Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 29347811

GI number: 29347811

Start: 2996511

End: 2997812

Strand: Reverse

Name: thrC [H]

Synonym: BT_2401

Alternate gene names: 29347811

Gene position: 2997812-2996511 (Counterclockwise)

Preceding gene: 29347812

Following gene: 29347810

Centisome position: 47.89

GC content: 45.39

Gene sequence:

>1302_bases
ATGAAATACTATAGTACAAATAAACAAGCGCCGATGGCTTCTTTGCAGGAGGCTGTAGTAAAAGGGCTTGCCGCCGACAG
AGGACTTTTCATGCCAATGACTATCAAGCCTCTTCCCCAAGAATTTTACGATACGATAGATACTTTGTCTTTTCAGGAGA
TTGCTTATCGGGTAGCCGATGCTTTCTTTGGCGAAGACATCCCCACCGATACACTGAAACAAATAGTGTATGACACATTG
AGCTTTGATGTACCGTTGGTGAAAGTGGCGGACAACATCTATTCTCTGGAACTTTTCCACGGACCGACTCTGGCTTTCAA
AGATGTAGGCGGCCGTTTTATGGCACGTTTGCTGGGTTACTTCATCAAGAAAGAAGGGCAGAAGGATGTGAATGTGCTGG
TAGCGACTTCCGGTGATACGGGAAGTGCCGTTGCCAACGGTTTTCTGGGTGTGGAAGGTATTCATGTATATGTACTTTAC
CCGAAAGGAAAAGTCAGCGAAATACAGGAAAAGCAGTTCACTACTTTGGGACAGAATATTACCGCTCTCGAAGTGGACGG
AACGTTTGATGATTGCCAGGCACTGGTAAAAGCTGCTTTCATGGATAAGGAACTGAATGAACATCTGTCACTGACTTCCG
CCAATTCTATCAATGTAGCCCGCTTCCTGCCGCAAGCATTCTATTATTTCTATGCTTATGCACAGCTGAAACGTGCCGGA
AAAGCCGATAATGCCGTGATTTGTGTTCCTAGCGGAAACTTCGGAAACATCACAGCCGGATTGTTCGGCAAAAAGATGGG
CTTGCCTGTCAAACGTTTTATTGCTGCCAACAATCGCAACGATATATTCTATCAATACCTGCAAACAGGTAAATATAATC
CCCGCCCATCCGTTGCAACCATAGCCAACGCTATGGACGTAGGTGATCCGAGCAACTTTGCCCGTGTGCTTGACTTGTAT
GGCGGTTCTCATGCTGACATTTCTGCTGAGATTTCGGGAACTACATATACCGACGAACAGATTCGCGAAACGGTGAAAGA
AACCTGGAAGGAACATCATTACCTGCTCGATCCTCATGGAGCTTGCGGTTATCGCGCTTTGCAAGAAGGACTGAAACAAG
GCGAAACGGGAGTCTTCCTTGAAACTGCTCATCCTGCTAAATTCCTGGAAACTGTAGAAAGTATCATTGGCGAAGCGGTA
GAAATACCTGCCAAGTTGCAGGAATTTATGAAAGGGGAGAAAAAGAGCTTGCAAATGACGAAAGAATTTGCAGACTTCAA
GAAGTATTTGCTTTCTGTTTGA

Upstream 100 bases:

>100_bases
AAGTGCAGACGTATGACGAGATATCGGCTTGCGATGGCAGTTACGGTGTGCTGAAAGAAGATGAGTTTATAAAAGAATTT
ATGAATCAAAAGAATATCCA

Downstream 100 bases:

>100_bases
TTGGGTTTTAAAGCAAGGTGTAAAAGAAATAATTATGCAAGATATAGTAAACGGACGCTGTGGTTGGTGTGGAACCGACG
AACTGTATGTGAAATATCAT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKYYSTNKQAPMASLQEAVVKGLAADRGLFMPMTIKPLPQEFYDTIDTLSFQEIAYRVADAFFGEDIPTDTLKQIVYDTL
SFDVPLVKVADNIYSLELFHGPTLAFKDVGGRFMARLLGYFIKKEGQKDVNVLVATSGDTGSAVANGFLGVEGIHVYVLY
PKGKVSEIQEKQFTTLGQNITALEVDGTFDDCQALVKAAFMDKELNEHLSLTSANSINVARFLPQAFYYFYAYAQLKRAG
KADNAVICVPSGNFGNITAGLFGKKMGLPVKRFIAANNRNDIFYQYLQTGKYNPRPSVATIANAMDVGDPSNFARVLDLY
GGSHADISAEISGTTYTDEQIRETVKETWKEHHYLLDPHGACGYRALQEGLKQGETGVFLETAHPAKFLETVESIIGEAV
EIPAKLQEFMKGEKKSLQMTKEFADFKKYLLSV

Sequences:

>Translated_433_residues
MKYYSTNKQAPMASLQEAVVKGLAADRGLFMPMTIKPLPQEFYDTIDTLSFQEIAYRVADAFFGEDIPTDTLKQIVYDTL
SFDVPLVKVADNIYSLELFHGPTLAFKDVGGRFMARLLGYFIKKEGQKDVNVLVATSGDTGSAVANGFLGVEGIHVYVLY
PKGKVSEIQEKQFTTLGQNITALEVDGTFDDCQALVKAAFMDKELNEHLSLTSANSINVARFLPQAFYYFYAYAQLKRAG
KADNAVICVPSGNFGNITAGLFGKKMGLPVKRFIAANNRNDIFYQYLQTGKYNPRPSVATIANAMDVGDPSNFARVLDLY
GGSHADISAEISGTTYTDEQIRETVKETWKEHHYLLDPHGACGYRALQEGLKQGETGVFLETAHPAKFLETVESIIGEAV
EIPAKLQEFMKGEKKSLQMTKEFADFKKYLLSV
>Mature_433_residues
MKYYSTNKQAPMASLQEAVVKGLAADRGLFMPMTIKPLPQEFYDTIDTLSFQEIAYRVADAFFGEDIPTDTLKQIVYDTL
SFDVPLVKVADNIYSLELFHGPTLAFKDVGGRFMARLLGYFIKKEGQKDVNVLVATSGDTGSAVANGFLGVEGIHVYVLY
PKGKVSEIQEKQFTTLGQNITALEVDGTFDDCQALVKAAFMDKELNEHLSLTSANSINVARFLPQAFYYFYAYAQLKRAG
KADNAVICVPSGNFGNITAGLFGKKMGLPVKRFIAANNRNDIFYQYLQTGKYNPRPSVATIANAMDVGDPSNFARVLDLY
GGSHADISAEISGTTYTDEQIRETVKETWKEHHYLLDPHGACGYRALQEGLKQGETGVFLETAHPAKFLETVESIIGEAV
EIPAKLQEFMKGEKKSLQMTKEFADFKKYLLSV

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=459, Percent_Identity=33.1154684095861, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI153792148, Length=424, Percent_Identity=30.4245283018868, Blast_Score=175, Evalue=7e-44,
Organism=Escherichia coli, GI1786185, Length=432, Percent_Identity=44.4444444444444, Blast_Score=357, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6319901, Length=457, Percent_Identity=36.980306345733, Blast_Score=272, Evalue=6e-74,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 47961; Mature: 47961

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYYSTNKQAPMASLQEAVVKGLAADRGLFMPMTIKPLPQEFYDTIDTLSFQEIAYRVAD
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCEECCCCCHHHHHHHHCCHHHHHHHHHHH
AFFGEDIPTDTLKQIVYDTLSFDVPLVKVADNIYSLELFHGPTLAFKDVGGRFMARLLGY
HHHCCCCCHHHHHHHHHHHHHCCCCHHHHHCCEEEEEEECCCCCHHHHCCHHHHHHHHHH
FIKKEGQKDVNVLVATSGDTGSAVANGFLGVEGIHVYVLYPKGKVSEIQEKQFTTLGQNI
HHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCE
TALEVDGTFDDCQALVKAAFMDKELNEHLSLTSANSINVARFLPQAFYYFYAYAQLKRAG
EEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
KADNAVICVPSGNFGNITAGLFGKKMGLPVKRFIAANNRNDIFYQYLQTGKYNPRPSVAT
CCCCEEEEEECCCCCCEEHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHH
IANAMDVGDPSNFARVLDLYGGSHADISAEISGTTYTDEQIRETVKETWKEHHYLLDPHG
HHHHHCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCCC
ACGYRALQEGLKQGETGVFLETAHPAKFLETVESIIGEAVEIPAKLQEFMKGEKKSLQMT
CCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHH
KEFADFKKYLLSV
HHHHHHHHHHHCC
>Mature Secondary Structure
MKYYSTNKQAPMASLQEAVVKGLAADRGLFMPMTIKPLPQEFYDTIDTLSFQEIAYRVAD
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCEECCCCCHHHHHHHHCCHHHHHHHHHHH
AFFGEDIPTDTLKQIVYDTLSFDVPLVKVADNIYSLELFHGPTLAFKDVGGRFMARLLGY
HHHCCCCCHHHHHHHHHHHHHCCCCHHHHHCCEEEEEEECCCCCHHHHCCHHHHHHHHHH
FIKKEGQKDVNVLVATSGDTGSAVANGFLGVEGIHVYVLYPKGKVSEIQEKQFTTLGQNI
HHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCE
TALEVDGTFDDCQALVKAAFMDKELNEHLSLTSANSINVARFLPQAFYYFYAYAQLKRAG
EEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
KADNAVICVPSGNFGNITAGLFGKKMGLPVKRFIAANNRNDIFYQYLQTGKYNPRPSVAT
CCCCEEEEEECCCCCCEEHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHH
IANAMDVGDPSNFARVLDLYGGSHADISAEISGTTYTDEQIRETVKETWKEHHYLLDPHG
HHHHHCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCCC
ACGYRALQEGLKQGETGVFLETAHPAKFLETVESIIGEAVEIPAKLQEFMKGEKKSLQMT
CCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHH
KEFADFKKYLLSV
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]