTGTTGCACGAATCATTCGCTACCTTTG
CAGCAGATAAAAAAGAAAGA

Downstream 100 bases:

>100_bases
AAGAATATGGAAGAAAAAGTTTATCTGGATAAGTTGGCAAAAAGAGACATCAAGCCGACGGCTATCAGACTTCTCATATT
GAAAAGTATGATGGAAGCGG

Product: cation-transporting ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 652; Mature: 652

Protein sequence:

>652_residues
MIMGHCSCCAHTHECAPEKHIEKKESIFAEYWKVGLSFILLISGIIMNALELPFFREGYFSLIWYVVAYLPVGLPVMKEA
WESMKDKDYFSEFTLMFVATLGAFYIGEYPEGVAVMLFYSVGELFQEKAVDKAKRNIGALLDVRPEEAAVVRDERVVIEN
PQSVKVGETIEIKTGGRVPLDGMMLNEVAAFNTAALTGESVPRSIRMGEEVLAGMIVTDKVIRIKVIRPFDKSALARILE
LVQNASERKAPAELFIRKFARVYTPIVIGLAVLIVLLPFIYSLITPQFLFTFNDWLYRALVFLVISCPCALVVSIPLGYF
GGIGAASRLGILFKGGNYLDAVTKINTVVFDKTGTLTKGTFEVQFCNCESGVSEEELIRMIASVESSSTHPIAKAVVNYA
GQRDIELSSVTDSKEYAGLGLEAAVNGIQVLAGNGRLLSKFQIEYPPELLSITDTIVVCAIGNKYAGYLLLSDSLKEDAK
IAIQNLKALGIQNIQILSGDKQSIVSNFAEKLGISEAYGDLLPDGKVKHLEELRQHTENQVAFVGDGMNDAPVLALSNVG
IAMGGLGSDAAIETADVVIQTDQPSKVAEAIKVGKLTRRIVWQNISLAFGVKLLVLILGAGGLATLWEAVFADVGVALIA
IMNAVRIQKMIK

Sequences:

>Translated_652_residues
MIMGHCSCCAHTHECAPEKHIEKKESIFAEYWKVGLSFILLISGIIMNALELPFFREGYFSLIWYVVAYLPVGLPVMKEA
WESMKDKDYFSEFTLMFVATLGAFYIGEYPEGVAVMLFYSVGELFQEKAVDKAKRNIGALLDVRPEEAAVVRDERVVIEN
PQSVKVGETIEIKTGGRVPLDGMMLNEVAAFNTAALTGESVPRSIRMGEEVLAGMIVTDKVIRIKVIRPFDKSALARILE
LVQNASERKAPAELFIRKFARVYTPIVIGLAVLIVLLPFIYSLITPQFLFTFNDWLYRALVFLVISCPCALVVSIPLGYF
GGIGAASRLGILFKGGNYLDAVTKINTVVFDKTGTLTKGTFEVQFCNCESGVSEEELIRMIASVESSSTHPIAKAVVNYA
GQRDIELSSVTDSKEYAGLGLEAAVNGIQVLAGNGRLLSKFQIEYPPELLSITDTIVVCAIGNKYAGYLLLSDSLKEDAK
IAIQNLKALGIQNIQILSGDKQSIVSNFAEKLGISEAYGDLLPDGKVKHLEELRQHTENQVAFVGDGMNDAPVLALSNVG
IAMGGLGSDAAIETADVVIQTDQPSKVAEAIKVGKLTRRIVWQNISLAFGVKLLVLILGAGGLATLWEAVFADVGVALIA
IMNAVRIQKMIK
>Mature_652_residues
MIMGHCSCCAHTHECAPEKHIEKKESIFAEYWKVGLSFILLISGIIMNALELPFFREGYFSLIWYVVAYLPVGLPVMKEA
WESMKDKDYFSEFTLMFVATLGAFYIGEYPEGVAVMLFYSVGELFQEKAVDKAKRNIGALLDVRPEEAAVVRDERVVIEN
PQSVKVGETIEIKTGGRVPLDGMMLNEVAAFNTAALTGESVPRSIRMGEEVLAGMIVTDKVIRIKVIRPFDKSALARILE
LVQNASERKAPAELFIRKFARVYTPIVIGLAVLIVLLPFIYSLITPQFLFTFNDWLYRALVFLVISCPCALVVSIPLGYF
GGIGAASRLGILFKGGNYLDAVTKINTVVFDKTGTLTKGTFEVQFCNCESGVSEEELIRMIASVESSSTHPIAKAVVNYA
GQRDIELSSVTDSKEYAGLGLEAAVNGIQVLAGNGRLLSKFQIEYPPELLSITDTIVVCAIGNKYAGYLLLSDSLKEDAK
IAIQNLKALGIQNIQILSGDKQSIVSNFAEKLGISEAYGDLLPDGKVKHLEELRQHTENQVAFVGDGMNDAPVLALSNVG
IAMGGLGSDAAIETADVVIQTDQPSKVAEAIKVGKLTRRIVWQNISLAFGVKLLVLILGAGGLATLWEAVFADVGVALIA
IMNAVRIQKMIK

Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=593, Percent_Identity=27.8246205733558, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI115529486, Length=736, Percent_Identity=25.5434782608696, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI55743073, Length=540, Percent_Identity=28.3333333333333, Blast_Score=185, Evalue=1e-46,
Organism=Escherichia coli, GI1789879, Length=614, Percent_Identity=36.4820846905537, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI1786691, Length=552, Percent_Identity=32.2463768115942, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786914, Length=467, Percent_Identity=24.1970021413276, Blast_Score=106, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17556548, Length=389, Percent_Identity=27.7634961439589, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320475, Length=635, Percent_Identity=28.0314960629921, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6319772, Length=482, Percent_Identity=24.2738589211618, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321271, Length=160, Percent_Identity=30.625, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221329854, Length=316, Percent_Identity=27.2151898734177, Blast_Score=112, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 71057; Mature: 71057

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMGHCSCCAHTHECAPEKHIEKKESIFAEYWKVGLSFILLISGIIMNALELPFFREGYF
CCCCCCHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SLIWYVVAYLPVGLPVMKEAWESMKDKDYFSEFTLMFVATLGAFYIGEYPEGVAVMLFYS
HHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VGELFQEKAVDKAKRNIGALLDVRPEEAAVVRDERVVIENPQSVKVGETIEIKTGGRVPL
HHHHHHHHHHHHHHHCCCCEEECCCCHHHHEECCEEEEECCCCEECCCEEEEECCCCCCC
DGMMLNEVAAFNTAALTGESVPRSIRMGEEVLAGMIVTDKVIRIKVIRPFDKSALARILE
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHH
LVQNASERKAPAELFIRKFARVYTPIVIGLAVLIVLLPFIYSLITPQFLFTFNDWLYRAL
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
VFLVISCPCALVVSIPLGYFGGIGAASRLGILFKGGNYLDAVTKINTVVFDKTGTLTKGT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCEEEEECCCHHHHHHHHHEEEEECCCCEECCE
FEVQFCNCESGVSEEELIRMIASVESSSTHPIAKAVVNYAGQRDIELSSVTDSKEYAGLG
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEECCCCCCHHHCCCC
LEAAVNGIQVLAGNGRLLSKFQIEYPPELLSITDTIVVCAIGNKYAGYLLLSDSLKEDAK
HHHHHCCEEEEECCCCEEEEEEECCCHHHHHHHCEEEEEEECCCCEEEEEEECCCCHHHH
IAIQNLKALGIQNIQILSGDKQSIVSNFAEKLGISEAYGDLLPDGKVKHLEELRQHTENQ
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCC
VAFVGDGMNDAPVLALSNVGIAMGGLGSDAAIETADVVIQTDQPSKVAEAIKVGKLTRRI
EEEEECCCCCCCEEEEECCCEEECCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHH
VWQNISLAFGVKLLVLILGAGGLATLWEAVFADVGVALIAIMNAVRIQKMIK
HHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIMGHCSCCAHTHECAPEKHIEKKESIFAEYWKVGLSFILLISGIIMNALELPFFREGYF
CCCCCCHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SLIWYVVAYLPVGLPVMKEAWESMKDKDYFSEFTLMFVATLGAFYIGEYPEGVAVMLFYS
HHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
VGELFQEKAVDKAKRNIGALLDVRPEEAAVVRDERVVIENPQSVKVGETIEIKTGGRVPL
HHHHHHHHHHHHHHHCCCCEEECCCCHHHHEECCEEEEECCCCEECCCEEEEECCCCCCC
DGMMLNEVAAFNTAALTGESVPRSIRMGEEVLAGMIVTDKVIRIKVIRPFDKSALARILE
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHH
LVQNASERKAPAELFIRKFARVYTPIVIGLAVLIVLLPFIYSLITPQFLFTFNDWLYRAL
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
VFLVISCPCALVVSIPLGYFGGIGAASRLGILFKGGNYLDAVTKINTVVFDKTGTLTKGT
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCEEEEECCCHHHHHHHHHEEEEECCCCEECCE
FEVQFCNCESGVSEEELIRMIASVESSSTHPIAKAVVNYAGQRDIELSSVTDSKEYAGLG
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEECCCCCCHHHCCCC
LEAAVNGIQVLAGNGRLLSKFQIEYPPELLSITDTIVVCAIGNKYAGYLLLSDSLKEDAK
HHHHHCCEEEEECCCCEEEEEEECCCHHHHHHHCEEEEEEECCCCEEEEEEECCCCHHHH
IAIQNLKALGIQNIQILSGDKQSIVSNFAEKLGISEAYGDLLPDGKVKHLEELRQHTENQ
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCC
VAFVGDGMNDAPVLALSNVGIAMGGLGSDAAIETADVVIQTDQPSKVAEAIKVGKLTRRI
EEEEECCCCCCCEEEEECCCEEECCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHH
VWQNISLAFGVKLLVLILGAGGLATLWEAVFADVGVALIAIMNAVRIQKMIK
HHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]