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The map label for this gene is metA

Identifier: 29347823

GI number: 29347823

Start: 3014212

End: 3015129

Strand: Reverse

Name: metA

Synonym: BT_2413

Alternate gene names: 29347823

Gene position: 3015129-3014212 (Counterclockwise)

Preceding gene: 29347825

Following gene: 29347822

Centisome position: 48.16

GC content: 46.3

Gene sequence:

>918_bases
ATGCCTTTAAATTTACCCGATAAGCTTCCTGCAATAGAATTATTGAAGGAAGAGAATATTTTCGTAATTGATACTTCGCG
TGCTACGCAACAGGATATTCGTCCGTTGCGGATTGTGATTCTGAACCTGATGCCGTTGAAGATTACAACGGAAACAGACT
TGGTGCGGCTGCTCTCGAATACGCCTCTCCAGGTAGAAATCTCGTTTATGAAGATCAAGAGTCATACATCCAAGAATACG
CCGATAGAACATATGCAAACGTTCTATACCGACTTCGAGCAAATGCGTAACGAGAAATACGACGGCATGATCATCACCGG
TGCTCCTGTGGAACAGATGGACTTCGAGGAGGTGACTTATTGGGAGGAAATTACTGAAATATTTGATTGGGCACGTACGC
ACGTGACGTCTACCTTATATATATGCTGGGCTGCGCAAGCCGGACTGTATCATCACTACGGAGTTCCCAAGTATCCACTG
GACCAGAAAATGTTCGGTATCTTCGAACATCGGGTGCTGGAACCTTTCCATTCTATTTTCCGCGGATTTGACGATTGCTT
CTATGTGCCGCATAGCCGCCATACGGAAGTACGCAGGGAAGATATCCTCAAAGTGCCGGAACTGACATTGCTTTCCGAAT
CGAAAGATGCGGGCGTTTATATGGCTATGGCACGTGGCGGACGTGAGTTCTTCGTGACCGGACACTCGGAATACTCTCCC
TATACCTTGGATACGGAATATCGTCGTGATCTGGGTAAAGGACTGCCGATCGAAATTCCCCGTAACTATTACGTAGATGA
TGATCCGGACAAAGGTCCGTTGGTCCGTTGGCGCGCTCATGCCAACCTTTTGTTCTCCAACTGGCTGAACTACTTTGTTT
ATCAGGAAACGCCTTACAACATTAATGATATTGAATGA

Upstream 100 bases:

>100_bases
TTAAATTGACTTAATTTGTACGTCTTCTAAATAAGCAACCTCCCTATTATGTGCTATATTTTTCGTATTTTTGCAGCCAA
ATTACTAATATATAGCGATT

Downstream 100 bases:

>100_bases
TCAAGCAGCGTAAAATAGAACTTCTCGCCCCGGCGAAGAATCTGGAATGTGGTATCGAAGCTATCAATCACGGAGCAGAT
GCCGTATATATCGGTGCACC

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MPLNLPDKLPAIELLKEENIFVIDTSRATQQDIRPLRIVILNLMPLKITTETDLVRLLSNTPLQVEISFMKIKSHTSKNT
PIEHMQTFYTDFEQMRNEKYDGMIITGAPVEQMDFEEVTYWEEITEIFDWARTHVTSTLYICWAAQAGLYHHYGVPKYPL
DQKMFGIFEHRVLEPFHSIFRGFDDCFYVPHSRHTEVRREDILKVPELTLLSESKDAGVYMAMARGGREFFVTGHSEYSP
YTLDTEYRRDLGKGLPIEIPRNYYVDDDPDKGPLVRWRAHANLLFSNWLNYFVYQETPYNINDIE

Sequences:

>Translated_305_residues
MPLNLPDKLPAIELLKEENIFVIDTSRATQQDIRPLRIVILNLMPLKITTETDLVRLLSNTPLQVEISFMKIKSHTSKNT
PIEHMQTFYTDFEQMRNEKYDGMIITGAPVEQMDFEEVTYWEEITEIFDWARTHVTSTLYICWAAQAGLYHHYGVPKYPL
DQKMFGIFEHRVLEPFHSIFRGFDDCFYVPHSRHTEVRREDILKVPELTLLSESKDAGVYMAMARGGREFFVTGHSEYSP
YTLDTEYRRDLGKGLPIEIPRNYYVDDDPDKGPLVRWRAHANLLFSNWLNYFVYQETPYNINDIE
>Mature_304_residues
PLNLPDKLPAIELLKEENIFVIDTSRATQQDIRPLRIVILNLMPLKITTETDLVRLLSNTPLQVEISFMKIKSHTSKNTP
IEHMQTFYTDFEQMRNEKYDGMIITGAPVEQMDFEEVTYWEEITEIFDWARTHVTSTLYICWAAQAGLYHHYGVPKYPLD
QKMFGIFEHRVLEPFHSIFRGFDDCFYVPHSRHTEVRREDILKVPELTLLSESKDAGVYMAMARGGREFFVTGHSEYSPY
TLDTEYRRDLGKGLPIEIPRNYYVDDDPDKGPLVRWRAHANLLFSNWLNYFVYQETPYNINDIE

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=301, Percent_Identity=47.5083056478405, Blast_Score=325, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_BACTN (Q8A531)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_811326.1
- ProteinModelPortal:   Q8A531
- SMR:   Q8A531
- GeneID:   1073610
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_2413
- NMPDR:   fig|226186.1.peg.2413
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- PhylomeDB:   Q8A531
- ProtClustDB:   PRK05368
- BioCyc:   BTHE226186:BT_2413-MONOMER
- BRENDA:   2.3.1.46
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35903; Mature: 35772

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNLPDKLPAIELLKEENIFVIDTSRATQQDIRPLRIVILNLMPLKITTETDLVRLLSN
CCCCCCCCCCHHHHHCCCCEEEEECCCCCHHHCHHHEEHEEHEECEEEECHHHHHHHHCC
TPLQVEISFMKIKSHTSKNTPIEHMQTFYTDFEQMRNEKYDGMIITGAPVEQMDFEEVTY
CCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHH
WEEITEIFDWARTHVTSTLYICWAAQAGLYHHYGVPKYPLDQKMFGIFEHRVLEPFHSIF
HHHHHHHHHHHHHHHHHEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RGFDDCFYVPHSRHTEVRREDILKVPELTLLSESKDAGVYMAMARGGREFFVTGHSEYSP
CCCCCEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCEEEEECCCCCCC
YTLDTEYRRDLGKGLPIEIPRNYYVDDDPDKGPLVRWRAHANLLFSNWLNYFVYQETPYN
EEECHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHEEEEECCCCC
INDIE
CCCCC
>Mature Secondary Structure 
PLNLPDKLPAIELLKEENIFVIDTSRATQQDIRPLRIVILNLMPLKITTETDLVRLLSN
CCCCCCCCCHHHHHCCCCEEEEECCCCCHHHCHHHEEHEEHEECEEEECHHHHHHHHCC
TPLQVEISFMKIKSHTSKNTPIEHMQTFYTDFEQMRNEKYDGMIITGAPVEQMDFEEVTY
CCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHH
WEEITEIFDWARTHVTSTLYICWAAQAGLYHHYGVPKYPLDQKMFGIFEHRVLEPFHSIF
HHHHHHHHHHHHHHHHHEEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RGFDDCFYVPHSRHTEVRREDILKVPELTLLSESKDAGVYMAMARGGREFFVTGHSEYSP
CCCCCEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCEEEEECCCCCCC
YTLDTEYRRDLGKGLPIEIPRNYYVDDDPDKGPLVRWRAHANLLFSNWLNYFVYQETPYN
EEECHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHEEEEECCCCC
INDIE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928